thank you, dear friends, i am eternally grateful to you, today we had cult musicians, alexey bilov, vyacheslav butusov, i’m vladimir legoyda, we gathered our thoughts about russian rock as a cultural phenomenon, thank you. hello, here you are. podcast schrödinger's cat and i am its host, the chief editor of a popular science magazine, who is also schrödinger's cat, and my co-host is barry the cat, he is my cat and not schrödinger's, and we talk simply about complex things, difficult about simple things, our guest today is konstantin severin, doctor biological sciences, professor, and a person who is now working on a project with a very ambitious name, 100,000 genomes

of russians, sounds downright scary, i read comments about this project, there were the craziest versions including that the genomes of russian people will be sold like oil, it was the most moderate version, and the worst thing sounded like they wanted to take away their genomes from the russians and deprive us of dna, in order to reassure our most active fellow citizens, let’s remind you what a genome is, what does it mean? and the carrier of genetic information, the material carrier of genetic information that we pass on to our children and receive from our parents, is a molecule called dna, deoxyribonucleic acid, and on this molecule, as on a material carrier, as on a magnetic tape, it is written that you - this is you, and i am me, and bari is bari , dna molecules are very long in every cell of our body, we have... hundreds of trillions

of cells, containing about 2 m, of these double helices of dna, which many probably imagine, imagine small, small cells, each crammed with 2 m of these tiny molecules , that’s the dna that is in our cells, we have it the same in our body, because we received half of our dna from our mother, and half from dads, so all this genetic information that makes you you, and me me, both bari bari, and it is called a gene, because this information can be read, there is a certain procedure, it is called sequencing, or in russian, probably, the definition dna sequences, where we really just read a set of such genetic letters, these are chemical molecules , but for convenience i will call them a g, c t. this long, long text, in the case of a person, it contains 6 billion letters, and is almost 6 billion, it is a gene, now a more complex question is what are russians from the point of view we exist within the political

borders of our state and for our project russians are residents of our country, it doesn’t matter if they are russian, jew, tatar, evenk or nanai - they are all russians. moreover, having a russian passport, a person born in england, for example, is also a russian for us, that is, genes are tied in this case to the passport, yes, but still the majority of the inhabitants of our country... and their ancestors lived within these geographical borders with to varying degrees of reliability, we are interested, in particular, in the genetic diversity, the demographic, let’s call it, of the inhabitants of our country , that is, to understand how, at the gene level, a conventional kumyk differs from a conventional tatar, it is possible, yes, but what is generally known about genetic differences between the ethnic groups existing in russia, it is better to first determine what is generally known about the genetic differences between

people in general, our genome ultimately determines our individuality, but if you look at identical twins, we can often confuse them just by looking on them, it’s hard to confuse you and me, right? so this happens because identical twins have almost the same genome, they are clones, identical twins occur when one fertilized egg, containing the genetic information of mom and dad, sharing gives rise to not one body but two bodies, but well, it’s obvious that genetic information is important so that it definitely determines what you and i look like, which is why identical twins are similar, and in a sense it is personal data, sometimes when i give it there, we have projects when we work with schoolchildren, and the children, they are so uncomplicated, beautiful, i sometimes discuss with them, what do you think, whose genome was determined, what it is

man, well, it’s interesting how this person treats each of us, so they begin to think, think, and then someone says with a depressed voice, he was probably a very good and kind person, i’m sure that’s true , we are all kind. yes, but in fact, if i’m not mistaken, this is some kind of american woman, no, but one of the genomes, the fact is that the procedure for determining the first human genome, and this was a kind of race, and there was a government program, this was carried out jointly british and american, and it was a private event, each of these works lasted about 10 years, thousands of scientists were involved, it was billions of dollars, in fact, but the participants seemed to win, so this race is considered, and a man named craig venter was identified, who led this project. but let’s return to how that genome relates to yours or mine, it turns out that we are all human, of course, but we are all variations on some theme, and each of us, on average

