would be the one to hold you down ♪ ♪ kiss you so hard i'll take your breath away ♪ ♪ and after i wipe away the tears ♪ ♪ just close your eyes ♪ [ cheers and applause ] this is "nightline." >> juju: tonight, the elusive search for the fountain of youth. >> i am planning to live to at least 108 years old. >> the bio hacking fad using fitness modification, supplements, and costing lots of money. >> i spent $2 million on upgrading my own biology and counting. >> juju: to try to live longer,

fitter, and better. but longevity experts are not all convinced. >> i really wanted to be a good, responsible field. otherwise people will be hurt. >> juju: is bio hacking the way to a longer future or a waste of time? sean paul. ♪ more than two decades since he became the first dance hall artist to top the billboard hot 100 with "get busy" now appealing to a whole new generation of listeners. >> proud to be part of the genre. just knowing that it's going this far. >> juju: dishing on his new tour, collabing with other artists. ♪ and raising the temperature of jamaica's deep musical legacy. and eddie murphy. returning to the role that once ruled the box office. >> a lot of blind spots in a snowplow. >> reporter: in a new beverly hills cop movie.

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♪ ♪ >> juju: thanks for joining us. tonight, it's called bio hacking. decades of longevity. the promised payoff for a mashup of tech, a.i., workouts, and work-arounds. but as more people jump in and pay up, does the science really add up? here's abc's ashan singh.

>> bio hacking for me is a mission. i am planning to live to at least 108 years old. i spent $2 million on upgrading my own biology, and counting. i'm planning to live long enough to meet my great great great grandkids and play with them. i decided i would use the computer hacking techniques that i knew from silicon valley to hack myself. take my shirt off to get the best results. that meant getting data. >> reporter: the fad of so-called bio hacking, the quest for longevity and wellness. >> here we go. >> reporter: aiming to slow down aging, revolutionize personal fitness, using a fusion of a.i., medicine, and tech. it's an estimated $17 billion industry forecasted to reach as high as $81 billion by 2031. high-end gym chain equinox the latest, launching a $45,000

membership later this year. >> how much total weight in two minute in this. >> 2,612 pounds. that means 156 pounds per second. jun >> reporter: the popular trend has social media on fire. >> getting the best sleep ever, 93, 94 score. >> reporter: fans reaching at the realtime personalize data optimizing results. >> it's a game changer in the gym scene. i don't think people realize that. i don't think people know. >> reporter: many of these methods are controversial and none of them are proven to extend lave span in clinical studies. constitute bio hacking craze have a sinister dark side? >> i've never heard a single argument of how it's going to help society. i think it ultimately is kind of a narcissistic fantasy. >> reporter: 51-year-old dave asbury starts his bio hacking routine the moment he steps out of bed. >> i take about 150 supplements

a day. this is what i'm taking this morning. i'll swallow these in one or two swallows. done. >> reporter: though he says he's monitored by his own medical team, there are concerns about his approach. >> those supplements haven't been tested anyhow. a lot of them haven't been tested in combination. it's really not proven. for me as a scientist, it's a really, really bad idea. >> reporter: asbury shares what he claims are fitness hacks through his franchise, upgrade labs, where customers can get a customized workout and recovery once minutes for a few hundred dollars a month. >> my breath controls my cardiovascular, not hard work. >> reporter: contrary to what you would assume, for over half his life asbury didn't have this lean six-pack or 6.4 body percentage at 51. >> when i was 26, i had weighed up to 300 pounds.

i had arthritis since i was 14 years old in my knees. i was diagnosed at high risk of stroke and heart attack. i had chronic fatigue syndrome. at first, i did everything the doctors told me to do to get better. and it didn't work. >> reporter: a self-made silicon valley tech millionaire, he turned to what he knew. >> use computer hacking techniques to hack yourself in the world of health. doing something, then doing more of what worked, not doing things that were supposed to work but didn't. >> reporter: having lost over 100 pounds and turned his debilitating health around, asbury left tech to become a health guru, creating a string of sometimes controversial bio hacking businesses, including the bullet proof diet criticized as a fad diet with little test. the fda asked him to stop promoting e iing subplements tol

