and then re injecting it in liquid form directly into the knee however there was a weak point with their technique. in order to solve with this problem i started to use the very same scale for the. yes you can imagine that. the foot would be here coming up yes if that. meniscus has no blood supply or if injury is the. wrong we are blind to resect so what you can do with this regenerative medicine is to take the patient's own cotton sheets from the same joint yes all the chain the confidence is essential company i see it does she engineer the cuts or not and that's why we're here yeah just half a gram of healthy cartilage is harvested it is then broken down with enzymes and then planted on

a college in scaffold designed by professor ought to after just four weeks the cells will have multiplied to form a four square centimeter disk. the surgeon then makes a template of the lesion and uses that to harvest some perry all still tissue from the shin bone. this will be the cover used to hold the new cottage in place so this is a model of someone's potentially regenerated cartilage but the beauty of it being the patient's own cells here is that it's not rejected you know the medicine from the viewpoint i mean you know roger reaction oh told you nasty issue is a topic. today this method has an almost ninety percent success rate and is considered a leading treatment fanie cartilage d. fax will what are the limitations of this can it be done better we need a larger scheme. that is invasive you

see painful. soul less invasive technique is desire i have another new proceed you're using the. the goal was to devise a less invasive procedure. much like the original idea of simply injecting the cartilage into the knee we inject so many serious. ten million serious we open our scar tissue in the knee joint. the you see the injectors so you can't. see if inject cells blindly into the fluid nuptial they go all over and that made scarring so you'd rather it just close to where there is actually enjoy the right pinpoint targeting so how did you achieve that so i decided to use small our young particle. to do that.

then come most films county public sites small i am part of the city actually stem cells not the aisle done fuck all the years then they can be controlled that direction with a strong man bent my lord that's a very big in the with a magnetic force. from here there's the injection thirds are attached to the defect here the it is being channeled that. by some sort of trick of nature the stem cells like to swallow are not honest which is this whole procedure hinges on that because then you can manipulate. that lucian of stem cells with a magnetic field. so not having to cut open the knee in any way you can attach those themselves to just the area where the cottage is broken down the different area how do you make them stay there is there a magnet on the skin just ten minutes from the outside of the ski you're really

a minute then he physically they start to be under here to the defective area it's amazing the bolotnaya this is a brand new. only here in. japan is aiming to be at the forefront of regenerative medicine and scientists are researching possible treatments for previously incurable diseases such as liver cirrhosis retinal generation and even outsiders but a crucial hurdle for many stem cell therapies is positioning the cells within the body this is led some to call professor archies magnetic breakthrough an important step forward in regenerative medicine in twenty fifteen this footage was shot by japanese television when professor archie performed the first ever magnetic cartilage restoration the patient was a semi professional tennis player and her cartilage injury threatened to curtail

her career. the procedure involves extracting some bone marrow to harvest stem cells after cultivation the eye and a few stem cells were injected and the magnets came out for the first time. a year on his back for a checkup. morning and the. new . sport. in the home of the q c i did it it is. going to. give us the accounting. i knew about i mean it's a bit like the bullet. in the. yeah. i code is ready for me which will reveal whether her wound has

healed following the magnetic knee regeneration procedure. first of all she's almost there scrubbing here we go is reading. this. repay out that yes this was a complete idiot. that's very much noticeably better yes yes what he first injected it but huge defect of redness and now it's all white it's covered in cottage now. it takes almost into who he is when i can see this idea. and so i'm very.

finished. at the moment professor all cheese technique is only optical to relatively young knee joints but he's already working on ways to adapt it for older patients suffering from also offline to come seventy years old i'd like to walk with my knee joint so and you can see it is a very very desirable. so i. hope by now you know he. trying to seize is a parasitic illness that is found mainly in the poor rural regions of central and south america and it is estimated that in excess of ten million people are infected with the disease. i'm dr jeff lacy and i'm in bolivia to meet a woman who may just have found a solution to this devastating disease. chuggers disease is caused by the parasite

. which is carried by the triad to mean bug known locally as winter when an infected bite someone leaves behind infected feces scratching the bite grabs the infected feces and. once in the body the parasites multiply and spread. the days of charge lasts approximately two months causing mild symptoms it then goes into remission and it can be decades later before the chronic stage begins where the parasites attack the heart and just of organs which can cause intestinal and cardiac disorders progressive destruction of the heart muscle can lead to heart failure and sudden death there is no vaccine. all are around when i was there. is an expert on the deadly vinci cure insect. here that i meant they were.

lost but it is. me that at this time of day we work to britain. we have does. not just. argue whether meaningless but on us. he's big they say she do. a lot of that is so i just take. a lot of. me a little. every how many years do you think are in this house than. you are going to travel now when i was really in the car see you know i will not focus on this night of the meeting to guess. one thousand in. the pain and suffering caused by

infection as a devastating impact on communities like the indictee of the two hundred fifty people that live there are brum estimates that up to eighty percent of china's we need to. what has been the impact of childhood disease on your life and your family . do you have a chance disease you're so. thank. you. it's. my dear. the bank the boat i went back. to the past fifteen years ago to people our military has been working into libya using an insecticidal paint to grade its effect to communities of the bin to create insect tell me about in this far this is the paint you have developed to combat

charges. but yes more. in other words the new paint is an advance on previous insecticidal paints because the insecticides. which slowly released them over two to four years containing the insecticides like this means that the concentration of chemicals can be lower and that several different pesticides which don't work if they are mixed together can be used. to carry so do i have to dress up like this ok let's turn this there's nothing i'd like to do more than put in over thirty five degree heat. which scholars this is going to look. for they're. not.

