when the stem cells here in the bones change in some way. well, there are problems. it's an anemia or something. here. now it's being treated, the next way you take this unfortunate person. you irradiate him or use radiation there or use chemotherapy to kill all the rapidly dividing cells in the bone marrow and actually kill them, and then look for, for example, first look for a compatible donor for him. maybe a relative, or maybe a complete stranger who, according to immunological some properties are compatible with this person, in order to transplant healthy blood cells after irradiation, well, blood-forming, or rather cells. well, hope that everything will be fine, that they will take root. these cells are a lot of people dying because the donor didn't find them on time or just a donor. no. so big problem. since many blood diseases are of a genetic nature and the genetic nature of this is understandable. it is clear which dna change in which place is responsible for this disease, here genetic

editing will definitely help and is already helping. namely, you take a bone marrow biopsy from a sick person. you know why he is sick , he has such and such a mutation, you have these cells in a test tube in a laboratory with the help of gene editing. once again, there is such a method, you change it so that the position, that is , the place in the dna that is responsible for the disease , becomes normal. yes. after that, you burn this person with exactly the same radiation and do chemotherapy to kill all diseased cells in the bone marrow, and then plant his own cells in him, but a little better, but also problems to him on compatibility are solved and it works. everything will not be taken for cash, the volume is normal. the main thing was the quality.

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make purchases return money so again and again a free forever super rate of nine eight percent. apply online or allocate and benefit every day. still, let's imagine a polyclinic of the distant future, they read all the genomes in general, not 100,000 from all, but 43 million. or how many russians there are, they put together a large database and processed it. i came to the clinic. here's what's happening. here are some things that can appear in a hospital in a polyclinic, which is fundamentally different from modern medicine about the appointment

medicines. this will happen in accordance with your genetics, that is, the doctor will look not only into your medical history, but he will also look into your genome on the computer to select the optimal method for your treatment. naturally, yes, and will receive information about what kind of medicine. the doctor will be able to have the best effect on you by looking at your gnome. uh, for example, uh, to make you some personal recommendations regarding. so we started talking about what to do, but not phenyls of nuria, but some rather specific ones. lifestyle changes that will allow you to significantly reduce the risk of certain diseases. you yourself will be aware of the fact that you have some kind of risks or carriers, which apparently will allow you to, if you wish, but plan your family. if you are also aware of your risks, if you want, for example, to make sure that your children are healthy or

at least, you should be aware that you may have problems of this kind. look well it is clear that the disease and prone to disease has something to do with what is written in the genome. and abilities propensity to professions intelligence can somehow be read on the basis of our dna. i know that this is already 100 years old, especially britain, i have scientific wars here. to what extent is our mind determined by genes, as if by the environment ah, here are 6 million, tell me is it a lot or a little? what do you think, still, let's imagine all the thoughts for six billion , which is a thousand times more letters than letters in two volumes of war and peace, but all, probably, war and peace school defeated, but now imagine a thousand of these pieces. this is not a meeting. lev nikolaevich is much more. this is our genetic information. here in this genetic information. your my sketch on more or less randomly 6 million changes each

of which yes and makes us no worse, no better, but together they determine our genetic individuality, it turns out that some complex traits. well, for example, intelligence, if we consider that in order for the first sign to be, you need to change it. what is intelligence? here they mentioned the british scientists intellect, there it is really measured with the help of this iq test. to reconcile, that is , in fact, it is measured, rather, ability. uh, take an iq test, not intelligence in general, uh, some kind of uh. hmm, i don't know an african who lived 20,000 years ago in the savannah and survived there, despite all these big cats. he was quite an intelligent person in the sense that he could survive at all. we hardly survived there with you. yes, that is, it cannot be said that he did not possess any intellect. it's all a measure that it’s hard to understand, these are not fins, nuria this is a complex trait and this trait to

some extent, probably, can be genetically mediated by these changes, but each influence, the influence of each change, can be tiny, very small, but all together. this somehow leads to some kind of visible change with genetics, like there is something that is responsible for this. there are genes for intelligence, but not. here is iq, uh, there are tests , they measure something, yes, if it is shown exactly what and what, what time in e, over 10 years, on average, the iq level increases approximately by five points, it is unlikely that we are getting smarter so quickly, yes, well, it’s just that we didn’t take the tests. well, we eat well. here. well, it's the flynn effect that is still incomprehensible. where does it come from? why do we know how, and then we move on, in general, for some reason, very many, but there is such a concept of consumer genetics , you know ostap bender said that there are 100 or how many relatively honest methods were known. and the topic of money among the population. there is also consumer genetics. this is where many begin to be interested in the genome

