(vo) at wells fargo, direct deposits come up to two days early with early pay day. what if everything came two days early? (hero) have a good weekend! alright now...have a good weekend. (co-worker) but it's wednesday... (co-worker 2) see you monday! (co-worker 3) am i missing something? (hero) it's the weekend baby... see you later. (vo) like getting things two days early? when it comes to payday, you can with wells fargo. (co-worker 4) what are you doing this weekend? not just any whiteboard... ...katie porter's whiteboard is one way she's: [news anchor] ...often seen grilling top executives of banks, big pharma, even top administration officials. katie porter. never taken corporate pac money - never will. leading the fight to ban congressional stock trading. e ly democrat who opposed wasteful “earmarks” that fund politicians' pet projects. katie porter. focused on your challenges - from lowering housing costs to fighting climate change.

shake up the senate - with democrat katie porter. i'm katie porter and i approve this message. a decision has been made. president biden said he has decided how the united states will respond to a deadly attack on american troops in jordan. exactly what course of action he is planning to take is still unclear and will it further escalate tensions in the middle east? plus, house republicans pushing to impeach a cabinet secretary? for the first time in nearly 150 years, the homeland security secretary in the hot seat for his response to the border crisis.

is cnn exclusive as the millions of americans each year wait for a life-saving transplant, researchers say they may have found a solution. pig organs. we get incredible rare access to a research facility that hopes to change the way we see medicine. we are following these developing stories and more coming in right here to cnn news central . president biden is facing potentially one of the most consequential decisions of his presidency, how to retaliate after a drone strike in jordan killed three west soldiers. a short time ago, president biden told cnn's harlan signs that he has decided on a course of action. listen to this. >> i do hold them responsible

in the sense that they are supplying the weapons to the people who did it. >> biden there is tying the attack to iran, but has clearly stated he wants to avoid a direct conflict with tehran. officials indicate this response, when it comes, will be stronger than recent actions taken against iranian backed militias in the region. we want to start off in the white house. the president says he has made a decision but the details, he is keeping close to the vest. >> yes, you heard president biden there telling arlette signs directly that yes he has made a decision on how exactly to retaliate after the deaths of these three american soldiers but as you can imagine, the white house has been very careful in recent days to not telegraph in any way what exactly that response would look like but officials have said the response we are going to see in the coming days is likely to be more serious and more powerful than some of the retaliatory sites we have seen in iraq and syria. it is clear

that the president is grappling with the reality that some of those strikes in the past have not successfully worked as deterrents. it is interesting when he was asked what would actually be different this time with this response, he responded, we will see. that was not exactly showing confidence about the fact that this future response is going to have an effect. we do know that the administration is clearly considering a range of options, as well. we heard u.s. secretary of state antony blinken alluding to some of those options. he said the attacks could be multilevel. they could come in stages and take over the course of a while and so, these are the decisions the president has been grappling with but again, he says he has made a decision, but it is an extremely complicated and difficult decision because there are two things that he wants. he wants to show force and serious force that is different from before but as the white house has made clear time and time again, the one thing they

do not want is for this conflict to broaden into a bigger regional war. >> we learned president biden has had contact with the family members of those killed enjoying over the weekend? >> we just learned the president made three separate phone calls to the families of the three american soldiers that were killed. we are told the president expressed his gratitude to these families and expressed his sorrow, as well, and made a promise to these families that their service will continue to be honored by the family. we are also learning from the white house that on friday, the president will be there to attend the dignified transfer of their remains when they arrive at dover air force base, and this is something the president raised with the families to make sure this is something they were okay with. they told us all three families were okay with the president's presence there on friday, so

all three of these service members will be returning home in the coming days, but obviously their death severally fundamentally changed and clarified the cost of the israel war and the ongoing conflict in the region for the united states. we want to take you now to the pentagon. on the military line angle here , is there a sense from the pentagon of what the u.s. response might look like? >> reporter: just as the white house is being very careful in terms of what it releases in terms of what the u.s. response will look like, they don't want to give the groups there, the militant groups backed by iran essentially a heads up on what is coming but essentials have made it clear this is expected to be wider, broader in scope and perhaps sustained over time, much more so than we have seen in previous u.s. strikes in iraq and syria. the question, of course, what does it look like and that is

