limits to market and because of the heat live stuck can stand up. they get sick from the heat. the extreme heat is slowing down business and the city just yeah, i got a van dyke. the heat is very high. i unplugged god to protect us. this is heat has made us suffer so many pockets within the heat. this here is terrible enough to you and estimates almost 20 percent of new. sure, as population will need humanitarian assistance to get through the government through this just over $450000000.00 to support pharmacy hit by pul harvest. but it's early the beginning of what's known as the lead season, a lot worse. the like up there in the, i'll get this area which is it does it's own, the temperature rise is exceptional, often reaching $45.00 degrees. this is unbearable for by diversity in general, like the plants and animals. for now that's little that can do with temperature is expected to remain high over the next 2 months. barbara and gray par. i'll just say

era. the hello again. i'm elizabeth rhonda mendoza hall with the top stories on alex's era. the us treasury secretary has ended her full day visit to china, stage media portions, chinese concerns about us economic sanctions. janet gallons had, had trip, had been direct and productive. the us in china have significant disagreements. those disagreements need to be communicated clearly and directly, but present in spite and then i do not see the relationship between the us and china through the frame of creek power conflict. we believe that the world is big enough for both of our countries to thrive. both nations have an obligation to responsibly manage this relationship to find

a way to live together and share with global prosperity. russia has appears, took care of violation. the president swap agreement by releasing 5 ukrainian come on the is that the resistance of the, as i'll style steel plants last year, but surrender to russian soldiers and from thousands of people defied a band to march in paris to commemorate a black man who died in police custody in 2016. tensions had been high and fond. foster police killed a 17 year old ninty 2 weeks ago, the sparking riots and protests across the country. a delegation of more than 30 ambassadors and the representatives as visiting janine and the occupied westbank 12 palestinians were killed in the major is where the assault on this refugee camp earlier this week, fell assess the optim off and damage cost homes and infrastructure is very bold as an, as strikes destroy roads, ambrosia and electricity lines. well, those are the headlines. the stream is coming up next. so there is no channel that

cover in the world to use like we do. the scale of this camp is like nothing, ever what we want to know how these things affect people. we revisit please stay, even when they're no international headlines. i'll just say we're really invested in that. and that's a privilege. as a journalist, the hi anthony. okay, sad to watch and the stream there is a wholesale to say you a and biotech research that is dedicated to i've a slowing of stuff in aging. what would you like for me like if we didn't age, is that even exit? cool? well, we have a panel of experts, so that kind of was scientists who are going to be here. ok, so your questions and your concerns. you can put your comments right here in the comment section on each time from the age of point 76 for every 3 years,

a year by age 277. that is to get like october, november, december, free. for the most i do age progress is to reimburse the agent that has happened so that i can be to stay in biological age. we all know how much money that our bank account we don't how much we way we know how many social media followers. yeah . we don't know our speed of aging, but how fast are you a unit? and if you had an aging point, like your bank account would, you spend a certain way is if we have asian points, we have an a bank account, then society could shift instead of us saying we're going to be a martyr or wealth or status or whatever would it change and that balance a little more be about 2 minutes and we become an excess about when he becomes this b. c. acknowledge as that was brian johnson. he has, he's 45 years old, but he really wants to achieve apply logical buddies of 18 years old. is it possible to stop aging or with us aging? joining us to discuss this, we have mingo, as a physician,

scientists and directors, the aging center. the university of california, los angeles, with us from bell, great stub yet, peter felt a chest founder and chief science officer at jerad. i'm joining us from berlin. andrew, still scientists right to an over the age this, the new science of getting older without getting old. is that possible? i'm good. always chasing somebody that actually is it possible with phone we live a certain amount of time with age of with fortunate enough to live long enough and then we die. how can you disrupt? i think the most important message i want people to come away with tonight is this isn't science fiction that can sound like science fiction. and i think the best way to demonstrate that is, well, let's think about what aging is best. if you're a human being your risk of death and doubles about every ideas, this is because of the increasing risk of diseases like cancer and heart disease and stroke, leaving killers in the modern world. as that means that may at the age of 37,

