tv PODKAST 1TV January 17, 2024 1:35am-2:31am MSK
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an auxiliary option, in this sense we usually compare the cerebral cortex and the cortex of the cerebral hemispheres, and the cerebral cortex is promotional skills, the cerebral hemisphere is rather a sensory , sensory emotional association, well , including working with words, and so motor skills without them no way at all, that’s why some shark has a man no worse than ours, in my childhood this is the same thing, when they wanted to offend or i wanted to offend, they said, remember about the convolutions, there are not enough convolutions, the convolutions will be like fingerprints, this is this
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on... that is, folding is needed simply in order to put into this head something that generally speaking does not fit there, just like folds in mitochondria, yes, why do you need cristae, to put more of these same enzymes in order for it to go oxidative phosphorylation, approximately in general , very often the idea of folding, it is used by nature, but folding does not develop as such, still, if you are born, when we are born, we are naive in a sense, but i don’t know if it is already there some connections or all connections are laid, their you just need...
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the formation of a network is the establishment of connections as a kind of rigid structure, when this neuron connects with this one, and not with another, this is what is meant, yes, yes, yes, a network means neurons that send out processes and form contacts with some nearby, sometimes very distant neurons, these are these swarming sets of these axons that grow somewhere and try to find, this really happens, this really
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happens, yes, this happens when these are not cockroaches in the head, these are neurons there somehow they whisper, crawl with dentritis, this is exactly what is happening in the child, most likely not, cockroaches in the head are, after all , impulses that run somewhere in the wrong place, we see the germination of processes in a small child for example , we observe when there was an injury , recovery is underway, well, let’s say in a person, this is despite the fact that there was this truth. that supposedly nerve cells do not recover, but in reality something happens there, yes, the neuron itself, if it dies, as a rule there is no replacement for it, well, with the exception olfactory zones and hippocampus , short-term memory zones, but that’s a different story, and usually the whole neuron dies, but neighboring neurons can send out processes to mend the hole, this is how recovery happens, for example after a stroke, in fact it turns out to be a tool. or
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an organ that perceives external influences in some way and becomes what external influences make it, possibilities, there can be a lot of possibilities, you can, i don’t know, it’s clear that it’s bad. some kind of free will, but, that is, you you can just hear something outside and then become one, because you just have a rigid structure created in your head that doesn’t allow you to become different, this... if it’s yours, remember this, this, because this is not me, this is school, family, education, that’s why, and i have absolutely nothing to do with it, by the way, this is a very serious legal problem, because who is to blame, if, if, if my brain is like that, then well, it’s possible for me, probably disconnect everything from the brain,
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here we are already approaching the problems more quickly philosophical and very psychological, but the trick is that we have there in this very model of the world, informational... not verbal, there is also, apparently, our model of ourselves, from this idea of ourselves the ability to generate behavior arises, not obeying external stimuli, but obeying some of its global plans, the fundamental soul, this is what is called the soul, because it is believed that there is some kind of grandiose gap, but between animals and humans and...
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and animals have some -that's the limit when i disappears, in animal psychology there are tests invented for self-awareness, one of them is a mirror, a well-known story about elephants, that is, for a long time it was believed that they did not recognize themselves in the mirror, and then, when they finally took a large mirror, it turned out that they even recognize it, but with apes it’s just as simple as what animal psychologists do, the chimpanzee is sleeping, they quietly stick it on the forehead. piece of paper and further the chimpanzee stood up, stretched, looked at herself in the mirror, my god, what is this taking away from me, and the female champagnezes take lipstick they paint their lips, by the way, crows also do this, it seems even social insects do just their lips, no,
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crows don’t paint their lips, but a chimpanzee paints their lips, well, because i’ve seen how women do it beautifully, well, there are whole series of amazing experiments when here is the speaker. you call everything words, you also show it in sign language , so that the monkey learns this language, because vocalization can’t be said in words, the vocal cords don’t work, but if you pair the stimuli with sign language, then it turns out that... well, 100 words per a monkey learns for a year, this , in my opinion, is the key word conjugation, you can also give electric shocks like pavlov or something else, but probably mozhelov, well, well, he had all the dogs, well, they erected a monument to the dogs, yes, yes, well, it’s like a little bit of a separate story , but with the monkeys, look, what if you then
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give such a chimpanzee, for example, cards with photographs of people, her own and other champagnezes, she puts it in two piles, she puts herself, people, that is, she, living in human society, considers himself too a person, which means these same ones, and this , this is all true, this is so wonderful, but i once read that a lot of these studies are not entirely correct, because the person who lives with the little animal falls in love with it, well, as it should, as we love our pets, yes, and we endow them with properties that in fact are not there, and there were these with buzzers with many others,
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the red circle is a banana and i don’t know the blue rhumbik - is this the word laugh or something else but there are hundreds of these buttons and i don’t know there something i. it turned out that the speed is approximately the same, even this language, yokish, was named after the yerksa center in the united states, where these experiments are carried out, that is, the work is done through the keyboard, so we actually see this communication, we see how - female the chimpanzee herself teaches this language to her baby, supports it, that is, a subculture arises of monkeys who speak, not speak, but gesticulate, it turns out.
