yes, sephila viruses, lasa, west nile and so on, according to the list, everything that is included, accordingly, there are about 30 pathogens in these, that is, such planned work is being carried out, if there is a deliberate, unintentional, no matter the introduction, we just have to be ready, well, besides, if we are talking about platform solutions, they allow, being tested, in terms of safety, in everything, to quickly change, accordingly, the filling, quickly change the genes to make a vaccine against that pathogen that is not included in any lists. therefore, but it will still need to be researched, to prove its effectiveness, and this or do you think that, in no case, in no case, thank you for the question, everything should be brought to at least the second phase of clinical trials, what does this mean, this means the entire clinic, including primates, that is, it is safety plus effectiveness on primates, it is safe, naturally, on other species of animals, and then the clinic, which reaches, we are convinced that the vaccine is dangerous,

effective, we enter the first, second phase, here we can preserve such a vaccine, as if it were a high degree of readiness, in my opinion, why can we preserve it, because imagine, a list of 30 pathogens, we need to conduct 30 phase three studies with you, and you can do this in your center, well, no one in the world can do this, because you are the third phase - this is in endemic conditions, that is, you must get to the outbreak, collect statistics there, you understand, yes, that is, you must junin, fever or there guanarita, you must fly somewhere to argentina in argentina to collect statistics of the third phase in conditions of some kind of ring vaccination in conditions of an outbreak or an epidemic, and you, but you need a pathogen to make a vaccine, that is, you have all these pathogens in the center of gomaleya in the center of moscow, no, we have all the pathogens up to, including the second group of pathogenicity, the entire first group of pathogenicity, this is our collaborative research the first is more dangerous, the first is the most dangerous according to our classification.

pathogenicity group in the city, within the city, that's why it 's happening tens or hundreds of kilometers from moscow. in the new season, on the first one. you have a good collective farm, and you'll try to make it rich, a millionaire, and you 've hardly aged. it'll probably be hard in the village, because they're not used to it. it's okay, we'll get used to it, but in our village, your hanky-panky can end badly. vadim, part-timer, are you sure, he 's a womanizer. "my valinka and i almost

broke up right before the wedding, because of him, and if i fall in love with you again, it's yours, do with it as you please, throw it away if you want, if you want to wear it, if you want to hide it, and he pestered you again yesterday, don't disgrace the family, kirill, i want to give you advice, as an experienced womanizer, don't pester a woman if she doesn't want it herself , you're ruining your life and hers, what will happen to you now, what will they push you away, these are not simple words, if necessary, i'll kill you, i wouldn't throw around such words, will you kick?" " i'll put you in jail, for what? we'll always find an article, i won't survive if you cheat on me, i can't live without you, premiere, tomorrow after the program time, i can't live without you, i'll wait in the new season one, come on, come on, can i ask you, of course.

that i love her, i've loved her for a long time since school, do you? on the back of her head wet from the heart, lipstick on the collar, for everyone we are the perfect couple, i don't want to be a thief, you understand, yes, but it seems to me that you yourself, yes, my wife asked me, left for another, why don't you go after her, don't fight, don't bring her back, i went out of my way for him, do you at least know how much they cost, and you weren't asked, and i'll ask you now, properly, choir, premiere of a multi-part

film, coming soon to the first. this is a baden podcast baden, i am its host konstantin severinov, and today we are discussing vaccination, that is , you have 30, well, let's assume that there are 30, well, let's say, 30 pathogens that are, well, representatives of some large group of related viruses, not related, well, no, each of them is, a representative, and you for each, and you for each of these, for each of these groups more or less. you understand what needs to be done, just as in the case of coronaviruses, yes, one of which is 2, in this sense you are ready, for most known viruses, of course, are ready, yes, but not for everyone, moreover, when you say, here comes a new virus, we were lucky with covid, we

knew what to take and what to insert, plus you understand that the mobilization of the resources of the entire country allows this to be done, there it is faster not in the sense that nine women cannot give birth to a child in a month. in this sense, but when you have the entire regulatory system built, government decrees 441 and so on, production resources are mobilized, this is one of the things that helped you, it is directly it was like a military mobilization, of course, the government and the president, not because i want to say good words to the government or the president, you just need to give credit, played a key role, without them, well, how could such a large-scale project be implemented surprisingly, that is, you and you are a hero of russia or not, no, no, but still.

