you're leslie not think about what the impact of your words particularly at the highest level of office in this country then you you are acting grossly irresponsibly well i think i've been toned down you want to know that i could really help it up because you know the media has been extremely unfair to me and the republican party with the pipe bomb suspect now off the streets a sigh of relief that nobody was hurt but still worry that unless a heated political rhetoric is halted next time things could be different. new york. a later at a campaign rally dan the postle bombs as political violence but he also blamed the media for trying to polarize society. political violence thus never ever be allowed in america and i will do everything in my power to stop it but the media is constant unfair coverage the possibility.

and negative attacks you know that only serve to drive people apart and to undermine healthy debate for example. we have seen an effort by the media in recent hours to use the citizen or actions of one individual to score political points against me and the republican party. all right still ahead on al-jazeera when we come back we want to know all we had to monies flow to benefits it will really benefit valen to clear his name the former prime minister accused of stealing billions from malaysia's state fund speaks to al jazeera plus i'm wayne hay impala indonesia where we'll tell you about a warning the government received years ago about some of the potential dangers of a logical and quite happening here and how it may influence the rebuilding of this

devastated city. hello there we've got lots of dangerous weather across parts of the middle east at the moment we've seen a lot of very heavy downpours we've had flooding in jordan flooding in the southwest in parts of russia and for us in turkey we've seen a lot of wintery weather now too particularly in the east now that system responsible is continuing its journey east as we head through the next few days in the still some pockets of very heavy downpours and mixed in with that we'll see more heavy rains as we head through the next few days i think for saturday stretching its way down through parts of iran and it will be around the caspian sea and towards the northern parts of the gulf where we see the wettest of the weather here in fact this system here looks particularly no state that will then sink its way southwards breaking up a bit as it does say but still for some of us around the arabian peninsula there's

going to be some fairly lifea showers as we head through the day on sunday so a bit closer then here is that very wet weather just to the southwest in parts of iran but since its way southwards and then it's line here as we head through sunday so doha is likely to see more thunderstorms and perhaps we'll see some in riyadh as well meanwhile towards the southern parts of africa largely fine and dry for many of us here on ten and a revise getting away with a warm day about twenty seven degrees and further west they should also be plenty of warm sunshine to enjoy as well cape town should get away with a nice day twenty eight. survival for haiti's poorest depends on illegal charcoal production. but for park rangers sworn to protect the dominican forests it can have deadly consequences . discovers the hidden world where the stakes for the environment and those

who make their living from it could be higher. by a thousand cuts on al-jazeera. you're watching a reminder of our top stories this hour jim mouse has shown fiance has given her first television interview three weeks off to the saudi germans murder in istanbul t.j. genius was critical of how the u.s. has handled the case she rejected an invitation from president donald trump to visit the white house. is them balls prosecutor has demanded the extradition of eighteen suspects from saudi arabia for the killing pressure also mounting on

riyadh to reveal the location of jesus' body turkey's president called saudi explanations so far comical and childish. a supporter of donald trump has been arrested on suspicion of sending at least thirteen pipe bombs to high profile critics of the us president fifty six year old says our side of his face in five federal charges after he was arrested floor. all sri lankan police leave has been canceled that's after the president sacked the prime minister there for president mahinda rajapaksa was sworn in as prime minister on friday he replaces a run with. but he says he is staying put and calling the decision to remove him illegal mail fernandes is live for us now in colombo so no stunning turn of events this in sri lanka just how tense is the situation there right now as

a result of this. right now basically there is a fair bit of uncertainty now here where i'm standing at is basically a view official residence of the former president mahinda rajapaksa he's still here and the crowds you see gathered before me behind me are crowd supporters well wishers who have all flocked to his residence where inside is a party a parliamentarian is meeting so all members of parliament of the joint opposition basically gathered being chaired at a meeting by the new prime minister of sri lanka in the rajapaksa so on the streets relatively sort of an uneasy calm there are sort of a few simmering tensions last evening some of the tensions spilled over at the state broadcaster we had the situation where basically loyalist of both factions those loyal to the former prime minister on a vigorous in her as well as those of the new prime minister mind the rajapaksa