, differs from the other by one dna letter , a thousand letters, well, in the dna sequence. so thus, this is 1/2% of differences, and this means that we have 6 billion letters in our genome, then each of us differs from the other by 6 million positions, or mutations, if you like, and these mutations may be similar, or they may be completely different, such imprints are scattered throughout this text, but still let’s return to the project of 100,000 genomes of russians, well, clearly this is not a secret conspiracy to steal our genes or create a superorium, but what is the scientific, medical, economic purpose for this this... the project is carried out within the framework technological cooperation with the state, the state has a large federal scientific and technical program for the development of genetic technologies, there is an understanding that we need to develop genetic technologies, the program is planned until the thirtieth year, the creation of a genomic center

where sequencing is carried out, the creation of a base, the project itself is called 100,000 plus me, i am anyone, well, in this case, i am this. this idea of ​​voluntariness should be present here, because it is voluntary, but i can donate my genome for 100,000? no, you cannot do this, because out of these 100,000, probably it should be called 100,000 plus we, you must understand that this is a corporate program, so it mainly determines the dna sequence of company employees, their family members, and also a very significant the amount of work is done with medical partners, these are leading medical and scientific centers, that is , if i am not... something genetically exotic, then you don’t need my genome, we need all genomes, but we are talking about whole-genome sequencing, objective of the project determination of the complete genome, for those volunteers who participate in it and the creation of a certain database, the analysis

of which will then allow a number of things to be done, we can then talk about why this may be needed, but such an analysis costs money, in fact a lot of money in the world, now the price of such an analysis has dropped by not... thousands of dollars, that is, what 20 years ago it cost about 6 billion dollars to read one genome over 10 years, is now done in 2 days and costs less than a thousand dollars, that is, the price has decreased millions of times, yes, yes, yes, this is this much cooler than with computers, what will happen in 20 years, well, in 20 years , well, now we are starting to talk to you about the meanings, because it is absolutely obvious that in 20 years it will cost very little, just like like with cell phones, all these classic examples of technology development, and this technology, it will change the world, because the analysis of the genomic sequences of each of us allows us to predict our genetic risks in life, the development of certain diseases

during life, allows you to predict the carriage or absence of carriage of some pathogenic mutations, which is very important to know, for example, when planning a family or for some such large... level of health care decision-making, and moreover, allows you to identify new conditions, new mutations make it possible to diagnose new genetic diseases, imagine, 20 years ago, well, 30 years ago, about sixty inherited genetic diseases were known, for example, sickle cell anemia, tolesemia, hemophilia, everyone there knows tsarevich alexei, and now their number is being calculated, but it has not yet reached 1000, but already more. 6,000 exactly, this is a condition that was isolated, identified, by studying, reading the dna of people who obviously had some kind of disease, that is, these people turned there for some reason, for example, they had some in their family , well, some cases, yes , which geneticists could track, but

could not find out the cause, now this is done in general as easy as shelling pears, just take relatively speaking, parents, grandparents and children who have in this family and do not have manifestations of such and such a disease, and after reading their dna, just compare to make such a, well, quite simple association, are there any characteristic changes, here those same typos, mutations in those in whom the disease manifests itself, in those in whom it does not manifest itself, and thus find, well, some conditions that apparently are either diagnostic, or associated with the disease, or cause disease, which is much more important, the first is needed for diagnosis, the second needed for treatment, now tens of millions of full genome sequences have been identified and deposited in databases in the usa, great britain, a very large european project is now underway in arab countries, china and so on, similar things in russia are at best stored in public databases, well, in accessible databases, unless we are talking about

private people who determined this genome in private companies, well, for their own interest, we are talking about less than 10,000 genomes, we simply don’t exist at all, not because it’s for someone it’s very necessary, we just didn’t have this technology developed and there wasn’t a single player who could take up this kind of project, well, after all, we read these 100,000 genomes, what’s that about? in general, we will be able to find out about the country, about health, about people, about ethnic groups, what’s new; we have a very large country, multinational, geographically diverse, very poorly studied at this genomic level, and this plays against us, because it is already clear that that set of these changes, once again 6 million changes, characteristic of each person, living, in relation to other people, these changes, on the one hand... make us individuals, but these changes , for the most part, do not make us smarter or