surprisingly, yes, because in japan no vaccine was created, where there is also a very large pharmaceutical pharma, it seems to me, they had great hope for the developments of other pharmaceutical giants, which they quickly declared, that's where it was very important, who would say it first, those who declared it first, in fact, that's what happened, remember , i don't know the order there, hundreds of vaccine candidates appeared after, but everything that appeared after, despite the fact that it worked, never took off again. that is, it was necessary to have an expensive spoon for dinner, that is, it was necessary to work very quickly, to work ahead of the curve, and this immediately channeled the attention of society, the attention, respectively, of governments, the attention there, well, in general, everything was focused namely on these developments, so it seems to me that this is more related to this, and the fact that

in our country, in fact , infectious pathology has never been forgotten, well, we went through different periods, also the nineties, when everything was not in the most. recent years in the country , i will repeat once again that investments in this area were absolutely sufficient and significant, this area was definitely not forgotten, when i say that we were developing a vaccine against mers, and before that we participated in the fight against the ebola epidemic, this is participation directly in our country, and we made a vaccine then, so in fact the attention never went anywhere, well definitely from the beginning of the 2000s and here... well especially considering that we continue to have and have a school and creation of vaccines, the fact that in general the level of sentiment against the vaccine is so high in society, this is of course a bit of a scandalous situation, but after all, as you said, that it always happens, well

, there is a rumor there was a case with measles, which is this is this is this is right now an anti-vaccine yes anti-vaxxers, of course, and measles - is it some kind of new vaccine? the only thing people don't understand is that measles is much more contagious, that is, if there is a coefficient yes the coefficient there is r0, yes, that is, which is calculated for covid there is 2 and a half, well when 3 and a half, that is, there is a certain range, the spread of this coefficient, that is , one person can infect there 2.5 - measles 12 18 '. if you come into contact with someone infected with measles, then you will be infected in 95% of cases, but those of us who are vaccinated, they turn out to be resistant for life, this is

what's the situation? yes, with measles there's a big positive in this, measles is exactly 12:18 due to the fact that it is very contagious, it is provided precisely due to a different reception, that is, there really is a very... lock, therefore all virus-neutralizing antibodies that block this high-fidelity interaction like a key to the interaction are really there, well, inactivating, that is, there you can induce immunity for life, because the interface as an antibody with an antigen is so rigid with high affinity, but with covid it is not so, with covid absolutely, in the case of measles, which is now rumored more than covid, that is, the fact that there is an outbreak, is it because the measles virus has become different or because the vaccines do not work why is all this happening at all? no, initially, it is because people did not have sufficient coverage, that is , in order to block the spread of measles in the population, it was necessary to maintain 90%, there was a whole bunch of very...

outbreaks of measles are happening now in ukraine and in other countries, it appears, well, either the government pays less attention, or, accordingly , the population begins to cheat, this favorite story that i did not vaccinate my child and he did not get sick, you understand that i did not vaccinate, he did not get sick due to other children, other children were vaccinated, you provided a ninety percent immune layer, then you ... in such a situation there is no place for the spread of measles, now measles is on the national schedule, right? of course, it always was, this means that it is in some sense inevitable, or or the fact, that something is on the national calendar does not mean that the child needs to be vaccinated? if he does not have a medical exemption, he must be vaccinated against measles. therefore , everything that is included in the national vaccination calendar is mandatory vaccinations, that is , i must do it, but i can not do it. yes, this is exactly what led to that situation with measles. and of course, as soon as you have a window of opportunity for the virus, imagine, you set purely evolutionary space for it,

mutations naturally occur, then how did this happen, for example with covid, it's very clear, well yes, it was all there, but it could be the same with measles, that is, in fact, if measles is widely represented due to circulation, variants that will bypass the vaccine in everyone else, of course, that will be terrible, well, in my opinion, of course, therefore there is some data that...

