in fact, everything is even more complicated, in fact, you need to take into account that no matter how uniform the vaccination of the population was achieved, that is, introducing coefficients, not, well, it seems to me, 99.00 versus 6.00 on the same sample of people, these are telling numbers, well, certainly telling , i was just trying to complicate something that was published somewhere, i honestly didn’t know about it, no, it’s on the moscow website.

what kind of vaccines are these, each of them will also need to be pushed through with such effort in order for it to be recognized? well anyway efforts will be needed, i am absolutely sure of this, the only thing is that if there is an even greater mortality rate, it will not be 1-2%. i wanted, you know, there is this disease x, for example, you are not working on disease x, well, this is a hypothetical concept, this is a hypothetical disease, which for some in this mind game it is assumed that it will have a mortality rate there of 20 times higher or how much. 10%, 20%, yes, yes, absolutely right, it is used for modeling, and well, except for the theoretical possibility, after all, no one could predict the epidemic coronavirus until it happened, so you worked quickly, everyone is grateful to you for this, but you can work on a vaccine against a pathogen that does not yet exist, you need to work on vaccines against pathogens that already exist, because when we talk about coronavirus, even covid-19.

research, that is, it is necessary to create vaccines that have a high pandemic potential, using platforms that are not necessarily single-virus, but can be used in addition to single-virus and mrna.

no, well, antibiotics partially, of course, solve the problems of bacterial infections, but not all of them, there are bacteria that initially in the course of evolution lived together with the same actinites, fungi, coexisted in the soil, they have natural resistance mechanisms and they in general, they use these natural mechanisms of resistance, and even exchange these natural mechanisms with each other; these super-resistant strains sometimes actually contain plasmids, and the genetic elements are resistant. re-preserve to a high degree of readiness and in case when such vaccines enter the territory of the russian federation, they are used accordingly to vaccinate the population, of course , of course, that is, there is a certain list that you or your colleagues are trying to close using your technologies. lasa, west nile there and

so on, according to the list, everything that is included, accordingly, these are about 30 pathogens, that is, such planned work is being carried out, if there is a deliberate, not premeditated, no matter the introduction, we just have to be ready, well, besides, if we we are talking about platform solutions, they allow, having been checked for safety in everything, to quickly change the filling accordingly, quickly change genes , and make a vaccine against a pathogen that is not included in any lists, therefore, but it will still need to be carried out. studies to prove its effectiveness and this, or do you think that the beaten path, in no case, thanks for the question, everything should be brought to at least the second phase of clinical trials, what does this mean, this means the entire preclinical including primates, then there is safety plus effectiveness in primates, safety naturally in other species of animals, and then the clinic that gets there, we are convinced that the vaccine is safe and effective, we are entering the first second phase.

we can preserve such a vaccine with a high degree of readiness, in my opinion, why can we preserve it, because imagine a list of 30 pathogens, we need to carry out 30. of the third phase with you, and you can do this in your center, this is no one can't do anything in the world because you're the third phase - this is in endemic conditions, that is, you must get to the outbreak to collect statistics there, you understand, yes, that is, you must have junin, fever or guanarites there, you must fly somewhere to argentina in argentina to collect statistics of the third phase in the conditions there some kind of ring vaccination there in the conditions of an outbreak there or there or in an epidemic, but you, well, in order to make a vaccine you need a pathogen, that is, in your center there are gomaleys? in the center of moscow there are all these pathogens, not so, we have all the pathogens, up to, including the second group pathogenicity, the entire first group of pathogenicity, this is our collaboration research, the first is more dangerous, the first is the most dangerous, according to our russian classification, the first most dangerous, according to the european

american classification, the fourth most dangerous, well, so as not to be confused, yes, the most dangerous, and these studies are all carried out in collaboration with the ministry of defense, that is, this definitely does not happen in moscow, not in the center.