clashed over control of the state broadcaster special task force troops had to be called in to restore order and control of the situation so most people waiting to hear more details about it obviously the joint opposition and the new prime minister very confident saying that you know he has basically taken power he's basically been sworn in as the new prime minister even thought he's pretty sesar the former prime minister is insisting that this new swearing in is illegal and that he remains prime minister so have sri lankans reacted to all of this mean did did anyone see this coming at all. that's just the point it's a come to lead sort of a blindside for more stray lankans with the b doors in the political arena people

indeed today live professionals last night when this news started filtering out everybody was taken aback i mean many people thought this was essentially some kind of you know a joke that people were playing sort of a game on them because. nobody expected the former president to come back i mean there had been indications that there was sort of wrangling there were power struggles there was disputes within the ruling coalition of president might be parlous seriously in a with his prime minister that belong to another party which came together in a joint coalition basically to defeat mahinda rajapaksa so no one expected this no one had an inkling that it was coming a few weeks ago there were reports that the two series and by him the rajapaksa had met but not much news coming out so very much a surprise and sri lankans just trying to come to terms with what this means for them and the country's future all right for the woman now for nando's life first in

colombo. twenty one people have died from flash floods in jordan most of the victims were children on a school outing near the dead sea hoda abdel-hamid reports from the scene. search and rescue operations started after daybreak several people were still missing rescuers shores of the dead sea resort area while army divers room to water but with every hour that passed hopes to find anyone alive became dimmer and we sat patiently staring at the horizon wondering where his son could be. i came here with my success we were having a picnic all of a sudden we saw the floods rushing down my son saw the children in the water they went to rescue them i was swept away to one died two were taken to hospital and one is still missing the count find him anywhere it happened when suddenly heavy rains

sent water surging from higher grounds in the jordan valley to school children were at a camping site near some hot springs furder behind that range of mountains now they were caught by surprise and the force of the water swept them away over several kilometers according to the civil defense on the valley and some of the bodies were found in the dead sea a bridge that leads to this site with the schoolchildren where when the water started surge and collapsed so drills were also used to search to rocky slopes and deep canyons surrounding the dead sea. divided the work into tang groups do continue searching drones are also searching searching the show and the mountains. heavy rains and strong winds were expected in the area they had already hit the capital in previous days they did see is an arid region the lowest point on earth at some four hundred thirty meters below sea level and is prone to flash floods the

school day trip was initially due to happen in another part of the country it's not clear why plans change to school decided to take to children to do one area authorities had warned against by late afternoon still had no news about his son he walked away overwhelmed with grief. at the dead sea in jordan. israel's prime minister benjamin netanyahu has made a surprise visit to the gulf state of amman he met the country's ruler sultan qaboos to discuss the middle east peace process the last time an israeli leader visited amman was in one thousand nine hundred ninety six netanyahu his visit comes just days after palestinian president mahmoud abbas made a three day trip to the sultan amman's foreign minister says his government is not officially mediating the human being because when it comes to many issues we are not mediate we don't mediate between parties who are capable of achieving what they

agree on we are facilitators in many situations that can help convince opposing parties on how to reach an agreement when it comes to the palestinian issue we believe the media to has to play a new role is the u.s. and particularly president trump. an investigation by the associated press found that hospitals in the democratic republic of congo routinely imprison patients who fail to pay their hospital bills as part of a wider investigation by the news agency into the state of health care around the world it happened in the copper mining city of basra she government has called the practice illegal and says it stops it when it can a formal asian prime minister najib razak has admitted that things in his words went wrong in the one m. d. b. fund from which he and his associates are accused of stealing billions of dollars