it is not necessary, there are schemes, in fact, they are more likely associated with age, not with a change in the quality of the drug, that is, well, for example, you were vaccinated with a polysaccharide vaccine, yes, that is, which was the original, then conjugated ones appeared. you have reached a certain age, for example, sixty-five years old, any doctor you use will recommend,

let's boost, you will be boosted with an already improved drug, naturally , well, so that you can re-vaccinate on top of the old one, rather, this is not the case, this happens with the flu, yes, for example, we all know that it will be very necessary to make a separate podcast about the flu, because this is an endless topic, immunity acquired as a result diseases or as a result of vaccination, these are generally comparable things, in the case of covid it was very active, because it was also discussed that i had already fallen ill, why should i, for example, get vaccinated, of course there is a difference, the difference, i think, is primarily in the cellular link of immunity, and simply much more ... when you have a clean slate and you get sick initially, that is, it's not even a question, no, having recovered then about the vaccine

then makes sense, or then in essence you were vaccinated, when you you get sick, you get vaccinated. on the contrary, we studied the antibody type, that is , the maturation of antibodies, which occurs throughout life, there, two-three-fold contact certainly forms a much more reliable immune memory, that is

, absolutely incomparable affidity, the strength of interaction, that is, there is actually similar to boosting, the levels in argentina were actually a very good study, they are unprincipled people there, they introduced absolutely all the vaccines, they needed... this and separately it was shown that all those who have recovered, well, who had contact with whom at the beginning or after, if they were vaccinated, they also have the maximum response levels, and we, for our part, have studied this from the point of view of visibility, that is , how much the antibodies that formed after 180 days, when you have two contacts or one contact, differ in how much they provide virus neutralization, much higher, if several they recognize the virus better and thereby better protect you from infection, that is, dry. the rest is that returning to those blessed soviet times, which many people talk about, i think there were special posters, yes, which called for vaccination, there was a cartoon about benemot, who was afraid of vaccinations and then turned yellow, that is, it seems that everything remained as it was, and it is really better to get vaccinated, it is imperative to get vaccinated, and today we have already started talking about

safety, probabilities, that is, any vaccine preparation is not a vitamin, yes, there are... they are all connected with immunity, immunity is a very serious thing and sometimes sometimes in one case in a million it makes mistakes and starts doing things that are not very good in general, but this is really a very big rarity, that is, if we take the additional cost of the vaccination program, then approximately one case in a million is added there of some complications. to those cases that are normal in the population, for example, normally in the population there are from two to 20 cases per million, plus one, if you are conducting a mass vaccination program, then what is there statistically, this is indeed a very small increase, it is connected with the action of immunity, but if we look at the mortality rate from the same covid, it is one case per 100, and in a good way, if we also count covid-associated deaths, then

it is two cases per hundred, that is, you get four orders of magnitude difference, if we sit down to play this game. purely mathematically, you will never win me, i will have four orders of magnitude, the probability of advantage over any of your combinations, so they ask, to vaccinate, not to vaccinate, but if you've studied math at all, four orders of magnitude is a big difference of 10,000 times. this was the baden baden podcast, we talked with the deputy director of the gomaleya institute, academician and one of the main developers of the russian sputnik vaccine denis lagunov about vaccines, the development of new vaccines. about whether it is worth getting vaccinated and what side effects there are from vaccines, they happen, what is the beneficial effect of the vaccine, how many lives they save. you can find all the episodes of the badden baden podcast on the website of the first channel.