more beautiful, they are just some kind of natural variability of a person as a species, but the presence of such a background , if you want, can greatly influence how truly pathogenic, truly harmful mutations manifest themselves, such, for example, as those that determine congenital genetic diseases, or for example, cancer, most cancers manifest themselves, are laid not at the level... when you are conceived, but simply over the course of your life , little by little additional changes accumulate in your dna , and the longer you live, the more they are imposed, my teacher said that we all, we will all die of cancer , if we live to see it, then ultimately you have some kind of genetic damage that causes the cells to go crazy, yes, so this is how all these undesirable effects from our point of view occur, strongly depends on this genetic background, which is individual and for each of us, with

on the one hand, it is certainly individual, on the other hand, there are some, it can be enlarged in this way, if you want, where some communities, ethnic groups are created, but in the most primitive concept, you know, there will be someone looking at the shape of the nose or something else... something, he says, and i know who he is, why, but because most ethnic groups were formed in historically, not very distant times, when some small group of people, perhaps relatives, separated from a larger group of people, and then gave the foundation... such a large colony, group, tribe, people, and so on, this means that within an ethnic group, people have a relatively larger number of common mutations and changes with each other than outside this ethnic group, this makes them similar in a sense, hence it necessarily follows that ethnically specific to general sets, some changes in dna, once again not affecting the mind, beauty , all other things would be very worrying, they can influence the manifestation of some , some harmful mutation

manifests itself, on the one hand on the other hand, these same properties, these same general background can influence which medicine a person or people from this group will respond best to , but where is figure skating? hopelessly on the first, we begin: the best skaters of the country at the start of the dream tournament, russian grand prix, live broadcasts on the weekend, on the first. old barrel cognac, product of the stellar group. the podcast is with you, schrödinger's cat, and i am its host, grigory tarasevich, together with my

colleague, pare the cat. and our guest today is konstantin severin, doctor of biology sciences, professor, and we are talking about the project of 100,000 genomes of russians. i understand correctly that when large amounts of the genome are read, it will be possible to go to a regular clinic and the doctor will take it into account when prescribing me pills. who i am, my ethnic group, or my personal motto, i believe that this should be the case, i believe that, well, in this ideal world, in the end, this will just be quite, in general, your genome is already there when you were born. your genome is already with you, so i’m sure that it will, of course, be determined and will be part of your medical record, and regarding this gene given to you by god, or rather by your parents, they will then look at how, as your life progresses , what else arises in you, because new mutations arise, some in the course of life, which, for example, lead to lycosis or something else, cancer, so

but ideally this should be so, and the future is most likely limited not by technology as such, because well, for 100 dollars, if it can be separated, then probably soon... it will be necessary for 100 probably enough money to store all this, but it will all be limited by the quality of the analysis education of doctors, this is not a russian problem, this is a problem of the whole world, that is, in america , where, for example, all this is very highly developed, and there the leaders of the medical industry moan and say that doctors don’t know anything about this, most doctors who they are treating now, they were in medical schools in the nineties, but what we are talking about actually happened, well, literally 10 years ago, they don’t know anything about it at all. we need to redo educational programs for doctors, it’s very difficult, but still, returning to the knowledge about my personal or your personal genome, we can say that there is a tendency to have a heart attack, so you better live, the tendency is a very strange thing, because all this is statistical data, and here we live with you

in the real world, and if you hit the wall with your forehead, then this is a certain fact, it’s difficult to argue with it, this is an improbability thing, yes, here - most of the data that is obtained from this kind of analysis is, it ’s not good to call them horoscope , this is very wrong to do, but they are still predictions, because they give you a probability, if it is stated that with your specific genome the probability of such and such a disease is increased, even 100 times, yes, you probably, being, if you are a hippochondriac, you can be very upset, but if it turns out that normally... the probability of this disease is very low, for example, five cases per million, then if in your particular case, statistically , after analyzing a huge number of people , it turns out that your probability of the disease is increased 100 times, it just means 500 million, for you specifically, should you go hit the wall after that, or just relax? no, the question is what to do,

