today on getting answers diagnosing the health of your brain. could the secret to discovering your risk for dementia be unlocked with a new phone app? plus, the build up to the bwc conference? the countdown is on for the women's

empowerment mega event, with some big names on board as always. but first, the travel troubles in the skies ahead of what the faa says will be one of the busiest air travel weeks of the year. is the industry ready? given recent united and boeing troubles you're watching, getting answers? i'm kristen sze. thanks for joining us. let's begin with the growing skepticism for americans in choosing to fly on united airlines and other airlines. just over the weekend, there was plenty of attention called to a united flight en route to sfo from frankfurt, germany. it had to return to frankfurt two hours into the flight because of an overflow from one of the plane's lavatories into the cabin, and with the possible humor aside, united and boeing are actually in the midst of intense week to week scrutiny, with their planes lately joining us live now is brett snyder, an airline industry insider and operator of cranky flier dot com. brett, thanks for your time. yeah thanks for having me on. a lot of travelers are pretty cranky.

these days, to say the least, with all these headlines. look, we've heard all kinds of experts and analysts the last few months really. but in your view, is the number of these incidents increasing or is it just somehow all making it into the news because of social media or what? >> yeah, i think it's more the latter. there aren't really a huge difference in the number of incidents, at least, that i've seen. i mean, some of the smaller types of incidents aren't really tracked very closely, like a lavatory overflow. so, but, you know, i think there's just a heightened sensitivity right now, especially with everything that's been going on with boeing . and of course, united's been in the news as well, with the faa, you know, has been in the news a lot. >> i mean, is it just bad luck? i mean, you know, other than what we mentioned, on friday, a united jet flying sfo to

>> i don't think that's likely the case. the faa has, you know, the faa is under scrutiny, by the public as well, for their role in a lot of what's going on with the boeing, max certification. and all that. so i think, you know, they want to be very present about it as well. and so they're showing that they're stepping up. but these are the kind of things that happen to all airlines fairly regularly. they're not really big safety of flight issues, at least most of these aren't, sometimes it's passenger comfort, like with a toilet overflowing, but, you know, there's not really a threat to people. >> i'm sorry. i forgot the lost wheel, though. that one happened at sfo, heading to japan, right after takeoff. i mean, that doesn't happen frequently. that's not just like a lavatory overflow. >> it doesn't happen frequently, although delta had, one that

came off of one of its airplanes as well. so, you know, maybe a week or two beforehand. so it's certainly not normal to have all this, in the news so front of mind. but these types of things do happen, you know, more generally. and i think there's just more scrutiny of it right now. so, once you have a couple of things in the news, then people pay more and more attention to those airlines. and it's apparently united's turn for that right now. >> that effect i do get. okay, so you're trying to tell us that the numbers themselves have just incidents not necessarily greater than any other given year, but given the concerns over boeing as well. and perhaps you know how tight they've been in terms of monitoring their own production line and their quality control, how are you feeling about that? and how do you explain to fliers who may be checking to see if their aircraft is a boeing? >> well, chances are you're, you know, for a lot of travelers, it is a boeing. it's either a

boeing or an airbus for the bigger aircraft, there are some smaller airplanes that are different. but, you know, boeing has thousands of airplanes in the air at any given time, certainly some of the things that have been coming out of the investigation into what's been going on with their manufacturing, that's absolutely concerning to people. but i think for most people, they need to have, faith that, you know, they're traveling on a safe system and the numbers don't really lie. if you look at the safety of the us air system, regardless of the aircraft manufacturer, you know, it's pretty impressive. >> all right, that being so still, i want to ask you, are we in a tough spot here? because i understand today, united asked their pilots to take unpaid leave, voluntary. i think starting in may because of boeing's shipment delays. and i assume those shipment delays are because of, you know, new procedures that need to be put in on the production line, i guess. what is the impact to the

whole industry? you know, with all this happening, especially with people wanting to travel again? yeah that that's a huge concern. >> so, boeing has not been able to increase their production rate of their 737 as they had planned to the faa has has prevented that until they get their house in order and so because of that, there have been significant delays. but it's not just that there are problems with airbus as well for different airlines that have different aircraft, it continues to be a real problem and there are fewer airplanes that are getting delivered, there are some that, you know, they just don't need as many pilots right now because they don't have the airplanes they were expecting to get. and the fewer planes, the fewer flights you have, you know, the higher fares can go. just because you have fewer seats that they can sell. >> right? i mean, that's going to be an impact to travelers. but can i get you to tell me how many fewer planes boeing is expected to deliver this year? for example? i'm just trying to get a sense for are we talking about, you know, a few or like