the team, because i think that a man should not talk about this topic, it is very delicate, yes, we will talk today about adultery, after all, the basis of the novel is

adultery, so i think that it will be appropriate to talk about, let's say, the modern context of this situation with women, yes, we are all married or were married, we have children, we are, so to speak, adults, experienced women, we already have some kind of... formed point of view on this novel, well, let me first mention that the novel anna karenina is considered a prose standard, the pinnacle of literature and russian literature. william faulkner considered this novel a masterpiece , named it three times as the best novel, he was asked: name the three best novels, and he said anna karenina three times, and we also know that nabokov was a big fan of this novel and... and i also know that this novel is in some sense a mystery, because we still do not understand why this theme, adultery, female infidelity,

so to speak, the fall of women in society, why is it a standard, the most read, the novel that is being adapted for the screen and is still the pinnacle of literary art. elina, please tell us about nabokov's lectures. i know that you are a big fan of these lectures. yes, but i am generally, generally a fan of bokvy, in principle, still very big, of course, if i were asked, i would name other shores, but i am not asked like faulkner, i don't know why, so, if we talk about lectures, nabokov has a wonderful vladimir vladimirovich wonderful lecture on russian literature and in general it is surprising, by the way, i have read anna korenina many times, and these lectures, probably twice, in my youth , having read the novel itself.

it changes and changes every time,

maybe that is the key, yes, this story, that it is interesting to reread, katya, you are an expert on tolstoy, you are an accomplice, let's call it that, yes, books, stories, real stories, please tell me. is there any parallel with tolstoy's biography in this story of anna karenina, we will talk about this a little now, then briefly describe the plot, what is happening, the main line, yes, the karenins, the novel, just anna karenina - it is known that there are two novels and therefore, if we talk about the story of konstantin levin, then we understand, in fact, that a lot of tolstoy's line is present there, if we talk about the story of anna korenina, then in this karenin line rather. stoy acted as an artist who, of course, took a prototype from life, but to say that such a situation happened in his life, or he was somehow personally acquainted with it,

probably not, in this novel they laid down, well several lines, yes, which happened in reality, there with his relatives, with acquaintances including his sister maria nikolaevna, yes to her family history, she married her relative, valerian tolstoy, who cheated on her with everyone. including there with the servants, with the young ladies, and it is even known that when they opened the attic, they found the corpses of small children, that is, this is some kind of nightmare, but this does not really look like stories, yes, but the point is that in her life there was a story of male infidelity, and from this nightmare she ran away abroad, where her love story actually happened, where she fell in love with the movardians. well, not exactly, but almost with a young man, yes, a frenchman, and gave birth to an illegitimate daughter from him, that's the story, a daughter born out of wedlock is complicated. her

presentation to the world, yes, of what was happening then, that's vanya karenina, you can see this line, and the case of anna pirogova herself is known, a girl who lived next door, was the housekeeper of bibikov the note was his mistress, that's when she was of noble origin, noble woman, no, no, when he decided... to get married, he was a widower with children, and decided to get married a second time, then she actually turned out to be superfluous in this situation, so she took the cat and threw herself under the train, writing a note that you will suffer, realizing your guilt, tolstoy came to honor the memory of the dead woman, well, it did n’t happen right before his eyes, but right there, when it became known that there was a woman

on the rails, he went... there is no beauty in suicide, let’s tell the truth, let’s talk about the plot, that is anna, a married woman with a child, 26 years old, yes , she meets a guards officer vronsky, falls in love, he is 23, yes, but he is not really much younger than her, here when she says boy, she rather refers to him, because she is already a married woman with a child, therefore much older than her, well , how much, her husband is rich 46, well, and she is 26,

living rooms, some dinners, yes, which everyone gave, well, and salons, that is, where with a man, women could not remain alone, in front of, well, in front of people, yes, that is, they should not see that someone is sitting in the corner and communicates together, or went into the next room, communicates together, this immediately gave rise to a wave of rumors and was indecent, so if communication occurred between a man and a woman, there were rooms in restaurants, and other places. there are, where this did not happen in front of people, respectively, lovers did not come to the theater together, sitting in the next box, yes, it was not accepted, because and she comes sronskim, in my opinion, to the opera, yes, she then wants, he does not go, but she wants to officially be present with her man in, let's say, public places, secular, but it is impossible, because in society she is the wife of another man, in general, society despised anna, she

