cancer, oncological diseases, the title of this chapter was the following: cancer dash is a genetic disease of somatic cells, in a sense, this is the cells of our body, yes, the cells of our body, somatic cells - this means those cells that will not transmit their genetic information to the offspring, there are germinal cells, cells that are either gomets, and cells that can become a new organism, and an egg, they form, they are formed in the body, if there is a mutation in these cells, it has a chance - continue in posterity. how do you determine where it happened? a mandatory, mandatory analysis at the start is a genetic examination of tumor cells in this case and it consists of several methods, yes there are the simplest methods, we are now getting a little loopy, this is the color of the cromosome, what is called standard cytogenetics, yes when cells fix chromosomes. are painted with a special paint,

the doctor looks at them under a microscope and says that, for example, chromosome number 12 exchanged a piece with chromosome 21 and formed there here is a chimeric gene that controls cell division, here are lycosis with rearrangement 1221, they are super sensitive to chemotherapy, they are very easy, that is, this is good. this is a good option, yes, but if, for example, in the genome of a tumor cell , again at the level of chromosome analysis, we have not yet reached the reading of letters, but at the chromosome level we see that there are not 46 chromosomes in the cell, but 39, this is precisely in cancer cells, yes, because in all other cells of the child’s body everything is like in humans, yes 46, in a cancer cell there are not 46, but 39, there is a loss of chromosomes, this called hypoploidy, yes, that is , there are fewer chromosomes than there should be and... these are

leukemias that are incredibly difficult to cure with conventional chemotherapy, almost all such patients need to undergo a bone marrow transplant, but we live in the era of so -called targeted therapy, when for all options at once, but drugs are gradually appearing that act on a specific protein formed as a result of such a chromosomal rearrangement, and in order to give such a medicine, we must know for sure whether the patient has this defect or not. famous... examples, the so-called philadelphia chromosome, a rearrangement at the chromosome level is called 92, the ninth and twenty-second chromosomes exchange pieces, a chimeric gene is formed, the so -called bcr able, that is, a gene that pathologically connects two ordinary proteins they begin to give to the cell a signal for us to share well and die badly, that is, is this a philadelphia problem or do we have it too?

with the help of one or more medications depends on the type of leukemia, well, except for the actual chromosomal rearrangements, which are simple, well, in a certain sense, simple to look at, but this does not exhaust all the diversity, hematological diseases of children, there are a lot of so-called single nucleotide polymorphisms, or, well, if you want point mutations, where one letter or several letters are replaced, that’s also yes several nucleotides, that is, letters. here in this

genetic code, and such a replacement can be no less effective in turning a cell into a tumor one, but it is impossible to notice it at the level of an entire chromosome, and here and what do you do then, and here you need methods of so-called dna sequencing, yes, that is, when these letters are read sequentially, and in fact we see, in fact, we see this as a typo in genetics. but what if, well, i imagine that in many countries, unfortunately, children get sick, there are countries where doctors and scientists work together to identify the causes of diseases, then, probably, articles are published and you can read this, and after reading this article, you just take it on faith or as a weapon you begin to introduce a new analysis, and relatively speaking, the child who came to you, you must analyze him; if the nature of the disease is unknown, it must be established for the purpose. attraction, you

just have to look at everything, all possible candidate points in the dna and say that this is all good or or or not. this is true, but the problem is divided into searching in known places. it's relatively simple, technically it's quite a complex procedure, but once you know where to look and what you're looking for, it's a relatively straightforward task, and much more a more complex story with the search for something new, yes, something that has not yet been described in the literature has not been proven, because when we can certainly find some kind of breakdown that looks like a typo in the genetic code, but it is necessary to prove that this typo is really influences cell behavior. it’s much more difficult to do this, and it needs to be done quickly, this is a disease that develops quickly, you need to catch it right now, urgently make a decision based on gene analysis, you know, i would say, the faster the better, but the starting days, when the patient is just starting

