tv PODKAST 1TV June 30, 2024 2:25am-3:11am MSK
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session, more, then the person begins to relate to himself differently, this is the task of psychologists, and if we go to a long-term consultation, the work takes a long time, then help the person to be a child, an adult, and much less often to be a parent, because here is a parent sitting with us automatically, we clearly control, that is, you should be like this, you should, should, should, that is, our little child runs around, does things, but he does not remain happy, he does not enjoy life, these are the rationalizing adults who you..
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in fact, she competes with herself, she will find the right path and the right strategy to really use age as wealth, and release her child into freedom, then everything will work out for her. psychic prompt, hello, this is. podcast baden badon and i am its host, professor severinov, our guest is dmitry alekseev, microbiologist, biinformatician and candidate of biological sciences, dmitry, hello, konstantin, hello, what is a biinformatician? i ’ll immediately take the bull by the horns of bioinformatics, but it sounds like it’s about some kind of bioinformation, yes, and so it turned out, i was lucky that, while studying mathematics and physics, i suddenly appeared on the scientific arena when i deciphered. dna has learned
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to load this information into a computer, bioinformatics is about how to bring this information into a computer into meaning, to some kind of understanding, to decoding, to understand what a living thing can actually do from this code, and you are a part-time microbiologist, because you use bioinformatics to prove that bacteria are even larger, and what are microbes, so you said bacteria, microbes are the same, these are probably viruses, probably, right? microbes is not a scientific word, first of all, it’s probably some kind of simple fungi of all sorts and others, and microbes were invented around the same time when levinguk began to look into a microscope, and this word simply meant all those who could be seen in a microscope, but not with the ordinary eye apparently, but according to the scientific classification, this really includes all these small creatures from one cell or viruses, bacteria and single-celled fungi, amoebas, amoeba is a microbe. "yes, well, we don’t see her armed
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with the eye, and what is the difference between them, simply? oh, well, for me, probably the biggest difference between viruses, bacteria and all the others is such an evolutionary one, for example, yes, that bacteria, we believe, were one of the first to appear on the planet, changed the environment in which we find ourselves, water, its composition, what do you mean, that they changed the environment, so the earth was burning." they created oxygen, in fact, thanks to oxygen, it became possible for larger organisms from a larger number of cells to exist, the opportunity has arisen for the mitochondria of such small power plants inside each cell to breathe with the help of this oxygen, a very fundamental process on the planet, for 1.5-2 billion years the microbes have been transformed.
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the body either arose from the outside, but in any case , once, somewhere it had to be self-formed, we are considered that we are the third generation of stars, probably on the second generation of stars on their planets conditions could exist for the primary broth to also here it seemed to be boiling, and some forms of life arose there, inside our cells contain dna and rna, that is , information molecules, one of the latest discoveries from... is that these
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molecules or nucleotides, yes, the components of these molecules, can be formed during space flights to... an asteroid, yes, that is, due to the effects of radiation and then it’s all like the components of a good borscht, but suddenly it appeared, but i’ll always tell you that borscht needs a housewife for borscht to appear, yes, that borscht itself does not exist, but let’s not talk about it for now i want to say that many scientists who have been studying this issue, they all often comment that it seems that without the hostess this cannot happen, and bacteria not only created the conditions for us to live, but then... gave us this view of things , well, yes, yes, yes, we believe that somewhere we all have a common ancestor, and he is so similar to a bacterium, so ancient, that is, we are relatives with them, yes, we are relatives with them, very -very distant, uh-huh, now what functions are performed by, well, bacteria and viruses,
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fungi, all this small fry, which we don’t see, they live in we call it homeostasis, but it’s a complex word, it’s generally balance, that is, everyone is holding back, life, it seems to me, is always trying to grow, everyone’s task is to give the maximum amount of space to their offspring , here at the crossroads of these different relatives, these different families, plants, fungi, microbes, bacteria and so on, they either fight or negotiate in such a way as to create entire ecosystems, that is, such niches, yes, for example, a forest or the ocean floor there or... our intestines, examples of such niches, within these niches, yes, they thrive, yes, that is, they produce the maximum number of their own offspring, and where then do what are called pathogenic bacteria come from, it is obvious that there are a lot of unpleasant ones things, diseases, it seems to me that from the moment such