i've got i won a 1000 shots dying this year. i'm not quite like those odds, but unfortunately carry on doubling and doubling and doubling a number. it can eventually get very big very quickly. so if i'm lucky enough to live into my ninety's, i'm lucky enough that we haven't made any breakthroughs and asian biology in the intervening time. my risk of death and one of those years will be one in 6 months, the life and death of the roll. the dice on. so the statistical definition of agent is doubling of mortality, right? every 8 years. that's one way of understanding the aging process. but if we look around the animal kingdom there on the most, he's risk of death. it doesn't change them out of how old they are. they're running most like tortoises, certain kinds of paste and kinds of liquids like solemn on this. these are capable of living, but they apparently don't get old. they can literally get older without getting old . and so i think there's no reason biologically, according to the laws of physics, while we couldn't apply the same titles to watch to we age name, that's certain questions that come up in this conversation that we don't use the all scottsdale, so we just accepted what do we age,

what is the scientific reason the humans aging? well, there are many ways. it's just that, oh, pick out i'll come, i'll come right back to me. i'm going to get me go 1st and you go 2nd fax. this me? yes. so there are multiple reasons that we would potentially what gets aged. so one is biological reason, so there are machinery in our body, no longer works so well, because we pay attention to frontier lity. so from a lucian already standpoint too, we humans as a space. these are the most important it's activities of life to propagate. after certain propagation that are there is no strong evolution already drive to keep us. wow, because historically we live, you roughly about thirty's to forty's and then we pass because then the resources

can be saved for you to your generation. however, right now life has changed due to technology advancement. we have the resources to support more people. so this is sort of a philosophical argument as well as biological argument. so. so usually we yeah, i strongly believe that we could reverse aging cuz this is obviously reverse aging or expand like yeah, she is a long dream over several centuries, but we in the past we failed. but however, when i was a ph. d student at university of california, san francisco. one of my favorite professors, cynthia, came in, wanted to expand, extend the life span, starting from a little worm known as c elegans. so these words live for 2 weeks.

and then what she did is she asked if she could extend the life span of these worms when she introduced gene mutation. as you could imagine, i was skeptical at 1st. however, shockingly, she did it, she and other colleagues of the other scientific field found that she and they were able to double the worms, maximum life span. interesting, they, this extension is both for life span and house span. not only do squirm flip twice as long the 2 weeks old worms, which would have been dead now appear useful and robust with robust movement. so and then install that would normally leads to brain, degenerative disease no longer did so. so then that would be the equivalent of a 160 years old in schuman yes, right? it would be a really healthy. well, let me put in pizza for one low,

and i come back to guess. this is pre to own on twitter. and i want you to understand what he's mission is. come over here to twitter on a mission to significantly extend how fee, human life span side is really important. the, the, the was, it jumped out to me was healthy human life. i pay the what do you want to ask also, so 1st of all, i will probably close out of our shipment. less thumb is increasing deep. our lifestyle changes across might be a 1000 years ago. okay. probably expandable after 30 years old. but how it takes 30 to 40 years old, just social nice or way. additionally, in the call. so howard professionals find 40 years old when houses, or when you're starting to, to, to, to decrease, excuse by apply or the last or how many peers i would respond almost doubling. it's not because too much decided to come along for all my life fun. just because of to call gen social changes, it takes longer for us to develop to socialize,

and that's why i would g somehow combine it in such a way that we delay our development on waste time about where life mama can use just normally just loops that away life, some even more. so you're asking about vision. important things here is that humans too much company page can be young can for you, or they can be open for help with this plan with them that is age. so this is kind of normal, so nobody, you know, don't stop the gymnast agencies like that. but if you have diseases, you'll have medical interventions. so i think the data context that has occurred and right now is that people start to look at aging prior. the occurrence of the diseases and what we're going to do, everyone is supposed to so aging before diseases stop purchasing those. they bought some features that problem facebook. we should be able to select all we, we, unfortunately. so she is up back in a moment, easiest, most, mostly, and physics as colton. topic is mostly not the deductible, is where the cost to go to my agent,