actually became a couple, yes, they stopped her... mother after she, opened, yes, this affair, with vronsky, they looked at her, whispered, that is, she actually turned into such a persona non grata, but she turned into it voluntarily, that is, she was warned, do i understand correctly that this would be, of course, even her husband warned her and he told her to dry her husband in these in this situation, the princess of troubles setverskaya she tells her the same thing, although betsy herself is, to put it mildly, good, in principle she lives in the world, she is a granddam. she observes the rules of adultery, as they call the rules of a secular adulterer, the rules of a secular adulterer, but anna does not, what do you think, now we have rules of secular adultery, we can draw such a parallel with a modern wife, but isn't it all the same, well, imagine in your media, let's say, a well-known media company, even, if we are talking about the world of that time - these are media personalities, you are married to a man from government, and you have a child, we will not

name exactly. suddenly you start to openly get caught, to have sex in a photo together, with some young mulatto, oh well, okay, not a mulatto, well, who can replace a guardsman now. a showman, yes, i don’t know, a musician, young, anyone, anyone, a young rapper, a young rapper, great, great, and your husband tells you, my baby, of course, i understand everything, but i’ve already seen this chronicle several times, yes, they bring me the society chronicle, everyone knows us, well , first of all, there is no need for an adult the man laughed, i am your husband, i provide for you, we have a child, and then karenin, as i understand it, thinks about the child, this flashes several times in the book, yes, what will happen to him. he thinks about anna, well, naturally, if anna's reputation is destroyed, then this will affect the fate of the child, his reputation, and there is such a passage, absolutely wonderful, i think, in modern times , the same can be said, and karenin says, i will give her a divorce, at the very beginning,

when he thinks, what will happen, he will leave her, then the next, then the next, she well, it goes from hand to hand, he cares and thinks, in general, karen loves tanya, husband, well, i think that yes, just imagine, yes, that... a husband from the government asks his wife, whom he provides with everything and gives her the opportunity to hang out in society and just be a beauty, to dress up, dress up, raise a child, he says, i'll pass you by, she raises the child, she takes out governesses all the time, here's seryozhenko combed, washed , fed, she just says hello to them, choose outfits from paris, which cost a fortune, i ask you for one thing, that it is necessary i didn't make fun of you in society, so that it wouldn't get into the newspapers, it seems to me that anna's actions indicate that she... all hotels on the waters, but this is in no way really cheating, everyone meets in and husbands and families agree with this, but it

must be that prevented her, seeing this world, from stopping striving for it, and from stopping deceiving her husband, for two years, in my opinion, to divorce him, as he suggests to her, but she doesn't do it, this is probably a manifestation of her character, as you do you think, elina, that a man, when he feels attracted to a woman, he thinks about whether she is intellectual, no, it is important to him, do you think it was important to the fat man that anna should

be smart, should she be smart to be liked, and no, but this is not important for the reader, the reader can draw his own conclusions, is she stupid or smart, let's say, she, it seems to me, is just a narrow-minded woman. and completely charming, but if we talk about my opinion, that is, do you think that she made this move, let's say, announcing in her novel, having started inviting her lover home, and even going out with him, she uh, didn't expect that it would have such consequences, she didn't think about it, she didn't think about the consequences, because for a long time she got away with everything, well, why did she need it, you know, it seems to me, this is an absolutely wonderful novel , step-by-step instructions on how to communicate and how to recognize a narcissist and a manipulator, that is, you consider it a narcissist and a manipulator, everything is written there in black and white, i can't fat refuse, you know, it's written in black and white, he's a sly manipulator, but i constantly have a burning question, who among us is not

a manipulator, we understand that anna is destroying the lives of people around her, this is objective, she destroyed karenin's life, she destroyed the life, perhaps, of her son seryozha, she destroyed vronsky's life, because in the end the novel... we understand that it is broken, both men lost their careers, the son lost his mother, had psychological trauma there, that is, i understand that anna has a bad influence on her surroundings, probably, this is her most a great sin, but can we say that she commits the crime consciously, that is , this is her manipulation, how it manifests itself, i would not say that she does it directly consciously. that is, she wants to destroy all lives, so i think that at some point she simply saw what she only wants, and began to subordinate all the circumstances of all the people around her to this desire, i want it this way and it will be so, yes