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multicellular living beings arose, yes, from the moment the first intestine, the first creature arose, every microbe immediately realized that living inside us is very... good, very good, because there , warm, warmer than in environment, it’s dark, that is, it doesn’t interfere with sunlight and doesn’t kill, someone else is constantly getting food, why kill, if it’s so good, then there are different strategies for life in this environment, and like people, microbes, two there are directions in which they can act, this is to learn to be friends for survival, to learn to conquer. convince to fight for survival, as we see, both strategies bring results, because there are both infections that cannot be exterminated, and there are beneficial microbes that remain with us, well there tens of millions of years, who is more
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, well, there is this idea, you know, that you need to wash your hands and there and in general do everything so that the ideal world, in the understanding of many people, is that there are no microbes at all, but this is of course a mistake, without germs... impossible, everywhere where there is at least some kind of power source, yes, even inside a nuclear reactor or on a spaceship, microbes will appear everywhere, maybe we just don’t clean enough, maybe we can set a task so that we don’t clean all very clean, i’ll turn away, let’s turn around, there will already be microbes there, yes, that is, it is impossible to make this environment disinfected, and worse, we tried to raise laboratory animals in this disinfected environment without... organs from childhood to adulthood do not develop properly thus, the wrong
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proportions of bone, muscle adipose tissue, immunity, it should actually be trained in childhood, it’s like a muscle, and microbes also play such a role here... the gym, pumping up our immunity, if the immune system is not trained, it can mistakenly start attack our own cells, our own organs. do i understand correctly that the absence of microbes or their smaller number in the world around us, civilized people, is one of the reasons for the supposedly increased frequency of autoimmune diseases, allergies, and so on. this is, thank god, i am not saying this, but the medical statistics of many diseases in developed countries show that the worse, the better, the dirtier. the worse, yes, right now we are discussing this, at first there was such a theory of hygiene that it was impossible to be super hygienic, otherwise a huge number of atopic manifestations, asthma and so on arise, then you can very often yes, everything is wiped with alcohol, now the new theory
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a lot of living beings live nearby in a very close area, then viruses or bacteria can jump from one to another, this is considered the most dangerous thing in the emergence of new diseases, yes, that is let's say the plague there is a transfer from rats infected there, yes, which were carriers, to the city residents there, rats die from the plague or only people die from the plague, well, they are long-term carriers and... we die because the plague is already adapted to very cells similar to ours, but we have
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rats and rats, yes, but we have no immunity, yes, that is, our mother did not pass it on to us, to the rat, my mother may have passed on this immunity, we acquire immunity in the course of life, why is our immunity with some it fights bacterial infections, but not some, well, firstly, these are the properties of the infections themselves, that is, they really learned how to kill us effectively, they decided that they would be a warpath. m part of these microbes, yes , and but in fact, they also produce such a selection from us of those who will die, and of those who will remain, and those who remain, they usually acquire such immunity and give, as it were, the flowering of a new, new generation of people, over time, then the pathogenicity of these bacteria should decrease, because will only those who are more and more resistant to them survive, if we leave them and attack us like this? there is no way to control this, then yes, in fact, if we did not fight the plague, did not exterminate it, and
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so on and so forth, then of course in the end there would only be those people who could not be infected with it, but these are monstrous victims were, the most grandiose event in modern russia, traditions and advanced technologies, the greatest achievements and discoveries, all corners of the country, all spheres of life, 247 days, 89 regions, more than 17 million visitors, we there is something to be surprised at, we have something to be proud of, the ceremonial closing of the russia exhibition on july 6 at... this is the badden baden podcast, we are talking with
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bioinformatics and microbiologist dmitry alekseev, here are antibiotics, for example, this is one of these measures, i suspect, yes antibiotics, they are able to kill bacterial cells without, as a rule, or having less effect on the cells of our own body, but antibiotics will kill not only the plague bacterium, they will kill the rest of all other bacteria, and... what did we think for 100 years about bacterial infections, about fighting them, well, the issue is really resolved, we just give antibiotics, little by little the dose of these antibiotics increased, they say that the first penicillin should be given in a hundredfold dose in order to kill the modern pathogen, that is, in 100 years all microbes have adapted to this way...