treatment, they basically follow this fairly standard pattern, where this molecular information is not used, but there are at least a few diseases where it... there is one form of leukemia called acute promelacytic leukemia , it has a peculiarity: at the very beginning of the disease, tumor cells secrete substances that unbalance the blood coagulation system, and such patients, during the first days from the onset of the disease, from diagnosis, have a huge risk of dying from bleeding or from thrombosis, at one time somewhere in the mid -eighties in china it was discovered that... a very simple substance, an analogue of vitamin a, oltransretinoic acid, these cells actually, well, block this feature of theirs and makes them turn into ordinary cells, but in order to prescribe this analogue of the vitamin, which exists in the form of tablets, you need to know for sure that this is the

same promylacytic lycosis, yes, that is , there is a situation, and i think there will be such situations over time more when there is medicine, which should be prescribed only to a patient with... a specific molecular breakdown, then the patient’s life generally depends on how quickly you find this breakdown, but for now for most patients this is not the case, for most patients this information is needed somewhere 2-3 weeks from the start of treatment, because it greatly influences the choice of the second stage and in general further tests allow you to find the desired answer in 2-3 weeks, but well, as a rule, you need a whole set of different tests, there is no such thing yet.. .

the entire funding system is based on the basic hypothesis that patients with one disease name, for example, acute leukemia, are more or less the same, then you can determine from a large number of patients whether some treatment works or does not work, and now imagine that you do not have a thousand patients with one disease, but a thousand patients, each of whom, in some sense, has their own disease, their own genetic change.

or about some kind of chromosome rearrangements, the medicine in this case is what kills diseased cells, this is the point of this medicine, the point of the medicine is that it kills diseased cells, but we need medicines that will not damage the normal problems of chemo, well, your kids, here i was, you had many kids there without hair , well, that is, this is all so serious, actual chemotherapy, well , hair loss is psychologically important, but of course this is not the worst thing that can happen to a person, i can, i can certainly testify to this. but the problem is that the chemotherapy that is used today it is not very selective, it damages tumor cells more, but it affects many other cells that quickly divide, in particular skin cells, epithelial cells, intestines, they, but this is then restored in case of successful treatment, yes, it is restored, but this may

be accompanied by severe complications, for example, infections, that is , the damage itself is restored, but it can trigger a cascade of events that can , among other things, end... which are found in large quantities in our intestines, but not should normally enter the blood, trigger what is called sepsis and septic processes, and the patient may die from complications not related to the tumor. this is the baden baden podcast and i am its host, konstantin severinov. today we are talking with professor mikhail moshchan about genetic diseases and what methods of treating them are available. well, is there? also these terms are remission, i know relapse, relapse is the return of the disease back, this is because

the same change in dna occurred again , or why there are relapses in exceptional cases, what you just described is a situation where a breakdown in the dna has occurred again, as if a new transformative event, rather in medicine it will be described by the term second tumor, this happens, but if the tumor itself is a rare event, probably like... the so-called predisposition syndrome, yes, that is, they have some kind of basic defect that, well, if you want, affects the stability of dna, a basic genetic defect, yes, a basic genetic defect, hereditary, that affects dna stability, then they may have this second event, that is , a tumor may develop a second time, these are just people who develop tumors more often in general, yes. exactly, but in most patients a relapse is not a repeated transformation, not

a re-formation of a tumor, it is rather like a few cells from the original tumor survived treatment, hid, were in a dormant state, sometimes for many years, then woke up and at the same time again about the tumor, in your case in the case of hematology we do not we’re talking about some piece, they can, they can form a tumor in the classic way. attention, yes, that is, they can, it can be everywhere, but it can be in one place, it can be a tumor of some lymph node, but most often with tumors of the hematopoietic system, yes, it is widespread in the blood, in the bone the brain, in the lymph nodes, and how to find out about the predisposition then, i understand that this is a smaller part of all tumors, is to find out about the predisposition, well, there are two, if you want , ways, the first is precedent, right? that is if there are tumors in the family, which in general tumors are not such a rare thing, yes,

