still because the majority of the parliaments are out of the old faces. it creates a lot of. insecurity it's creates a lot of tension so the sooner we get rid of this tension the better it is for everybody. i mean eons expect last thing changes but need to patience for refashioning all media will take more than just elections it will take time. al-jazeera yerevan a minute's silence has been held on the first anniversary of a massive bomb blast which killed an investigative journalist in malta hundreds of people gathered at the scene of the attack to remember daphne koller one. she'd been looking into corruption between businesses the police and the government her family is the man being a public inquiry to find out who ordered her this. for years historians believe the ancient city of pompei was buried by

a volcanic eruption on august the twenty fourth in seventy nine eighty eight but i knew discovery suggests mt vesuvius may have erupted two months later a new excavations a found a charcoal inscription dated october seventeenth. barbara starr in london here are the top stories on al-jazeera saudi arabia has prevented turkish police from searching the saudi consul general zinni stumble residence the consul general himself meanwhile is actually left turkey investigators had been waiting hours to enter the site turkish officials have told al jazeera they have evidence that the missing saudi journalist jamal ashaji was killed inside the saudi consulate on monday turkish investigators spent twelve hours combing through the building which ashaji was last seen entering exactly two weeks ago.

right now as you are well i thought result of our contacts the search process in the consulate ha started yesterday there was an intense process until morning but it we continue my hope is that we can reach conclusions that we give us a reasonable opinion as soon as possible the best a geisha is looking into many things such as toxic materials and those materials be removed by painting them over. meanwhile the u.s. secretary of state mike compares says he's seen a serious commitment from saudi leadership for accountability over her shoulder disappearance from peo met with both the saudi king and crown prince mohammed bin salon in riyadh he says they pledged to conduct a thorough and transparent probe the us president says he's also spoken to the saudi crown prince who denied any knowledge of what happened to jamal khashoggi says this case is another instance of guilty until proven innocent. the u.s.

treasury department has hit iran with another round of sanctions accusing the country of recruiting child soldiers as young as twelve to fight for bashar al assad's regime in syria the sanctions primarily targeted the resistance for that's an arm of the revolutionary guard corps the treasury also imposed sanctions on a network of businesses that were financing it. the organizer of a migrant caravan travelling north from honduras has been detained in neighboring guatemala and will be the ported own trumpet. tens of millions of dollars in aid if it didn't stop a group of two thousand migrants reaching the u.s. border those are the top stories the cure revisited. millions of people across india miss out on medical care but a hospital train is delivering doctors and hope to those most in need. boards indians lifeline express. zero.

some tricks of nature these stem cells like swallow on. which this whole procedure is all bad they look like cupping but it's more sophisticated inside their dignity is that by your body american micro consolation.

it doesn't matter that worldwide three hundred fifty million people are affected by genetic disorders closed by faulty d.n.a. these genetic defects can lead to a variety of conditions like cystic fibrosis which leads to conic and also cite a long sections and at the moment the system and here i am dr elizabeth healy in the u.k. to see how groundbreaking developments in gene therapy could one day transform the lives of people living with genetic disorders. that may l.l.s. but not marry bond on a is sixteen years old and was diagnosed with cystic fibrosis at the age of one. america tell me from your perspective what is your day like living with cystic fibrosis. arum when i asked her i guess op take my interview arises off eyes. and then harass again my x. tears. and i asked you i know you guys are

failing. and they're nasty to my physio if. i do spiral a.j. and i'm going to go out and just plain for their help in me. and then off of our ass to do a nothing up the lies well. there are still more positives. and then yeah i will need space for city of about how to learn. and an hour a night. when mary was first diagnosed up to stuart she would only live until the age before. i decided i was dazed and not ready until marriage or. unknown house to turn around i thought i'd like them on occasion the knob ok. there's never a day goes by either and todd everybody forgets the whole thing and i got up so i know it's always there. married to use me to the children that cystic

fibrosis. mark on his cell voice if i meet one of them there were no pos i just want to me or on one particular one to them so now it was a question isolating condition to hear because i was in a special and i was not so yes patient now all right. so and we used to send or letters to each other our. because they couldn't me if they said they saw me fly now last night at the moment mary is not really understanding everything about c.f. she she does now know that it is life show me that she doesn't know that it cannot be kids. but things could be about to change scientists have proven for the first time ever that an experimental technique called gene therapy can improve the health of those with cystic fibrosis i've come into central london to meet the

doctors and the clinicians involved in the gene therapy trial and to cystic fibrosis. resting back and. adding it. to stick fibrosis is as you know a genetically inherited disease parents who pass those copies on to their child and they have cystic fibrosis during the first year of life most babies will experience and lung problems and those relates to the buildup of sticky mucus within the airways and that sticky mucus attracts bacterial infections and the bacteria infections become chronic and they eventually cause quite significant lung scarring in the u.k. around ten thousand people with cystic fibrosis at the moment on a registry about one in twenty two of us is a carrier of the mutated gene most of us won't realise and about one in two thousand babies are born with cystic fibrosis the genetic nature of this and other conditions mean that treatment has focused on managing the sentence as best as

possible but a new and experimental technique called gene therapy replace the faulty gene with a functioning one this is the largest and the longest duration gene therapy trial using a liquid formulation for cystic fibrosis that has ever happened in the one hundred sixteen patients completed the protocol and took at least nine be nice doses over the course of a year and it was in that group which was defined as being the group we were going to look at that we saw a significant impact on lung function at the end of the year. we can thank the patients and their families in earth because without patients like mary and her mother we just couldn't have completed this trial so we're really grateful. these results would not have been possible without the perseverance of scientists who spent years developing the gene down. we started this program and it's thought it would be very easy for patients to just impair the gene research and if it gets