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from the same amount of food this person gets more calories, grows more, but what if a bacterium eats part of the food? in fact , we have an agreement with them, and our digestive system is ours. in particular it is arranged so that the first 12 hours in the stomach, in the small intestine our enzymes work, and we take from food everything that we can absorb, the next 12 hours microbes work in the large intestine, and these microbes are actually what we cannot digest and it would come out of us, they begin to digest it and share it with us, yes, that
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is, as such an agreement, basically it is just the indigestible part of the plant cell wall or dietary fiber or cellulose, and what contribution do microbes make to our overall energy balance? before we can additionally get 20-30% of calories from a variety of plant foods - thanks to microbes, if well, there are problems with modern man, because he doesn’t really eat fiber, and his food is quite refined, and microbes probably don’t get it there, but if we will look at ancient man, there are very clear examples when people lived in the desert and there was a period of drought, in mexico in the chivahua desert, people during the period of drought ate only cacti, we can determine this by their teeth and fossils coprolites, and it turns out that it was only thanks to the microbe that they cried, but continued, there was nothing else, and
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they consumed 120 g of fiber daily, this fiber was mainly called inulin, we cannot digest inulin, we don’t seem to have enzymes. that people survived precisely thanks to microbes that live in the large intestine, but how? that is, why do we have such microbes, and they have different ones? where does all this even come from? when a child is born, he is probably sterile, right? well almost, yes, we believe that it is almost sterile, at least, yes, none microbes do not play any role in his intestines, immediately passing through the birth canal, through vaginal juices, and the child is contaminated with healthy fermented milk microflora and on the skin and then swallows. and then the goal, since we are born underdeveloped, and the immune system will mature, well, over the next 6 months, very strong changes will occur in the mucous membranes of our intestines, and so it will mature up to 3-5 years, this is the task of these first mother’s microbes to perform a protective function on the entire surface of the child’s mucous membrane,
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it is interesting to protect something from pathogens, because that a child is a sweet pie for all the microbes in the world, he is absolutely. do not eat the third largest component of mother's breast milk, called oligosaccharides of breast milk, again a person cannot digest, these are three sugar molecules or more, a person cannot digest them, it all goes to microbes, and the microbes produce that same lactic acid, for example, which reduces the level of acidity, well, for example, our
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blood is 7.4 ph, a healthy vagina is 4 and a half, the child is small, well, probably 5-6. there must be a ph at this ph, that is, at such high acidity, pathogens, that is, bad microbes do not multiply, it’s hard for them, it’s like the good ones like it to be sour, the bad ones like it to be sour , i honestly don’t know why it works this way, it’s a universal law here is our world, and you and i know it very well from sauerkraut, because there the same fermented milk microbes create an acidic environment around this cabbage, it does not spoil. that is, no one settles in it, no one settles, the one who can eat it, the one who can eat it, yes, yes, yes, yes, it is safe for us to eat it throughout the winter, this is how our ancestors survived, in fact, when they did not have enough food in the winter, they prepared it, fermented it in the fall, but this is the protection with the help of acidity - this is the basic mechanism in a jar of cabbage, in a small child, in kefir, by the way, yes, the same thing, fermented milk products, that is
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, it is not the bacteria themselves that are important, you just need the food to be sour, that’s enough , in this sense, bacteria. are this biotechnological engine for creating the first stage of protection, of course, is in our intestines, during evolution our immune system gets used to the fact that these microbes should live there, when it doesn’t see them, it seems very surprised and begins to go a little crazy and again worry, turn on the inflammation regime, you say, when conditional mexicans don’t get cacti, they have the same as someone gets up, like when a child has. there are no normal microbes, then the immune system begins, that is, a signal that a piece of our good microbe comes into contact with a cell of the immune system, it is also very important. this way we control that everything is in order in the intestines, what you are saying turns out, well, as i imagine, people lived there, 1000 years ago, it was very segmented small groups, everyone ate what
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was around, who -some cacti, someone i don’t know, rotten herring or some other lethal thing, for example tamos and so on, each of them had their own private microbes, which they probably received with the same food, this it’s not that they come from mom, but that is, it’s a way of life generated some... 50% of my mother's inheritance, by the age of 30 up to 20%, that is, indeed, with age, our food washes away or our lifestyle, our environment. if we look at ancient people, and there
