regarding vaccines, well, plus there is still no culture of vaccination in adult society, what does this mean? well, we always vaccinate quite, as if we vaccinate our own children with good readiness, it’s not a pity, yes, at the same time, as soon as it concerns oneself, it immediately becomes scary, it’s scary to remove a tooth, it’s scary to get vaccinated, but why, well, if you don’t talk about a case of covid, this is still an emergency, why should we adults get vaccinated if we already experienced all this as children, since we were in the law. obedient soviet society the national vaccination calendar affected us and avoiding it, as far as i understand, was very difficult, well, an adult does not need to be vaccinated, you are right, because we get the basic version is not a problem, there is vaccination of older people, it is also included in the national vaccination calendar, because that immunity, you know, there is the concept of immunosen, aging of immunity, accordingly, renewal is required against a number of pathogens of the immune response, that is, boosting. strengthening, that is,

streptococcal infection, you know, yes there pneumonia in the first place, hemophilius influenza, and, of course, the flu, how and whether it is necessary to combat the generally not very positive perception in society in the broad sense of vaccinations, and there is a feeling that we are still developing and developing in the 20th century so on and so forth, it turns out that the level of the population’s attentiveness to this is rather falling, but unless these are some kind of internet effects, i just want to say that any developments.

society, it doesn’t change, i don’t know why i mean that this is such refractoriness this, well, i can try, today we are trying to explain what this is connected with, but in fact it did not disappear anywhere, it has always been there, there has always been distrust in vaccination, what is it based on, this is what the numbers began to say , one in a million, not one in a million, past vaccines, now they say that past vaccines were good, yes, everyone says that there were soviet vaccines.

they were dangerous, but they also did more good than harm? of course, they brought more benefits, this is absolutely certain, even such poorly purified vaccines. at the moment, the regulators of any country in the world, simply by allowing nucleic acid, local proteins, will not allow a single such vaccine, that is, everything that is being developed before, everything that is being developed again, goes through a huge number of purification stages, for example, about our vaccine, even if we talk about it, we...

these platforms are that the technological platform itself has been developed for 40 years, well, you know, at your institute, at our institute in the world, we naturally do not distinguish ourselves as some kind of separate institute, separate from the world, no, i mean as a scientific platform, and over 40 years there were about 400 clinical trial protocols, then there was an application for fever in africa, there were more than 100 thousand people who received the vaccine, several of us received ours...

so there were long-term studies of the effectiveness of the vaccine, which are over the horizon, you know, after its development there were 5 years, 10 years, when they remember the good soviet times, they say that the vaccine later, quite rightly, there were absolutely different history, soviet vaccines, many were, for example, generally attenuated, and you understand that testing an attenuated vaccine is attenuated when it remains weakened alive, that is, this is residual pathogenicity, and there were examples, including with flu vaccines, when problems arose strains. they returned, there was a reversion to the wild pathogenic phenotype, genotype, this is the vaccine of the old generations, it can cause the very disease against which yes, in particular, the vaccine against influenza, modern flu vaccines, they have already learned to avoid this, they have made

subunit vaccines, and a live vaccine, there are certain cold-adaptive mutants, mutations that do not allow reproduction at normal human body temperature, that is, now in modern...

one single severe , a serious undesirable effect, it happened in a woman, in my opinion, it was somehow connected, yes with the situation with the thrombus, and with thrombus formation, the case was, in my opinion, non-lethal, non-lethal, that is, it was a one in a million report, then there is, if we compare with any other vaccines, including the one in a million, then it will be approximately absolutely the same, but the only thing is that we have incomparably less myocorditis, which is what the tamk vaccine has, it is simply incomparable, therefore it is modern. so one in a million is undesirable, and this is not yes, not not death, but something like this is the story in russia , why do you think that in russia it’s the same, no, in russia the same raid, more, more i i think that in our case much more doses were used in total

in the world, i just when russia, you know, they always start to doubt, you come to the state duma, you come somewhere else, they tell you, well , you yourself drew it, we say well, there is hungary, there is argentina, we cannot influence ...