that he was facing thirty eight charges of corruption and money laundering in an exclusive interview with al jazeera is one on one east he denies any wrongdoing saying he was not in control of the fund florence louis reports from kuala lumpur. not you brought up once seemed untouchable son of a former prime minister who rose to power himself but he has since fallen from grace charged with corruption money laundering and criminal breach of trust over accusations of stealing billions from a state investment fund called one m. d. more than six hundred eighty million dollars which the u.s. department of justice says can be traced back to one m.t.b. was deposited into not jobs bank account in an exclusive interview with al jazeera as one zero one east denies any wrongdoing. they kept on accusing me of receiving a huge sum of money but they forgot to mention that the bulk of the money was

returned four months after the general election i mean there are six investigations going on around the world into corruption related to one and. what what does that tell you you know there were things that were in wrong in one name d.p. . world many yes fine let it not let let them do their work we want to know where the monies flow to who benefit it will really benefit from the whole one m.t.b. issue not jobs claims of innocence do not surprise analysts at this figure he has repeatedly said even when he was in power i think a little likely to be his main defense so he probably beauty of it because he had the such feeling against it it was partly this feeling of anger that helped propel ninety three year old mahathir mohamad himself or former prime minister opposition

politician back into office following a general election in may since taking power there has reopened investigations into one and d. b. but not yet says the charges against him are part of a political vendetta you must realize that this current government you know when they were running for office they had already. made this political narrative. that they were going to take action against me not to men taint he's done nothing wrong and has pleaded not guilty to all charges his trial is due to begin in february not yet has said that the trial will afford him an opportunity to clear his name florence slowly al-jazeera. i mean the ages government has declared an end to the emergency response phase following last month's earthquake and tsunami with large parts of ireland still in ruins the focus switches to

rehabilitation and reconstruction white house reports symbols of pride and strength still flood amid vast wastelands of destruction it's been four weeks since the earthquake turned the suburb of power loose city into a muddy graveyard where many bodies are still buried when the earthquake struck these communities largely disappeared in a process called liquefaction when the earth beneath the surface turned to mud swallowing people and buildings it's an inhospitable landscape but as traumatized as survivors are some want to return to rebuild here even when they see that a hole in the ground is all that remains of their home. so i'm so terrified when i see this place my children said mom once the government clears up we should just move back in we don't have to build a permanent house we can just use word so i finally agreed i have to follow my children we don't have anywhere else to live so who just come back here that may

not be their decision to make though if the government goes ahead with a new master plan to rebuild the city. those that used to live in this suburb of aurora and a neighboring community will be relocated the government says the ground is too unstable to rebuild here which it seems has always been the case since the disaster it's emerged that the government knew areas like this were particularly dangerous six years ago its own experts drew a map of city highlighting areas where there was a high risk of liquefaction occurring in an earthquake this was one of those so-called red zones where hundreds if not thousands of people died. local government leaders wouldn't give al-jazeera an interview experts say the map should now be studied very closely as part of power lose rehabilitation which is expected to cost almost one point five billion dollars so the idea should be placed as a green zone as well you know. to make a people or so

a kind of like the buffer zone and green zone with the forest and things like that as well as for the monument for the people so the national learn something that would not be built the people who lived here say they had never heard of liquefaction before the disaster there was no education about the danger beneath their homes knowledge would have saved everyone but it may have saved some now the excavators have come to a standstill the search for the missing is over whatever the syria becomes it will also remain a mass grave wayne hay al jazeera palu indonesia. this is adds iraqis get a roundup of the top stories turkish prosecutors are demanding the extradition of eighteen saudis accused of killing and. they've sent the request to the foreign ministry turkey's president says the suspects should face justice in turkey he

described official saudi explanations as comical and childish. fiance has given her first television interview at t.j. jean geese spoke of her anguish and revealed why she rejected an invitation to the white house. trump invited me to the united states during the first days of the process but his statements had very short time periods in between and they were contradictory i perceived it as a statement to win the sympathy of the public a man from florida has been charged with sending mail bombs to prominent critics of u.s. president donald trump says it is a. hughes of sending thirteen devices to figures including former president barack obama the f.b.i. is warning more packages could be found. these tours actions must be prosecuted and punished to the fullest extent of the law we all know. and i want to applaud the

