to you are watching the news coming to you live from berlin after the break, the medical revolution that's being fueled by an ingredients in camel's blood. say to for that i'm terry martin the and all of us here at the w news. thanks for watching the, the coming 0 sent excels 3 trans people. stories is not kind items that feed us complex stores. sometimes from here, so efficient chip in search of the 3 generations, one to any thoughts, july 7th on d, w. the

chemicals have a reputation for being malcontents nom is to be ingram. that alpaca is the best known for that high quality will codes the most surprising that the expensive camilla di family. a spoke to a medical revolution. like so many medical revolutions, had begun with a co incidental discovery at the free university in brussels. the,

the more precisely in the department of applied biological sciences says small demands was part of a research team in 1989 headed by professor remo thomas, the modem is today, often recounts the historic discovery to students. i will give you the story of the practical since we need to stay 35 years ago with the students. you all know, yvonne for the easy infective to read it back to you. yeah. our immune system, we generate antibodies against those bacteria. and so the anti bodies damien bind to get back to area and they're going to destroying the bacteria, the antibodies that key elements of the immune system

that created specifically to detect and eliminate for and substances or anti gents, but got into our bodies the, on the day of the discovery professor homeless students were to isolate and identify antibodies in blood, but the costs didn't get tough to a very good stops. well, we had our students that refused to donate, blocked, and they would also afraid from the brought to a point that colleagues, because if mike, based on time in age or tweet about dieties or h, i v. and there, if you're stuck in a boss for a stupid practical. so therefore, we're said, well, you know, we have seen in our freezers some brought from a dromedary. blood from the one home to campbell was used instead, the dispute is got to work. but were in

for a surprise, alongside the plastic antibodies. the experiment revealed other anti bodies with a much light to molecular weight. the they have only the weight teeth both $90000.00. and that was surprising because normally, that wasn't never seen before in human in rabbit, in most, in group of the unit. and we can, you always have agencies with the most of the weight of 160000 professor homeless students had stumbled upon a previously unknown anti body and a living creature. the anti body had just to poly peptide chains as opposed to the 4 in plastic on to bodies giving it's an unusually low molecular weight. the finding then have to be confirmed and repeat experiments. professor homeless

used fresh blood samples from the brussels to, to replicate the test, but not just with blood from campbell's, from lummus. and i'll pack as to the results show that all the animals possessed to know certainly the usual anti bodies. but also things really discovered many antibodies scientists, one did with these just the remains of a primitive immune system where they functioning antibodies to find out the research as needed, not just mole blood, but the whole campbell, they needed to vaccinate it. in other words, injected with an anti gen a piece of an in activated virus, for example. then they have to wait and see if the animals immune system would produce a response. using these unusual many antibodies. the scientists

how to improve lice, the zoo animals couldn't be tapped a 2nd time. we didn't have any money anymore. and therefore, we have to ask our technician that wasn't brooklyn, to take a few other trends in his luggage and to reset this own thing at the atlas mountain to immunize the drama there for his own cause, a farm. but as long ago, it was immunized using drama down summit holiday movies a few times. so we close at one year and a half before we have to any overlooked how did the dromedary use immune system react? did it produce many anti bodies specifically targeting the intruder? scientists wherever, eventually able to test the animal's blood. the message shown here use the color reaction to make the antibodies recognition of the anti gen visible

the t or not. but there was no reaction that would have meant that chemical couldn't produce and immune response to the end of june to the vaccine they're going to the office and going through the next hour. or will there be no point in continuing aria, the, the quantity the sample began to turn yellow, about half an hour into the experiment down. so it was clear, the mini antibodies worked antibodies attach themselves to an outage in to trigger and immune response and eliminate the intruder. but session moved to mind's made a crucial discovery when he looked at the very tip of the camel anti bodies. a variable pod can adapt to any kind of virus bacteria or other anti gen, detach itself to it,