hundreds of thousands less? i i mean, so the rate that they are, i believe frozen at is 38 deliveries per month, if i recall correctly. >> and i have to apologize, i don't have this in front of me. that's either where they were frozen at or that's what they wanted to go up to. so, you know, you're talking a handful of airplanes per month, but it's still enough. combined with all the other problems they've had. yeah. you know, united has been trying to get, the bigger version of the 737 max, the dash ten southwest has been trying to get the smaller version of the dash seven. those still aren't certified, so many different issues right now with aircraft manufacturing. >> and i imagine that must mean the airlines will have to fly their older planes longer, right? when they're ready to retire them, but can't. is that an issue? >> in some cases, yes. in other cases they may just not be able to add flying that they hope to add. and so they just stay smaller than they otherwise would have been, but yes, there are, you know, in general when

it comes to the airline industry, they like having newer airplanes. they're more fuel efficient. so they're less costly to fly. they're more economical to operate, but older aircraft are perfectly fine as well. they're maintained. it can be expensive to maintain them, but there's no issue with keeping them going. if needed. and so the airlines will do that for some of the routes that they really need to have a specific level of capacity. you might see that a lot on, for example, san francisco to new york, where the, you know, the max ten was supposed to be the airplane that was going to replace some of the older aircraft flying that today , and that airplane is not certified yet. so it's a mix of strategies depending upon the airline. >> now, you had mentioned that all this could lead to us paying higher airfares, right. but i also wonder if this means maybe the airlines will fly to fewer cities and fewer markets, and maybe you can't get right to your city. maybe you have to fly somewhere and then drive two hours. or maybe they're just

fewer flights. you know, maybe not every day of the week. >> and they've already done a lot of that that we saw during the pandemic. we saw many small cities actually lose their air service. and so it wouldn't surprise me if we did see more of that. but the reality is that the smallest of cities, those tend not to be served by boeing aircraft anyway, those are the smaller regional jets, which haven't really had any of the same types of manufacturing issues on that end. so that may not be the biggest issue. it may just be the number of flights, the number of seats that are in some of the medium to larger markets. but you know, this is something the airline network teams, they have to figure it out. they have fewer airplanes and they want to serve all these cities. so how do they distribute what they have around to make it the best they can for what travelers demand? >> all right. well, to sum it all up, it sounds like brett, you're saying like it's it is safe for you to fly domestically, internationally right now. but it might be more of a headache and you might have to pay more. >> absolutely. and i know, you know, it's scary when you see

these things in the news all the time, but these aren't really things that should be overly concerning from a safety perspective. the bigger issue is just the airlines need more airplanes. and when you see some of these safety issues, it could mean more regulatory scrutiny and that could slow the process down even further for getting more airplanes going. >> all right. brett snyder, operator of cranky flier.com. thank you so much. >> welcome. >> aging is something we all have to think about at a certain point. but what if there's a way to know where you stand far ahead of time in terms of up here, the new app designed to detect

developed right here in the bay area may be a game changer for detecting a form of dementia hitting people under 60. it's not on the market yet, but it holds a lot of promise. joining us live now to talk about the research ucsd clinical neuropsychologist and associate professor, doctor adam zaffaroni. doctor zaffaroni, thank you for joining us. >> hi, kristin. thanks so much for having me. >> i guess, to have this conversation, we should explain what is ftd or frontotemporal dementia and how is it different from alzheimer's? >> yeah. so frontotemporal dementia or ftd is the most common early onset form of dementia striking before the age of 60, it's a progressive brain disease similar to alzheimer's disease. but unlike alzheimer's disease, that primarily affects the memory circuits of the brain early on, ftd causes changes in personality and behavior. things like disinhibition and apathy. it can cause changes in language and speech, and it can cause

movement changes, it can also change, aspects of cognition, something we call executive functioning. so this is multitasking planning and inhibiting. >> is this something that's pretty common? what are the numbers. >> it's not that common of a disease. it's not nearly as common as alzheimer's disease. for example. it's less than ten and 100,000. yeah. >> okay. so given that, you know, you talked about some of the symptoms, it sounds like how does this new smartphone app detect early signs of it? >> yeah. so as i mentioned, one of the common features of ftd is difficulty with this executive functioning. and so the company that we've been working with has developed a number of different tests that that look at executive functioning. and we can do it on the smartphone, and this is, i think, really helpful for a number of reasons. currently, we're limited to bringing people in person for our research studies and our clinical trials. but given that this is a rare disease, we need to bring in people from really