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such a spasmodic evolution. on air podcast baden baden, the most truthful podcast about medicine, and i am its host, konstantin severinov. today we are talking with moscow state university professor, neurophysiologist vyacheslav dubynin about the brain. why do we sleep, it’s the brain, the brain obviously works differently, but on the other hand it certainly works, just like you see some nightmare. even if he didn’t work with sleep, in fact the story turned out to be very complex, again, as always, not fully known, but there are two states, the so-called sleep-rest, slow waves appear on the electroencephalogram, and a paradoxical dream, when there are waves on the electroencephalogram, as if a person is actively doing something, we see images, we all see dreams that we can later tell, we actually lived there, but, although these are unreal events, that’s when the moment when there is a paradoxical sonado.
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, it’s easy for you to remember what an orange is, to remember something that you studied as a student and there seems to be an “a” in your record book, it’s already more difficult, but you don’t remember something at all, and it’s like, well, there is evgeny onegin , for example, you can probably read him , you can enjoy him, you can learn him, then you can play him, well, if there is anyone who wants to listen, first the short-term block is responsible for memory, then the long-term, short-term is the hippocampus, it turned out that the hippocampus he trains quite well, and his volume grows, and the ability to spark in the head grows in the head, such a thing grows in the head, yes, that is , this very neurogenesis is possible in the hippocampus, that is, one of the zones where neurons
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continue to divide, complicating the network. this very hippocampus increases in volume, and if you have taken the path of learning foreign languages or complex poems, only complex complex ones, yes, i understand that well, i usually tell you that eugene onegin did not take me, this is the most divine comedy i took it in italian, no, i taught it in russian, in italian it would probably be even cooler, but unlike evgeny anegin, there is a heavier text, even in lazinsky’s translation. there, as dante begins to list his enemies, or there are these very ancient gods, and there it is directly loaded , loaded, and really at some point the hippocampus once again becomes more effective, but in fact, well, for me, if we talk about life hacks, of course the most the important thing is to reproduce what you know, here are the actors then, then the actors must be the smartest,
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i recently read torkovsky’s memoirs, he wrote so many nasty things about them, but in principle, an actor as a profession is memorizing a huge amount of information and reproducing it, but a very very specific university professor is even more noticeable you think i ’m speaking from a record, but that’s because in fact we have to not only attach emotions to this, but really keep in our heads a complete picture of sometimes very complex events and learn to reproduce it for others doing so. regularly and this is the most wonderful thing in my opinion for memory, that is, you are not only at the entrance, but also at the exit, this repeated playback radically improves your mental activity and even works as a protection against alzheimer’s disease and so on, here about alzheimer’s, in the end, all this can still deteriorate, but this wonderful system, it would seem, it would seem,
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everything should only get better with age, we have more experience, more opportunities to share it, reproduce it, and so on. we are not destined for immortality, yes, each individual individual, it should be, even if the arms and legs don’t work, it’s a mind, that’s what a place has become, yes, but unfortunately, firstly, they still say that old people are wise, no one no, they are weak, but, but there is a certain perception of old people as wise people, but, well, because not only have they accumulated experience, they have also correctly generalized it, yes, that is, this, that is, their brain has become better, their model of the world has become better when something happens... or is it some kind of genetics or what is happening? well, as in many similar situations , the genetic contribution is very large , 60-70%. genetics, and what does contribution to genetics mean in this case? the simplest
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and then oops, it turns out that these 400 genes, yes, are responsible for or correlate, and choleli correlate with the occurrence of the disease 400 genes - that’s a lot, we only have 20,000 genes, if anything is to be treated, if it turns out that even here a little - a little, and here a little, and there a little, where, where, where beg, this is the problem, so , it would seem, there is a simple version of neurodegeneration, and there, it would seem, in general everything should be simple, treatment, you mean, no, there is the origin itself. yes , with huntington’s chorea, there is a single gene responsible for it, and at the same time there is also a dominant olele, that is, if you got this option, then by the age of 40 you will 100% get sick
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with this pathology, which in its manifestations is very similar to alzheimer's, much less common, fortunately, yes, but very similar, and there is also these amyloid plaques are all the same, there are not amyloid plaques, there is a cellular accumulation inside, well, like tau proteins in alzheimer's, and there actually...