it seems to us that cancer is something, well, this is not very common, in fact, what is called risk, yes, that is, there is a risk of getting a tumor in the course of a person’s life is approximately 25%, yes, that is, after all, for babies for children, for children it is very low, yes, but i mean the total risk of a tumor, and the peak for a tumor in adults is somewhere around 65 there. 65-70 years old, if the doctor meets with a patient whose tumor developed early age, for example, a tumor before 40 years of age, this is rare, or if a doctor meets with a family where many family members develop early tumors, or there are family members with repeated tumors, there it makes a lot of sense to be examined and look for the cause, this is precedent-setting . after all, you say that the risk is, in principle, high , the second, second way, which will probably gradually dominate, as

such full-scale genetic studies enter the practice of medicine, it will be, you know, like a find in clinical examination, yes, that is, in fact, that is, you donate your sample, donate a blood sample, studies are performed such as whole genome sequencing or whole exome sequencing and... there are some genetic variants that affect medical risks, including oncology, if the cure rate grows, as you said, by leaps and bounds over the years, due to the interaction of doctors, of course, apparently families, patients, philanthropists and scientists, then this is still, that is, it seems that there is some kind of light in end of the tunnel, but even a small one, well, to be honest, in our profession, without seeing this light, it would seem to me very difficult to live and work, because the number of failures that a doctor in this area is forced to face

during his professional life is well, it greatly exceeds the possibility of a normal psyche, it seems to me, that such coexistence with failures is possible, but just some vision of this light at the end of the tunnel, the feeling that you are moving in the right direction, it allows you not to give it all up. thank you, mikhail, good luck to you and, of course, to your patients, thank you, konstantin. i'm larisa guzeeva, let's get married. good afternoon today the bride is svetlana, elena and olga, and our groom is pavel! pavel, 37 years old, owner of the largest construction company in bashkiria, lives in ufa, drinks a glass of milk every morning, listens to psychological audiobooks during workouts, spends all weekends with his children, warns that

he will always help his ex-wife, admits that he does not hires employees. who evade the elements. pavel will never be interested in a housewife and will not enter into a serious relationship with a frivolous young lady. his ideal life partner should have graceful hands, thin ankles, her own business and no more than one ex-husband. hello. hello. glad to see you. thank you for visiting us.

they were definitely setting up red flags, i want it for a rich man, i want it without children, i want it to be like this, i have a mother, i have one, accept it as it is, then the choice is up to your partners there, you know, when he says , not really, i would like a mistress, but if she doesn’t know how to do anything, i do it myself, then a year later , already divorced people come to us in the second round, look how she smiles, sweetly, behind such brutality lies.

divorced, that is, without a fight, without, without any conditions, but if you don’t give me children, this was nothing, the wife depends on you, the ex, yes, it’s clear that the hero is taking care of himself, yes, he has a smile beautiful, you were in bashkiria, no, you weren’t there, maybe this is a chance to visit, she doesn’t have her own business, her own business, now she already does, starts studying, look, when... adult people separate, look, we are not philosophizing now, adult people get divorced in different ways, we are now talking specifically about you, my ex-wife is a very close relative to me, she is a holy woman, firstly, she gave birth to my sons, secondly, how old are the boys - almost four and 12, a wonderful age, yes - that’s it, she’s great, listen, she really

gave birth to your sons, why did they get divorced, their feelings cooled, but for me i've never had any experience with men, it's a little confusing the fact that there is a wife, an ex, who is a holy woman for him, if i heard correctly, a holy woman, yes, but you understand, if at 37 years old a man has never been married, there is also a big question here, she got married, no, who the first one suggested, let's get a divorce, you know, rather she, it was mutual, because... for the last year we have lived in such a way that i work a lot, this is always the case, you either have to accept it or not, no, well, if you give houses , apartments, cars, yachts, ships, factories, then naturally you work a lot, so i just as a working woman, i understand all this, well, that is, everything is fine with you, you see your children, yes, it’s true that you bought her a house next to you, well, yes, how close,

through the fence, no, in fact, i left the house. but she just asked her to take it closer to the school, so that it would be more convenient to transport the children, so she took another one, next to her, well, next to the house with which you lived, no, the difference is five kilometers, well, the walk there is only 5 minutes, yeah , is it true that you bought your mother’s house too, in my opinion, yes, i’m with you, built, built on your territory or between you and your ex, no, no, no, this is next to me, after all, my ex-wife, natalya, she lives... at a distance there is a serious, brutal man, it is very valuable that he , well, look how close he is to his mother, if he values ​​his mother, then he will value his future wife, do you pay alimony, yes to the children, or some kind of agreement?