a separate question, is it necessary, for example, that is, is it necessary to make any decisions after this. fateful, a separate question is whether you want this information to get to your employer , a separate question is whether you want a pilot who flies a passenger plane, and that he has a reduced average risk of sudden death, but it would seem from a sudden cardiac arrest of death, but it would seem that i would like, so that this does not happen to him, but even if in the case of a genotype associated with an increased risk, it is still hundreds in a million, then it seems like... there is no point in denying a job to this particular person, but statistically, yes, there is, no, well there are situations when it is even clear what to do, but in my opinion the most classic example of finilkitonium, which is determined, is this, but it is very classic, but it is also very unique, that is, there really is a genetic disease, when if you don’t know what you have it, then you will die, in

in a young state, and if you change your diet, then you will live happily for as long as you like, another question is, then you will pass on this same gene to your offspring. just in case, i’ll repeat what was discussed, there is a disease called finilkitonium, which , including in russia, is scanned in infancy, they just say: you have it, but it doesn’t manifest itself in any way, it’s sitting somewhere in the genes and somewhere already in adolescence it turns into a terrible disease that can be prevented by quite simple diets, non-lethal ones, even tasty ones for yourself, here is an example of how by studying the genome, you can prevent a disease, in general development, do you want to know this, here you go, but knowing is important, because in this case it is a simple disease, because it can be prevented dietaryly, it’s not a problem that you don’t cure it, there are a lot of diseases or predispositions that are revealed as a result of, well, a massive analysis

of whole-genome data, they are not the majority, almost all, they are not like finilkitonia in that i mean, no valuable advice. what should you not do, well, except don’t smoke, don’t drink, and so on, it’s impossible to give you , well, for some reason, follow up more, maybe, yes, okay, but let’s still touch on such a complex topic as editing genome, come on, i was born, i have a child, you looked at his genome, compared it with your giant database, you say he has a tendency, i don’t know, for something bad, i don’t know, for gastritis. well, gastritis, damn it, you can live with gastritis, come on, schizophrenia too you can also live with her and even a very talented person can have a heart attack, well, well, yes , let him have a tendency, even if not a tendency, let this child develop and not... there will be a severe genetic disease, like that, let's aggravate it, yes , the child has already developed, yes, that is, they already go to kindergarten there, no, so, as a rule, most of these types of diseases manifest themselves

so early that everything happens before kindergarten, before kindergarten we saw what he has, not god forbid, of course, this happens to no one, some kind of genetic disease, can we somehow sharpen, correct its genome in order to eliminate this disease, you know, when is it too late to drink borjomi, so in this case, whatever it is, there is one problem. and this kind of disease that you are talking about, they are usually congenital, that is, they come from the parents, yes, but when the parents are a carrier of some unsuccessful version of the gene, and the other gene is normal, we are all duplicated, we have these 6 billion letters, three from dad, three from mom, and dad and mom give us each of the same set of genes with typos, but our own, so that each of us has two genes, each, and we give the children one, such a special process. what’s important is that if dad was a carrier of a certain unfortunate mutation in one gene, but didn’t know about it, because the other gene was normal, and mom was

the same, then directly according to mendel’s law, as they teach in school, it seems to me, are still taught, then every fourth child in such a marriage will receive two unsuccessful variants of the same gene and this can lead to very serious consequences, but in principle, at the level of in vitro fertilization, this problem can be solved this way, that is...' it is possible, not just any embryo can be allowed to develop, only one that does not contain a double copy, spoiled, a double damaged copy of the gene, this can be done, but you can imagine that for some reason this cannot be done, then you just have to accept that all the cells grown from this this organism grown from this embryo will be affected, probably there will be an early death, therefore, if it has already come to the point that the child is born, it is absolutely impossible to repair all these cells, then we come to the emryonic. “stop, before we plant all this on mom , we’ll tweak it a little here,

we’ll correct these two bad gene variants to normal, but there are a number of ethical prohibitions on this, and one of the people who allegedly did this work, hizanka and this chinese scientist, well, he spent the entire pandemic in prison, but now he seems to be out, if a person has already been born, what to do, so that it is not very difficult, because it is difficult to correct everything in all cells, there are certain cases of some specific, for example, blood diseases, when this can be done, the fact is that our blood is like this, it is a little, it is very healthy structure, we have hollow bones in our large bones, there is bone marrow, there are hematopoietic cells there, they are constantly dividing, dividing, dividing, dividing, and from there, when they divide, blood cells come out into the blood, for example, red blood cells, white and they work there for a week or so, then are thrown away, they are so disposable, that is, we have a motor here in our bones that constantly produces blood cells throughout... our life, but sometimes a problem arises, blood cancer, when the stem cells here in the bones