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from an individual molecule to total cellular changes and further to changes at the level of the neural network at the level of all behavior, we are with a huge we trace with difficulty, therefore , therefore, therefore we cannot treat, that is, we can only watch, register changes. a healthy lifestyle, yes, a healthy lifestyle is always good, because it definitely won’t harm, yes, it won’t will definitely do harm, because it starts with the fact that you have healthy blood vessels, because in fact, half of dementia is not something like alzheimer’s, but the blood goes into the prick, yes, yes, with the appearance of these very cholesterol plaques and all that stuff , and this is also, as it were, dementia, but there are completely different approaches, with dementia... the brain cells are affected, they are probably different in some way from healthy ones, in general immunotherapy, and you will kill neurons, but you
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only want to kill those that are already in general some kind of it’s still a very bad option , the problem is that you can’t kill anything in the brain, because well, i don’t know, something like alzheimer’s happens to the liver, tendons, and other tissues, old age is called, if there’s accumulated defective proteins, you... kill this cell, and the neighboring cell divides and replaces it, for the brain this does not work, because each neuron is inserted into its own network, it is connected by information, but there is no duplication, maybe you can try as a child create two systems, you say that we have a lot everything that is not needed, two motor systems, so , apparently, there is duplication, of course, but it only withstands up to a certain level of defects, and the same alzheimer’s disease, it doesn’t suddenly appear, right?
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very optimistic. for a while, because these drugs don’t stop degeneration, but still, well because it is intracellular and moves by itself, but in alzheimer’s the flow of excitation is too strong, then drugs help. well, there is a molecule called memontin that reduces the level of excitation, that is, when such symptoms appear, the doctor tries different molecules, and if it works, then they can delay the development of the pathology for several years. in the case of parkinsonism , at the beginning they give the so-called eldof, that is, a substance that is a precursor to dopamine; when it stops working, agonists are used dopamines, substances similar to dupamine, but they already begin to have side effects, because
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they increase aggression there. strengthen cliptomania, well, that’s a different story , cliptomania seems to me to be one of our main programs, we all have our own programs, this is mine, that ’s what it is, yes, that’s why we have them in the amygdala, they they are so well studied, of course , but still the news is more bad than good or not, so i don’t understand, you know, i still expect molecular biologists to come up with something, because i don’t care personally, it seems that... then if we manage to create some kind of antisense rna that would influence the appearance of tau proteins or betaamloids or the same huntinggin, and we are able to target these rnas to certain types of cells, then maybe something will work out. thank you very much, vyacheslav, thank you, it was very interesting, good luck to you. this was the baden
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baden podcast, i am its host konstantin severin. and we talked with moscow state university professor, doctor of biological sciences vyacheslav dubynin about the brain, about the most important thing. greetings, friends, i am evgeny dodolev, this is a podcast of the chronicle of the end times, i will tell you about... those new year's meetings that i personally remember. 30 years ago, 1994, we met on the ocean shore, in the city of miami, as i call miami beach. and on this day i found myself in handcuffs for the first time, that is, despite the fact that i had, in general, experience of criminal prosecution as a student in the soviet union, somehow i managed without handcuffs there. in america, i want to
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warn you right away. being handcuffed is nothing special, it’s just instead: hello, when the cops start talking to you, and they can handcuff you, even children there - american police even have special little handcuffs for children’s wrists, there a five-year-old can end up in handcuffs, and it was just in the nineties that there was a scandal that - a boy for truancy of zero grade... that is , he was six years old, and the police detained him and handcuffed him, they wrote a lot about it, recently, by the way, several years ago there was the same story that hit the tv screens, i mean, in general i didn’t do anything like that, but in more detail, it means who we are - i was in america at that moment, starting in september of ninety-three internship at the new