where president biden has options. he could carry out strikes in iraq or syria or both. he could go out after weapons or facilities or go after leadership, which the u.s. has done on occasion. the strikes themselves could be sustained over time. they could have a cyber element, as well and that doesn't even get into all the special operations forces options so the president certainly has his options. it is the pentagon's job to come up with those options and then biden makes his choice on what he wants to do here. two things are clear. it is expected this will be calibrated to not spark a regional war with iran. let's talk about this now, former nato supreme allied commander general wesley clark. thanks for being with us. you hear the administration indicating the response is going to be bigger than what we have seen previously. what could that look like?

>> it could look like strikes in both syria, iraq, and maybe even something on the coast of iran. it could go after headquarters and leaders as well as the militia themselves. it could be repeated in a sort of action, evaluate, attack again, evaluate, attack again, evaluate cycle . it could go on 3 to 5 days or longer. we could be listening to what is set after the first several strikes and find out where the enemy is getting directions from, go after that site next. there is a lot that can be done militarily help. it is that the president doesn't want to reach a regional war and that is the art of this. >> when blinken says it could be multilevel and sustained over time, explain what that means.

>> i would be surprised if there is not an economic component to this, some tightening of sanctions, some seizure of assets somewhere, so that is one level. i think a cyber attack is a second level and then i think were used -- where you strike and what you use as a set of third level actions, so you could strike where tomahawk launched attack missiles, fired from navy ships, you could launch airborne, there are helicopters you could use the there are different ways of going in and then special forces could do rates on the ground, take out headquarters, capture people, grab documents and so forth, so there are a lot of different ways to go after this.

>> some republicans want the strikes inside of iran, which obviously, that is different than what you are talking about here. is that a serious proposal, in your opinion? >> i hope it was one of the options that was being looked at. if i had been in the chain of command it is what i had recommended because i think you have to cap this off. you have to put at risk, assets that iran really values and they are getting away for free with this proxy war on the united states. they don't care how many militiamen are killed out there, there's dozens of them and multiple headquarters and multiple people standing up to be the next in line to get knocked off but what they do value is their own revolutionary guards chain of command, their assets and so forth, so yes, that should have been a serious consideration. when you weigh the pluses and minuses, you talk to the diplomats in the region, you talk to allies in the region, you make sure you have support people who understand what you

may do, maybe you come back with a different answer but i certainly would've been pushing for the top end of the strikes because i think it's important to stop and get out of an action-reaction cycle and get control of the initiative to convince iran to call it off. enough is enough. >> it is broadly understood that iran stands to gain from a proxy war, and you also have republicans calling for strikes against iranian leaders. something like the sole money strike that trump ordered, that does not seem on the table. that according to the u.n. violated international law. it was controversial but to your point, how important is it the administration do something that has some iranian leaders looking over those shoulders and how high up to those leaders need to be? >> i would think it is important and i think the leaders need to be the revolutionary guard command level. i don't think you're going after the ayatollahs, obviously.

it is not against civilian targets but it is against this revolutionary group. when the iranian foreign minister says we didn't do it maybe he said sincerely believes that but we know what the intelligence says and we know these facts are supported, organized, equipped and they have technicians there to make sure the equipment works properly. so, we know there is a big iranian hand behind us and the question is, what does it take to get iran to the side that this campaign is not in their interest? right now they are getting away for free. and the president has got to convince them it's got to stop. >> we are going to see what that is that he tries to convince them with. general clark, great to have you. thank you so much.

right now, homeland security chief alejandro mayorkas is in the crosshairs as congress gets ready to take impeachment against him. plus, new video revealed in court of the interaction between the oxford high school shooter and his parents when they first saw him after the shooting. what it could mean for the case to hold his parents criminally responsible. after 87 years, has amelia earhart's plane been found? we are going to speak to the ceo of the company who believes they have discovered it.

