central to the project, just before the 1st time of resistance excess people, one criminal is not the top and far away unless the criminal response of their family. that's why it's also necessary to have a judge of committed to the project. it's up to the judge to decide who qualifies for the model. present prerequisites are good behavior in the long sentence. so inmates have time to finish the rehabilitation program. domingos has serv half of his 7 year sentence. he's finishing his legal studies, hopes to make a career as a single monica. you're not, you're all just sierra some phone though. hey, presume the, this is all this era and these are the top stories now. human rights watch says to me is it has kind of down to what it calls collective expulsions of black african refugees and migrants. hundreds hopping, rounded up and sent towards libya where they've been denied entry,

leaving them stranded. the us house confirmed is we'll send a widely band across to munitions to ukraine. on friday the you and the secretary general's office said it was against the continued use of cost of weapons. germany is, government says it opposes sending the file to a case of president legit. to add one that says he's working to extend to the brain export due between ukraine and most good kinds of precedent for that. so lensky is, and it's done both the talks with him, the agreements which it shows ukrainian, the brain can be transported through the black sea, is due to expire. on july 17th. it's seen as critical for food security, especially in developing countries that would want to assess the hopes that will be extended for another 3 months. that's 5 minutes to mot. russa's coalition that has collapsed, often failed to agree on a new migration policy. but to announce to resign, it says the next step, probably

a general election. i don't mention the time sheet is full, but it's no secret that the coalition partners have very different views on migration policies. and today, unfortunately, we have to conclude that those differences are irreconcilable. that's why i will immediately offer the resignation of the entire cabinet to the king in writing. i will of course, also send a copy of this request for dismissal to the house of representatives. fighting between sedans, warring factions, has intensified in cartoon. wow. 5 gunfire and multiple explosions have been reported near the capital. army come on to say fights is from the rapid support forces. attacks the headquarters in a month. since the font is begun in april, at least a 1000 have been killed and millions more displaced. there's all the headlines and these continues have on august the are often the st. the,

the thing is i pushing the one to blow by the perspectives, the high fmi. okay side. so watching the stream there is a whole field of stay eula and biotech research that is dedicated to i've

a slowing all stuff in aging. what would you like free? like if we didn't age, is that even at the cool? we have a panel of experts, so that's kind of with scientists who are going to be here to ok. so your questions and your concerns. you can put your comments right here in the comments section, and i'm from the age of point 7, ready for the year by age 277. that is to get like october, november, december, free. for the month i do age progresses to reimburse the agent that has happened so that i can be to stay in biological age. we all know how much money that are make account. we know how much we way we know how many social media followers. yeah, we don't know our speed of aging, but how fast are you a unit? if you had an aging point, like your bank account would, you spend a certain way is if we have asian points, we have an a bank account, then society could shift instead of us saying we're going to be a martyr for wealth or status or whatever would it change in that balance

a little more be about human. so we become an excess about when he becomes this b. c. acknowledge you. gimme a call. that was brian johnson. he has, he's 45 years old, but he really wants to achieve of my logical body of 18 years old. is it possible to stop aging or with us aging? joining us to discuss this, we have mingo, as a physician, scientists and directors, the aging center university of california, los angeles, with us from bell, great sab, yet peter fetish of founder and chief science officer at jerad. i'm joining us from berlin. andrew, still scientists right to an over the age this, the new science of getting older without getting old. is that possible? i'm good. always chasing somebody that actually is it possible with phone we live a certain amount of time with age of with fortunate enough to live long enough and

then we die. how can you disrupt? i think the most important message i want people to come away tonight is this isn't science fiction that can sound like science fiction. and i think the best way to demonstrate that is, well, let's think about what i think is best. if you're a human being your risk of death doubles about every 8 years. this is because of the increasing risk of diseases like cancer and heart disease and stroke, the leading killers in the modern world. as that means that maybe at the age of 37, i've got i won a 1000 shots dying this year. i'm not quite like those ons, but unfortunately carry on doubling and doubling and doubling a number. it can eventually get very big very quickly. so if i'm lucky enough to live into my ninety's, i'm lucky enough that we haven't made any breakthroughs, nation biology, and the intervening time my risk of death and one of those years will be one in 6 months of life and death of the roll. the dice, i'm sorry, the statistical definition of aging is doubling of mortality, right? every 8 years. that's one way of understanding the aging process. but if we look around the animal kingdom there on the most, he's risk of death. it doesn't change them out a whole day all around a most like tortoises,