room and there are 5 km about nothing, for example, the wife says, pasha, i’m the same with the girls there, let’s have a couple of days with your children, yes, okay, that is, this is how it all happens, well of course she won’t say, because this is a respectful attitude, it should remain, what pashenka is there, i ’ll take the children with the girls for 2 days, yes, my love, yeah, yes, my happiness, you say, yes, dear, of course, where are we going, and tell me, holidays, new year, birthdays? well, we’re a family, you have to understand that understand, no, no, i ’m just trying to convey, i’m still nervous, girls, there are family events, there’s

a new year, in which everyone has to get together in any case, there’s there, there’s birthdays, let's say if it's her birthday wants to spend it with her friends, she spends it there, if it’s the children’s birthday, naturally i’ll come too, most likely it will be, probably at my mother’s house. no, it’s a family day, sunday, i’m ready to come into my home, to welcome children, but yes , i don’t think i have a wife, but then he has, i hope,

that he wants more children, and so that there are many children, they will be friends with each other , i can see it all right away, barbecue, i don’t know, animation, the neighbor’s children, everything is fine, you have a room, the weekend, that’s all, i can see this picture right away, i just don’t see it. future darling, future my wife, i can’t have her in this one yet, and in this beautiful one, i’m where she is, where she ’s playing in the house, i’m natasha, you’re tanya, where she ’ll squeeze in, here’s your new one, with whom you can leave today , this is what will be allotted to her, look, i look, pash, no, i’m fine, listen, i know how, this is what i have, what my ex-wife has. build your life, this is objectively so, but why did you separate, because i have a rule, do not waste your time or the time of another person, that’s right, this is normal, accordingly, the main problem is to

let’s say, bring a person to introduce you, if he is the right, high-quality person with certain values, look, let’s do this, yes, i’m a simple woman, look, here you have a full vessel of love, mutual understanding, respect, children, mother, mutual friends, relatives , holidays, weekends, it is filled to the brim, where, if a drop of your wife, the real one, appears, she will also be with her friends, maybe even with her children, with her relatives, with her ex, in which, with which is in a relationship with a hickey, and there is also all this is happening, where can she fit here, squeeze into this overflowing vessel of love, just tell me what her place is? just a single person will not come to you, well , such a mary poppins, who flies all the time and does good to everyone, she will not come like that, she will come, you are already 37 years old, she will

also come with her luggage and with... her past , well, he’s serious, he’s looking for a like-minded woman, that is, he’s not looking for some girl, a domestic cat, you know, that’s where your strength lies, you have a favorite thing, and well, this is yours advantage that she should accept, firstly, my ex-wife, like my family, are the people i will take care of in any case, yes, here is the second point, do not count my finances, this is always, that is, this that, that i don’t think yours,

you never think, when she’s chattering two in her mind, you won’t even suspect that she will build a parallel airfield for herself, or such a cunning one that you won’t even believe about, i have a lot of girlfriends who are divorced from rich men who have also already learned everything, okay, i’ll come in,

there, you know, everything will remain on the shelf, but i think that i should still make the relationship with his ex-wife adequate, respectful, again, i worked in a kindergarten, i know how to communicate with children, with a four-year-old just for a moment , are you a professional psychologist for a minute, the last question, what are the red flags for her now for the one who will come to fight for you, never?