change somehow thus, well, problems arise, there is milk there, something else, now it is treated in the following way, you take this unfortunate person, you irradiate him or use radiation or use chemotherapy so that all the rapidly dividing kill cells in the bone marrow. you kill, and then you look, or rather, first you look for an immunocompatible donor, maybe a relative, or maybe a complete stranger, who , by some immunological properties, is compatible with this person, in order to transplant healthy blood cells after irradiation, well, hematopoietic ones, or rather cells, well, hope that everything will be fine, that these cells will take root, a lot of people die because donors were not found for them on time or there is simply no donor, this is a huge problem, as many diseases blood have genetic. and the genetic nature of this is clear, it is clear which dna change in which place is responsible for this disease, then genetic editing will definitely help, it already helps, you take a bone marrow biopsy from

a sick person, you know why he is sick, he has this -there is a mutation , you are these cells in a test tube in the laboratory using gene editing, again there is such a method, you change it, so that that place in the dna that is responsible for the disease becomes normal, right? after that you are this person you burn with radiation in exactly the same way and do chemotherapy to kill all the diseased cells in the bone marrow, and then give him his own cells, but slightly improved, the problem of immunocompatibility is solved, and it works, well, let’s still imagine a clinic in the distant future, read all the genomes of not 100,000, in those 143 million or how many russians there are of us, they would put together a database and process it, i came to the clinic, this is what happens, these are the things that can appear in the hospital, in the clinic, which

fundamentally different from modern medicine. the prescription of medications will take place in accordance with your genetics, that is, the doctor, to choose the optimal method of treatment for you, will look not only into your medical history, but he will also look into your genome, on a computer, of course, yes, and will receive information about about which medicine will best affect you, the doctor will be able to look at your genome, for example, make you some... recommendations, relatively, so we started talking about what to do, but not tenuria, but some fairly specific changes in lifestyle that will allow you to significantly reduce the risks of developing some diseases, you yourself will know that you have some risks or carriers, which, apparently, will allow you if you wish , plan your family, if you your partner also knows about his risks , if you want, for example, to make sure that

... your children are healthy, or at least you should know that you may have problems of this kind , look, well, it’s clear, that diseases prone to diseases are somehow connected with what is written in the genome, and abilities, propensity for professions, intelligence, can somehow be read based on our dna? i know that this issue has been going on for a hundred years, especially in britain, there have been scientific wars, to what extent is our mind determined by genes, here are 6 million, tell me, is this a lot or a little? how do you think? well, look, what? well, after all, let ’s imagine mentally, 6 billion is thousands of times more letters than the letters in two volumes of war and peace, well, that’s probably all war and peace they took it to school, but now let’s imagine 1000 of these things, this is not lev nikolaevich’s collection , this is much more, this is our genetic information, in this genetic information, yours, my genome

is sketched out more or less... randomly 6 million changes, each of which, yes, does not make us worse or better, but together they determine our genetic individuality. it turns out that some complex traits, for example, intelligence, if we consider that in order to firstly measure a trait, what is intelligence? then you mentioned british scientists, intelligence there is really measured using this iq test, there is even a joke, all intelligence is what is measured by the same. rather the ability to pass an iq test, and not intelligence, generally speaking, some kind of, i don’t know, african who lived 2000 years ago in sovan and survived there, despite all this big cats, he is quite intelligent, he was a person in the sense that he could survive at all, it’s unlikely that you and i survived there, yes, that is, it cannot be said that he did not have any intelligence, this everything is a measure that is difficult to understand, this is not finilki, tanuria, this is a complex trait, and