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york times company, and because. ninety-three, the head of the most trendy, most fashionable, youth television channel in the country, tv6, it was december 31, ninety-three, ivan and elena flew to us - in miami, my wife and i met, and decided to celebrate twice new year, that is, once moscow time, that is, when it was midnight in moscow,
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is a separate norm according to which you cannot catch and eat those frogs that participated in jumping tournaments, and also in california and you cannot walk with an elephant without a leash, but there are cooler things, by the way, in the state of south carolina, for example, thongs are prohibited, they cannot be worn, moreover, they cannot be sold. in some states, alcohol is sold in special stores; in this store, where alcoholic beverages are sold, you cannot sell, for example, soda or just water, that is, in general , there are a lot of these wonderful laws,
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i’m just coming to the point where i actually fell for what law, we went to the beach, and, well, it’s clear that these are the nineties, we we decided... that of course we would celebrate the new year with champagne, but we couldn’t find champagne in local stores that cost more than $100, it was believed that buying champagne there would be cheaper than $100, but it was just, well, not up to par, we also wanted to definitely celebrate the new year with red champagne, so we literally, they started celebrating the new year, i still have poloroid... pictures that ivan demidov bought poloroid there, take such very small pictures with poloroid, it was a new format, by the way, it somehow didn’t work, because then poloroid they returned to their usual square shape, this is ivan ivanovich
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demidov without glasses, by the way, his country has never seen him without glasses, he, the helmsman of the garbage truck, was certainly wearing glasses, this is lena demidova, this is my wife, natasha, this is it. the very bottle of red champagne, why do i say that we we were practically alone on this shore , didn’t disturb anyone, because it was december 31st , we settled down, this is the ocean, right there, this is the white beach and uh, ocean water, we naturally swam, but someone - or me i don’t know, was it necessary to look through binoculars or did someone knock that there was drinking of alcoholic beverages going on? you can drink alcoholic drinks, but they must be in a paper bag like this, in short, since the bottle was in my hands, i ended up in handcuffs, it was ocean drive, ocean drive is what it is
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the street is very fashionable, if you watch any hollywood films, it happens on the ocean shore, it’s either vinnys beach in los angeles, or ocean drive miami beach, where everything is there. these boutiques , closed clubs there, versace there on this ow killed, this is such a very, very hot place on the one hand, on the other hand the most glamorous, i remember what we saw there and once in one of those cheap shoe boutiques how liza mineli bought some glass shoes for 10 dollars, that is, this not some kind of pretentious, prestigious place, but very... so, well, fashionable, in short, uh, two people came up and immediately put it on me very politely, that is, without rudeness, no pressing with the throat, there was no knee , right in my shorts, exactly in my shorts
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, because i wasn’t wearing swimming trunks, but like in the photo, they just led me to the car in my shorts, explaining, well, what i was actually guilty of and uh, what the consequences would be, the consequences could have been quite serious, but when they realized that i was dealing with such a russian asshole, and of course, the context of the new year , that the new year is coming, especially since these events of the autumn of ninety -three, about which they wrote a lot in the american press, had just passed, then i just stood in these handcuffs for about seven minutes at the car, explaining to them how -something there, trying to somehow include a joke, a joke, said that my friend was a television star, there was no internet, that is, he did not have the opportunity. go google it and check that ivan demidov is really ivan