new testimony in the historic trial of jennifer crumley. today jurors heard from oxford high schools former dean of

students. he testified that he had no reason to discipline crumley. she is facing four counts of manslaughter. >> it all started that morning, the morning of the mass shooting . jennifer went to work as a normal day then she gets a phone call and gets the text of this picture that her son is drawing in school of a figure of guns and bullets in my life is worthless, the world is dead and so she summoned the school so she went there very hurriedly then she came back after that meeting and spoke with andrew smith, her boss. she spoke to him after that meeting. he testified what she told him at that point. >> i recall walking up to her and asking her if she was doing

okay and i recall her mentioning that she had to get her child counseling. she seemed down, she mentioned her car, she mentioned that the dog had passed away and grandparents had passed away. whenever she seemed down she said she thought she was failing him. >> when she said i feel like i'm failing him, who is she talking about? >> apparently her son. >> the focus at that meeting in school that she had with the dean and the counselor, her husband was there, ethan was in the room also, was suicidal ideation.

they were concerned he was going to take his life because he was depressed because there were mental issues. so, she is back at work. the day is going on. at 1:09, she gets an emergency text from oxford high school big words, active shooter and she immediately panics and she ran out the door wanting to go to that school. she contacted her husband. her husband had already called police and turned in ethan. he believed he was possibly the shooter and then it all culminated that day where they went to the sheriff's department. they were in that room with ethan for just a split second. she was angry, james was sobbing and it was a few days later that they were both arrested for involuntary manslaughter themselves, homicide. >> and we are seeing the moment here in the wall, this moment where they saw their son briefly . what did we hear from the schools former dean of students? >> this was reasonable suspicion

is the test as to whether they could've looked in that backpack so here are the facts. on monday, he was researching bullets. he was then watching between monday and tuesday at school, he was watching a movie they said where someone was shooting and killing someone, murdering someone and then there is the math drawing, for he has the stick figure and bullets and blood everywhere along with my life is worthless, but the dean said that there was no discipline involved necessary for any of that and no reasonable suspicion to ever look in the backpack and he was the one that went and got the backpack out of the math class to again give it back to ethan, which was shortly before that math -- mass shooting happened. in his defense he said there are state laws, rules we have to follow and i was just following the state mandates. >> really interesting. thank you for following this for us. it is a rare moment on capitol hill as republican lawmakers push to impeach homeland security secretary alejandro mayorkas, and we are live on the hill following the very latest.

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waiting for an organ. these are not just any ordinary pigs. there are some of the cleanest genetically modified creatures on earth. dr. sanjay gupta has this exclusive. >> these pigs could one day provide a nearly endless supply of organs. he kidneys, hearts, livers, it is called zeno transplantation, and what you're watching at this research facility has never been seen by the public before. >> we usually try to limit this to only the staff that takes care of the animals. we rarely let other folks come in. >> mike curtis is my guide today. he is ceo of genesis, a company

devoted to raising pigs to try to solve the organ crisis. >> everything is controlled. the feed is clean, the water is clean. you can see the staff is trained to try to maintain a very clean environment here. i should just point out that i walked into her room, turned on a filter, essentially clean the air for five minutes before i could then go shower. that's why my hair is wet. i washed myself. i put on everything new here, clean underwear, socks, shoes, everything is different just to be in this room. that gives you an idea of just how clean it is in here. >> it's more than i typically do to prep for the operating room all to protect the pigs from us. >> i got to tell you, i did not know what to expect. it is powerful just to be here with these pigs. >> these two in those three and the little guy here, they can carry a total of 69 edits to the genome. >> that makes them among the most genetically modified animals on the planet. >> how much has to happen to

that pig genome to make them compatible? >> our approach is three- pronged, where we are trying to reduce the risk of disease transmission from the porcine donor to the human. we are editing in a way that reduces the risk of rejection then we had genes to control rejection. >> they do all this with the help of crispr, knocking out or adding in jeans, in this case to make a pigs organs were compatible with the human recipient. >> to keep the consistency of the genetics, we establish a cell line and use cloning to produce consistent donors. it is akin to what was done with dolly back in the 90s, cloning. >> it is essentially a modern day assembly line of genetically modified pigs. >> we selected this big because their organs are correctly sized for a human recipient. as much as we talk about the