certain kinds of paste and kinds of liquids like solemn on this. these are capable of living, but they apparently don't get old. they can literally get older without getting old . and so i think there's no reason biologically, according to the laws of physics, why we couldn't apply the same house to watch to we age name. that's certain questions that come up in this conversation that we don't use the all scottsdale, so we just accepted. what do we age, what is the scientific reason for humans aging? well, there are many ways. it's just that, oh, pick me, i'll come, i'll come right back to you. i'm going to get, let me go 1st and you go 2nd fax. this me? yes. so there are multiple reasons that we would potentially when it gets aged. so one is biological reasons. so there are machinery in our body, no longer works so well, because we pay attention to for, to lity. so from a lucian already standpoint, too, we humans as a speech,

these are the most important. it's activities of life to propagate. after certain propagation that are there is no strong evolutionary drives to keep us. wow, because historically we live you roughly about thirty's to forty's, and then we pass because then the resources can be saved for you to your generation . however, right now, life has changed due to technology advancement. we have the resources to support more people. so this is sort of a philosophical argument as well as biological argument. so. so usually we have a strong believe that we could reverse aging because this is obviously reverse aging or expand live is a long dream over several centuries,

but we in the past we failed. but however, when i was a ph. d student at university of california, san francisco, one of my favorite professors, cynthia, came in, wanted to expand, extend the live spam starting from a little worm known as c elegans. so these worms lived for 2 weeks. and then what she did is she asked if she could extend the life span of these worms when she introduced gene mutations. as you could imagine, i was skeptical at 1st. however, shockingly, she did it, she and other colleagues of the other scientific field found that she and they were able to double the worms, maximum life span. interesting. they this extension is full for life span and how span not only do squirms flip twice as long. the 2 weeks old worms,

which wouldn't be dead now appear useful and robust with robust movement. so and then install that would normally leaves a brain degenerative disease no longer did so. so then that would be the equivalent of a 160 years old in schumann. yes. right. it would be a really but healthy. well, let me put in pizza for one low, and i'll come back to guess. and this is free to own on twitter. and i want you to understand what he's mission is. come over here to twitter on a mission to significantly extend huffy human life span. sadie is really important the the, the was, it jumped out to me was healthy human life. i pay the what do you want to add also, so 1st of all, i will probably close out of our streaming. less thumb is increasing the depo lifestyle changes across the opposing tiers are going to keep all the way

expandable after 30 years old. but now it takes 30 to 40 years old, just so to socialize a way. additionally, it's in the goal. so how are professions for 40 years old? when houses are we are starting to, to, to, to decrease, excuse by apply or the last or how many peers our life on almost doubling. it's not because too much decided to come along for all my life fun is because of to call gen social changes. it takes longer for us to develop, to socialize, and that's why i would g somehow combine it in such a way that we do like our development on waste time. but we're life amount of things. just knowledge of groups that are a life, some even more. so you're asking about vision. important things here is that humans too much company page can be young can for you, or they can be open for help with this plan. that is age. so this is kind of normal, so nobody, you know, develop stops, the gymnast agencies like that. but if you have diseases, you'll have medical interventions. so i think the data context that there's

a cutting right now is that people start to get aged prior dakota until the disease of what we're going to do. everyone is supposed to so aging before diseases stop purchasing those. the important features that up on the facebook, we should be able to select all we we unfortunately, she is a document agencies, most mostly in physics, is colton. topic is mostly not the deductible, is where they have to go to my uncle bill, which is pretty low century concerns for any most mapleton painters that can just off wage as somebody else so much to stop it. i think somebody will stop waging and maybe a few minutes here, something major revolution. i must apologize for now. i have to use all day reliable biotechnology and i'll just will stop agent right now on to the doors about this topic right before she use it. let me just bring in a voice from out for the community. this is only the grey as she talks about what one of the biggest challenges right now as a human race is this is aubrey told us that yeah,