to the right area into the right cells in the lung it turned out that was much more difficult so how are you getting this healthy new gene into the areas and learn to do the job of the some teaching. for the try that is just finished but actually using a very simple minded cure it's a had it lifted but we did this we used the chin and we mixed it with this fat chick and this formed a small complex that complex it is then inhaled it into the lungs of cystic fibrosis patients the dose of gene therapy that the trial participants received does not determine the correct the faulty cystic fibrosis d.n.a. but scientists are working on finding a longer lasting solution clinical trial results have been very encouraging but they're not quite good enough to turn them into treatment yet so we have plans for another trial where we give more to some gene complexes and more frequently basically in addition to that we have to developed by wrists that this is very very

efficient in getting chines into the lungs do you think you see how fires might be more efficient than using the fatty possibly using them and we certainly think so based on all the evidence we have the virus is at least a hundred fold more effective writing very exciting you know. these success stories represent a huge step forward for people. matt did you notice any changes touring the course of the treatment i thought i had no more injury i didn't need my elbow cherry more k. . were christian tradition was the best so i prayed still going up let's get into a lot done. and how does that make you feel when you submit cheating so mean that a mission where you get to know i could die i die i could do that and i know i can get the hope is that one day gene therapy will be approved for use and widely

available to those with cystic fibrosis older people that are studying and working to get this drug to work even better than it did is just hope and pray they can get it done and they can get funding and if it doesn't come soon enough mary she's helped other faithful if it's not. the next generation of children born with cystic fibrosis in the city some are. going to begin. by south korea how corning it speaks for seniors. is that really nice. alum are back again. things can stay here.

by the age of eighty five nearly half of us will suffer from august damage to the name which can lead to chronic pain and disability bouts because cartilage unlike other tissues doesn't have its own blood supply so heals very slowly i'm dr dobson when i'm in hiroshima japan to meet the surgeon pioneering new techniques in regenerating on names. professor mit so old she. is one of the world's leading nice surgeons and a revered figure in the world of regenerative medicine. professor to be here. ok thank you.

jay tech is an enterprise focusing on tissue engineering and has spent over ten years commercializing professor archies research. associate in. a law that's nice to see how you very welcome things are back. in one thousand one thousand for my dad's on paper was published by swedish group. the swedish team had developed a way of regenerating cottage in a lab and then re injecting it in liquid form directly into the knee however there was a weak point all with their need. in order to solve this problem started to use their he saved for the. yes you can imagine that. the the foot would be here coming up for years if that.

meniscus has no blood supplies or if injury is the. song we are the light to resect say what you can do with this regenerative medicine is to take the patient's own cotton sheets from the same joint yes all the pain the confidence is essential company i see it does she engineer the cuts. and that's why we're here yeah just half a gram of healthy cartilage is harvested it is then broken down with enzymes and then planted on a college in scaffold designed by professor ought to after just four weeks the cells will have multiplied to form a four square centimeter disk. the surgeon then makes a template of the lesion and uses that to harvest some perry all still tissue from the shin bone. this will be the cover used to hold the new cottage in place so this is

a model of someone's potentially regenerated cottage but the beauty of it being the patient's own cells here is that it's not rejected you know the medicine is on the viewpoint of a reaction oh told you nasty issue is a topic. today this method has an almost ninety percent success rate and is considered a leading treatment fanie cartilage defects. what are the limitations of this can it be done better we need a larger scheme. that is invasive. painful after surgery so less invasive technique is desired i have another new proceed you are using the magnetic. the goal is to devise a less invasive procedure much like their original idea of simply injecting the cartilage into the knee we inject so many serious. ten million.

we are teach in the knee joint. cd injectors so you can't see if inject cells blindly into the fluid they go all over and that makes scarring so you'd rather just close to where there is actually enjoy the right pinpoint targeting so how did you achieve that so i decided to use small are young park. didn't do that. didn't come or stimson count up or fight small i am part of the action stem cells and not the iron can fuck all this then that they can be controlled the dying the action with the strong money money law would that so many in the with magnetic force. from here there's an injection throws out attaches to the defect

here it's been channeled that way i can see very clearly by some sort of trick of nature these stem cells like to swallow are not honest which is this whole procedure hinges on that because then you can manipulate. that solution of stem cells with a magnetic field. so not having to cut open the knee in any way you can attach those themselves to just the area where the cottage is broken down the defect area how do you make them stay there is there a magnet on the skin just ten minutes from the outside of the ski you're really a minute then he physically they start to be here to the defective area it's amazing the bolotnaya this is a brand new. only here in. japan is aiming to be at the forefront of regenerative medicine and scientists are

researching possible treatments for previously incurable diseases such as liver cirrhosis retinal generation and even outsiders but a crucial hurdle for many stem cell therapies is positioning the cells within the body this is led some to call professor archies magnetic breakthrough an important step forward in regenerative medicine in twenty fifteen this footage was shot by japanese television when professor archie performed the first ever magnetic cartilage restoration the patient was a semi professional tennis player and her cartilage injury threatened to curtail her career. the procedure involves extracting some bone marrow to harvest stem cells after cultivation.