it doesn’t happen that a person was in your life, then he disappears, even if he dies, in this girl you almost won’t recognize the child who 5 years ago i lost the most precious thing, my mother, i don’t think that i am without her, i have a pile of memories, but this is my mother, yulia nachalova died very young, at 38, leaving her beloved daughter, vera, to her parents and ex-husband. i said that, unfortunately, i have very difficult news for you, that mom is no longer with us, what? at that moment, that evening, he, only he knows, it’s a big responsibility to tell his child that his mother passed away, how did yulia’s only daughter survive this loss, what path did she go after her mother’s death? i some kind of really mega-strong, i felt like everything was just like that, i pulled myself together, that

is, our exclusive 5 years of adult life of a girl who decided, no matter what , to become a star in memory of her famous mother . when you appeared, my life changed. i will always be with you. exclusive with dmitry borisov. on saturday on the first. in the new season on the first. a woman is killed, and we are talking about the devil and our hearts are not broken. do you know how it breaks? so only the shoulder is removed and the elbow is pulled. well ok, let's think about it. let's say you're a mole, you're wanted.

show up at the control room and mobilize all our employees, everyone you can, the whole version is going to hell, the man was a stutterer, suddenly he speaks like cicero, i really hope that you don’t have to blame yourself for not wanting to help us, you very good shooter. hello, colonel kostenko, confrontation with the prime minister based on the legendary book by yulian semyonov. this is the podcast baden baden, i am its host konstantin severinov, and today we are discussing vaccination,

that is, you have 30, well, let's assume that there are 30, well, let's say, 30 pathogens that are, well, representatives of some large group of related viruses, not related, well, no, each of them is. yes, yes, according to the phyllo of the virus, for each of these, for each of these groups, you more or less understand what needs to be done, just as in the case of the coronavirus.

after all, we as a country are quite far behind, well, in the field of biomedical research we are certainly lagging behind in some surprising way in the country they managed to make a working good vaccine that saved hundreds of thousands of lives, and you see, for example , in france where there are companies that have created no vaccine for igpharma , it’s hard for me to explain this, in japan there was no vaccine created either. a very large pharmacological pharma, it seems to me that they had great hope for

the development of other pharmaceutical giants, who quickly announced, it was very important who was the first to say, those who were the first to say, in fact, the same thing happened, remember, there i don’t know the order there, hundreds of vaccine candidates appeared there after, but everything that appeared after, despite the fact that it worked, never worked again, that is, it was needed as an expensive spoon for dinner, that is... it had to work very quickly, to work ahead of the curve, and this immediately channeled the attention of society, the attention, respectively, of governments, the attention there, well, in general, everything was focused precisely on these developments, so it seems to me that this is more likely connected with this, but the fact that in our country, in fact, we never infectious pathology was not forgotten, but well , we went through different periods, also in the nineties, when everything was not in the best condition, loss of personnel, and so on and so forth. years in the country , i will repeat once again that investments in this area were

absolutely sufficient and significant, this area was definitely not forgotten when i tell you that we were developing a vaccine against mers, and before that we participated in the fight against the ebola epidemic, this is participation directly in our country, and we then made a vaccine, so really pay attention hasn’t gone anywhere, well, certainly since the beginning of 2000 and here, but even more so considering that we continue to have it. school and the creation of vaccines, the fact that in general there is such a high level of sentiment against vaccines in society, this is, of course, a bit of a scandalous situation, but after all, just like you said, this always happens, well, what’s worse is the case of emergency, which is this is exactly the price of effort, but anti-vaxxers, of course, and measles is some kind of new vaccine, but no, of course, measles is a vaccine , it’s the good one. good, an old, proven vaccine, of course, the only thing that people don’t understand is that measles

is much more contagious, that is, if there is a coefficient, yes, the coefficient there is r0, yes, that’s the calculated coefficient for covid there is 2.5, well, when it ’s 3, 5, that is, there is a certain range, a spread of this coefficient, that is, one person can infect there 2.5 3, then the core is 12-18, the root is incredible, an infected person can infect while he is infectious.

coverage, that is, in order to block the spread of measles in the population, it was necessary to maintain 90%, there was a whole bunch of very smart, cunning people who said i don’t talk about our country. about all the countries in which there were outbreaks, there are now outbreaks of kuri and in ukraine, in other countries, it appears, well, either the government pays less attention, or accordingly the population begins to be cunning , this favorite story is that i did not vaccinate my child and he did not get sick , you understand that i did not vaccinate, he did not get sick due to other children, other children were vaccinated, you

provided a 90% immune layer, then in such a situation, there is no place for measles to spread. this means that it is in some sense inevitable, or or the fact that something is on the national calendar does not mean that the child must be vaccinated, if he does not have a medical exemption, he must be vaccinated against measles, so everything that is included in the national vaccination calendar - these are mandatory vaccinations, that is, i have to do it, but i may not do it, but this is what led to this situation with measles, and of course, as soon as you have a window of opportunity, virus, just imagine, you are asking purely...