they lie square, the socks are in a certain way, then he is a perfectionist, he even has jeans from all the mess that can arise at his home, this is only dust that has collected in one day, this is why , of course, everything should be clean and so on, cleaning is a rare case, but it is desirable that she still does it, moreover, he distributes, his wife should or the wife should manage the cleaning, yes, of course. you don’t have to do anything if you don’t want to, no, well , look at the house, you want it here, you don’t want it, if you have at least 500 square meters there, you’ll just die, wipe the dust alone, they’re not needed, but he always distributes responsibilities in the family and gives everyone a task, then is it in the morning, you can send it or now you can send it over the phone, start a general chat, such a man will be bored with a woman who will just be a housewife doing laundry, cleaning and there will be nothing to talk about with her, he

probably communicates in such circles, communicates with. .. interesting people, he’s not greedy, but he counts the money, well done, and so am i, but i’m also greedy, that’s what i have in connection with this, and what kind of wife do i need, i’ll even get to that first, model appearance, she has there must be aristocratic behavior, stately presentation myself, so that there is a point, thin hands, long fingers, thin palms, it’s you, larisa, this, thin ankles, the only thing that is thin is broken, you know, that’s why...

we said that the wife is your family, although i have an ex-wife, but wife, wife - four capital letters, that is, it is important for you that she remains for you. maybe you have this gene, the second wife will be a concubine in terms of her importance and value, what is her function, well, she is only a concubine in this, i don’t need to exaggerate, here firstly, this is your ex-wife, this is the mother of my children, this is your wife, this is your eldest wife, no, judging by the care towards you, she remains your wife, it’s another matter whether you sleep with her or not, come on, i know, well, on us something like this, but she remained your wife, you have the right, it’s like every hut has its own rattles, we’re not in terms of judgments, we’re in terms of an agreement,

so that on the contrary it would be very easy for us, that’s what you have with me now such a question, please tell me, if your ex gets married, will you stop these cash flows, care and so on, no, these are my children there, and if she... gets married, her husband will say: listen, pasha, something has gotten too much of himself, thank god, i’m still a healthy man, and let him take care of the children, but i’ll take care of you somehow, let’s do these and in this case, then maybe we can find a husband right away so that our girls can bring this to you, so well , in principle, everything is clear to me, you’re such a khanbata with such a mentality , what the hell is this, this is normal for me. not everyone is ready to accept, we need to marry her off, then i think she will become safe, you can take a woman with children if you like it, well, it will be strange if she doesn’t have children at that age, but tell me, if the husband is as active and

as sympathetic as you, you can come to an agreement with everyone , that is, you will also allow friendship and communication such care, every weekend, and he will talk about her, she is mine... it’s still family, she is my wife, i cannot remove him from her life in any case , he is the father of her children, firstly, secondly, if we raise our children correctly, here i am i must set an example for my sons , two wives will take me in the future, i am an example, what should i say, guys, i will take care of you, and let your mother do what she wants, that’s it, no, i must set an example, a man must take care about his mother, about his sister, about his wife.

will listen to your mother, when you love, you want to possess, you want to be the only one, so to speak, yes, you want to be the ruler of her everything, past, present, and future, you don’t understand any of this, women plus property to everything, you know, what if

a woman lives with you, how can she not be aware of, for example, your financial affairs if you are officially married, and you still want children, a daughter? you will, for example, have a common child, how this will not be known, that’s all, this is the basis of the foundations, this is your foundation, no matter how much she lacks, what difference does it make, she will not consider that there is a series of the magnificent century, we now we are directly observing the very beginning of it, here is the sultan sitting, look at the turkish, it’s very interesting, i’m talking about something else now, pavel, i’m interested in your very interesting the peculiarity is that you don’t hire a man who owes him alimony, that is, you go through the database, well, figuring out this story, and why you don’t hire him. if he knew that either a friend, he stopped communicating, if he knew that a friend had a mistress, and they were together in the same relationship at work, he said,

if he cheats and deceives his wife, who bore him children, strokes, cleans, washes, cooks, and so on, he can deceive me, in general, he will do it easily this time, so you know.