, exactly so, but is this about love, listen, but there is a certain heroic paradigm, yes, such a certain heroic myth, that the hero destroys, the not good enough world creates another, yes, that is, his some revolutionary act can change the world around, we can say that anna wants to change the world, to change the hypocritical. society or not? no, i think that she does not want this on purpose, moreover, does she change anything, does she build something new and good, that's the question, listen, i wanted to talk about this, and it's very good you brought me to this question, can we say that leo tolstoy is a moralist and a fallen a woman dies under the wheels of a train, precisely because she deserved it. well, he, at least, that's how he positioned himself

, what do you think, tolstoy condemned anna, if in life, and tolstoy had communicated with a woman who acted like that, he would have condemned her, i'm sure of that, i'm sure of that too, but here he acts as the author of a novel, accordingly, this is his heroine, he is in love with her, makes others fall in love with her, i don't think he's directly in love with her, but he was enchanted there in some sense by that energy.

a disastrous situation, by the way, don't forget that anna is a morphine addict, in the time of tolstoy

, actually anna korenina, morphe was the only painkiller, and therefore they did not yet understand how it affects. it must be said, with voronsky, they have a conflict at this point, he is against it, that is, he understands that it is not very adequate, let's say, she had already used morphe as a sleeping pill, as a means to calm down and why was she worried, how did her relationship with ronsky develop after they fled to this... it's complicated, how did the relationship develop, it was difficult, why? because anna demanded proof of love, and the man who had already sacrificed his career, and so to speak, who had fit into this strange revolutionary situation, he went to meet her, that is, he stayed with her, he did not abandon her, he could have run away, he talks her into getting a divorce, he takes responsibility, that is, the man is a good man, by the way, he behaves in this case. is there such a feeling

or is this some kind of fantasy of anna's? i think so, anna created this feeling with her own relationships, because she, well, for the first time, yes, experienced some strong feelings and passion for one man, i here together thought that probably the problem is that she no longer had a choice, well, that is, she saw this vronsky and to him. then there was a bro, as katya said, whoever

came across her path, to whom she gave everything that had accumulated, perhaps, by the way, that since she could not work, express herself in another way, she expresses herself on the topic of love and personal life, i will say, i will say, yes, about i could not work, and leo tolstoy, by the way, was very respectful of married women, and there is a passage about kitty, that levin lets her rest and somehow behave in general.

but instead she is terribly irritated that vronsky is wasting time on this, you are talking about that part of the story when the woman has already lost. does, dances, dances, well, look, the whole situation is built in this novel, that leo tolstoy is very convincing, let's say, convincingly brings out anna, when you read it for the first time, i remember it well, and even second, you believe everything she says, only after some, well, this is how it is with me,

a certain time after reading you pay attention to the fact that, let's say, she says, god, i love chrysanthemums so much, if you knew, i adore chrysanthemums. i would surround everything with horizonte, as soon as she is given charizontemas, she throws them away with disgust, she sneezes from an allergy, and that is , something happens to her, she tramples these horizontemas, but at the same time she sentences god, i love horizontemas so much, i can't live without them, what a pity that i don't have them, here with kiite such a situation happens, she comes to reconcile, by the way, steve, her little brother, also in general moral qualities whose wife left, did not leave, but was going to cheat on her with the maid.

well, in general, probably, yes, i think that, well , how to say, you can love, you need to love, but you can't lie and be hypocritical, and you can change your life and you need to change your life, but you can't destroy the lives of others, in the same way she is hypocritical, on the contrary, she tries to be all the time, just from morning to night, she says what is convenient for her when it is convenient for her, well, when it comes to divorce, you can't get a word out of her, they ask her karen, tell me what you are?

the book the true story of anna karenina, they are mostly negative, women don't like anna karenina, they are aggressive towards her, and people, well, older women who have lived through some kind of life experience, they are an ancient owl themselves, well, this may already be such a kind of maternal over-straining is born, that i know how to live and i will kind of teach you, but i will tell you how not to, here you did something wrong.