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demidov, the great helmsman of the muzaboza, but since the police are people who are usually good psychologists, that is , they have this built-in scanner, that is , they scan a person, and they can easily understand whether he is driving or not, that is, they have such a good experienced policeman who has his own personal lie detector, that is, in general , somehow they realized that everything i said was true, they laughed, took off the handcuffs, wished me a happy new year, and more moreover, they even gave me a package, here is a brown package, where you need it i was supposed to put down a bottle of champagne and finish it, but we finished it after the new year had arrived in moscow, that is , it was already a few minutes after five, but of course i remembered it, we later told this story, laughed, and uh, in general, when i was at internship, i was very... immersed in journalistic work, in mastering
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a craft, that is, some everyday american things were not clear to me, i didn’t know a lot, i didn’t understand a lot, in particular, it was quite ridiculous car situation, first car, which i bought in america, it was a cadillac, we once went into this absolutely non-greek store, where there was not a single white person at all, and we were like, in general, well, new year, cheerful, hi- hee-ha-ha, they knocked over the water, i was looking for coffee, i’ll tell you about coffee now, why i was looking , i didn’t find coffee, and at that moment a police car drives up , a policeman , also a colored man, comes out, comes up to us, and asks what what we’re actually doing here is, well, we’re explaining that we’re kind of... tourists, not tourists, vacationing, celebrating,
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he said, you know, i’ll get you in the car, i’ll take you out of this area and you have a map, well, naturally, there were no navigators, no gadgets, i repeat, this is ninety-three, the coming ninety- four, naturally there were paper ones maps, and right there from that car of ours on this map he marked areas that... we whites don’t need to go, well, that is , in general it’s absolutely forbidden if we value our health and life, that’s how i learned about the existence of racism, so he described it in great detail on the map which areas we are not allowed to appear in at all, in which areas we can appear during the day, in which areas we can drive through, but it is advisable not to even stop at a red traffic light, but... i’ve already brought something difficult into this area, here we all listened
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to this with such eyes, that is, it was, in general , such a discovery, later i found out that in all major cities there are such zones, and here i must explain to you that miami, what we call miami, these are actually several areas of the island of miami beach, this where they live... representatives of our bageme, all the famous actors, they have apartments there in these huge condominiums, by the way, the american elite, including the hollywood elite, who, of course, have real estate in may, they never these people don’t live in human settlements, they buy some small mansions there on the canal, which by the way cost the same amount. there are apartments in the pethouse, this price category
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is the same, that is, here it’s not about money, but about traditions and habits, so in fact, miami itself is a fairly large city that looks like a modern, well, chertanovo in moscow, that is , this is an alternation of some kind of khrushchev-era buildings, well, not khrushchev-era buildings, of course, i mean such things as five-story buildings, small buildings and so on..
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what was the cause of the energy crisis? it was an explosion from nord stream 2. this did not happen in norway, it probably happened in sweden and denmark. i passed on everyone. show vavan and lexus. premiere. tomorrow on the first. every time the same question, how do they fall for all this or do they agree? i don't know. i think that cinema only shows love stories, in war films, we are talking about the love of guys for weapons, in gangster films, about the love of guys for robberies, the truth is rubbish, and the new wave brought love for cinema, without love there are no films, he - a child
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of cinema, he himself says that he grew up in the cinema museum in paris, he knows the roles. we continue our conversation about celebrating the new year, i’m talking about my personal experience, this is a podcast of the chronicle of the end times, because in fact, every time a year ends, a new one begins , the same thing with times, some times end, others begin, we come to the second
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episode with handcuffs, because for the second time i also found myself in handcuffs, in the same ... city, but not anymore not in miami beach, not on the ocean, but since we had this format of traveling for the sun on this very cadillac, because it’s quite cloudy in the winter in miami, the water is very warm, 25-26° there, because in the summer it’s generally impossible there, in summer it is very hot and humid, and in winter it’s just comfortable, but cloudy, and we just see being in one place or another.