the modem, and showed that the antibodies tip could be separated from the rest without homing it. the minutes school antibody fragments proved can also need to be true resistance, but it's binding capabilities remained fully intact. the tip is what's known as a nano body, a structure that no longer acts to trigger and immune response, but to size resistance and binding properties make it an extremely promising tool. so medical science a dental center, never forget something like that. it's like with both of your 1st child, but opinion if it gets all the if they then his baby was soon ready to leave the university lab and into field research. but 1st session load demands and colleagues, remo from us and say see

a custom on peyton to the discovery in 1993, giving them the so rights to commercial development for 20 years then they published the discovery in the science, general nature, the debut for the small calculated antibody with a detachable head for such as under the birch trees around the world was responded among them a lot in must say from a structural biologist allow, who said begin studying the new antibody. as soon as he found out about it the same way they have to do that for me. yes to, to you at the end it's here and marcy that the 1st and auto body structure was modeled in parallel with our colleagues in brussels, south carolina. we could see the sheets that gives them more to its properties. i don't need either precisely anything to them. or there were 3 large loops

a bit like 3 fingers. so i thought that i could grasp the end of june key, so it didn't work. he's all of a new condo it on his end. he knows even more now, thanks to progress in scientific modeling, but it's being confirmed. it's an atomic level that the know tips binding. paola is this precise and effective assess of a classic antibody. so nobody can book with a to 14, the existing auto body, like many protein 1st step is composed of various areas that are more or less flat, a hollow and bumpy. these hollows and bumps, there are the bumps and hollows of the empty gen c on the 2 molecules fit into one another. and thanks to the perfectly complimentary shapes to their surface. so i'd like to know what that data. so 1st of the fact that it's still hung on it to me fitness test that i've shown since that deal. and if we take a closer look at this interactions on, that, if you look at his atomic structure, then we can see that the atoms really do touch each other as these relatively

strong bonds between an oxygen that so a nitrogen active good binding the entire antibodies onto the integer because of the surface complementarity is in nanometers. we're talking 10 to the power of minus 10 meters. don't quit. and that's the magic of natural biology. see for my mom to that i must either that or given us either put in a to the tip is atomic high tech about a miniscule vehicle ready for use at any time of the stuff? scientists dream of the discovery that required a large dose of free lock. the history of science is full of accidental breakthroughs over such that produced unexpected results from aspirin to dynamite, x rays, and the structure of dna. all these coincidental discoveries came from

a mix of good luck and ingenuity, retiring phenomenon known as serendipity, the and the origin of this term is for this anti body. quite surprising. it refers to a 16th century passion fairytale, that recounts the journey made by the sweet princess of 7 dead and how they were able to precisely describe the characteristics of a camel, the troubled the rates before them. the combination of count substations and insights resulted in serendipity. and now once again, the camel is the stuff, the cook,

but the discovery of the cumberland. nun ability has also raised many questions. could they actually be used on humans work? therapeutic applications could be developed and marketed, says more demands prefer to lease the answers to others. your articles go to school . please get the to see what they think was too much of a scientist, a and i didn't want to get involved in projects needed. it's a commercial product with with you. i wasn't interested them as you stop talking to me as a follow over, just you to stayed on that with the academic movements has never looked back though he did keep to alpaca is from the adventure that really need you to now is to keep the growth and he so what should trend to say? this is paco itself and that's a popular stuck with bob black pack and popular to cartoon cartridge, the 2 road explorer was escaping the bomb. the gas these 2 ruins,

escaping from the middle of it found the night. the one is optic them so it was in belgium, the nano bodies potential applications were 1st explode and some a stomach machine capabilities came to lights and then a few of them on t conducts research at the university whether or not it bodies with us discover it in 2014, to begin to focus on the disease that's read but still lee, so strikes it's caused by bacillus versus a complex and relatively under studied bacterium. the, the 1st time we hear about i'm trucks is in the bible, it was the 5th flake of,

as you just say, that it has been always, there is, this is really affecting or warm blooded animal, including us. so it spread everywhere in the words. and there are to be some way to get things to infection by skeen respect, sorry, and in the gulf, and that'll be infection cause of systemic in the blog. and then it's really, really difficult to be treated as instructs infection via the respiratory system is particularly deadly. so deadly. in fact, the seats inspired biological weapons projects in the 2nd world war. it's nearly 2 weeks as a 1st struck tax in the united states. the circumstantial evidence is low, american is leading the authorities to investigate possible links between the anthrax and a solid. been loves, network 5 people in the us actually died from left to is laced with and strikes in 2001. so how can we protect ourselves, process and exceed? yeah, so this is let us to class security by law. and

