good evening, i'm antonio mora, this is al jazeera america. the fight for michigan. the issues both are voting on to win votes in the delicate rich state. >> he was lucky to have, he would be the first to acknowledge that. she will be missed president obama remembers first lady nancy regan, we look at her life, and legacy war games - a strong reaction from the communist north as hundreds of thousands conduct drills. >> immunotherapy is the ultimate medicine. >> a ground-breaking treatment

to fight cancer and the role it played in helping former president jimmie carter beat cancer no one is calling tomorrow super-tuesday, but the next 24 hours could be pivotal in the white house race. voters could cast ballots to choose nominees. they'll kauk cows in hawaii, and both taking part in primaries in michigan. we have a report on how the political news came from a noncandidate. >> reporter: the big news is michael bloomberg decided not to run. the reasons given is he didn't see a path for 270 electoral votes.

the house of representatives would decide who the next president would be, he didn't want is to be donald trump or ted cruz, a de facto endorsement of hillary clinton. she has to be pleased. on the republican side in michigan, it's a tight race for second or first. at 36%. he'd been as high as the mid 40s. the numbers came down. 23%. and john kasich had a surge in michigan, up to 31%, where does it come from. marco rubio, who is not at 15%. the minimum you need. if he doesn't meet that, it will be a tough night. we go to the democrats reporting in michigan, talking about the autobail out. that they mischaracterised it.

they didn't want to mix the funding. it was a big thing at the debate in flint. now bernie sanders need a good showing. to continue his viability as a candidate tributes to nancy reagan continue to pour in, dying from congestive heart failure at hear home. the former first lady will be buried beside her husband at the presidential library later this week. jennifer london is there. nancy regan's death sparked an emotional response. >> good evening. it certainly has, nancy regan remember for her enduring role and love and devotion to raying junior. and plans and preparations are under way at the presidential library for her funeral. the death is called the end of

an era, not just for the presidential library, but also for the nation. as the clouds broke, flags outside the ronald reagan presidential library were lowered to half staff. the president and mrs. regan believe in freedom and democracy, and whenever president regan saw the american flaing, he saluted. to have it lowered. it meant a lot. i felt both of their spirits. >> friday, mrs. regan will be buried alongside her husband, the 40th president. every detail of the funeral planned by the former first lady herself. melissa giller is the library spokesperson. for those walking with the kaz get. family members and the people participating, they are

hollywood people, government people, friends of the family. >> the funeral will be a closed service. 1,000 invitations have been mailed. two days before the funeral nancy regan will lie in repose so members of the public can pay final reports. >> the presidential library is closed. outside well-wishers left flowers and notes. inside a look at the gallery. here you see the glamor of old hollywood. mrs. regan's famous gown is on display. warned to poke fun that she was too fancy and lavish during economic times. >> she showed up at a dinner in ab outrageous mismatched outfit. rain boots, flour, skirt, mismatched. the point that she didn't take herself seriously.

at washington d.c. next to a portrait. a condolence book is available to sign. >> i know how much she meant not just to president regan, but as a whole. she was lucky to have. she'd be the first to acknowledge that. she will be missed. >> earlier this evening, the white house, president obama will attend the funeral service on friday. later in the week. you don't see more invited in the private ceremony. nancy regan played an active role. and was active in the operation of the institution. >> many called nancy regan, the

driving force behind the island, instrumental is the word i heard today. including an exhibit about the vatican. it was supposed to open. she visited the grounds often. we were told by staff that she would come every year. she would sit by the grave site 15-20 minutes. we know that she would be buried alongside them this friday. the u.s. and south korea kicked off the annual joint military exercises today, including rehearsals of strikes on north korea's military facilities. north korea is accusing the two countries of trying to overthrow their government and promised a pre-emptive nuclear strike. it is the biggest ever involving thousands of american and south