this... the trait to some extent, probably, can be mediated by genetics, these changes, but each influence, the influence of each change can be tiny, very small, but all together, this somehow leads to some kind of visible change , there is genetics, it seems there is, there is something that is responsible for this, there is an intelligence gene, no, there are iq tests, there are , they are measuring something, yes, it is absolutely clearly shown that, what in 10, over 10 years, on average...' and the iq level increases by about five points , well, it’s unlikely that we are getting smarter that quickly, yes, well, we just got stuck on taking tests, well, we eat well, well, this is the flynn effect, which is still unclear where it comes from, why we are smarter, and then we move into some, for some reason very many, but there is such a concept, consumer genetics, you know, ostab benter said that there are 100 or whatever he was known about honest ways of taking money from population, there is also consumer genetics, and here, many are beginning

to be interested in the beauty gene. the hijacking of beauty and the opportunity to either tweak it in yourself or pass it on to your children and so on , it always seems to me that beauty is in the eye of the beholder, beauty is, well, a historical phenomenon, it depends on the society in which you live, it generally depends from a million all sorts of things, it does not exist in the sense that it cannot be measured objectively, but still with intelligence, if we take not the specific individual me or you, but let's take ethnic groups, yes, there is no , no data that... within ethnic groups there are reliable changes, firstly , we still have to measure intelligence, if we are talking about intelligence in relation to what is measured as a test, then yes, of course , those countries in which iq is measured, on average, will probably show relatively and for quite a long time higher indicators than those countries in which iq is not measured, but from the same considerations one can, for example, say that one is intellectually connected ,

for example, with the ability to speak swahili. but for everything else, no. and it turns out that the people who live somewhere there on the territory of somalia, they are extremely, extremely advanced in this regard, these are all bad things, because. here, always in this kind of questions, when people were engaged in this, evgeniyka did not just arise, and then, thank god, faded away, as a rule, it always turns out that when asking this kind of questions, the one asking them already from the very beginning placed himself in the top of the food pyramid, and puts everyone else, but in an obviously losing situation, let's the last question, are you ready to donate your genome for sequencing, i’m not only ready , i donated it, the fact is that, well, our project assumes that a significant part of the 100,000 genomes... is done for employees and members of their families, well, since i run an organization that is fully funded, it is obvious that i was among the very first to identify my genome, well , i determined what the problem is here, that is, in

principle, i can simply do this in any private company, of which there are a certain number in russia, but i am also filled the database, i don’t want to consider that it’s 100,000 plus me, but among these 1000 i ’m there, i must say that my specific result was quite entertaining. we call it a genetic portrait, where we use thirty popular traits , give some predictions and some popular scientific information, because people need to be informed about all this, we didn’t talk about this, but informing people about what it is, what is this for and so on, it seems very important to me, so after i received my specific prediction, i i started to think that i was doing something wrong, something like this arose. what was it that you said? but for me, this really offended me personally, because out of these thirty signs, one of them was related to alcohol, there is a gene encoding

a protein enzyme that breaks down alcohol, well, alcohol, in our bloodstream and this leads to the formation of aldehydes, which cause a hangover, intoxication, and all sorts of unpleasant effects. so it was written to me by our own employees, bioinformaticians, who, who analyzed this and who created this genetic portrait of us, all the texts that i have a genetic, i have been diagnosed with a genetic intolerance to alcohol as recommendations, i was asked to drink little and drink rarely, that is, you are ready to talk directly to the camera , what is in your genes , what is it, look, the genome of each of us is quite meaningless. if you are not comparing her to someone else, we have a genetic portrait that we give to all our volunteers, and in this case i am a volunteer, which contains

in yourself, well, the ability to digest lactose, something related to age-related aging of the skin, because well, aging caused by light, it in general is really strongly determined by genes, and the tolerance of women faava, gluten, wait, you age faster than, i don’t even that’s what i wasn’t so interested in, i was looking at you. how old are you in general, i’m 55 years old, yeah, well, they won’t tell you that, but gyno still works here, here are some things related to vitamins, well, we also do the origin, and the origin, now you’re ready say right under the camera who we are, the thing is that the quality of the origin of the definition very much depends on the database, so i’ll give an example, i have a researcher who actually runs the very center where the devices are made work and... are found , dna sequences are determined. and some time ago he worked in the uk and there he passed a genetic test to determine the genome. and in great britain, where all this activity is very well developed, for the indigenous inhabitants of the british isles, for