people don’t apply, yes, but you can easily look at the mortality rate, and here moscow conducted a very good, correct study, because in fact, maybe for... there on ventilators there, a month after that, they don’t make a diagnosis that it was covid 19 , yes, so

if we evaluate covid and covid associated deaths in this group, well, in both in both groups, then you get the following figures: about 100,000 people died in the unvaccinated group, about 600, in my opinion, more than 10 times died in the vaccinated group. we need to take into account, in fact, everything is even more complicated, in fact, we need to take into account that no matter how uniform the vaccination of the population was achieved, it did not work out, that is , to introduce coefficients, no, well, it seems to me 99.00 versus 6.00 on the same sample of people, these are telling numbers, yes undoubtedly speaking, i was just trying to complicate it, it was published somewhere, i honestly didn’t know about it, no, it was on the moscow website that anastasia vladimirovna rakova spoke with these stories when she was preparing, she accordingly, well, because. the data is not ours, it’s the department’s data, so it’s good that it’s not yours in this sense, you’re not particularly interested, you couldn’t help but be

interested, no, you’re certainly interested in the result and to show that it all works, but the data , respectively, objective - these data are not the center of gomals, but what does this mean for the future, but covidid is in a sense history, although not entirely, but you are probably using an adenoviral platform to create new vaccines, what kind of vaccines are they, each of them will also need this. .. to push through efforts so that it is recognized, well, in any case , efforts will be needed, i am absolutely sure of this, the only thing is that if there is an even higher mortality rate of not 1-2%, well, that’s what i would like, you know, this disease exists x, for example, you are not working on disease x, well, this is a hypothetical concept , a hypothetical disease, which for some in these mind games it is assumed that it will have a mortality rate there that is 20 times higher or there is 10%, 20%, yes, yes, absolutely right, it is used for modeling and...

which initially, during the course of evolution, lived together with the same actinaceae, fungi, coexisted in the soil, they have natural resistance mechanisms, they use, in general, these natural resistance mechanisms, more exchange these natural mechanisms with each other, these super-resistant strains sometimes actually contain plasmids genetically in order to try to solve the multiple problem simply. to the territory of the russian federation

to reactivate such vaccines, use them accordingly for vaccinating the population , work now, of course, of course, that is, there is a certain list that you or your colleagues are trying to close using your technologies, lasa, west nile there and so on, according to the list , everything that is included accordingly is here about these there. 30 pathogens, that is, this planned work is being carried out, if there is a premeditated, not premeditated, no matter the skid, we just have to be ready, well , besides, if we are talking about platform solutions, they allow being.

this is safety plus effectiveness in primates and safety, naturally, in other species of animals, and then the clinic that gets there, we are convinced that the vaccine is safe and effective, we are entering the first, second phase, so we can preserve such a high degree of readiness of the vaccine, in my opinion look at why we can preserve, because what, imagine, a list of 30 pathogens, we need to conduct 30 studies of the third phase with you, and you can do this in your center, no one in the world can do this? because you, the third phase is in endemic conditions, that is, you have to get into the eye to collect statistics there, you know, yes, that is, you have to junin, fever or guanarito, you have to fly somewhere to argentina in argentina to collect statistics the third phase in the conditions of some kind of ring vaccination there in the conditions of an outbreak there or there or in an epidemic, and you, well, to make a vaccine you need a pathogen,

that is, in the center of gomaleya in the center of moscow you have all these pathogens, but we don’t have all the pathogens. then including the second group of pathogenicity, the entire first group of pathogenicity, these are our collaborative studies, the first is more dangerous, the first is the most dangerous, according to our russian classification the first is the most dangerous, according to the european american classification the fourth is the most dangerous, but so as not to confuse, yes the most dangerous , these studies are all carried out in collaboration with the ministry of defense, that is this is definitely not happening in moscow, not in the center of moscow, in certain territories, yes, of course, but it is simply prohibited. there is a special decree that, yes, yes, well, in general in large cities, in moscow for sure, in particular it is forbidden to work with the first group of pathogenicity in the city, within the city limits, so this is happening tens or hundreds of kilometers from moscow, and it’s good that it doesn't know

about someone like me. i still won’t leave him, because he’s good, good, of course, everything that concerns you, everything that concerns me, god, what a man, and i want, the main thing that a man has, fantastic, tomorrow on the first, this is the podcast baden baden, i am its host konstantin severinov, and today we are discussing vaccination, that is, you have

30, well, let's assume that there are 30, well , let's say, 30 pathogens that are...