more than 100000 people die of aging every day. and they do so after a long period of debilitation and decline. and now vice is the number one problem across the world, even in the poorest countries of the world. because every country has an average life span of at least 50 now. so we absolutely must address it with that i can say, and i'd like to say, but we're all making progress, but we need to make progress much more rapidly. we're getting some really interesting questions, andrew, on youtube. i can also take on this one. and one of of us as a key part of a healthy life is being able to accept via thanks to ality of death, trying to take away into a tunnel you for being a move tool is a waste of time, a fast. i don't waste of us trying to maybe be a see a spiritual power rosalyn accepting that with me

a few minutes. that's so treated as like no, i'm sure you're nothing. so i'm going to get this a very, very quickly to have that conversation with, with some of our peers i'm doing. he stopped putting you guys 2nd. yeah, i think that this is a very common question like actually, and i can completely understand where people are coming from when they ask this. but the challenge is that when you're thinking about treating aging, most of us on super interested in and we'll tell it to you and i go over some generally sweat off and ask about actually what we care about is this with me. mentioned earlier, it's health spine, it's about the amount of your life that you can spend free from disease. so gonna come so as a disease essentially caused by the aging process, heart disease is essentially caused by aging. stroke out time is dementia. all of these diseases, the leading candice, the leading causes of suffering as it will be mentioned in the modern world are caused by this process is biology that we call aging. and so we want to tackle the aging process to remove that suffering. and people will live longer because they're not going on well as a result. and she necessarily think that's a bad thing. i think you know, death is a tragedy. there is, um, you know,

you never go to a funeral and say, oh my god on go have they died. it really gave that life, meaning i use it just to so a story that we tell ourselves to try and justify the fact that we do, you know, we do eventually go out and die. and i think that as we, you know, we do have to accept that human beings, but we shouldn't accept the suffering that comes along with it. and that's what aging biologists really care about. basic i had, i was just, uh, think about the world in which uh, national, just uh can i start the quote on those quote uh, leave for another 10 years more display stories. i ended up the bar code in europe another as a forwarding domain. i think today would be fine too much or was it just sends you some time of booking about 1005 extension to well think about the world where steve jobs probably for another 10 years. i think what the agent essentially uh, did you face out the most successful professionals uh, from us uh, those guys have own chunk. so to, to complete video traditionals,

which means. busy agent, uh, think solid was held for you. what was your flight creepiness from the wall? it's not true. the under the personal decision. it's also huge at the moment, i think and also guys, look, we don't die. so i'm kind of your wrestling. this is just as much as you would you'd, we'll die from jim. so as, as much as we used to have as the you're, you're still to think about dimension. and then just think what happens if it don't stop agent kind of what would be the amount of truth on some sort of around let's towards this fantastic african problem that whenever someone dies, a library buttons, i just really captures the fact that, you know, all of his knowledge is wisdom is accumulated in life experience or the social connections, everything just up in smoke. i mean, not really to crystallize is what people are saying or what is human tragedy of aging. and yeah, because of the oil, which addition of some traditional societies well that hopefully you pass that on to the next generation. so your library at lives on the, in

a younger generation being, let's be very specific about what is being done right now. that is relevant to us aging, in terms of drug technologies and research, what he told us about the one getting an extra, like doubling life span, but when not once so was going to help us write. now i have a great question. so what i was trying to say is to stop 18 or extend my span is possible, this work was done 30 years ago. and as my colleagues have already told you about, there is a lot of work that has been done to extend healthy spend in animals. there is no reason to believe that humans, we don't work that way because in many other circumstances, we humans just use the same kind of tools and more. that is to

say, right, but what is the actual research that's being done? so we understand that there's certain animals that get older, but they don't age a well, you've managed to double its life span. but what about us right now as an aging population around the world? what is that for us right now? so they are, all right, let me, let me get, let me, let me have a little chat with me and then i'll come back to you. so of course, there are several ways to answer these questions. there a potential medication interventions. there are also a lifestyle interventions, so with a common goal to reduce the disease of aging, the burden of disease of aging. so which are heart disease, cancer stroke, dementia frailty, also preserve per process and increase propensity for infection and so on, so forth. right now, the medications potentially that are not necessarily approved or anything and