beauty regions of beauty and the ability to either twist them in oneself, or pass them on to your children, and so on. it always seems to me that beauty is in the eyes of those who look . there is no million of all kinds of things in the sense that it cannot be measured objectively, but still with intelligence. if you take not a specific individual, they changed you to take, for example, this is it. no no data that there are, uh, changes within ethnic groups credible on the first, intelligence. we must still measure, if we are talking about intelligence as measured, which iq test is there, of course, and those countries in which iq is measured on average will probably show relatively and are measured for quite a long time higher rates than those countries , in which iq is not measured, but for the same reasons. for example, you can take and say that it is intellectually connected. well , for example, with the ability to speak dry, but

everything else is not, and it turns out that people who live somewhere on the territory. somalia, they are extremely advanced in this regard. these are all bad things, because here it is always in this kind of questions, when people dealt with this . the one who sets them has already placed himself at the top of the food pyramid from the very beginning and puts the rest of everyone, but in a deliberately losing situation. let's have one last question. you are ready to give your gnome for sequencing, just ready. i gave it away. the fact is that well, our project assumes that a significant part of the 100,000 gnomes is made for employees and their families, but also as i run an organization that is fully funded, it is obvious that i am among the very first of my genome . well, yes, i determined, what is the problem here? that is, in principle, i can simply do this with any private companies that there are some in russia,

but by doing so, i also filled the database. i don't want to think it's 100,000 plus. i am among these hundred thousand. i need to eat there. say that my result is a specific port extractor component, we have us both in quality. thanks to our volunteers, we give them. we call it a genetic portrait, where we are on thirty popular traits, but we give, well , some predictions and some popular science information, because people need to be informed about all this, we did not talk about it, well, informing people about what it is, what it is for, and so on. it seems to me very important. that's after i got my specific prediction. i started to think that i was doing something different from what you have in me. you know, phantom geneticists in genetics, a corrupt girl of capitalism and so on, what they said in that, but i was very offended personally, because i had one of these thirty signs, and about alcohol. there is a gene that encodes a protein that breaks down alcohol. well

, alcohol, but we have in the shrimp and this leads to the formation of aldehydes, which are hangover intoxication all for any unpleasant effect. so it was written to me by our own by the benformatics who analyzed it and who created it. this is our genetic portrait of all the texts that i have genetic, i have a genetic intolerance to alcohol and as a recommendation. and i was asked to uh drink little drink rarely. that is, you are ready. right here under the camera to tell what you have in your genes , and why, uh, look, the genome of each of us is pretty meaningless, if you don’t compare with someone, we have, uh, a genetic portrait that we give to all of our volunteers. and i am in this the case of a volunteer who contains. well, the ability to absorb lactose has something to do with age-related skin aging, because well, light-induced aging is in general,

really strongly determined by genes, and bean tolerance is gluten. wait faster than that, he was not so interesting to me. i was looking at important things. and how old are you, in general, if not a secret, i am 55 years old. yeah , but i won’t tell you that it still works with genes. here are some things related to vitamins. well, the origin. we, too do, and origin. now you are ready to tell right under the camera who, well, we have here. the fact is that the quality of the origin of the definition depends very much on the database . here, i will give an example. i have a researcher who is actually the head of the very center where they are made, where devices work and are controlled and dna sequences are determined, and he worked in the uk some time ago and passed a genetic test there to determine the genome. and the uk where is this whole activities are very well developed for the natives of the british isles. and for each individual person, you can determine

its origin. well, or there from different ones up to the county, and sometimes even better in the case of this particular person. well, who is a russian, he is the most smolensk , he was told on this map that you are from eurasia , so we cannot do this kind of work until we fill our base. here we did a much simpler analysis called this haplogroup, relatively speaking, this is inheritance looks at the midrial dna, which is transmitted only through the maternal line and you can determine yours. those people who you are similar to in terms of mitochondrial dna or yormania. well, here's some good news. it was written there that my haplogroup is the same as about benjamin franklin but on the other hand. it was written there that, generally speaking, most people from this group are samoyeds themselves, who live in the very north of finland. well, some kind of nonsense. thank you very much. thanks for the interesting conversation. thank you for your genome that you contributed to a common all-russian base. it's a pity that he

can't, but it may be the next stage, when there will be a million genomes. i am sure that this initiative will develop 100.000. yes, a drop in the sea. here i would like to say again that what we are doing now is the basis, the core for the development of the future , there is simply not a single player in russia now who could just have such a snowball effect. someone has to blind. the first snowball, thank god for this. well, if anything, i solemnly promise that my genome will be the first opportunity is ready to give on science and there is nothing terrible in this. thank you very much you had a podcast. schloeddinger, i am its presenter grigory trasevich and co-host the cat bari, and our today's guest is doctor of biological sciences professor konstantin severinov.