hello pavel, i think i forgot the whole speech, which i prepared because i was fascinated by you and what you said, nice to meet you, hello, thank you, nice to meet you. let's go to! svetlana, 36 years old, psychotherapist, lives in moscow, drinks tea with milk every morning, keeps a diary of her feelings, is fanatical about cleaning, but regularly uses food delivery, and is proud that she took herself to the maldives. the needle found in the wife’s car became for svetlana at the same time a knife in the back, a vaccine against unhealthy love; she hopes that with pavel she will not have to suffer. hello girls,

hello, what a beauty you are, thank you, mutually, well, you can’t take your eyes off you, visually pleasing, well, it seems, but it seems to me that she’s such a bitch, you’ve been married for 36 years, you have children, no, you want it, very much, tell me what for a needle, you can find anything you want in machines, but a needle, what kind of needle, a sewing needle? or you know, if he were a bastard, i would be happy, but no, this is an addiction, a dependent person, and this was such a final touch to the end of the relationship, after which i decided to divorce. svetlana, i was married to a drug addict, i know what it is, i know all these stages, but when i left, i didn’t know that i was stupid, i thought that drug addicts were only abroad or in prison, i didn’t think that there were drug addicts. when you got married, did you know that he was using? no,

i didn’t know, but i found out about this a year after the start of the married relationship, i already mean, and they told me about it, his friends opened my eyes, because, oddly enough, he has such a healthy... that environment, part of it, they told me that the light is so and so we can’t hide and let’s save, and i saved for 8 years, everything is like me, a very beautiful girl. she found herself in such a situation, really, and indeed, apparently, she loved him, since she decided to save him, yes, you know, this is also about some kind of relationship, here is cartman’s triangle, dependent, rescuer, but there is only one option get out of this relationship, but tell me, did your parents know, but they knew, they didn’t say, sveta, put your feet up, you’re not a doctor and you’re not mother teresa, run, you’re wasting time from him, no, first of all,

how old were you years? i got married at 22, then have you not received this education yet? no, no, it was already over, it seems that he swore, swore, every time you caught him, he swore, he cried, asked for forgiveness, said that he was hardened, of course, of course, flowers, gifts, i’m sorry, i won’t do this anymore i will, oh, sister, well, in short, everything is clear, why are you saving a person who doesn’t want to be saved, this means that she herself has problems, but damn, she has rescuer syndrome, he doesn’t take it with her. yes, yes, yes, yes, that is, for her there was some kind of

there was some kind of situation, perhaps not noticing some of your problems, your cockroaches, save, it’s scary, light, and then they began to cut it, i did it abruptly, that is , this needle was such a trigger when i realized, that everything, look, light, except for one nuance, it means that my first husband was also imprisoned, but he was such an idiot, he was imprisoned for a fight, because he was a hooligan, but yours was given 15 years, and that’s already... you’ll be his , unfortunately, unfortunately, nothing scared me then, i had eyes, hearts, in fact, a wounded, traumatized person, very strongly, of course, my husband, when he came to meet my parents, was lying in the garden, sunbathing, on one leg, so it was written like this, here he was lying on his foot, a judge, on the other a prosecutor, and my mother came out of the kitchen

he looks and says: poor boy, how much he has gone through, you should feel sorry for him, this is a russian woman, my mother didn’t say. run, daughter, don’t, there is no future, mom said, you should regret it, she regretted it, yes, yes, yes, absolutely one on one, she is so beautiful, no one took her away from him, well, apparently this is was her path, something she also, apparently , worked in herself for 8 years, what time did you leave not, how old were you, well, i left 29 , i was 29 years old, so why 7 years you didn’t did you find anyone to give birth to, or to give birth to a family, or did you study? i studied, yes, i first got out of that relationship, then there was another short one, well, in general it was and was, light, look, you are 36 years old, you have a lot to do, if you want children, you have wonderful people almost the same age, by the way , the habits are similar, she is the same perfectionist, he wipes the dust all by himself, he doesn’t even invite anyone,

he will do it all herself, depending on how much, you know, and two children will arrange something for you there over the weekend that you will have to spend the whole weekend ...