realtor can science of gene editing, ultimately you've got to get the science right. >> less than 1% of the people who die every year die in a way that they could ever even be considered as organ donors so even if you optimize everything, there still would not be enough organs. >> dr. robert montgomery's director of the transplant institute at nyu langone health. he is also the recipient of a heart transplant. >> i had a heart transplant five years ago. i had seven cardiac arrests and still is not sick enough to be able to draw an organ. >> that experience became a rallying cry for him. >> we need a sustainable, renewable source of organs from something else other than humans dying. >> are animals the answer to that? when the y are the answer to

that. >> specifically pigs, besides the similarities, pigs have several piglets with each pregnancy, making them a quickly scalable source of organs. one day we might see facilities like this all over the country. >> we've been doing research on xenotransplantation for decades, pig organs into and doing teen edits and that work has progressed, but there was still this question of, are those results translatable to a human? >> have we learned everything we have to learn about transplanting these organs into nonhuman primates? >> i think there were diminishing returns. >> the problem was the fda still is not ready to give the green light to transplanting a pig organ into a human being. so, montgomery proposed a provocative idea. what if the first human recipient was brain-dead? >> the heart is still beating, they can be retained on a ventilator and you can see what

the human response is going to be. >> on september 25th, 2021, montgomery perform the first- ever genetically modified pig kidney transplant into a brain- dead human and it worked. for 54 hours, but each time they tried, the results got better and better. >> we've done this five times. the first four, two kidneys and three hearts were just for two days, but this last kidney was for two months. >> he and his team shared the findings from their last patient with me. >> you see that red? that is hemorrhage. we did have a mild rejection and we were able to test and make sure we can treat that using conventional antirejection drugs. >> then in january of 2022, for the first time in history, a team at the university of maryland medical center transplanted genetically

modified pig heart into a living human being, someone who is not brain-dead. it was allowed by the fda's compassionate use pathway for experimental treatments, something used when the patient has no other options left. >> you have a patient imminently facing death, why wouldn't you try? but how far we still from this becoming a reality? i think for the right patients were going to see in the next couple of years. >> pigs that could save human lives. >> these are the cells that we used to do embryo transfer is in. >> i never expected to feel like i was immersed in a really scientific place in the middle of a fig -- pig farm. >> the discovery of crispr, transplantation, we are integrating five nobel discoveries to make this a

reality. >> i've got to tell you, it is just incredible science and really has the potential to change the way we think about transplantation overall. as you heard, maybe even within the next couple of years. there can be ethical challenges here. how much should we be interfering with the genomic sequence of an animal? how much should we be relying on animals to preserve and protect human health? big questions. we could not even show you where we were exactly because of security concerns. i think what we learned is this is happening, it is happening quickly, and poised to make a big difference in terms of how we look at transplant in the future. >> stay with cnn is central. we are back in just a few moments.

not just any whiteboard... ...katie porter's whiteboard is one way she's: [news anchor] ...often seen grilling top executives of banks, big pharma, even top administration officials. katie porter. never taken corporate pac money - never will. leading the fight to ban

congressional stock trading. and the only democrat who opposed wasteful “earmarks” that fund politicians' pet projects. katie porter. focused on your challenges - from lowering housing costs to fighting climate change. shake up the senate - with democrat katie porter. i'm katie porter and i approve this message.