covid. his events showcase speakers, bio hacking poster boy and billionaire brian johnson. the theme, live beyond 180. >> this is r&d for upgrade labs. >> reporter: his austin home is stacked with bio hacking gear, a practice to which he dedicates two hours every morning. >> this is 43 degrees. this is my hyperbaric chamber. all i do for this is i hop in, close the door, and breathe oxygen for about 90 minutes. want to see what it's like? >> reporter: it's pretty simple, you just sit here. i can feel the pressure changing. it's like you're going down from a tall building on an elevator. asbury's regimen includes a host of procedures backed by mixed or limited evidence. he's a self admitted guinea pig in his own experiments. is it really possible to hack our way to youth? >> we can target this biology of

aging. we can stop and reverse aging in certain ways. so this is all science now. >> reporter: dr. barzali is one of the world's leading researchers in the field of longevity. >> this is boxes with samples that are kept at minus 180 degrees. >> reporter: his mission, to make legitimate scientific progress available to everyone and questions whether high-profile bio hackers are putting their wealth to good use. >> what kyle will happen to him can be bad or good, but it cannot be translated to others. the only way to bring it to the masses is do clinical studies. we want those billionaires to join us. i could design a study that would be really relevant for all of us. over two years, you can get significant results. >> reporter: he's skeptical about the self-experimentation

taken on by influencers. >> some of those influencers are using a variety of techniques that haven't been approved or validated. >> reporter: without a solid scientific foundation, he worries about what lays ahead. >> we're trying to realize a promise. if someone is going to die, it's going to derail us for a long time. so i'm worried about it. this is my role as a leader in the field, to say, i really want it to be a good, responsible field. otherwise, people will get hurt. >> reporter: and there is another controversial aspect to extreme longevity. >> i think we're being selfish. if we have large numbers of people living into their 120, 150, 200, that it really could cause a societal collapse.

>> reporter: this bioethicist worries about drastically extended life spans on tax the resources. >> we have a planet bulging at the seams with humanity, and it's caused all kinds of problems. i worry about extended life spans leading to even more and more generations that we're going to have to figure out how to supply with food and with jobs. >> reporter: like almost all the world's resources, bio hacking tools are not likely to be equitable distributed. >> we're going to get into the bio hacking arms race where people are going to have to take interventions in order to stay competitive. i worry deeply about how that may split our society into bio hacking classes with the haves and have nots and the enhanced and unenhanced. >> you want a strawberry smoothie? >> reporter: at least some bio hacking tricks are no longer just for millionaires. jamie salazar is a full-time mom of two young children.

>> i'm definitely a bio hacker in the most successful way that you can get. >> reporter: with limited means to spend on herself, for the last year, she's been creative in hacking a bio hacking routine. >> pathetically, historically, i just would go and try and cobble together everything from -- whether it's my friends' amenities in their buildings, get a cold plunge there. go to my doctor's office and sit in the pmf chair. >> reporter: wanting to get back in shape before turning 40, she goes to a bio hacking studio. >> all right, let's do this. >> reporter: believing she can geeze are squeeze in a rigorous workout in a mere half-hour. >> headed to porto for bio hacking. get some feel-good endorphins going. i go three times a week. i'd go every day, if i could. >> reporter: at $1,200 a month, it's not accessible to everyone yet. >> happy monday! i'm pamela gold. i founded portal. i'm excited.

new york's first bio hacking fitness studio. i think after working out like this most people will want to work out like this for the rest of their life. >> reporter: gold says this type of studio is the future of our workouts, using algorithms to precisely calibrate time and effort for maximum impact. as with many bio hacking claims, definitive scientific backing still isn't there. while studies show regular exercise is correlated with a longer life span, there is no established fitness routine that will make you live to be over 100. >> this is where the magic happens. we're the only place in new york city that has all this equipment. >> reporter: jamie gets scanned. >> i get body percentage fat read and lean mass read and what gets measured gets improved. >> in these two 20-second sprints, she's getting the metabolic benefits of a 45-minute routine. let's get into recovery so you can rest and recharge. i definitely foresee a world where most gyms are like this.

as the market gets educated, there's simply no reason to go back to how it has been. and there's no reason to keep overtraining or undertraining and not being able to tell because you don't have the data. >> reporter: dr. barzali says the best bio hacks are already scientifically proven and free. >> all of us can and should bio hack our aging in four domains. one is exercising. second is diet. three is sleep. and social connectivity. those all have biology that was proven to change the rates of aging. and this is something that we have to do and maximize or optimize. >> juju: hour thanks to ashan. when we return, sean paul gets busy with a tour, new music, and his place as modern-deja make can dance hall statesman.