for each individual person, you can determine his origin, or from there, to the accuracy of the county, and sometimes even better. in the case of this particular person, well, who is russian, he is from near smolensk, on this map they said that you are from eurasia, so we cannot do this kind of work until we fill our database, so we did a much simpler analysis, this is called a hoplogroup, relatively speaking, this is inheritance, it looks at mitochondrial dna, which is transmitted only through the maternal line and you can determine your those people on who do you resemble, in terms of mitochondrial dna or chromosome, well , the good news was that it was written there that i have a gopla group. like benjamin franklin, but on the other hand it was written that, generally speaking, most of the people from this group are themselves, samoyeds who live in the very north of finland, well, some kind of nonsense, thank you very much, thank you for the interesting conversation,

thank you for your genome, which you contributed to the general all-russian database, it’s a pity that mine is not possible, but it may be the next stage when there will be a million genomes, no, i am sure that this initiative will develop, 100,000 for a drop in the bucket, so i would like to say again that what we are doing now is this base. this is the core for the development of the future, there is simply not a single player in russia, now , who could, this is such a snowball effect, but someone has to make the first snowball, thank god, we are doing this, well, if anything happens, i also promise : that he is ready to donate his genome to science at the first opportunity, and there is nothing terrible about that. thank you very much, with you there was a podcast by schrödinger's cat, i am its host grigory trasevich and co-host bari the cat. and our guest today is doctor of biological sciences, professor konstantin severrinov.

this is a podcast of the first persons and me and its host natalya losyeva, the person who today became my guest as an official or unofficial symbol of the pandemic, well, in any case, that’s what many journalists decided, his face was on billboards, on the covers of newspapers and magazines, although he is a doctor, anesthesiologist-renimatologist, doctor of medical sciences, chief physician, famous... hospitals in communarka, denis protsenko, hello, denis nikolaevich, hello, well, how was it for you to see yourself on billboards, it was probably unusual, it remains to be unusual, because somehow medicine, by and large, does not involve these stories, in fact, this a feeling of unfamiliarity, maybe even some kind of discomfort, it persists, how did people react to you on the street, now, when? when did you become famous? well, they reacted

accordingly that it was impossible to go anywhere because they asked to take a selfie photographs, i never refused, but i can’t say that it gave me pleasure, that it gave me pleasure, now from time to time they probably recognize you, fortunately, less often, now they probably still recognize me more, my colleagues, when you now remember the pandemic, that’s what you, you know, have some kind of slight nostalgia for the time in which? was there drama and tragedy at the same time, romance or shudder has not yet recovered? no, probably, if not with me, if not with us, some kind of movie has been covered up, like a headache, yes, you know, they say that the brain tries to forget all the negative moments, for example, an unconscious comatose state, the brain blocks it and doesn’t want to remember some unpleasant emotions, probably the same with the story with covid, but was it scary?

no, it’s probably not a feeling of fear, i don’t know how we’ll formulate it now, but you and i will definitely formulate it, no, it might be more of a feeling of confusion, because you, especially in the first wave, don’t know , you don’t understand, protocols change, world wide protocols are changing, such information chaos with throwing to the sides, from side to side, i’m talking about drug therapy, about approaches to respiratory support, probably today ask what i would like most, i would probably most like to i wasn’t asked a question about covid, so globally, well, i’ll ask, just a little bit, but did you, you know, have such a fear that you won’t save someone important? no, by the way, there was no feeling of fear, probably for one simple reason, i was not alone in this situation, i was a whole team, a commune team, a team of moscow chief doctors, this is the entire social block, and you felt support, attempts to solve problems. not one on one, all together, and i think it’s this

feeling of an elbow, that feeling of a team, it largely determined the absence of this fear, it’s probably scary when you can do something and don’t do it, then it’s probably scary, a lot people stayed with you after that period, someone left, you broke up with someone because you realized that you ate this path of salt together, but no, you know, the main one the core that came, it remained. we parted ways with the guys, with the doctors, with the nurses, with the medical brothers, with whom we had an urgent contract for a temporary hospital, the main team stayed the other way around, so if he talks about some stories within the corporate there, this covid has really united the team, because there are always some therapists, surgeons who are a little cooler, and there are some, there are some between specialties.