all around the country and all around the world into these studies, so having something that we could do in their home would be useful. i think the behavior and the movement symptoms of this condition also make it difficult for people to get to the clinic. so, the more that we can do to bring this to people's homes, i think the more inclusive we can be in our studies. >> i gotcha. yeah. so they're on their phone. and what kind of tests might they be run through to test executive functioning? >> yeah, they're gamified versions of things that we've been doing in the clinic for many years. so, asking people to you know, inhibit one of the, one of the responses that they may want to do, respond quickly to a number of tests, do some problem solving on the phone as well. these are all the types of things that we're testing. >> you mentioned that it has some advantage over clinical testing and that it's certainly more convenient. right. and more affordable and wider reach. but are there disadvantages? are there things that you might be able to find out in the clinical setting that you can't get from this? >> yeah, certainly. and just to say, i think there's advantages

beyond just the convenience as well. we can also test people more frequently. so we currently rely on a single annual snapshot , often to give us a sense of how somebody is doing with the convenience of the smartphone, you can collect more repeated evaluations over the course of the year. and i think give us a little bit more of an accurate sense, particularly of how somebody is doing. we we're starting to show that this early sensitivity of the smartphone based testing. but i think you're right. i think there's there should be caution that's applied to this, in the study that we recently published, we did most of this testing unsupervised. so nobody was watching it happen. so there's a lot of things you can imagine going on in the home that might affect the testing, so i think ultimately having something like this that is then verified by a clinician in a standard setting would be really important. all right. >> and we're looking at some images that you sent us from the app. however, it doesn't seem like i mean, it's not public. so it's not like everybody our viewers cannot participate yet. right >> that's correct. so currently

this is a research grade device. so it's being used in a number of different research studies, both a frontotemporal dementia and other conditions, we've also partnered with the ucsf brain health registry to, collect this in people who are normally aging as well, to give us a sense of how we think people should be performing on these tests, but currently this isn't available as a clinical tool, so it's only being used through research at this point until we feel really confident in, in the results that we're getting, how many years do you think that might take? oh, i mean, it's hard to put a number on it, but i might i think there's a lot of very rapid evolution of this field. and i think within the next five years, the use of digital testing, both through smartphone apps as well as wearables and other devices, is going to be a much more common part of medical practice. >> and there are lots of clinical trials underway for ftd, right? >> there are number there. it depends how broadly you define ftd, but up to 30 that are either planned or ongoing.

currently >> all right. and perhaps this app will play a role. but until it is public, what do you suggest to people who may be concerned that they or relatives may have ftd, what should they be looking out for? and if they see some of those things, what should they do? >> yeah. so, you know, this is a disease that strikes later in life. so we see a new onset of these symptoms. these behavioral and personality changes, things like people becoming very apathetic, becoming disinhibited really a change in their personality, you know, quite substantially from who they were previously, changes in language functioning is also a red flag, or new onset changes in how somebody is moving, and i think, you know, if there is concerns, raising this to your primary care physician is probably a good first route, we do second tertiary evaluations and secondary evaluations in neurology clinics as well. >> and are there ways to slow it

down, so to speak, if you do have it? >> yeah. so currently there are no treatments that can slow it down. again, we're very enthusiastic about treatments that are being developed currently or are being tested. yeah, there is some evidence. so there are, there are genetic forms roughly 30% of ftd is due to a mutation in a, in a gene. and so 50% of people in these families develop ftd. and what we've seen there is that, people who are physically active who are cognitively active, who are socially active, this can actually help slow the onset and the progression of the disease, a little bit, even in these genetic cases. so i think these are all good recommendations for people. i think they're good for, for people in general. but, i think can also help potentially, slow the progression of the disease. >> that's true. and whenever you talk to the centurions, how did they do it? they they cite a lot of those things as things that they embrace for life. doctor adam zaffaroni with ucsf, a clinical neuropsychologist

there. thank you so much for your time. >> thanks so much for having me. >> empowering women in the professional world and beyond. it's the mission of the annual pwc conference, and we're going

professional business women of california conference. this message is as important as ever. wow. it's a lot of power in here. >> right, ladies? >> advancing the rights and opportunities of women and girls is the great unfinished business of the 21st century. >> the annual gathering and celebration of women and their careers is happening on may 23rd. but now is the time to register. joining us live now to talk about this year's conference theme and the great workshops, is one of the keynote speakers, pb, pwc board member and chief physician executive