f.b.i. the secret service. and all say local federal officials for their incredible work in this investigation i mean they did a credible job. this is finding truly a needle in a haystack when you think about it israeli forces have killed at least five gazan protesters thousands gathered for a weekly protest to the mom palestinian rights more than two hundred have been killed since smallish light to israel bomb several islamic jihad and hamas sites in gaza the military says it was a response to fourteen rockets fired into israel egypt in the u.n. are trying to broker a long term truce between palestinian factions and his row sri lankan police are on high alert after the president sacked the prime minister former president mahinda rajapaksa has been sworn in as the new pm those are the headlines we're back with

more after the cura revisited. swear every.

top us think of this story it's. the wow. so this is the explosive yes it's basically a wearable robot. research and development for new medicines is costly and time consuming and almost always profit driven so where disease affects only the poor that market is neglected meaning no new medicines. to tropical disease it's the world's second largest processor killer off to malaria killing forty thousand people every year but has had no new drugs developed for decades i'm dr dobson when i mean ethiopia to explore how big pharma mobilized in an unprecedented global initiative to find and fast track a cure for. colors are also known as visceral leishmaniasis is

a parasitic disease transmitted through the bites of infected sounds like. when they feed on humans parasites infect the body and the internalised by microfiche is immune cells designed to protect us from infections. here the parasites multiply and destroy the last infecting other. the parasites that moves through the lymphatic and vascular systems infiltrating the bone marrow. liver and spleen. symptoms include fever weight loss enlargement of the liver and spleen anemia and the weakened immune system. the disease affects millions across ninety eight countries. little and rural it just north of the equator here due to the hot climate an agricultural lifestyle colors are as endemic . ethiopia learn has more than four and

a half thousand patients every year many of them male migrant farm workers working long hours in the field. with them it's a three to four hour drive to the nearest treatment center but for those are unable to pay for transport it's a long walk. fortunately their destination is the center for the treatment of color. for the last ten years going to university hospital has been conducting successful clinical trials involving the combination of two all drugs so damn stupid lou can eight or s.s.g. and param of mice. in twenty ten the world health organization officially adopted this combination as the new first line therapy for callous in east africa it's the first movement in half a century and dr aramis deros has been leading the way. our previous regimen was so

demonstrable to commit for seventy days with a combination we were able to shorten that arrangement to seventeen days that's good yes indeed and if you could see was more cement factor sent so you managed to cure ninety five percent of patients which is the new combination is that much better than before well in terms of. more or less similar. but in terms of. hospital hospital base ten source for ten base to seventeen that's a big achievement. vist to drug combination therapy is safe and has almost half the hospital stay of the earlier treatment. that's a crucial reduction for both patients eager to return to work and the health sector struggling to accommodate everyone currently all twenty six beds here are full. plate everything is love it must be nice to meet if you're welcomed this is it yes

leishmaniasis research treatment. after the heavy demands of this year's high season the hospital has run out of power m m i said and despite the new w.h.o. guidelines is forced to return to full thirty day regimen of painful and toxic s.s.g. injections. so this is one off or worse. hello he feels very heart fever how long have you had fever. because you know better but. gosh he has been sick for around six months now. i have pain in your stomach that i don't think you. know who was first suspected of having malaria due to the similarity in early symptoms. but after not responding to treatment he was referred to another clinic

which finally diagnosed colors are. now six months after he first fell ill he's in good hands but if it was left any longer he might not have been so lucky. three more places not able to find out. subsequently when the really weak and. then they go. and now that you're here in hospital. not working how does that affect your earnings as clinician return can change its source and then there are tons. and in which they stand and being. mad at us a nation can lead to. them but who is likely to normalize within a week still like all colors our patience due to the dangers of s.s.g.