although it ceases to reverse energy consumption. in the most important thing is like you can store wage as somebody else so much to stop it. i think somebody will stop wages and maybe a few minutes here, something natural evolution. i must apologize for now. i have to use hold a reasonable by technology, and i'll just, i'll just, i'll page and try to go on to the doors about this topic right before she uses it. let me just bring in a voice from out poor to community. this is only the grey ad she talks about what one of our biggest challenges right now as a human race is this is aubrey told us that yeah, more than 100000 people die of aging every day. and they do so after a long period of debilitation and decline. and now that is the number one problem across the world, even in the poorest countries of the world. because every country has an average life span of at least 50 now. so we absolutely must address it

with that i can say, and i'd like to say, but we're all making progress, but we need to make progress much more rapidly. we're getting some really interesting questions angel unusual. i can also take on this one, and one of of us says a key part of a healthy life is being able to accept the thanks show ality of death. trying to take her away into a tunnel you for being a move to is a waste of time, a best. i don't waste of us trying to maybe be a see a spiritual power robson accepting that with me. humans that so created is, i know you're noting, so i'm gonna get this a very, very quickly to have that conversation with, with some of you as i'm doing. he stopped putting you guys 2nd. yeah. i think that this is a very common question like actually, and i can completely understand where people are coming from when they ask this. but the challenge is that when you're thinking about treating aging, most of us on super interested in and we'll tell it to you and i go over some

generally sweat off and ask about actually what we care about is this with me. mentioned earlier it's health spending, it's about the amount of your life that you can spend free from disease. so gonna come so it's a disease essentially caused by the aging process. heart disease is essentially caused by aging, stroke outside of dementia. all of these diseases, the leading candice, the leading causes of suffering as we mentioned in the modern world, are caused by this process, this biology that we call aging. and so we want to tackle the aging process to remove that suffering. and people will live longer because they don't hang on well as a result. and i thought she necessarily think that's a bad thing. i think you know, that is a tragedy. there was um, you know, you never go to a funeral and say, oh my god on go have they died. it really gave that life, meaning i use it just as a story that we tell ourselves to try and justify the fact that we do, you know, we do eventually go out and die. and i think that as we, you know, we do have to accept that human beings, but we shouldn't accept the suffering that comes along with it. i'm not so agent biologists really care about basic. i had all just uh,

think about the world in which uh, national just uh, construct a quote on those quote uh leave for another 10 years more display stories and the top bar code in europe. another as a forwarding domain, i think today would be fine too. much over it, it just sends you some time of booking about 1005 extension to well think about the world where steve jobs probably for another 10 years. i think what the agent essentially uh, did you face out the most successful or professional uh from us uh, those guys have own chunk. so total compete very traditional, which means. busy the agent takes our was held for, you know, as long as you live typing this phone to work. it's not true the, on the personal decision. it's also huge at the moment, i think, and also guys, look, we don't die. so i'm kind of your wrestling, this is just as much as you would you'd, we'll die from jim. so as, as much as we used to have, as we used to think about dimension, i mean,

just think what happens if it don't stop agent kind of what would be a fair amount of truth on some software at all. let's towards this fantastic african problem that whenever someone dies, a library buttons my name, i just really captures the fact that, you know, all of his knowledge is wisdom. this accumulated in life experience or the social connections, everything just up in smoke. and not really to crystallize is what people are saying or what is human tragedy of aging. and yeah, because of the oil tradition of some traditional societies, although hopefully you pass that on to the next generation. so your library at lives on the, in a younger generation being, let's be very specific about what is being done right now. that is relevant to us aging in terms of drug technologies and research. what he told us about the one getting an extra, like doubling life span, but we're not once so was going to help us right now. like

a great question. so what i was trying to say is to stop 18 or extend my span is possible. this work was done 30 years ago, and as my colleagues have already told you about, there is a lot of work that has been done to extend how they spend in animals. there is no reason to believe that humans. we don't work that way because in many other circumstances, we humans just use the same kinds of tools and more. that is to say, right, but what is the actual research that's being done? so we understand that there's certain animals that get older, but they don't age a well, you've managed to double it sliced by. but what about us right now as an aging population around the world? what is that for us right now? so they are, all right, let me be, let me get, let me, let me have a little chat with me and then i'll come back to you. so of course,