korean defense. >> this is a perennial rhetorical war we see between pyongyang and the united states, and frankly the neighbours in the region, it's interesting they use the word nuclear more than ever. they conduct the fourth test. they see it as a mantle of legitimacy. >> the nuclear test, last week the united nations improving its toughest sanctions yet. a u.s. air strike in somali killed 150 members. saturday night strike was carried out using a combination of manned and droned aircraft targetting fighters in a camp. it posed a threat to u.s. and african union troops in somali. the white house disclosed the number of people killed by

drones and counterterrorism strikes since president obama took office. it included combatant and civilian death. it will not cover conventional combat zones, including iraq and afghanistan. white house's counterterrorism officer believes providing transparency will maintain legitimacy of the programme a promising cancer treatment may have helped save jimmy carter's life. we look at immunotherapy, what it is and isn't. and the fracking industry - scientists blaming drillers for increase in earthquakes in the state.

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the west coast coast has seen severe weather and los angeles, thunder and lightening setting palm trees on fire also an unusual site, pamps

of ice from -- patches of ice from hail that nel in the storms. heavy rain caused street flooding. jimmy carter has turned the corner in the battle against cancer. doctors have not seen signs of tumours and he doesn't need treatments for now. carter, who is 91, will continue to get check ups. doctors had discovered mel yn oma in the river, spreading to the brain. he under went a new form. of treatment call immunotherapy we are joined from cleveland by dr andrew shown, the director of brain, tumor and neurooncology center. good to have you with us. you studied the ix uno therapy drugs. how effective are they in fighting cancer?

>> we are beginning to see, they are f.d.a. approved in three types of cancer. melanoma, lung cancer and renal carcinoma. we are using them in other types of cancers. sometimes with preliminary very impressive results. >> they hold promise behind the cancers? >> absolutely. >> is there a clear sense of what did what in president carter's case. he received radiation, is there any way of knowing how much credit the new therapy had compared to the old? >> it's hard to be certain. typically with radio therapy to brain metastasis they may shrink. it's my understanding that he had four and they disappeared. >> he had four lesions in the brain, and surgery for one on the liver. >> that's right. >> radiation and chemotherapy,

effect, work as poisons for the cancer cells, and hurt healthy cells. an advantage is they tart the cancer -- target the cancer cells? >> well, it's not quite right. basically the conventional chemotherapy drugs basically targeted and killed or damaged the cells. that's why people have side effects. the cells in the gut divide, the skins in the call divide, they lose your hair. you get tire ear and vomiting. the immunotherapy drugs prevents a mechanism that the tumor cells have for turning off the immune system. they have some side effects

sometimes, but they are not - they do not kill cells. what they do is allow the immune system to function and kill the tumor cells which normally they can prevent. >> do you see the future of battling cancer in the designer drugs, ones that can be tailored to individuals? >> well, i see that it will be part of the future. immunotherapy is the unemployment personalized medicine. while we do have targeted agents so if you have a tumor with a mutation or egfr mutation, there are drugs that target them. they eventually find ways to use other pathways and become

consistent. whereas the immunotherapies allow the immune system to attack the tumor, no matter what abnormality. and that makes them time hours. is president carter an exceptional case or is what happened to him, should it give others hope. >> we don't have a lot of data on this drug. the check point inhibitors. there are anecdotal cases. some report effects similar to president carter. we don't have a lot of data to consider this anecdotal. they give us hope that in other brain cancer there are three different trials on going with

checkpoint inhibitors, gbm. >> we are glad it has helped the former president carter. dr andrew shown from the case medical center. good to have you with us tonight. >> it was my pleasure the supreme court upheld parental rights for a lesbian adoptive mother, the alabama supreme court went too far when it refused to recognise adoptions of her partner's children. it had been granted in georgia. >> oklahoma is expanding regulations to reduce earthquakes rattling the state. frequency increased when fracking companies tipped a billion barrels into the ground. >> reporter: waiting for a catastrophe. >> everything was coming off of

the shale, and the shales were swaying back and forth. it was very scary. >> oklahoma saw a 600% increase in noakes, since the boom in 2009. researchers say the wells used to dispose of fracking are to blame. the mar waste water injected into the ground, the details of the relationship are murky, turning oklahoma into a testing ground of how far oil and gas technology pushes the bounds of science. >> the experiment that has been run is a failed experiment. it exposes too much risk to life and limb. so far they have not caused death or injury. as the quakes increase in frequency and magnitude