what design instructors even look like. how this for me and then send them in again she was interested in one specific characteristic of the bacteria. theses buses or some charges. it's so long save muscle lie. it's makes change made of the certain data they are covered by it or not more that is made of little pieces that are trophies, it works so i can make those kind of them. and if you remove the ottoman or the bacteria are getting a signal at austic and they are not defending more. and i came up with the idea that, well, what if i can destroy is our thoughts turned to the nano bodies

discovered by how university colleagues might they be able to use them in a school size to infiltrate the bacteria is alma like tiny miss styles that code for a nama, the protein that makes up the bacteria is um, uh, was injected into the beast. and after a few months, phenomena had created no bodies, specifically targeting this protein field of anti, then introduced, and then their bodies to the answer. i expect tyria the results were astonishing. those of the known cheese themselves, you see they have these uh, as most shape. but when you treat them, we did not know bodies based factory to wrinkle, and then they collapse. they were able to stop the protein to make the armor and without the support of its exoskeleton, the bacterium folds the pops. so it's really like the nano bodies are the key of

the story going between the i'm and these assembled just and that nobody was possible because of the size, the that success come to, to test and no bodies in the lab. in other words, on living mice, the, my swear infected with on trucks and then getting the nano bodies twice a day for 6 days. well, i really so the, we're going to die on a sleeve, me and my colleague of sleep fluids doing the experiments. and then the my subject to, to get better, get better, but getting better. and on sunday morning i get this cold from sleep like so. why is that? that was why the control group got old dad. i remember really excited jumping. i was like maybe my peach, i'm having remco and i have something something you likely to use because, oh my god, we said something this, this, this isn't,

this is huge. is that it's worse. so there's a lot of invest phase of my life. this opens up really a lot of light over upstairs and also the opening of new fossil treatments for under my kids that have such a higher. this is huge versus in the belgian city of gin, twin unable to use of enjoyed the most spectacular success. this is the headquarters of abilene, a scott top founded in 2001 to develop applications for college, not able to use the assign to fix success story. the discovery of a special type of small anti bodies and cabinets, sparked decades of innovation. and it led to the foundation of abilene is in 2001 at that time, the small anti body, what's the name?

amount of body and the start of the company have 10 employees. so is a 15 is blink, 6 fluid potential applications for various types of diseases. investors gradually began seeing the advantages of using calculating non abilities and in 2018 they hit the jackpot. the goal process i know situated both it was a good investment it out though who hosted a meetings 3900000000 years and amount equivalent to the promise held in the timing on a buddy's. the 1st actual use was a drug center fee began selling in 2019 caps decision map. ready a drug tobacco to an auto immune blood disorder that's very rad, but faithful in 90 percent of cases, if left untreated, a t t p. the

nice and e suffers from the disease acquired from both text from both side to peanut poor poor the today. thanks to capt decision map. she's in the class. she's returning to the hospital for a checkup with professor couple an a t t piece specialist the cause of treatment work the summer. yes. very well as oh, okay. on it on us, everything's really back to normal. now. we just need to check every 3 months and probably for the rest of your life a lot faster. it is solely on the good, multi it from what a real prostitute, the i just and all that stuff to get bruises. so my buddies that have pizza? no reason for the stuff is on my legs and then gradually all his all you too bye.