it’s hard for me to explain this, to be honest, but a vaccine was not created in japan, where there is also a very large pharmaceutical industry, it seems to me that they had great hope for

the development of other pharmaceutical giants, who quickly declared that there was really it is important who is the first to say, those who were the first to say, in fact, the same thing happened, remember the order there, i don’t know, there were hundreds of vaccine candidates that appeared after, but everything that appeared after. a spoon for dinner, that is , it was necessary to work very quickly, to work ahead of the curve, and this immediately channeled the attention of society, the attention of governments, the attention there, well, in general, everything was focused precisely on these developments, so it seems to me that this is more likely related to this , but the fact that in our country, in fact, we have never forgotten infectious pathology, but well, we went through different periods too...

before that we participated in the fight against the ebola epidemic, this is participation directly in our country and then we made a vaccine, so in fact the attention did not go anywhere, well exactly. and measles is some kind of new vaccine, but no, of course, measles is a vaccine, that this is the same good, kind, old proven vaccine, of course, the only thing that people

don’t understand is that measles is much more contagious, that is, if there is a coefficient, yes the coefficient there is r0, and that’s the calculated coefficient for covid, it’s 2 and a half, well, when it’s 3 seconds to, that is, there is a certain range of variation in this coefficient, that is, one person can infect there 2 seconds to... then measles 12:18, the root is incredible an infected person can infect while he 12:18, can you imagine how much there, if you count as a percentage, then if you come into contact with someone infected with measles, then you will be infected in 95% of cases, but those of us who are vaccinated, they turn out to be stable for life, what kind of situation is this? yes, with measles there is a big positive in this, measles has exactly 12:18 due to the fact that it has a very high contagiousness, it is ensured precisely due to.

of course, therefore, there is some data that this is happening, that is, measles as a species, variants arise, delta gamma and about variants arise exactly containing a mutation, but so far there is no convincing data that this is such a strain of vaccine escape that he avoids, well, immunity there, so there is no reliable data confirming this yet, but monitoring this can definitely do is happening, monitoring is carried out even at the level of the department of health, where i do not belong to the moscow health department, but i know that moscow.

the old one is being finalized from the point of view of safety, that is, they are changing, more safety, of course, that is, it’s more likely that it’s changing like this, if a new improved vaccine has appeared, does this mean that those who were vaccinated earlier and the worse vaccines should be thickened or do something on this topic, there is no need, there are diagrams, in fact they are more likely related to age, not with a change in the quality of the drug, that is , well, for example, you were vaccinated with a polysaccharide vaccine, yes, that is , which...

these are generally comparable things, in the case of covid it was very active, because it was also discussed that i was already sick, why for example, for me to get vaccinated, of course, there is a difference, the difference, i think, is primarily in the cellular link of immunity, and there are simply many more clones, cells, what is better, to get sick or to vaccinate, no, well , this is not a question at all, of course, it is better to get vaccinated in any case and even if with over time, you encounter a pathogen, there will be a certain morbidity there. then it is of course incomparable with the fact that when you have a clean slate and you get sick initially, that is, it’s not even a question, but no, having been sick then about the vaccine then makes sense, or then you, in essence, you were vaccinated, when you get sick , you get vaccinated and even vice versa, we studied the type of antibodies, that is, the maturation of antibodies that occurs throughout life, where two or three times contact certainly forms much more reliable immune memory, that

is, absolutely incomparable fidiness. the power of interaction, that is, they are actually similar to boosting, the levels in argentina were actually a very good study, they are unprincipled people there, they introduced absolutely all the vaccines, they needed to protect the population, they brought all the vaccines, vaccinated the first, what are the second , what they are, in the end they got a bunch of groups, simply mixing, given that the vaccination is double, they combined, in the end they got it turned out there, well, a huge number of groups were compared and it was shown that the best answers were when there was a vector plus, so these were the best answers, and separately it was shown that all those who had recovered, well, who had contact with whom at the beginning or after , if they were vaccinated, they also have maximum levels of responses, but we, for our part , studied this from the point of view of visibility, that is, how much antibodies

have formed. not a vitamin, yes, there are, respectively, these are one case in a million, by the way, why does it happen