seismologists warn of a massive quake in haiti, what it may be around the corner. what is at stake here. >> lives, and the legitimacy of government. a state government accused of putting it ahead of safety. it took three years for the state of oklahoma to recognise the link between the wells and seismic activity. now they are trying to get up to speed. >> all i can say no one tried to tackle a problem like this. >> monday, it reduced waste water injected into the ground. >> is it asking or selling the operators. >> it's a voluntary directive. if they do not follow, the course is legal action. >> it was in the industry's

favour. there's concern about well operators self-reporting how many water is put into the ground. the company is not required to use real-time monitors. >> the technology exists, what does not exist is the political will power. the cost is phenomenon. >> reporter: the question is what happens if oil prices rise. the dip in disposal has less to do with regulation, and more to do with the economy peyton manning is going out on top. the quarterback is hanging up his jersey after a second super bowl win, controversy could follow him into retirement. and software that shows apple software uses may not be as safe as they thought.

eyes apple computer users who thought they were immune from hackers have to face reality. an some ware virus hit macs and was downloaded on 65% of computers. it was believed to be the first successful attack. the hackers asked for ransom to unlock files. a national jury awarded $65 million to sports caster erin andrews, she sued two hotel companies and a stalker. the jury found barrett and the hotel liable allowing him to rent a room next to hers. barrett recorded video of an undressed andrews through a peephole tennis star maria sharapova is facing a ban from the sport

after failing a drug test. maria sharapova will be professionally suspended starting march 12th. the national institute of health said it helps speedy recovering, enhandlesed function. maria sharapova has been taking it for 12 years or health issues. >> i wanted to let you know a few days ago i received a letter from the itf that i had failed a drug test at the australian open. i did fail the test. i take full responsibility for it. >> maria sharapova won five grand slam titles. she's the highest paid woman in sports. meldonium was banned by the world doping agency. peyton manning retired after an 18 year career. he is living under a cloud. we are joined now with a look at

his career. >> whatever you see about peyton manning, this is the end of an era, because peyton manning exits the stage. we thought it was flaw s, until the end when two awkward questions propped up. and they won't go away for him. ever since super bowl 50, the world wondered will he, won't he. at a denver broncos facility, we learnt the answer, peyton manning is retiring. no more number 18. >> there's something about 18 years, it's a good number. and today i retire from pro football. >> number 18. peyton manning. >> peyton manning, one of the biggest names anderbers that the nf -- and earners is going after a number of seasons. >> there are players more talented, but no one could outprepare me. because of that i have no

regrets. i fought a good fight. i finished my football race and after 18 years, it's time. good bless all of you and god bless football. >> in his years with the broncos and the colts manning was named m.v.p. 5 times and helped win the super bowl twice. in december he denied using growth hormones after an al jazeera america investigation. an intern at a clinic said hgh was shipped to manning's wife. at the time he played for the colts. sly is trying to recant his story, manning stood by his denial. >> it's fabricated, junk, garbage. i can give you a list of words. >> reporter: manning answered no direct questions about the al jazeera documentary, but pushed

back hard about a sexual harassment case. >> i did not do what has been alleged. and i'm not interested in relitigating something that happened when i was 19 years old. sportswriters like harold say the stories will dogmaning even in retirement. >> the unanswered questions will not go away. >> reporter: as this member, his brother eli is the starting quack for the giants. it's likely we'll hear from manning, he's bankable for companies like papa john. >> he's the winningest starting quarterback to have won two super bowls with two different franchises and one of the biggest earners over the course of his career i'm antonio mora, thanks for

join us. head over to aljazeera.com. ray suarez is up next with "inside story", have a great night. night. ♪ >> you have probably heard it's an age of personal responsibility. you don't want some big government getting you ready for retirement. make your own plans. paddle your own canoe. has this country moved away from millions with pensions to millions feathering their own retirement nest, something frightening happened. hah they either don't think they are going to live very long after they have