literally stuff is moving up. is said to swamp, which is up to several feet. i suppose i bashed into something and so not realize it because i'm very active. i'm a primary school teacher, so so do go go and my children are very young. i'm always moving around to her. it's happened over a couple of weeks. it's an eyesore since if it smells like hey, something's wrong and is because the bruises started to appeal of my oh yeah, i had a huge one on my hand and i'll see if that's my thought to myself is on that there's something wrong. tricity, it gets closer to the box and the, the key. it's a disease that's linked to the formation of small clots in the vessels of emotion organs because of the typically the brain and the heart, but also the digestive tract and the kidneys. and if we do nothing, the organs fail, then the patient dies on gun a mushroom on. as soon as the opportunity my not the not know body see

count the blood proteins involved in the disorder detached themselves. they replaced the platelets that caused the blood clubs and prevent them from company to come and live. not able to use make it possible to attacks that diseases and know what kings associated kip, this is us since we added campuses, a map to plasma exchange and other immune suppressive treatments. patient responses, not chosen pastor. it's also long. last angle. that's what's new. it does take us a 2nd. my know what the, how did this off thanks to this, we can now stop plasma exchange much sooner than before. currently, we estimate that with the addition of capital susan that we can cut treatment time in half. lashona dysfunction some of the or the none of the bodies. and now such an integral parts of medical research that,

that origin in the calculated immune system is often overlooked. the well gave camels, these unique superpowers, the native vienna, austria permanent book studies, the genetics of the very ancient camella di family choose a specialist on the origins of the cumberlands, which is undergoing surprising changes during that evolution. the camels to originated in the northern america and it was about maybe like 40 to 45000000 years ago at the very beginning. do the very small, like a goat and um, over the millions of years developed into different camel types, lie to a smaller thoughts around 50000000 years ago. they split into the tool on

images and i believe the new wealth camels and the old solid candidates. and the new world kimberly they migrated down to the southern america, which i represent as now by the nama. i, papa, the, we're not going to be calling you. in the old world, campbell's day migrated various via the bearing land preach to asia and from the out in to africa. it's the illusion of the nano bodies. it's it also very, very old development must have been older even than 15000000 use ago. because both kimberly niches have it. so the system does not know bodies must have developed before display of these totally ditches. they have developed over the millions of years, very successful mechanisms to fight against diseases. the

low need solution has left it small come the species. but white cabinets in particular, i would to face by chance, a lot of people, lucian thing happened by chance, trial and error. so something which has been successful survived and evolved. and if it was too much of a cost to keep, then it would have been abandoned again by the species. but why out of mammals would not have developed the same strategy. i don't know. cumberlands may still have the other secrets, but for now the sharing the benefits of their immune system with humans. these alpaca is for the king, the paris belong to the us, the cheapest. they play an active role in some major research. the

immuno logistic pa fi is the ship it to this small research heard the ticket was a uh go to interested in cumberland antibodies about 20 years ago because of professor how much work in brussels. yes, i would said us all the people 1st thought it was funny that we were working with alpaca. so as soon as of now it's become so important that everybody understands remote. i'm facts and i've seen them against various proteins, really against outside was in particular, how did you feel home to put to you about the ones that vaccinated would take a blood samples of continual work in the line? it could have useful to please continue. i thought i gave them, we leave the animals alone for a couple of us. what it is, some key to call, don't presume, is that okay with them? now if you 2 years of peace and quiet the, the next step,

extracting from those few sentences of blood, the anti bodies, the animal has produced in response to the protein characteristics outside this disease. fewer than a dozen house of several 1000000 antibodies, louie passed developed the rabies vaccine in these buildings in the 1880s. and the institute continues to welcome promising treatments, thanks to it, sell pack as many antibodies. the book fair these on to call a for call. we can make antibodies against cause a to see again see kind of an recently against monkey pox. ok, so we can make them, it gets up and brain cells flatten the containment for service on the ship to include minor search focuses on out. so i'm just a big, we're trying to extract the antibodies specific to outside the school, the diagnostic, and eventually for treatment will call for the different let's take a look for that to help with the nano bodies that could

recognize some of the diseases degenerative characteristics. and in this case, no bodies specifically produced by elpac, cuz the, the 1st stage is to extract the dna from all the nano bodies in the blood sample and then introduce it to the bacteria dual credit. oh yeah. i mean, yeah, direct can we have 1000000000 bacteria containing the dna encoding for about 100000000 nano antibodies. we call the feel it through selection method so that we gradually isolate the 10 best amount of bodies, if it to the email and then don't keep cool do lunches and do the the, the selection is ruthless. they 1st use a virus that can eliminate 99 percent of them suitable not able to use