doing they are loved that's right. sure we're similar in some of the stories from those books. and then just. ok. currently each home costs approximately two hundred us dollars to pay with the financial support coming from various organizations and private donors. in the last fifteen years her team have treated six thousand homes in ninety three communities across the region which are home to twenty four thousand individuals incredibly the number of new cases of trans disease in these communities has dropped to almost zero. is because.

yeah. yeah this is a very sad this is. the back to the house. with the inside and outside painted the house will be clear of the insects within twenty four hours. following its success one thousand targets disease the pain is now being used to come back then the fever and malaria in communities are gone. bob rita lives in one of the first villages that people are treated in bolivia. can you. describe to me what your house was lived before the painting was done. but it's only a week or so with lots of interest in your house see the body i'm a bit better so i don't know what i'm looking. learn all those for

me and then check us free yes you have you know us a little thought to. the end of. the diagnosis he has been sick for a long six months now the challenge ahead there one of these ninety six could be a new cure or the basis of a new cure for colors are their illness or disability al-jazeera examines priam meaning treatments so this is the explosive yes it's basically a wearable robot that kira we visited on al-jazeera. when people need to be heard. but it's been for a few jomo still is life it's not

a normal life sure and the story needs to be told to do stories that have impact also say i testified in the fall of law to make sure that the bad guys are both behind that al-jazeera has teams on the ground to bring new documentaries and live news on air and online. brother leader or brutal dictator. with discontent spreading through north africa time was running out for libya's self-styled king of kings. in the first of a two part series the big picture charts the rise and fall of one of the few and the events that helped fuel the violence of his final hours. from lost for libya on al-jazeera.

east and the differences. and the similarities of cultures across the world. al-jazeera that is a perfect formula for authoritarianism and here let me ask you straight up close is the two state solution now that the lights are on and there's no way it's high up front which hangs on and which is in. the saudi consul general's residence in istanbul its search for evidence into the disappearance of journalist. the washington post newspaper releases her last opinion piece in which she wrote about the silencing of journalists in the arab world.

and this is al-jazeera live from doha also coming up no progress in brussels as e.u. leaders meet to discuss bragg's it with the irish border still the main sticking point to a deal. i would myself be moving. stepping down after four years in the job the un special envoy for syria stuff under mr resigns. the. turkish investigators have left the saudi consul general is residence in istanbul up to nine hours searching for clues into the disappearance of journalist . he was last seen entering the saudi consulate two weeks ago took his believe he was killed shortly after arriving there al-jazeera has the latest on the investigation in istanbul. on wednesday turkish investigators turned their attention to the saudi consul donal's home after finally being given permission to

enter it's a team of forensic experts some police headed by the attorney general's office began combing through the residence from inside and out all in the presence of saudi officials the exception being the consul general himself who unexpectedly left turkey the day before. by the evening of facials had told al-jazeera that investigators had uncovered more evidence in the case of missing journalists. down the road a second search of the consulate itself was conducted on wednesday with police focusing on the c. block section of the compound where they had previously uncovered evidence that they say proved she was murdered more and more information is being revealed as a clearer picture begins to form albeit slowly of what's happened to jamal khashoggi turkish investigators have identified this man made her more trip a member of crown prince mohammed bin one man's personal detail as a main suspect he had accompanied bin sandman on several foreign visits in recent

months turkish intelligence leaks a motorist made four phone calls to the crown prince his own personal secretary on the day she went missing and it was under more trips name that the private jets used by the saudi hit team were hired turkish investigators say they already have the evidence that proves that jamal hustle he was murdered and his body dismembered they say the reason why they insist on conducting searches like the one in the building behind me is so that they can establish all of the facts sarky says' it will go off to anyone and everyone responsible for this crime even if that includes one of the our wallets most powerful man. is stumble let's go live now to charles stratford he is outside the saudi consulate in istanbul so charlie turkish investigators finally being allowed into the residence of the consul general what more can you tell us. yeah well it's once again what seems to be authorise at the consul general time as you say lasting at least nine hours we

understand a lot of the focus of that was in the garden of the consul general so we understand that there was some digging that went on dogs used some sort of x. excavation possibly also a lot of focus on the gallery of his residence we understand. that concentrating on what we believe was one of the vehicles that was seen on the day that crucial as he disappeared moving from here at the consulate behind me to his residence we also get reports a few hours ago that said there may well have been some pills found inside the consul general said home that matched samples here found at the consulate now we don't know what those samples are we can't give any more details at this stage. around one thirty am members of that team we don't know whether it was the entire scene themselves left the consul general's home and came back here to the cold for