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were hunters and gatherers, it turns out that their food diversity was actually higher, yes, because despite the fact that we have a lot of different food in the supermarket, we buy a very meager selection, yes, and the ancient man, he came, walking through the forest and field, he collected everything, because he really wanted to eat, yes. and he ate leaves, roots, and twigs chewed, and picked berries, and mushrooms, and so on and so forth, in his diet per year there are 400-500 plants, a modern person has 10-15 plants a week, well, maybe he reaches a hundred in a year, but why is that it’s important, after all, in my mind, prehistoric people lived brightly, but briefly, yes, now we live in a different paradigm, well, did they eat their herbs, and did they have some? microbes, that is, we should regret about them about these microbes, this is some kind of lost heritage that could be useful to us, again here on statistics come to our aid, which
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show that the more diverse the microbiome of a modern person, that is, the more different microbes, most likely beneficial , lives in his intestines, the more he is protected from non-infectious, chronic age-dependent diseases, that is, it seems about... the following picture occurs: as we become more urban, more industrial, the number of food sources decreases, the number of different microbes also decreases, at this moment this is a bad signal for the immune system, simply because. that over many millions of years she has become accustomed to the fact that there must be many different microbes , they give her different signals, and in this meager diversity, the immune system switches to mode... inflammation, and this inflammation, well, at the moment, as one of the theories aging, inflamaging, in russian, this is inflammation, yes, this kind of inflammation caused by the scarcity of our
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microbiome, it seems that it exists, at least in statistics we see it, well, we are called bad from dietary supplements, but there are also probiotics , as i understand it, this is some bacteria that someone said were good and we could take them, apparently. to increase the diversity of our microbiome, but as far as i understand you, this is a completely pointless thing, because if we don’t also change our diet accordingly, then those additional bacteria that we took will simply not take root, right? they will not take root for many reasons, and for most probiotics we see this story: a person takes them, they live with him, multiply, and stop within 2-3 months they disappear, that is, the task of probiotics at the time of intake is to support our.
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probiotics are interesting because most of the microbes that are used for probiotics are taken from some, they are also intestinal of healthy people, yes, that is, everyone got diarrhea, but this person didn’t have it, let’s see what’s wrong with him resists the microbiome, and in order to understand the procedure, it should not be the most pleasant, feces are taken, apparently from this person.
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in tablets in liquids and so on and so on. very interesting or instructive the story is about one of the microbes in breast milk, there was this guy of ecuadorian origin, a little guy in the eighties, he worked in a pharmaceutical company, he realized that there should be beneficial microbes in breast milk, probably here in america breast milk has become worse, he went to home to ecuador. i found such a beneficial microbe in breast milk, today it is one of the most studied microbes for children's health, it can be given zero plus to children over the last 30 years , some beautiful latin name protectis, it’s called a protector, yes , indeed, we modern people are losing those very indigenous microbes that should live with us, one of the microbes, again here are the statistics, a child’s microbe that knows how
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to eat... all the oligosaccharides in breast milk should, in theory, be in 100 % of children, it is called infantis, among modern americans, about whom we know statistics, only 5% of newborns have this infantis passed on from their mother, yes, that is, 95% will not be able to absorb breast milk entirely, here is the story about newborns, one of researchers looked at the acidity of children's stool in studies with 1900
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microbes, don't look, that is, you take a sample, in this case a stool sample, and somehow the entire microbial population that is present there and which somehow signals that there is really in the intestines, you translate it into numbers, and then you see who lives there, who lives there, and this is interesting, because for a very long time microbiology was sown something on dishes, but then it turned out to be at the turn of the 20th century what...beyond the cups there are still a huge number of microbes that we cannot grow on dishes, even for several years there was such a concept as dark matter of the microbial world, then it became clear that we cannot grow a lot of things, technologies for reading dna appeared, without accumulating a large amount microbes, it is really possible to simply wash microbes from feces with a filter, then destroy all the cell walls,
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extract all the dna. read its pieces to restore from this using mathematical algorithms, as it were computer science, well, that is, the simplest idea is that we ’ll take a piece of clothing from each muscovites there, a jacket from someone from someone, a sock from someone, a watch, and so on and so forth, so we’ve collected it all, let’s see and from these pieces of clothing we are trying to reconstruct what kind of socio-demographic way of life is here in this moscow, who lived here? what next, let's look at the iskoves, but in another experiment, let's take a stool test from each of them, then see what microbes live there, and someone is lucky, he will have various microbes, as i understand it, you want them to be diverse, for some they will be less diverse, but i suspect that, generally speaking, what is produced depends greatly, for example, in particular on diet, nutrition here now, that is, yesterday i ate, what i ate yesterday, that is