? very good, but this is really very rare, that is, if we take the additional cost of the vaccine program, then there is approximately one case in a million. any autoimmune complications appear there - to those cases that are normal in the population, normal in the population there is from two to 20 cases per million, plus one, if you conduct a mass vaccination program, then according to statistics, this is really a very small increase due to the effect of immunity, but if we look at the mortality rate from the same covid, this one case per 100, but in a good way, if you also count covid-associated deaths, then these are two cases according to nastomer, that is, you get four orders of magnitude. the difference is, if we sit down to play this game, purely mathematically, you will never beat me, i will have four orders of magnitude, the probability of an advantage over any combination of yours, so it kind of asks to vaccinate, not to vaccinate, but if you have studied mathematics at least a little, four orders of magnitude is a big difference of 10,000

times, this was the badonbaden podcast, we spoke with the deputy director of the institute gomoley, academician and one of the main developers of the russian sputnik vaccine, denis lagunov. about vaccines, the development of new vaccines, whether it is worth getting vaccinated and what side effects there are from the vaccine it happens what the beneficial effect of the vaccine is, how many lives they save. you can find all episodes of the baden badden podcast on the channel one website. hello everyone, this is a free program podcast, i’m maxim tronkov, our guest is maestro ilya overbukh. ilya, hello, hello, and first of all, thank you for inviting me,

because i always watch with pleasure, it’s such a calm time at night when you really dig deep and have sincere answers, everyone here on this chair opens up very much, and i i was waiting for this invitation, honestly and... when it sounded, i pushed everything aside, immediately galloped up, now the federation pays a lot of attention to the development of the artistic side of skating among athletes, that is, in principle, now the field for your activity is directly open, there are a lot of requests, they ask coaches , they call and ask to put on programs, well, quite a lot, quite a lot, in general i’m so proud that there are many programs in general sports programs from which...

i worked with dima aliyev, of course, i would like, maybe with mark kadratyuk too, because the guy is very artistic, he directly feels the world, we are very similar to him, this is his charisma, but so far we have only left such demonstration dances, now the international figure skating federation is just thinking about in order to move from technical complications to artistic ones, how do you feel about this, about this initiative? well , of course i should advocate, i should of course shout that yes, yes, because figure skating is eternal and it’s an art sport, i still i think that this story, connected with

the exorbitant bar of jumps, it certainly excites and delights people more than these moments of art, even take the fantastic breakthrough of our girls, when our girls jumped these... ultimate quadruple jumps, and this the fight of quadruple jumps, anyway, we talked first of all about this, when everything comes together, when it’s really not just gymnastics, well, in terms of execution, when it... also fits into a single image, for example, probably from such programs that i didn't put it there, but i think absolutely there, these are alley ballers, yes, well, you can simply admire this program endlessly, when every jump is organic, this is of course the highest story, everyone dreams about this, but if you still compare, then probably the technique of the elements wins in i wonder why you, being a director from god? you always talk about dancing, comment on dances,

but you never work with the tops in terms of performances, dancing takes a lot of time, well, objectively, firstly, sasha zhullin can handle it himself, and we have leaders copes well with his team, why it doesn’t work out, i don’t know, well , now i just think there ’s so much of these ins and outs in ice dancing that i’m not yet... not entirely interested, probably, but also honestly, on the other hand, no one, as i said, no one invites me, yes, if, of course, the seniors invited me, but who would be happy, then a couple in general, look at them, just just do the running ones and you’re already you get aesthetic pleasure, because well, they are both absolutely beautiful guys, and of course this such material, but here i am - directly in public, so that sasha doesn’t think, they’re lying, that i ’ll catch him there, i directly ask you, let me do a demonstration dance with him, and if... zhulin offered you such an option that you put

next year, for the russian call, you give kotselap’s number, but you don’t ask anyone else, or it’s already a question of money, but so far something with money is not very good, you’re always not very good, everything is fine, it’s jewish, yes, you know, here i am i'm not lying to be honest, you can pick me up at my word later, i even - probably in any case, but of course, this is hunger and the thirst, well, honestly, not for money, but the thirst to be with everyone, to show your versatility of your talent, of course, it comes out of you, but this year i realized that i am because i had quite a lot of numbers, i missed some things, i didn’t have time to look through them, for example, work with your students, well, from your school, tara morozov, i kept it. there is dissatisfaction here, i didn’t finish it, well, no,