a second chair we understand they may well have been focusing on the c. block of this building which we are told is an area inside embassies and consulates is a place with only diplomatic stuff can enter and we understand that a vehicle the last vehicle involved in this investigation left from a rear exit of this building around an hour or half ago i'm tony what more details are emerging about these fifteen saudis suspects were implicated in his disappearance. well as we heard in geology poll there is a lot of focus on this man ahmed look save who we understand is a very high up member of mohamed bin solomon the saudi crown prince he's personal security operation now certainly according to the sources that have leaked

information to the media they're calling this man the coordinates the man that hired the planes that brought these fifteen suspects over on the day that crucial she was killed and the man that is alleged made full phone calls directly to i haven't been solomon's private secretary on the same day looking at the other members of this group turkish government sources will certainly what we believe was actually one of the prosecutors involved in this investigation that has been leaking information to the media says that this group of fifteen was split into three specific groups with three different if you like job descriptions there was the interrogators group. the killers themselves and then those responsible for covering up the evidence there's also a lot of focus on this. expose a man called mohamed el to blakey who is believed to be a member of this group he apparently according to the new york times

a pioneering. autopsy expert to has done a lot of work on d.n.a. analysis he actually according to the new york times presides over theses close's own idea analysis of both d.n.a. . and we understand according to these leaks from the government that these fifteen as i say they came to turkey on the day that he disappeared on to private jets and they left later in the day on two private jets one to the u.a.e. and one to egypt so you can imagine as this investigation goes forward as we wait for analysis of some of the evidence that may have been found inside these buildings there is going to be a lot of focus on the individuals involved in this alleged murder all right a chance in istanbul charlie thank you now the washington post has published the last opinion piece written by jamal khashoggi just before his disappearance the column focuses on freedom of expression in the arab world the newspaper says it was

submitted to them by jamal's assistant a day off day he was reported missing the washington post says it held off publishing until now having hoped to edit the article with. meanwhile in the u.s. there is growing pressure on donald trump to take action against the saudis despite his refusal to condemn riyadh over the case my kind of reports from washington d.c. . president trump will receive a personal report on the case in coming hours he's urged turkish authorities to hand over any audio and video recordings they may have we've asked for if it exists i'm not sure yet that it exists probably does possibly. the president has been reluctant to criticize saudi arabia or discuss any sanction that may be imposed dismissing allegations of saudi complicity as and i quote another case of guilty until proven innocent they are and now we have other very good allies in the middle east but if you look at saudi arabia the. tremendous purchasing of not only

military equipment but. president trump is awaiting the report from the secretary of state who were sent to the region in the face of the growing political uproar mike pompei oh spent time with senior saudi figures during a visit to riyadh and said they had denied any knowledge of the matter and had started a full investigation. he also met with the turkish president in ankara shaking hands for the camera but insisted it was too early to go into details about the journalists disappearance and talk about any of the facts. that they didn't want to either in that they want to have the opportunity to complete this investigation in a thorough way and more pressure from congress the house speaker paul ryan saying action must be taken we have laws for this we recently passed the magnitsky act which is a man who was killed in prison in a russian prison so we have sanction laws on the books in terms of this bipartisan

action president trump is given one hundred twenty days to decide on what sanctions to impose a group of democrat senators have demanded that the trump family disclose any business ties that may have had with saudi arabia in the past decade but this is legally and enforceable and likely to be brushed aside by the president and to remind of the man who's at the center office under. in crisis the washington post has published an opinion piece written by jamal khashoggi shortly before his disappearance in a t. criticizes the lack of international response to the abuse of journalists in countries like saudi arabia and egypt he writes these actions no longer carry the consequence of a backlash from the international community instead these actions may trigger condemnation quickly followed by silence as a result he continues arab governments have been given free rein to continue

silencing the media at an increasing rate chilling words from a man who may himself have been silenced by kind of. washington so who is the man at the center of all this jamal khashoggi well the saudi journalist was once close to the inner circles of the saudi royal family he earned his reputation as a reformist by pushing boundaries and questioning government policies in two thousand and three he became media advisor to prince turki bin feisal the prince headed saudi arabia's intelligence service and later served as ambassador to the u.s. but last year went into self-imposed exile in the u.s. after becoming concerned about the actions of the crown prince mohammed bin sound man he told down to zero in march that he left the kingdom because he didn't want to be arrested it's now just over two weeks since he was last seen his laura byrd manley with a timeline of the key events since then. jamal khashoggi visited the saudi consulate in istanbul on october the second as he collected documents to get married it was the last time the saudi journalist was seen alive his fiance had

t.j. shinji says she waited outside for him into the night but she never saw him again while saudi officials confirmed his disappearance the next day they said he left the consulate but they didn't provide any proof turkish security sources say they have information he was tortured and killed inside what saudi arabia cause it's all baseless lies and in interview with bloomberg crown prince mohammed bin some months said enter the concerts but left a little later and didn't return to riyadh he said turkey could inspect the consulate any time but investigators won't allowed in for another two weeks while turkish media publish the names and movements of what it calls a saudi security squad that landed in is some go on board two private jets on the same day because shock she disappears where u.s. .