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, it may very well be that the composition... in general changes from day to day, and are there any practical recommendations in this regard, what to do, given that which, as far as i understand, is the case with probiotics, as a certain a mechanism for restoring diversity, if we assume that this is necessary, then probiotics, as a rule, are only a very narrow set of some microbes that do not really reflect all the diversity that exists, but you see, yes, here - most likely, such an analysis is for everyone he’s a very special muscovite, he’s more of a fan. yes, it’s rather useless, but what we see in the statistics, yes, we see that, for example, those muscovites who on average eat more different vegetables will have greater variety, well, if we talk again about baht, baden baden, if you can’t eat your amount of vegetables, try to find fiber, yes, as a source of at least fiber, and it’s much easier there, there’s a spoon, you only need to eat 30-35 g of fiber per day, and this is the norm. in fact
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, you can eat at least 10 g of this with the help of additional fiber, and again, from my point of view, this is not bata, it’s just a piece of food that was pulled out at production, this is also very funny, if it’s siberian... kelchatka we will imagine that this is basically wheat husk, that is, they make it for us very soft bread, the wheat husk is removed and we chew it with a crumb, it is very tasty, then separately we go and buy this husk from this wheat in order to restore the deficiency that arose due to the fact that we love very soft bread, that is it turns out that the solution to the problem is not microbial, in fact, yes, a change, a systematic change in diet for a wide range of the population, especially if. this is connected, for example, with aging, but then this is not scientific, if all this has already been shown, then all that remains is to simply introduce some, well, appropriate measures, well, standard examples, we use whole grain flour, in particular for bread, because back at the beginning of the 20th century it turned out that a lot of problems with the thyroid gland and
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so on were due to the fact that some people living far from the sea simply do not have enough iodine enough, but it was decided once and for all, now yes, absolutely, it seems exactly the same, for the benefit of people it is necessary to do with food, add. in consumer products, fiber is the first deficiency; in fact, if we look at the nutrition statistics of the russian population, this is deficit number one, because it’s cheap, probably, the cellulose is very, it’s inexpensive, yes, history, that is, it can be added to cutlets, yoghurts, well , it can be added to a large number of food products, are you speaking conventionally as scientists or what is it? , well, it would seem that if this is really a health problem, then we probably have one. in general, science and mass healthcare, there is a gap between them, yes, the task of scientists, including showing measures, economically justified measures for mass
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health care, yes, that is, that is, for example, we can take one of these recommendations with food manufacturers, a good question, in general to the region of the russian federation and there they will begin to introduce a standard for the production of, i don’t know, sliced loaves. what you don’t want to do, no, well , just eating a variety of foods from the store, just trying to diversify our diet as much as possible, for example, artificial consumption of probiotics, rather as such a supportive measure, will not work only
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after we have been sick, we should also think about supporting our microbiota with fermented foods , again, feed your microbes, restore the mucous membrane, use probiotics for this. this is a justified story, and seasonal allergies are also related to what happens in our intestines, that is, to reduce our inflammatory background by taking, preventive intake of probiotics or supporting yourself with fermented
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foods is a good strategy if you react sharply to flowering, but there is a high probability that you will not react so strongly to it, but this is standard medicine, these are the blogger’s tips, relatively speaking, or this is what doctors... i know and say, if someone has a therapist who is treating a person, he will suggest this, look, a therapist, we have a doctor of evidence-based medicine, his responsibility, we have a podcast, in general speaking about evidential. it is his responsibility to study modern research and he can make his own decisions based on the analysis of scientific publications, which is justified, for example, to use probiotics, probiotics and publications about this, it seemed to me that doctors largely act according to the protocol as part of standard non-service, but this is not the case , of course, in the scheme, the only place in the world where probiotics have been introduced into government schemes, in my opinion this is australia for premature births... the benefits of using probiotics
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so proven, so victorious is this question of life and death that it is used, well then we will probably end up with the fact that time will tell, because the verdict has not yet been made, that is, this is all probably very encouraging, but on a wide scale in the standard medicine, this is not common practice. the only thing that once again, perhaps i did not emphasize, in modern clinical recommendations, is to use probiotics after antibiotics, this is present. no one argues with this anymore, so a doctor in a regular clinic can tell you write this out. thank you very much, thank you, this was the baden badon podcast about evidence-based medicine, we talked today with dmitry alekseev, a microbiologist and bioinformatician, about the role of microbes in the development of diseases, about the role of microbes in the healthy life of each of us.