the remaining 1000 candidates to attend as a, to a robots which one by one test their ability to identify the outside that protein. the entire process takes around 3 months just to if the original $100000000.00. none of the bodies remain standing the, the chose and unable to use it, then taken to the us, the to do several, the power sprain institute to help conduct research and outside this p a p. i. left size antibodies are always eagerly awaited, especially by adults, have been why the lead to who is exploring new methods of diagnosing the disease. the

outside this directly affects the brains neural communication network, the, the formation of protein deposits, known as i'm annoyed. cox looks the flow of information, but the disease also causes the new runs themselves to degenerate and die. the outside is initially effects memory. before closing and reversible damage in the other areas of the brain for treatment to be effective outside this must be diagnosed as early as possible. the goal is to detach the amyloid packs that build up in the patient, sprains from the stops the into the nano bodies. but that responsiveness must 1st be tested

to die. so footage doesn't accomplish what trivia is quite interesting to include. the 2 anti bodies really work very well and this one recognizes the family plaques . and so i've done some tagging on a transgenic most that's full of amyloid flags. and you can see they're all tactic to this really resembles what we see in the brains of alzheimer's patients. idle to go into the anti body is very precise and we recognize there's only one thing. there's no background noise. so take a look if it really is perfect and you and the other anti body recognizes the 2nd classic lesion of alzheimer's disease, ero, 5 blurry tangles. dr. glenn is useful. you can see that all the lesions have been carefully detected by most of the naval campus to go, which is the memory center for humans and animals. you can also see all the time you are on is recognized by the body work. when you follow the logic, all the 1st experiment was conducted on brain tissue extracted from mice.

it will now be repeated on living animals to delete the most there under the microscope on the aim is to see if the nano bodies can cross the blood brain barrier. speaking body, i'll keep them in assets. name suggestions is a body or the isolates the brain from the plot through fi. because the blood carries pathogen talks that molecules that mustn't enter the brain that they're inside of this battery or is that important molecules like anti bodies, count the process to go. except maybe camella down to body is the small size is the key. trouble supposedly claim you can see for now it's very flag inside . you can just start to make some shapes appearing and real time it can, you can see the active on the exit. the vessel is crossing the blood brain barrier and it will gradually spread and gather at the sight of the amyloid black sea. so can we do any where they pick any? enjoy the job. that's cool. and you can see the prox claim

a little some old attacking is done by the anti bodies. but this time sits within vehicles were enough to slice unimaginable just a few years ago. the technology opens up new opportunities for treating outside this disease since just the sea level to call these nano anti bodies or nano bodies, but clearly have a feature by combining them with elements that can be picked up on an m r. i will be able to carry out early, high resolution diagnoses on patients through affinity, but as soon as well as monitor of various therapies on the regression of these lesions, no longer this website isn't these a high hopes in the fight against a disease that afflicts hundreds of thousands each year in europe and an estimate to $10000000.00 worldwide. but none of our buddies can go even further and highlight all the processes that occurred deep inside the human body.

the literally schwartzbar wants to use the nano bodies, tiny size to infiltrate living cells and wanted to what goes on inside them. a joke that requires a slight upgrade to the 9 a bodies, the nano bodies are invisible. since we can see them, we must make them visible. we link the nano bodies with a small source and protein to make a chroma bodies to that in coma for this and the rest. and it's not a body that makes it possible to navigate within cells and ups of some of the biological processes live. these are dynamic processes taking place inside sales. and that's where the chroma body has the

additional advantage of functioning and living cells. the cells processes can be displayed and the dynamic modifications within can be visualized in real time. and when does it say that each side is what i can see inside the cell, the crime a body binds itself to a its target. it traces the targets come tools and reveals its movements. you'll see that we can see the chroma bodies, the signal of a chroma body that has bound itself to the h i. v virus. we can observe and find detail how the h i. p virus attaches itself to a sales plasma membrane and it's been discharged to infect neighboring cells. i'm not able to send it to you from my body's are already used today to study the effect of 2nd drugs on cells in particular for cancer treatments.