i won’t hide it a little bit of me, tell it like it is, don’t choose your words, okay, yes, there was some anxiety, pavel, yes, that such a connection, first of all, there was respect for the fact that such a clear position, such principles, but this anxiety that the wife so close, but then again, since you are here, i have great hope, which means there is a place in my heart, then some kind of, hello, garage, hello, psychologist, my good one. it’s either all or nothing, he’s very, very greedy for feelings and for the body, for time, for

money, for everything, he wants to have, uh-huh, the proposed circumstances tell you this: no, don’t discuss it, i asked a question, ross, don’t answer for her, but i forgot the question, i say again, you will come to a ready-made family, you have money, you have a place to live, you have a job, you have an education, they tell you, all you have to do is be a good wife, a lady, not argue, don’t get involved in my financial affairs and never say: “why is your wife celebrating the new year with us, and he will answer you, because she is my family, she gave birth to two sons, and you will say, you and i are sick of you.” with your children and your ex, that’s it, it will be like this, but i just know, listen, well , they broke down in such situations, only very

cunningly, alone for the whole world, for the whole union of the former famous person who said, i will always love. i want to be the first and unique, and it seems to me that here it is possible, depending

what kind of feelings there are between people, the fact that there is a family, it’s wonderful, you can generally just make friends with everyone, another thing is, i don’t know what kind of relationship there is with my wife, if i’m with my ex-wife, that’s even how i say, yes with my wife, if everything is adequate there, then of course, i understand that the man has, and it’s wonderful that at 37 years old there is a marriage behind him, there are children, there is this one: and we are ready to spend long winter new year’s evenings, and in a circle, well, that’s right long winter, no, not ready, no, you don’t know my ex, but winter evenings, they always long, just a second, look, you turned it a little wrong, i’m silent, i won’t argue, please, okay, you just don’t know my ex-wife, and my ex-wife is not going to spend the new year’s holiday. with another present, for example, or a future one, you know, children, okay, but this is a self-sufficient person, there is a difference, holding

events and spending time together, there are significant events where both parents should be present for children, this is mandatory, the new year is such an event where people should be present parents, so i ask, who will you choose, will you celebrate the new year with your new wife or with your old one? with whom will you celebrate the new year with your old or new wife, you can answer the question, i will celebrate it or not, that’s the choice, either this way or that way, it won’t work out that way, but since it will work out in the movies, i didn’t have time, from three to first, where are you? i mean, i ’m with my family, i have a big family, i have an ex, two children, a mother, a sister, a twin, an older brother, and we are correcting. with a large family such large events, and my wife will say, i want it by candlelight, on red square, and then go with you to paris,

together, imagine, this is not my wife, this is not a bit about my relationship with my wife, i can’t go and say something, you can talk to me about agree on something, but just telling me or setting conditions won’t work, not two people have already understood it, i generally dreamed of a huge family, so that grandparents, aunts, and uncles would gather. with children, that’s how my grandparents celebrated their golden wedding when i was a child, others events, you say, i even get goosebumps, we also had so many of us, it was so fun, and if the older sons come to the house, then it will be somehow more interesting, i’m not saying that i was i would be glad for my wife, if only she has a husband, we are trying to explain this to the bride. it will be very difficult to agree, it will be difficult for you, but you have to. like an eastern wife to say yes, dear, look like this all the time, well, you and so you and you immediately put on makeup in the morning,

beautiful clothes, no, look, one woman says, what’s wrong with this, it’s natural, for me it’s normal, i agree, but the other one won’t even listen to the end, you know, she’ll say, no, no, not my passenger, i have one life, i apparently have flashbacks from the past, that is go to the energy, to the image, to some kind of response, you hear, you should have given birth yesterday. rosa, everything is fine with me, i was examined, everything is like an astronaut, svetlana, how do you like this story? a stone wall, yes, but sometimes there is such a stone wall, you won’t break through it, so that later it will become your grave, it will become a slab, a slab on the grave, stone,