they are several ways to answer these questions. they're a potential medication interventions. there are also a lifestyle interventions, so with a common goal to reduce the disease of aging, the burden of disease of aging. so which are heart disease, cancer stroke, dementia frailty, also preserve per process and increased propensity for infection and so on, so forth. right now, the medications potentially that are not necessarily approved or anything and then more work needs to be done. the treating intriguing possibilities are related to and then medication known as met foreman, which is a n t diabetic medication by certain retrospect, to studies in the literature. it appears that it would potentially reduce the propensity to develop heart disease, cancer, and so on, so forth. currently,

there is a large prospect to clinical trials that is being planned on to formally address if this medication can be really reversing. h of other studies including medication, no that's from mice in which has being shown to affect aging in animal models. so those are just, are we talking about mice thing? are we talking about? 2 mice can become, i'm sorry, it was none of these makes no perfect. what can we, i to be formally proven to delay aging in humans. yeah, those are interesting. be that the research community following through. all right, piece out, what do we have right now? what are you working on right now to extend a healthy human life span? oh, i just, i wanted to bring up this edition i study month,

which is called part of yours is where it was whole him, the picture can connect separation system. so if you don't come to the mice, compare frustration whether elder of orange doesn't get to younger. i'm the unfortunately, the younger more, she's just molder. so that clearly factors are someplace in practice in my block of mice, at least that could be associated with those aging questions that you don't control age which i've been using for very much stuck with sense of humor, of blood samples. and we identified the fact that they should remove from the shop collision naturally stand slash from mice and forget the just television that you monday or don't have to have a pool that this was for consumers as well. but essentially what impact or engage was a novice or mundane crowd to share of the younger blocked, at least so welcome from from college. of course of the ocean stuff going to do what are some crunch? getting staging quickly slid away to life. all right, preachers, you were to, hey, andrew, is making a face, thought it was a good face or 5 face, articulate your face under guide. there was

a good face. i'm very excited by this stuff because we have literally thousands of ideas on the table. and the way that i often try and write these down is to think about something called the whole marks of the aging process. i know it's because biologists finally have some really strong ideas for the underpinning. sally, not my let, cannot biological mechanisms because us to grow old. these changes in our biology that happened as we age on the pin. the whole gamma of age we like to change is not just a cancer with heart disease of the story from the dementia, but also the ring cause the grey had a frailty that incontinence. all of these different things that happened to us as we get older are fundamentally caused by some collection of biological changes. so to give them a concrete example, one of these hallmarks is accumulation of walk whole semester. so semester is just a so technical term for old. and these are cells i've been speaking to is the current of your body for a long time. and as a result they've stopped dividing. yeah. and when i still, i'm always on task sticker, 100 mation, can you, can i show it? it's about select yes. all right, hold tight and then i'll get,

these are pick up off the back of this video. this video came from a bio take organization. they're trying to make a book on drugs to stop senescence. and andrew is just about to explain what some essence is. but next let the animation do that as i've look. you may not feeling that as your body ages, it can be an accumulation of malfunctioning so school semester, which is likely linked to many common age related diseases. as these things have cells and they begin to a large quantities of full protein causing inflammation. tissue. a differential worsening of underlying conditions set a rate tissue damages disease. so i'm really proud of. i know it's an essence, is andrew, please continue. the absolutely yes and the animation shows you what's going on inside all of our bodies, all of the time the semester is how it's coming to be. now you might think it's weird why the cell is not potty imaging. this talks it comp time with molecules. if

you now think, excellent, all right, smart truth might be old at the aging process. the answer is, according to the name system to assign higher, hey, i'm a dysfunctional, wholesale. can you come and, you know, clean me up and then a young person, do you mean system is very effective? it comes in, clears the sinister cells and there's no problem. as we get older, the cells accumulate more and more quickly. and also one of the other hallmarks of aging is a reduction in the efficiency of our immune systems. and we've all seen already, you know, tremendously powerful example of this in the last few years when we saw how much older people were much greater susceptibility from a disease like kind of virus. because that mean system is a week or less able to find that often unfortunately. but the immune system is also i, i could sort of a police force within our own bodies as well clearing out the scent sense house. and this might be a very depressing story. sondra so identified some cause of aging. but the good news is scientists have also identified something that we can do about it, which is that we can give these things what send out electric drugs. these are drugs that killed us and i some cells believe the rest of the sounds with the body intact uncertainty. so given these to mice industry and what they found was they basically made these mice biological younger site a little bit longer,