i didn’t see it, no, i didn’t finish it, after all, there’s still time to go, it could be done so that, if this the idea, then it had to be conveyed, or vice versa, as i did in the previous season with lesha yagudin, when we did a dance, it seems to me that no one has ever seen it like this, it was the blues, it was such a sophisticated story , we tried to make humor with the sounds there, so he makes this humor, i sit, there are 2 days left, and i say, lyokha, this is complete, this is simple, this is not... impossible to watch, this is not humor, this is a failure, and we we start sitting all night and exposing, but there are some top plans, at first no, well, how many everyone has already rolled over again, so on mikituba, but then i understand that it’s still like that somewhere, those elements that were already collected, somehow you understand that were there, we changed them here, it came in and by the morning the picture was formed and i realized that there wouldn’t be any questions here, when he and lyosha understand, everything works out, i didn’t have that kind of time. that’s when you’re just chasing here without a day, when there’s nowhere to retreat, you’re going,

you should have looked, maybe you should have just said, so it’s all put off, now there’s another option, and even more so with their professionalism it was possible and, because of this race, because there were many numbers, i would think that if i were like this right here, where you can tell yourself everything, but in one pair, yes , i would refuse all the others, well, we are just looking for ways to neutralize alexei yagudin, because not everyone is happy with his constant victories, but i repeat that for me it is lionel messi, who will receive the golden ball every year , maybe we will succeed after all, thank you very much in fact, you are talking about the fact that you can win more than once, lyosha, a truly outstanding skater, and that it is not so easy to actually find those elements, because of course, well, the base, vocabulary, lead, of course, he already has well, not the one that was and which the guys have now. they skate at the same time, but he has a fantastic magnetism, he just, like

a boa constrictor, takes over the entire refereeing team, takes over the hall, finding this solution with which he could surprise was really very difficult this season, so lyosha probably devoured me from everyone else, and he planned me right here , but i’ve been with him for so many years, and he just seemed to let go, well, like a child who doesn’t care with jealousy, well, yes, yes, please, i... you just need me now, i need it now, that’s what’s here, you know, and every time i’m alyosha, well , like lyosha, and of course he didn’t let me run for everyone else. find this solution, find a topic so that he can talk and tell and take away, i think that lyosha should beautifully give the opportunity in the next year for others to win, he showed himself perfectly, he is above the fray, or maybe he was just

distracting you so that others wouldn’t achieve masterpieces, well, he wasn’t distracting, i don’t think that ’s what he’s like, he just wanted to, he really really really strongly wanted... and this story, in principle, happened so that when lisa tuva called and also sent music, i realized that we, in principle, are practically the same as lyosha, only well recorded, yes, and i say, lis, well, you know, well, it’ll just be generally the same thing, i’ll just do it and here and there, we have poems there, there is an instrumental here, he says, i’m sure that lisa too, i think that, of course, ideally, yes, i don’t know what lyosha will tell me after this, but ideally.

lyosha: you are touching such, touching such a serious literary source, such a hero, this is a very difficult, dangerous and responsible path, so only i understand, at the beginning of this path, i wish you success in comprehending this path, because knowledge and translation these are the highest ideas for your art, for your technique. this is a very difficult and long way, i i wish you success, and now i want to say my opinion, i gave alexei yagudin one point, victoria senitsina and nikita kasalapov two points, and i gave three points to elizaveta

tamysheva, here lyosha took those points when it was already clear that everything was over, and that’s just it, but... in general, i want to say, as a person who puts it on, i just bow deeply for the jury, which has already been sitting on the russian cart for 2 years in a row, this is fantastic, in all 16 years i have never managed to get boris eifman a jury summer period, although we were constantly doing this, because this is of course such a peak, it’s just enough, of course, the actors are all outstanding, well, for me, of course, i try to look at everything through the eyes of boris eifman, but for me it’s like such a supreme comerton. tragic numbers or lyrical ones, they are much better appreciated, more in demand by judges and spectators than numbers that are cheerful, positive, cheerful,

perhaps. what topic would you suggest for the next russian challenge to satisfy everyone so that this scales. at least it swayed, okay, it didn’t stand straight, but it didn’t tip to one side, this is the eternal problem of the ice age project, dramatic numbers always win over life-affirming numbers, so yes, they’re funny, superficial, just about happiness, therefore, since i direct the entire episode myself, and even when, despite the fact that sasha zhulin is working, we still don’t care, i say that there should be at least two life affirmations.