house republicans taken a big step today in their efforts to impeach homeland security secretary alejandro mayorkas. right now republicans are preparing to move ahead with the resolution that could make mayorkas the first cabinet secretary to be impeached in nearly 150 years. the two articles in the rev -- resolution accuse him of refusing to comply with the law and bridging the public trust. mayorkas is defending his record, saying this in a letter addressed to the committee's chairman, quote, your false accusations do not rattle me and do not divert me from the law enforcement and broader public surface -- service to which i remain devoted. let's discuss with the republican member of that

committee. congressman, thank you so much for being with us. secretary mayorkas serves at the pleasure of the president. he follows the guidance outlined by the white house on how they enforce immigration policy so if he does not set that policy, what proof do you have that he has committed a high crime or misdemeanor? >> listen, he's hiding behind changing policy and not upholding the law. the law says pretty quickl y -- clearly that anyone asking for asylum in the united states needs to be detained either inside the united states or in a third country. the law also says very clearly that you don't issue parole on a mass basis. the issue at on a case-by-case basis. he obviously clearly violated that. the law also says that when you have a deportable aeolian criminal, that the individual be deported. he put a new policy that says you have to take other things into consideration. and so, he has clearly violated the law. he's hiding behind polic y and

it's not really a policy discussion. it's really a violation of the law. they changed the policy, which in turn, we think, violated the law. he has also breached his duty to protect the american homeland. you know, there is no doubt that fentanyl seizures have increased by 500% which means we've had a 500% increase in sentinel here in the united states during his reign as the chief -- as secretary of homeland security. it's killed over hundred 50,000 americans in the number one duty of government is to protect american citizens and to protect the united states of america. >> multiple, well-respected constitutional scholars have weighed in and they point out that he is essentially following guidance. he is not setting that policy and acting unilaterally.

i want to highlight one of them, jonathan turley, a well- known conservative who has testified several times against the impeachment of former president trump. he argues that the border is a mess but he says you don't really have a case and adds that there is a danger to this, that this could potentially lower the bar for future congresses to impeach cabinet secretaries over actions that do not amount to crimes. are you concerned about setting a precedent? >> look, here is what i'm concerned about. i'm concerned about the southern border. it's chaos. we are being overrun. it puts america at risk. i'm concerned about enriching the multinational cartels down in mexico where they used to be making $500 million a year and now they are making $1 billion a month on illegal human trafficking. i'm concerned about those migrants that are crossing the border, many of which perish. i'm concerned about the minors that are crossing the border unaccompanied.

many of those are being used for forced child labor or trafficking. i'm concerned about all of that and i am also concerned that the secretary, and yes, i do believe he is following the orders of the president, are violating the law for a means or an end which i still haven't figured out but look, i've been saying for a long time that this is on purpose. this is not by accident. we've had many people come in front of the committee saying hey, we've told the secretary exactly what he needs to do in order to get this under control. he refuses to do it and so i have said this is on purpose, so he is violating the law on purpose and if it is at the direction of the president that he is violating the law, also. >> as sounds like you're not concerned about the question of precedent, but there is the question of whether you will have enough votes to actually impeach him. republicans have a very narrow majority.

you can only afford to lose two votes. either way, if he is impeached, he's not getting convicted in the senate ultimately isn't this just a symbolic, political move? >> no. we have to do what we have to do. our duty, and the only recourse we have here in congress, is to hold secretary mayorkas responsible and impeach him. what happens at the senate happens at the senate but my conscience is clear that i'm going to abide by my duty. i'm going to try to protect america and the american people than it is up to the senate to do what they need to do. that is out of my hands. >> a question on what is happening in the senate, specifically, the deal that we are expecting to see the text of soon on immigration, also tying in ukraine and israel. the leader republican senator, james langford of oklahoma, says it is by far the most conservative border security bill put forward in decades. he has expressed concern that house republicans are not open to supporting it because donald

trump does not want to, in his words, give the white house a win in the election year. are you open to seeing what is in this deal and what is your response to senator langford? >> absolutely, i'm open to seeing the deal. i don't know what's in the deal. if it is the most security border security to come out of congress, i will be certainly happy to see it. obviously, it is subject to interpretation whether it is conservative or not but if it turns out to be what he says, very conservative, i'm certainly open to the idea of supporting it when it gets to the house, so i haven't seen it so right now it's speculation. >> congressman carlos giminez, we have to leave the conversation there. we look forward to talking to you about the deal once we see the text. after 87 years, have we finally found amelia earhart's missing plane? a deep-sea exploration company believes they may have located it. we are going to speak to that