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♪ ♪ i got the right temperature hold on ♪ ♪ got to get the right things to turn you on ♪ ♪ girl i wanna be the pop you can be the mom north. >> juju: that's sean paul's classic "temperature," the grammy winner out with new music and he's known for his dance hall hits and collaborations. he credits the infectious grooves of his native music with

helping him forge so many alliances. here's abc's morgan norwood making her "nightline" debut. >> reporter: sean paul, welcome. thank you for being here. when we instantly hear those songs, it's just something that comes out of you. you've got to hit a little move. what is your secret to longevity with your music? it's really stood the test of time. >> dance hall music is really spicy, you know? it's infectious. basically, honestly, i love the music and the culture. just being in it is awesome for me. i think when you love what you do, you can go a long way. >> reporter: it's been 21 years since the classic "get busy" topped the radio charts. i want to take a listen to that song, is that okay? ♪ get it on get it on girl it's all good yeah turn it on ♪ ♪ getting it shake that booty nonstop ♪

>> reporter: such a timeless song. i remember where i was when that video dropped. when that song first came out. it's now taking on a new audience right now. sean paul, i don't know if you know this, it's treading over tiktok. are you surprised gen-z is picking up on this as well? >> as i said before, very infectious music that i'm proud to be part of the genre. just loving that it's going this far. it's about feeling itself, feeling the vibe, at least my version of it. very danceable, very party music. >> reporter: your version of it. have the lyrics changed in terms of meaning over time? >> somewhat, somewhat. i have a couple of songs that are may more meaningful. "calling so me." i had an album a few years ago with a song, "tough love." ♪ love don't present calling calling calling on me ♪ ♪ i'll be there for you ♪

>> it's about family, it's about life. i've written songs recently like that, you know? i have two young k■ids,7 and 4 years old. so many times people are like, "that song was deep." i'm like, "i'm talking to my son and my daughter." >> reporter: you've had influence on so many young artists. we hear it in the samples of a lot of songs that come out today. what is your message to the newer artists out there? >> what can i say? remember that -- i think we're the only animals on earth that create. you know, it's a special thing treat it -- yeah, it's fun, yeah, we need to wild out and rave with it. also treat it with honor as well, you know? yeah. >> reporter: and why is honor so important when we're talking about the genre of dance hall? >> some great people came before me and put down stones for me to step on.

bob marley, jimmy cliff, third world, abandon, shaggy, all these people. they put footsteps before me. and so, you know, you have to honor what came before you. it's what makes you be here. >> reporter: what can fans look forward to? i know you're on tour as well. ♪ any new music? >> yeah, we're on tour for most of the summer here in the states. also in europe and canada. in the meantime, i was putting on music. there's a song out there with j. lo, the remix of "can't get enough" is the name. ♪ i wanna celebrate it can't nothing take me out of my zone ♪ >> also songs with kabaka pyramid. he won the last reggae grammy, "energy." ♪

i'm putting out songs with jada kingdom coming soon. becky g. is also in the mix. >> reporter: cooking that up? >> yeah. this summer, i'll be releasing as well as doing the shows. we're looking forward to doing the shows and seeing everybody come out and enjoy themselves. >> reporter: we can't wait to experience it all. sean paul, thank you so much for being with us. >> thank you. appreciate it. >> juju: our thanks to morgan. and welcome to the "nightline" family. when we return, eddie murphy returns to the beat that made him a box office sensation. olits or crohn's disease... put it in check with rinvoq... a once—daily pill. when symptoms tried to take control, i got rapid relief... and reduced fatigue with rinvoq. check. when flares kept trying to slow me down... i got lasting steroid—free remission... with rinvoq. check. and when my doctor saw damage,... rinvoq helped visibly reduce damage

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>> juju: finally tonight, eddie murphy returns to the big screen as axel >> jesus christ. >> juju: 40 years ago this year, eddie murphy cemented his movie star status in "beverly hills cop." ♪ walking the line between hilarious scenes and one-liners showcasing murphy's comic genius. and action scenes. >> you changed, man! >> i'm telling you to get back, i'll blow your -- >> juju: the trailer for "beverly hills cop: axel f" has a lot of familiar faces and hits screens in time for the fourth of july. gives us something to look forward to. that's "nightline." watch full episodes on hulu. see you right back here same time tomorrow. thanks for staying up with us. good night, america.