which i guess is a good stock. you're trying to site on the aging process, but not stretching out the frailty at the end of life. these animals that they get us disease, they get less cardiovascular disease. the goodness comes to the fuel cataracts, that less frail the healthy. so if you stick them on a treadmill and then the mice and this time, you must always trick when we start using the experiment can run further and foster on this treadmill often by taking the drug that appears to slide on cognitive aging . and frankly, you know, it's worth doing a web search, or some of these are some pictures of these animals because you do not have to be an expert to see that the animals i've had this in essence how treatment they just look fantastic the caustic effect. well, that's great. first i'm kind of the skin, they just look like help the fun, tacit looking nice running around. all right, i, i want to bring in the voice of charles brenda because we've been talking about how are we able to look at us was anti aging. what is the outset and charles, when did you make this point? let's bring him in and then we can talk about it personally. aging is it normally

process required to convert fertilize a to a mature reproductively capable. adult agent is not a disease. you're going to eat better with good nutrition being mentally and physically active. and basically falling mob suffice, you can age worse by over eating, drinking smoking, taking non prescribed drugs being violent situations. unfortunately, there's an incentive structure in science that has rewarded height in the anti aging space. and it is not at all clear that one can directly target the aging process as a drug approach, despite what's your viewers may have heard. so is that is tells contradicting evident we've been talking about the drugs. conte help us just, i'm just going to get you to do to also read it briefly cuz i've got some questions as well for my view as me. but yes,

what charles has been mentioning is a very good point in the sense there are some pharmacological interventions, but most probably more importantly would be lifestyle interventions. and so much pressing here is about certain diet, certain ties, activities, not no toxins including smokes, better, sleep, a good amount of stress, but not bad stress. yeah. social functions and so on. and so for okay, like i mean, as long as i think some questions for my views and they really came to, to what you could just read in spots and thoughts. this one is for you, please edit, can very quickly on youtube. how much will this cost is this kind of technology available only for the wealthy pizza instant reaction? go ahead as well. it did not. busy cost a lot, the cost you'll have to make the customer spending on customers. think about that quite honestly, for 20 years, 10 years is required to do your clinical trials. 20 s plus these will be

a genetic buck with no cost. okay. all right, this one i know 1st question, andrew, what are the possible psychological and emotional effects of living longer on? definitely bulletin anxiety depression. this one is going to, i'm just going to say 30 seconds the whole time 100. i think this is so he just dramatically ever played actually because we think it's going to be this huge transformation of the human condition. but i just want you to think about how you conduct your everyday life. how many of your plans are predicated on the front? you're going to die in 20 or 30, or 40 years in the future. people to obviously cipher time and i've got pension, but i think mostly we live. i live some day today. if we happen to be healthier for longer, our friends and family were healthier for longer. this would be a fantastic thing. we've just carry on living our lives as we do now. and i bridge, i think this idea are getting bored holes much water. all right, you've made me so here's my me, saw piece of we are out of time, but it's over years from our conversation as so much more to talk about much more research to take and really appreciate you being pita,

andrew and view as on youtube for your excellent questions, i'll say next time, take care of everybody. the the, where is the western agenda heading? that's the g 7. really even matter any. who's more electable, joe biden, or donald trump, or journalist in the media undermining our society. can americans cross their supreme court is not corrupt. quizzical look us,

pull it to the bottom line the by pushing the one to blow by the perspectives with loud west struggle gives us to true passion. where freight just where humanity defies.

expectations with freedom is always west twelves and untold stories from across asia and the pacific $11.00 each on outages era. the we believe that the world is big enough for both of our countries to thrive. us treasury secretary janet. yeah. then close her visit to china, productive, bought significant disagreements remain the dominance of a toronto and this is alice as they are live from the also coming up.