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-- an exhibition group from south carolina thinks it is. the teen captured the sonar image after instance of deep sea search using a high tech drone to survey thousands of square miles across the pacific ocean floor. now it is fuzzy, but you can make out with the right kind of eyes what looks like an

aircraft, the group thinks, that just might be earhart's. >> earhart of course vanished 80 years ago as she tried to circumnavigate the globe, and finding out what happened to her has sent explores on quests ever since. and one of those explorers is tony romeo, who is joining us live now to talk about this. he is the ceo of deep sea vision, the company that led the expedition team that captured this new image. all right tony, talk to us a little bit about the expedition in the technology that you used to conduct the deep sea search, and this image that you are seeing here. >> sure, thanks for having me on. first let's talk about the image. there are three things about it that we really like that you posted on the screen there. the twin vertical -- were very clear on the sonar image, and those were very distinctive of amelia earhart's aircraft. we were very happy to see those. the second thing is that we got the sonar image of a very flat sandy surface. so to see anything protruding up or sitting on the sea floor

would've been very unusual. and then thirdly, the size of the target was actually fitting very closely to what we would expect for her aircraft. the technology we used was a hugin 6000. there are only a handful of them in the world, and the 6000 mean 6000 meters, and so we can go all the way down to the full ocean depth of 6000 meters to the bottom of the ocean and then it basically flies like a drone back and forth, scanning the sea floor for anything interesting. >> does the discovery geographically track with what is known about her disappearance? like other other details that lead you to believe that this is close to conclusive? >> we do, and verified by third-party sources as well. the smithsonian and the scripts institute, a large institutes of folks who have studied amelia's last flight most believe she was very close to a destination. i think it's a testament to how

good of a pilot that she was. we found a target within a 100 mile radius of the island, and that is where we've always expected her to be. >> so how will you work to test this hypothesis, to see if this really is the real deal, this is her plane? >> sure. what we need to get back to a couple of steps now that we need to take. first is confirmation. we need to go and take a look and put a camera basically on the target. we need different equipment, probably and rov to go down there with some pictures that can take a look at the target, take a look at how it is sitting in the soil in the mud on the sandy bottom of the sea floor, and then confirmed this. it could be another plane, but the inner 16 to 0 to 0, once we see, that we can positively identify the plane. the next step would be to carry the site and, in other words, take a look at what debris is

around the plane, how it is sitting around the sea floor, and we can engineer a solution to possibly bring it up. >> that effort sounds challenging and expensive. what is the process going to be like to getting that confirmation? >> what we are looking for partners. we don't have an rov, we have a auv but not in rov. we're looking for media partners, we're looking for folks with the skill sets to go down and do that. >> why is it so important to you, tony, to answer this question, this great mystery? >> sure, well i think she is america's favorite missing person. she has been gone for 87 years and some people call it one of the greatest mysteries of all-time. i think it is actually the greatest mystery of all time, and it's older players found, there will be somebody out there looking for it or concocting some crazy idea of what happened to her. >> i guess this might be a dumb question, but i'm curious. what do you think it has taken so long to figure this out? >> no, it's a great question,

and actually it's key to the whole thing is that such a remote part of the world, she crashed in lake michigan, we would've found two years ago, but it is such a remote part of the world. to mount an expedition to go out and search for her is incredibly difficult. >> yeah, it certainly is. i can't believe that honestly this is a question that has not been answered. so tony, we wish you all of the luck. >> and if you see resources, rihanna is an excellent swimmer, she can hold her breath underwater for a long time. >> for like 30 seconds, i will be of no help. [laughter] but tony, we will be watching very carefully, because i know that this is going to affect so many people, a lot of people want to know what happened. thank you so much for being with us. >> great, thank you, appreciate it. >> so elon musk says that his start-up has implanted a chip in a human brain for the first time. we are going to take a closer look at his claim, and we are going to talk about what this ship actually does, ahead.

♪ ♪ ♪ president biden says he has decided how to respond to the drone attacks that claimed the lives of you three u.s. service member. throwing to take a closer look at the different options facing the president as he tr