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someone else, lera, yes, this is lera kudryavtseva, here the two of them, gosha kutsenko and lera kudrya. started under the leadership of lena demidova, in short, both demidovas had a lot of plans, and they came to us, in my opinion, in total, well, on these same new year's holidays, that is, for 10 days , so these were rushing after the sun, because during these 10 days, in general, i wanted not only to drink, eat, but swim and sunbathe, so... during another such trip we got carried away to the kubinsky district, it was already getting dark, we realized that we wouldn’t find the sun and we decided to slow down and sit down at a restaurant. in cuban, there was live music, this is the same restaurant, these are the cubans who sang something to us, the miami cubans are
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a completely separate category, that is, this people who hate and, well, hated , let’s say, fidel castro, these are people who fled from the island of freedom, and they had a corresponding attitude towards the soviets, well, that is, towards the russian-speaking people, because the russians were... the soviets, and we they couldn’t understand why there was any sense of ill will, but because we were russians, that is, we were associated with the very communist regime from which these people fled, and naturally it ended in a fight, and again ivan ivanovich somehow , i don’t know why he is at this moment or went somewhere, in short, i found myself in the bracers again. the only one from this whole company, and this time, by the way,
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it didn’t work out, that is, something like some kind of protocol was drawn up, and then i had to go to some kind of courses after dimidov’s departure or something like that, in general , several times i went somewhere and was imbued with - responsibility and norms of behavior in - in society in ... television dishes, it was possible to receive a signal, and it turned out that i deceived i remember there was no internet, but there were these
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my friends, because i could not install this plate, it turned out that in america , according to the law, in life in this association, i must fill out some kind of application at the meeting that will be there, well, i don’t know, they were held there once a month . what i want to do in my yard, i will repeat, that is , put a plate in my backyard and either get permission, or receive an unmotivated refusal, that is, the myth of a capitalist society collapsed instantly, something like there’s money there, money decides everything it was in our country that capitalism was built then , precisely according to these patterns, you have money , you solve the problem for this money, put plates, spoons, forks, tables there, where you see fit, if you have enough money for it, in america so it turned out that it didn’t work, that is, i bought this
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plate, and called a specialist, and the master installed it for me, but the neighbors just knocked, and there, in principle, unlike us, there is this culture denunciation in a good way, because that's what the legal system is really about. build what neighbors watch each other after a friend, and if they notice something wrong , they are right there, they don’t sort things out with the neighbors, they immediately knock on the police, there, for example, according to the laws of that time, i don’t know how it is now, a child under 14 years old was not allowed leaving one at home, that is, we have five-year-olds and first-graders going home with a key around their neck, this is mandatory there... a child up to this age had to be a nurse, if the neighbors noticed that such a child had been left, they did not carry out
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educational conversations with parents or they didn’t offer their services, they were just stupid they knocked, in principle, this is a working system , this is a good help to law enforcement agencies, i say this without any banter, because in soviet times we had vigilantes who patrolled there with armbands, but here a significant part of the population ended up in vigilantes such voluntary police assistants , i had a neighbor with whom we were friends there, and because they are all so very friendly, the americans are very friendly, here you are in these areas, at least the ones i’m talking about, that is, when we arrived , they brought us something new, baked something for us, suggested something, helped with advice, then i built some kind of fence there. not knowing that the height of the fence and the format of the fence in general is regulated, again by rules and laws,
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again there co... the police arrived, that was much later, we’re not talking about the new year now, i’m saying, i’m just here for - so to speak , to indicate the context, let's say, they said that the neighbors wrote against you for treasure, i was amazed, i told the neighbor, then i said, saiman, why didn't you tell me that, well actually, well, this fence, well, it’s so very , well, he looked at me like i was a blockhead from outer space, like a person who doesn’t understand some basic... i dealt with issues of corruption as a journalist and was amazed that in america there is a monstrous corruption, that is, on a scale
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that it never existed in the soviet union. it was already much later, when we were going to officers, they didn’t take them, which for me was also a discovery and not the most pleasant, because this is what i mean, the performers of simple orlando to meet their friends, the demidovs already we left, we were late and i exceeded the speed limit, quite seriously, i just whistled past
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the patrol car, because it was not a classic police car. with flashing lights, but just this kind of jeep, made to look like wood , these cars were generally popular in america, it had, naturally, something written on board, and there was a flashing light inside the cabin, but when i whistled past, i naturally i didn’t see this, well, she immediately turned on the flashing light, and he caught up with us, i stopped, here i made my first mistake, i tried. well, in the soviet union it was customary that if a traffic cop stops you, he is waiting for you in the car, like the master of the situation, you run out, run to him there with something, well, with documents there or something else you can add, so i tried to get out of the car, a gun was immediately pointed at me and they shouted at me to stay
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in the car, i was like yes yes no question at all. well, that is, here are the documents for the car , i put 100 dollars in there with what seemed to me a charming smile at the time, and my wife tried to also appear on the assault seat i say, you know, we’re going to pick up friends and we’re late for the airport. here - we’re guilty , please forgive me, he looks, there’s a hundred dollar bill there, and he clarifies, this is for me, i’m like, well, of course, i’m saying, who else, this is for you, immediately i was pulled out of the car, hands on the hood , for the third time in handcuffs, because it was a bribe to an official, and it’s good that i was with
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