then more work needs to be done. the intriguing, intriguing possibilities are related to an event medication known as met foreman, which is antibiotic medication. by certain retrospect, to studies in the literature, it appears that it would potentially reduce the propensity to develop heart disease, cancer, and so on, so forth. currently, there is a large prospect to clinical trials that is being planned on to formally address if this medication can be really reversing. h with other studies including medication. no that's from mice in which has being shown to affect aging in animal models. so those are just, are we talking about mice thing? are we talking about? 2 mice can become no none of these many perfect. what can we,

i to be formally proven to delay aging in humans? yeah, those are interesting. be that the research community following through. all right, piece out, what do we have right now? what are you working on right now to extend a healthy human life span? oh, i just, i wanted to bring up this edition study month, which is called part of yours is where the pothole in the picture can connect separation system. so if you don't come to the mice, compare frustration whether elder of orange to get the younger and the unfortunately, the younger marshes molder. so that clearly factors are someplace in practice in my block of mice, at least that could be associated with those asian question. do you want control age which i've been using for very much. busy sense of humor, of blood samples. and we identified the fact that they should remove from the shunt collision naturally stand slash from mice and forget the just television that you

monday or don't have to have a pool that this was worth, and humans as well. but essentially what impact or engage was a mattress and one big crowd to share of the younger blocked, at least so welcome from from college of coastal ocean stuff. going to do what are some french getting stage and produce literate in life? all right, preachers you what to, hey, angela is making a face thought it was a good face or 5 face. articulate your face, andrew guide. there was a good face. i'm very excited by this stuff because we have literally thousands of ideas on the table. and the way to i often try and write these down is to think about something called the whole marks of the aging process. i know it's because biologists finally have some really strong ideas for the underpinning. sally, not my let, cannot biological mechanisms because us to grow old. these changes in our biology that happened as we age on the pin. the whole gamma of age we like to change is not just a cancer with heart disease of the story from the dementia, but also the ring cause the grey had a frailty that incontinence. all of these different things that happened to us as we get older are fundamentally caused by some collection of biological changes. so

to give them a concrete example, one of these hallmarks is accumulation of what i called the semester so semester is just as a technical term for old. and these are cells. i've been speaking with the current of your body for a long time. and as a result they've stopped dividing. yeah. and when i still, i'm always on task sticker, 100 mation. can you, can i show it it's about so that yes, all right, hold tight and then i'll get these are pick up off the back of this video. this video came from a bio take organization. they're trying to make a book on drugs to stop senescence. and andrew is just about to explain what some essence is. but next let the animation do that as i've look you may not feeling good as your body ages. it can be an accumulation of malfunctioning so school semester, which is likely linked to many common age related diseases. seasons have cells. they begin to nods quantities of full protein, causing inflammation, tissue,

a differential worsening of underlying conditions, etc. ray tissue damages disease. so i'm really proud of i know it's an essence, is andrew, please continue. the absolutely yes. and the animation shows you what's going on inside all of our bodies, all of the time, the semester. ssl has come into being mnemonic, it's weird why the cells not potty imaging this talks it comp time with molecules if you now think excellent. all right, smart truth might be oh that the aging process. the answer is, according to the mean system to assign hire over here i'm a dysfunctional, wholesale can you come and, you know, clean me up and then a young person, do you mean system is very effective? it comes in, clears out the sinister cells. there's no problem as we get older, the cells accumulate more and more quickly. and also one of the other hallmarks of aging is a reduction in the efficiency of our immune systems. and we've all seen already, you know, tremendously powerful example of this in the last few years when we saw how much older people were much greater deceptive of di from a disease like carrying a virus. because our main system is a week or less able to find that off unfortunately. but the immune system is also i,