while variants exactly containing mutations are emerging, but so far there is no convincing data that this is such a strain of vaccine escape, that it is running there, well, immunity, so for now there is no reliable data confirming this , but it definitely may arise, monitoring of this is happening, monitoring is carried out even at the level of the health care department, where i am not part of the moscow health department, but i know that moscow is sensitive to this, and genetic monitoring of those variants is carried out are revealed. and if, god forbid , something new happens, that is, here is a calendar, a national vaccination calendar, it is something that is already cast in bronze, exists all the time, or there is some kind of movement, no, of course there is, on the basis of which , absolutely everything is the same scheme, yes clinical studies, clinical studies, what to make a vaccine against, of course, as soon as it is decided as simply as for covid,

genetic monitoring, you identify the variant that becomes dominant, adapt the vaccine to this variant and ... use for here in your professional life, how often do changes occur, changes occur in the national vaccination calendar, practically does not happen, practically does not happen, that is, a stable thing that for decades is like, well, the only thing that is modified is the quality of vaccines, that’s it, where did what i say happen, that there were old vaccines, no matter soviet or non- soviet, now they are all good, no, in fact, you see that there is a dpt vaccine, the criti has just changed. new ones appeared there vaccines, yes, that is, not in the sense that something has changed, but vaccines have appeared there, conjugated there, yes, that is, if before they were just polysaccharides, now they are conjugated with taxoids, and there are very good answers to the polysaccharides of those pneumococci, hemolysum, other pathogens, that is, it is being finalized, new vaccines appear in it, vaccines

that the old ones are being finalized from the point of view of safety, that is, they are changing, there is more safety, yes, that is, it is more likely that this is changing, relatively, if a new one has arisen an improved vaccine, does this mean that those who were vaccinated earlier and with worse vaccines should be boosted or do something about this, there is no need, there are schemes, in fact they are more likely related to age, not to a change in the quality of the drug, that is well , for example, you were vaccinated with a polysaccharide vaccine, yes, that is, which was originally, then a conjugate vaccine appeared, you reached a certain age, for example, sixty-five years old. any sane doctor out there will recommend it, let’s boost you too you will be boosted with a naturally improved drug, well, so in order to be re-vaccinated on top of the old one, this is most likely not the case, this happens with the flu, yes, for example, we all know that the flu is changing and we will each make a separate lining for the flu, because it an endless topic, immunity acquired as a result of illness or as a result of vaccination,

these are generally comparable things, in the case of covid it was very active, because it was also discussed that i was already sick, why should i, for example, get vaccinated, there is certainly a difference there is a difference, i think, primarily in the cellular link of immunity, and there are simply many more clones, cells, which is better, to get sick or to vaccinate, no, well, this is not a question at all, of course, it is better to get vaccinated in any case, and even if with the passage of time, you encounter a pathogen, there will be a certain morbidity there, then it is certainly not comparable with the fact that when you have a clean slate and you get sick initially, that is, it’s not even...

the names that many people talk about, there i think there were such special posters, yes, who called for vaccination, there was a cartoon about a hippopotamus who was afraid of vaccinations and then turned yellow, that is, it seems that everything has remained as it was and it’s really better to get vaccinated, it’s mandatory to get vaccinated, and today we started talking about safety, probabilities, that is, any vaccine drug - this is not a vitamin, but accordingly there are these one case in a million, by the way, why ... it happens, because you and i know the syndromes of heinabar, transverse melitus and other complications, they are all are associated with immunity, immunity is a very serious thing, sometimes sometimes in one case

in a million, he makes a mistake and starts doing things that are not very good, but this is really very rare, that is , if we take the additional cost of the vaccine program , then approximately one case per million adds some autoimmune complications to those cases that are normal in the population.