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“i’m so white and fluffy,” snow said , descending like an avalanche on the mountain village. hello, today we are gathering our thoughts on a very serious topic: humor and laughter. greetings, dear friends, andrey knyshev, writer, director, satirist, gavriil gordeev, media manager, actor, producer. sir the director is far away with everyone with all the stops that i forgot, yes, i am vladimir ligoida, dear friends, i invited you to tell you the most unpleasant news, let's talk seriously about humor, it won’t work any other way, it won’t work any other way, i i must admit that i deliberately did not say that this was your phrase, but i am correcting myself, yes, a wonderful phrase about snow, you know why i chose it, it seems to me that these are the facets that i... would like to touch on humor, a serious facet ,
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it contains, but how do you answer question, what is a sense of humor, analyze what a sense of humor is, well , let it really be done, probably by some learned psychologists, some kind of somatics, and you can answer metaphorically, i don’t insist on an academic definition, we thank god in such a free philosophical space, and not a university audience, in this case, i don’t know, that’s how much? i relate, as they say, to this feeling, but in general no formulation was ever born, some associative phrases that are alien, that if a person does not have a feeling humor, then he should at least have the feeling that he has no sense of humor, yes, but i say again, this is some kind of completely elusive substance that helps us, so to speak, some kind of navigation in space.
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since we are sounding on such a philosophical note, how do you like this idea from one modern philosopher, quite professional: philosophy and humor are two inseparable things, they tend to confuse our ideas about everyday things and turn our world inside out, and he also says that philosophy and humor are the pleasure of thinking differently, when even a simple desk... desk is under suspicion, i will support the first or second thought here, the thought about philosophy and humor, that they are inseparable, if we dig even deeper. into ancient greek comedy and tragedy, then well , essentially comedy is philosophy, comedy motivates to think and reason, and due to comedy, due to paradox, due to the opportunity to look, even within the framework of a short reprise, at the same problem from a different perspective on the other hand, this is a very philosophical concept,
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yes, such an attitude towards oneself with humor, how important is this for a person, yes it is necessary , it’s just that in general people who don’t treat themselves with a sense of humor are not able to do this, all the same, some kind of heaviness emanates from them, some kind of fear arises around them, because it’s really already somehow it’s all heavy, they even have some kind of facial expressions a peculiar thing arises, body language, postures, it’s very... it’s also interesting to pay attention to at what age, at what moment, out of a child, out of a toddler, this guy emerged, yes, who doesn’t have, who carries his own monument in his pocket, yes and periodically pulls it out to look at it with admiration, right? well, in general, this is the genre itself,
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it’s true that talking about these near-naristic things, talking about it seriously, analyzing it, and even so ungrateful in general. without the ability to laugh at oneself, it’s impossible to even become a humorist, that is, you can be a satirist as much as you like, yeah, let’s not point fingers, but then no no, well, it’s not a straight line , it’s just a clear one, but there is a difference, that with... and so on, but he can do it right laugh at yourself, which is much closer to the audience,
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which at one time or another listens to him, well, look, since we are still trying to steer some kind of serious conversation, because in fact, it’s clear what ’s important there... be able to be ironic at oneself, maybe laugh, but with on the other hand, one smart priest once said to me, never take yourself seriously, but take what you do seriously, but how to catch this line, well, when you take yourself seriously, this is too much, this is the way to delusions of grandeur, when you take your business seriously, you even begin to do humorous things, you begin professionally, this guest in red says interesting things, that is, in all seriousness. if vladimir romanovich decided to wear this burgundy cardigan, then it’s probably doubtful, but if it’s for business, then okay, he said, he never likes the way i’m dressed, despite the fact that i’m absolutely convinced that i occupy an honorable second place on dandy’s list, but at the same time, that’s all.
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