i could sort of a police force within our own bodies as well clearing out the scent sense house. and this might be a very depressing story, sondra, so we're going to find some cause of aging. but the good news is scientists of also identified something that we can do about it. which is that we can give these things called the senate electric trucks. these and drugs that killed us and i some cells believe the rest of the sounds of the body intact uncertainty. so given these to mice industry and what they found was they basically made these mice biological younger site a little bit longer, which i guess is a good start if you're trying to site on the aging process, but not stretching out the frailty at the end of life, these animals that they get us disease, they get less cardiovascular disease. like i said, i comes to pick a few cataracts of that less frail and a healthy a. so if you stick them on a treadmill and then the mice and this time, you must always trick when we start using the experiment and run further and foster on this treadmill often by taking the drug that appears to slide on cognitive aging . and frankly, it's worth doing a web search, or some of these are some pictures of these animals because you do not have to be an expert to see that the animals i've had this in essence how treatment i just looked fantastic. very caustic effect. well,

that's great. first i'm part of the skin based. this looks like how do we order, fantastic looking mice running around. all right, i and i want to bring in the voice of charles brenda because we've been talking about how are we able to look at as was anti aging. what is the outset and charles we need to make this point. let's bring him in. and then we can talk about it personally. aging is it normally process required to convert fertilize a to a mature reproductively capable. adult aging is not a disease. you're going to eat better with good nutrition being mentally and physically active. and basically, following mom's advice, you can age worse by whole reading, drinking smoking, taking non prescribed drugs being violent situations. unfortunately, there's an incentive structure in science that has rewarded height in the anti aging space. and it is not at all clear that one can directly target the aging

process as a drug approach, despite what your viewers may have heard. so is that is tells contradicting everything we've been talking about the drugs conte help us. just, i'm just going to get you to do to also read it briefly cuz i've got some questions as well, from my view as me. but yes, what charles has been mentioning is a very good point. in the sense, there are some pharmacological interventions, but most probably more importantly would be lifestyle interventions. and so what i'm seeing here is about certain diet, certain ties, activities, not no talk sense, including smokes, better, sleep, a good amount of stress, but not bad stress. yeah. social functions and so on, and so for okay, like i mean, as long as i think some questions for my views and they really came to talk because you've read in spots and thoughts. this one is for you piece. and again,

very quickly on youtube, how much will this cost is this kind of technology available only for the wealthy pizza incident reaction? go ahead as well. it did not. busy cost a lot, the cost you'll have to make the customer spending on customers. think about that quite honestly, for 20 years, 10 years is required to do your clinical trials. 20 years plus these will be a genetic buck with no cost. okay. all right, this one i know 1st question, andrew, what are the possible psychological and emotional effects of living longer on? definitely bulletin anxiety depression. this one is going to andrew, i'm just going to say 30 seconds the whole time. 100. i think this is so he just dramatically ever played actually because we think it's going to be this huge transformation of the human condition. but i just want you to think about how you conduct to your everyday life. how many of your plans are predicated on the front? you're going to die in 20 or 30, or 40 years in the future. people to obviously cited for time and i've got pension,

i think mostly we live, i live some day today. if we happen to be healthier for longer, our friends and family were healthier for longer. this would be a fantastic thing. we've just carry on living our lives as we do now. and i bridge, i think this idea are getting bored holes much water. all right, you've made me so here's my me saw piece of we are out of time, but it's over years from was conversation as so much more to talk about much more research to take and really appreciate you making pizza, andrew and view as on egypt for your excellent questions, i'll say next time, take care of everybody the the

environment. so let's say one of the stray is most range source on the top of the penalties protested when, when a speech those prepared to break out his ear asked, we can narratives from africans perspectives which are the want in terms of what came up performed to show documentary spot african filmmakers have been on the to on for over 20 is future with fish from the ship and the queen from nigeria, new series of africa, direct on colleges 0. when the news breaks, i'm in front of the building up was hit with a drawing i talked to you and that's when people need to be hot. and the story

needs to be told. i wanted to cry as if i'd never see my parents and country again with exclusive interviews and in depth reports the irrigation canals are nearly empty. i'll just see where i have teams on the grass. they've just staring interaction here and been dr as to bring you more award winning document trees and life news. the real world war read the video to i'll just hear a games exclusive access to hundreds of my goods trying to meet soon as you look in for the the hello am dire in jordan, this is obviously your allies and don't. so coming up to us defends this decision to send cluster munitions to ukraine. weapons that abandoned by more than

a 100 countries. the dutch government collapse itself and disagreements of the migration countries. longer 7 funding is done, we resign.