side effects from the vaccine, they happen, what is the beneficial effect of the vaccine, how many lives they save. you can find all episodes of the badden badden podcast on the channel one website. let's start, oh, play! arrived, hello, hello, welcome, wait!

the city of yelets, lipetsk region, zhemchuzhina, black earth region, a historical city, one year older than moscow, famous throughout the world for yelets lace and the piano accordion, the composer tikhan khrennikov was born here, the writer ivan bunin lived, and here the game and game festival takes place for the thirty-eighth time harmony yeletskaya, on which we actually arrived. let's start

our program from the song that crowned one of the first programs, play the accordion, of course, which our father gennady zavolokin filmed back in 1986, eleetskaya lace, let’s remember. isn’t it a woman’s soul flaunting itself in lace and lebskaya’s accordion singing in them? it seems to me that lace and fishing line are either white, smoky, or tender.

in the fall, it brightens for me in the winters, turns blue in the springs, turns yellow in the fall, guys, you will never know this wonderful thread that always sounds in me, like a mother’s song, lace, kileska, now i spin with white, now tender i turn blue, it brightens for me in winter, it turns

blue in spring,

and you are from voronisk, and we are from lipetsk, and why did you gouge your eyes out at us, don’t look, you ’ll break your eyes at us, but you’re a bastard, you don’t know, thank you!

friends, thank you, igamon, thank you, low bow into the veil.

play it, play it, play it. don’t be bolder, don’t be bolder than your brother-in-law.

high is my voice devalasi what'.

russian perky! well, here, dear tv viewers, look, here... i’m demonstrating one option, what

a beauty, the second is lilac, look how delicate work, there’s just some kind of cobweb in your hands, look, oh, and here further from the pot, i, you have one pattern, look, and i have another, look, oh, then there are pictures, and a coat of arms, and paths, yes, and the coat of arms of yelets. myself, i have the most beautiful one, yes, well , me too, well, you just have a big postulate, hang it up, it will be beautiful, yes, for example, a lacemaker is sitting there and i really want to hear that sound of pooping, how this lace is woven, well- ka, ka, ka, ka, oh, beauty, here it is, let's listen, let's listen, its own music, if anything, yes, well, now, in my opinion, it's time to hear the sounds of yeletskaya. piano accordion musical lace performed by the accordion player

of the golden ten of russia sergei ivanovich vlasov suffering and admiring the lace.

how did you find me? listen, well, i’m a cop, i didn’t go around like that, he could ruin everything, he won’t have time. you are an investigator for particularly important cases, for what purpose did special missions come to us, they returned, well done, but you must understand that it’s not good for you to be with this cop, it’s dangerous, i got the money, five tickets are enough, two adults and three children up to moscow, why are you silent, are we going or not, look, the kremlin, the kremlin? kremlin,

movlyudo, hello, no, well, just like that , i moved from the basement to three rubles, and oh, women, look how men need to be clamped, and in our yard, today on the first floor, whiskey manketer, a product of the lor group, cnop gin . product stellar group cognac monte chococa product stellar group rom castro product stellar group.

here on this stage there is a real holiday, two stars, fathers and sons, look after the evening news, the city of eleet. ascension cathedral, fast pine river, look, it’s really fast it’s coming, they say, in the spring it floods all the edges of the coast here, all the edges of the coast, yes, that’s what it is, over there, that’s where the red temple is, the accordionists have gathered there, you can even hear it,

i’ve traveled half the earth, i’ve won a lot, but my life , home, family, yes, a long journey, we are companions, friends, in a bag, a mug-spoon, my piano accordion is always with me, oh the kielce accordion, yes the piano tuning, dear to my heart, lace picker, i am the kielce accordion, bronze slats , and the fire burns in the soul from the bottled gelchanka, let’s remember about our fathers and grandfathers in the villages, they walked like this, with the gentlemen, with the girl and at the table they suffered, and now there is only a disco, a little joy,

the lady cannot replace the russian accordion for me, oh elekskaya harmony, piano tuning, dear my heart. lace picker, i am a kiletsk accordion , bronze slats and the fire burns in my soul from the draft elchanyka, oh yeletskaya harmony, and the piano tuning, dear to my heart, lace picker, kiletsk accordion. bronze slats and a fire burns in the soul from the fir tree on tap and a fire burns in the soul from this monkey.