hill require around the clock monitoring and toxicity testing for the entire thirty one days of treatment. the new combination therapy is an improvement but until these toxic drugs are replaced entirely by new safer and more if acacias ones it's still not good enough. as a neglected tropical disease. is desperately in need of a new research and development boost. a few thousand miles away help is at hand through a new global initiative. we're here in geneva not far in fighting the un and the world health organization but over here we're going to meet the n.t.i. the drugs the neglected diseases initiative. d n d i r the nonprofit organization behind the s.s. g.p.m. development. founded in two thousand and three with the help of medicines of

frontier nobel prize money they've been rallying commercial pharmaceutical companies around the world to share their resources. already access to a limited selection of big pharma drug libraries and now have a portfolio of fifteen promising new drugs in various stages of trial for several neglected diseases but now it's a particularly important time for them to see charlie mowbray head of drug discovery is the architect of the all new n t d drug discovery booster a project is. and to access and speed up new therapies for color as well it's a great time to visit here's an email i'm just about to center for the world's leading pharmaceutical companies ok so after america ace high qaeda quickly ok you can see here there's a chemical structure or some information here of different ways of depicting the structure or its activity against the parasite also it happens to kill t. crusie that causation i guess so this compound will kill the parasites that cause

disease and reshma narcisse really we will have screened one hundred thousand compounds maybe to find this one they really precious the parasites are really difficult to kill the properties of this is still quite a long way away from what we need for something or long from only become an oral meds from swallow and it'll kill the parasite so we would normally have to start making compounds my hand one at a time really slow really expensive but the companies that have been working in drug discovery for fifty or hundred years already have big collections hundreds of thousands or even millions of compounds and they're going to have some good look a bit like this one this is drug discovery. d.n.d. i is essentially on the hunt for a look alike to this compound one that may have even better properties for the purposes of a new drug for colors are. but they can't do it alone that's where the booster comes in each participating pharmaceutical company has effectively opened their entire back catalogue and what's more they'll lead the search themselves have you

persuaded these companies and it's in their interests to do. what i think was many many motivations but one of the things i write on a scientist i used to work for france a pharmaceutical company the people on the other side of this project and no different from me they're really excited about working on a disease like this because we can all see the appalling need here most people want to help and i hope some other companies are going to join this project quite soon so we really want this to be a global consortium the name and shame the ones i haven't signed yet. where we're working hard with some other companies but you noticed it. it takes a long time in discussions like this we hope some of the companies will join us here and so you're going to click send well i'm just about to do that so so yeah we can send it. and i'll be off the office as in in the u.k. and japan at the end for drugs will be made available at no cost or low cost to the patients that need them so an exciting time fingers crossed.

for pharmaceutical giants have so far signed the boost to contract which means the n.d.i. now gain unlimited access to millions of compounds one of the company's astra zeneca is in the u.k. the other three are in japan shinobi. and days i have received charlie's emails with the seat. we're looking for the man who received the email from the n.t.i. i believe is that here. high or low it's nice to meet you let me have that so you look at structure of molecules on computer models as well as in real life technically sure yes you can use only what you do for us that's a fluke out there and i think if this is going to vessels the three dimensional structure. to give us all these compounds that see the compounds and imagine this is the seed that came from the n.d.i. the n.d.i.

seed is seventeen parts carbon four parts nitrogen fifteen parts hydrogen and one part chlorine connected into this unique shape. this combination and shape closely fits and binds to a vulnerable spot on the leash mania parasites interfering with their mechanics by so far unknown mechanism but the fit could be better just like fitting a key to a lock by intelligent trial and error one point zero is a shop for food fight this is simple ok this is not a sin but you don't have to be a chemist to say that this doesn't look like that so. i would such a compound to base own chemical for an update so dan and i took jan so the fact that it's all screening is out romney oh yes it's generally quick around just trial a ninety four percent and you can see two rings two rings trying girls and the next one is eighty five percent and so on so forth.