you see for an hour or stephen, all right, and you can also see a criminal body in the living cancer cell. the chroma body collides with the nuclear membrane. so we can observe the division of this cancer cell. it's an important process the most, for example, if we want to now develop a drugs that prevents cancer cells from dividing, we can test them in the cell line. we will know immediately at what moment and then what quantities of drug stops this cancer cell minute. and we can see it in real time on this kind of monster tongue lice, mitchell flu. so this is what this helps us choose medicines at a very early stage and saves money and the development of new active ingredients and expulsion none the abilities of the greatest hope in kansas, the treatment of 18000000 new counts the cases, the diagnosed every year of nearly 10000000 people die from the disease.

most current counts the treatment, slack precision, the team, the therapy attacks, no certainty, cancer cells, but healthy ones too, were such as they're looking for more targeted therapies. and none of the bodies have become a new precision weapon in the fight against cancer. the, the number of potential applications is growing. so i'm a designed to inhibit to cim as gross, while others destroy the cancer cells. a strategy adopted by belgian stop personality rex. it relies on no body special ability to bind on to other molecules to form a bond with a radioactive isotopes. the treatment is still in the test face,

but some potential uses already being assessed in clinical trials. here in a 1st stage, the no body is being added to a trace of the cheese, very slightly radioactive. it's mission to seek out disease cells and attach itself to them. here we say an x and i remember floats with an high uptake. and here, as we can see, the rest places also very good uptake on the tray sooner than anybody's target is a protein called her to that's a characteristic of 2nd types of cancer. for us, it's very important to know if there is a higher her to expression in the tumor and then the best assist of the tumor and then the best place to live snows. because we know in that way,

if this patient will respond to therapy. another advantage as a to now is the treatment to be tailored to the nature of the cancer. however, there is such as long term goal is to equipped to no bodies, but the phone will power full radioactive payload. so the nano will be east present into 2 more but the few to couple the same nano will be with that. so if you trivialize it to so you will, you read the aids to 2 more. and so the cancer cells, so specifically targeting to, to more cells while sparing to the healthy tissue what you want the small size, these very beneficial for this approach. once you administer it to a patient diffuses through too much to, to hurry fast. on the other hand, of course, you're working with the very both and the radio is it to for, to predict use. and you don't want the friction that is not bound on the, to mark to stay along the body. and because of the small size you to clear out very

fast from the body, which is perfect for the safety. now the young style top must complete the expensive series of required tests to guess its treatments approved to the clinical studies to prove that their drug is safe and a fetus from all the way from the camel. if you want hold to the patients and the told so i need to take more than 10 years. i'm not able to use have to potential to revolutionize therapies and diagnostic procedures now and in the future. the growing number of companies offering custom made nono bodies is proof in itself the, along with the physical and chemical benefits. the single domain antibodies are also especially lights and an expensive to produce these practical and economic

advantages make them affordable. so many research labs, stimulating innovation, the candidates may look very unassuming, but them must as a minute to rising antibodies, which has made them into the kings of biotech. something no one could have predicted. the fact that should cheer camel's unplug, as unlike the

of the eco africa saving indigenous medicinal plum from extinction, jeanette to character yamaha gold. these plums have such a powerful effect that they can even fight to malaria. a success story full of the agent. eco fixed. in 30 minutes. oh d w. i knew that what happened to me was that right? i just didn't know where i could share at west who is going to believe

me. this is greg was staring iced against her well, in canada. as with thousands of indigenous women from the 1970s to present a global membrane in 90 minutes on dw, the get ready for an exciting i've been trying to look surprised. hi irish. and i'm ready to dive into the hands of human to do you have you have a one, the front porch and the on expected side to side. the

a this is dw news coming to live from berlin. motors and france flocked to the far right supporters of the national rally celebrate their strong lead and the 1st round of step parliamentary elections, party leader, marina penn says president mccullin's centrist campus all the way down. she's urging voters to give the national valley in absolute majority and next sundays funnel right. also coming out hundreds of ultra orthodox joyce band flash with police as they protest the court ruling. the entered their decades long exemptions from compulsory military service and rates.