for kaiser permanente. doctor rita ng, doctor ng, thanks for coming in. >> thank you so much, krista. i'm so excited to be here. speaking about a topic that i'm very passionate about, i know, i know, you're here in person with us, and this conference is going to be in person this year, right? >> is that the first time since the pandemic? >> first time since the pandemic? we've had a bunch of virtual conferences that have been very well received. and this is our keynote marquee event of the year gathering many, many women from across the state and across the nation, right? >> i mean, i saw the lineup. i know it's exciting, and we're going to ask you about that, right, to talk about the event. i know that's why you're here to rep that, but i really want to just talk about you for a moment just so our viewers know about you. okay, graduated from phi phi beta kappa from stanford med school residency at ucsf. chief cardiology fellow at cedars-sinai heart institute, and now physician in chief for kaiser permanente oakland and on the kp board. can i just say this is the level of the women who are going to be giving you

advice, sharing their stories, did you achieve all this by being you as the theme suggests? >> well, i, i'm very humbled to be here, and i'm just i feel so blessed to be a part of the pb pwc organization, a professional business women of california, i feel just i've had this incredible village around me as i've been growing up, and a lot of it was very strong mentors, allies, as well as men and women who have helped me throughout my career. so all right, i'm sorry. >> i didn't mean to embarrass you like that. i mean, and you're just lucky i didn't manage to get the pictures of you as miss california back in 2000. >> we're looking for them. >> i was, i was, and miss america, i think your second runner up, which is fantastic. i think the first asian american, miss california. right, did you ever worry about doing that? it's. i know you wanted to do it. did you worry about. oh, would this hurt me professionally? right. what? people's biases might be? >> yeah. you know, i think there's a lot of expectations and stereotypes about women in general, entering the miss california pageant and the miss

america program was not something that was ever in my life plan. i actually had gotten into medical school and deferred it. my sister entered me in the program unknowingly. i had never been in a program ever before in my life. sisters and it ended up being one of the most remarkable experiences of my life because it gave me the opportunity to see a world that was outside of medicine. it's made me a better doctor, and all the miss californians and i are sisters. it's a it's like a big sorority. we're actually all joining together in june for the 100th missed miss california pageant. wow. >> that's great. and speaking of sorority, that is why we have pb, i think. right absolutely, so tell us why people should attend. what will they get there ? what will they hear? what will they learn? how is it structured? what's the programing? >> so the professional business women conference is this is the 35th year, the first time we've done it again live since the pandemic. we have a powerhouse group, a lineup of speakers, which we're going to talk about. very exciting. i don't know about all of you, but i am a big

fan of issa rae, president barbie, and martha stewart, the og influencer is what sports illustrated called her on her. she was that. yes, as well as other kara swisher, who is a really accomplished writer journalist with the new york magazine, as well as bestselling new york times author. so really exciting lineup. i think the beauty about this conference is that it collects the brilliant minds of women and their allies from all across the state, and you get the opportunity to truly be you know, i don't know if any of you that speech in barbie really resonated me with. it is so hard sometimes to be a woman. yeah, there are lots of expectations. you must be kind. you must be smart, strategic, thoughtful, emotional, beautiful, a little bit of everything. >> and assertive but not aggressive, assertive, aggressive. >> and so this conference really embraces the beauty of being a woman and beauty in all forms mental, physical, emotional and

how you balance that. you network, you meet tremendous leaders from across the business world, and it's an opportunity to network and really grow and be you authentically. >> yeah, i mean, that is fabulous. and i just want to ask you before we let you go, obviously, people register for the conference pbwiki.org, but what advice would you give to women and young women, older women, wherever they are in their careers? >> yeah, i think it really is to be you. i think sometimes as women we are afraid that we need to conform to a certain stereotype type. i feel really privileged and blessed to be a physician, but also a mom. i have a three year old, a seven year old, and a nine year old, and i'm able to balance being a mom, working as well as having a professional and personal life, and really being able to lean on an amazing sisters like you and so many other professional business women across the state. >> doctor rita yang, really a pleasure meeting you, and i hope i'll see you at the conference. >> absolutely. >> can't wait to see you all right. there's still plenty of time to register and get your tickets for may 23rd. just visit

bwc.org to register n

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area. see you back tonight, breaking news as we come on the air. a driver ramming into the fbi office in atlanta. and severe storms sweeping east, tornado watches up right now. multiple states. and in the east, bracing for heavy rain and snow. first tonight, the images coming in. a driver crashing through the entrance gate of the fbi field office in atlanta. the driver in custody at this hour, and what we know. steve osunsami at the scene. severe storms, tornado watches up as we come onig