now the mexican government announced that the no fishing area will be enlarged. victory to the scientist, a further lifeline to the by key to an a problem. for fishermen. you say they're already struggling. don't homan out to 0, simply pay mexico. the you're watching. i'll just say are, these are the headlines, this alley you as president joe biden is in the u. k. fand talks with prime minister where she's so nag by them will go on to a change in nature assignments and miscellaneous on tuesday, and it's showing solidarity with ukraine. my kind of has moved from washington dc. on his way to view k, president biden held a phone conversation with the president of turkey at risk of the one in which the issue of sweden's membership of nato was discussed. took it as opposed to giving membership to sweden because it says that sweden has

a security issues which has got to guarantee before we can consider membership. president biden pressurizing took it to accept sweden as a full member of nato. russian officials say a defense systems have intercepted full ukrainian missiles of the crime in peninsula. the governor of the annexed regions says there was no major damage. they sell strikes have been reported in southern russia and rosters and brands to museums. president chi said has rejected criticism over the mistreatment of black african migrants and refugees on each border with libya. $700.00 people are being left stranded without food or worship for days. sedans, warring factions are engaged in heavy sizing and the capital cost too. heavy a strikes, continuing in nearby, on demand, where at least 22 people were killed on saturday. the un secretary general is wanting sedans. war is at risk of the stabilizing the regions west african latest

retaining into dates on that same gimme the sounds. capital with regional security, talking age and members of eco was dealing with a surgeon attacks by groups linked to iso and al qaeda and number of people killed by floods in pakistan has arisen 27600 is the worst effected region. torrential downpours triggered it, flooding and land slides over the past 2 weeks. and to present it from britain's national, broad cost of the bbc has been suspended. the corporation is investigating claims he paid for sexually explicit photographs from a teenager. is newspaper reported the mail present? it paid. $45000.00 for the material. all right, those are the headlines. i'm emily anglin estate. you now for vestry. i'm charles don. the rate of 400 sites dramatize podcast from i'll just here to invest facing

re here from some of history's blogs, notable women and unconventional and extraordinary office. i am 40 that kind of the communist revolution of everyone in china, new my state. you've heard all of them power it's time you have from these and 6 of hindsight is out now subscribe wherever you listen to pope cast on the high end, semi ok side to watch and the stream that is a wholesale to send you a and biotech research that is dedicated to i've a slowing all stuff in aging. what would you like free? like if we didn't age, is that even at the cool? we have a panel of experts. so that's kind of with scientists who are going to be here to ok. so your questions and your concerns, you can put your comments right here in the comments section and i'm from the agent moines. stuff is getting ready for the year by age 277. that is to get like october,

november, december, free for the month i do age progresses to reimburse the agent that has happened so that i can be to stay in biological age. we all know how much money that are make account. we know how much we way we know how many social media followers. yeah, we don't know our speed of aging. but how fast are you a in a few 100 aging points like your bank account would you spend a certain way is if we have asian points, we have an a bank account, then society could shift instead of us saying we're going to be a martyr for wealth or status, or whatever. would it change in that balance a little more be about human. so we become an excess about when he becomes this b. c. acknowledge that was brian johnson. he has, he's 45 years old, but he really wants to achieve of my logical body of 18 years old. is it possible to stop aging or with us aging? joining us to discuss this, we have mingo, as a physician,

scientists and directors, the aging center, university of california, los angeles, with us from bell greg stub yet piece of furniture founder and chief science officer at janet. and i'm joining us from button andrew. still, scientists, writer, and also as a, just the new science of getting older without getting old. is that possible? i'm good. always chasing somebody that actually is it possible with phone we live a certain amount of time with age of with fortunate enough to live long enough and then we die. how can you disrupt? i think the most important message i want people to come away with tonight is this isn't science fiction that can sound like science fiction. and i think the best way to demonstrate that as well, let's think about what aging is best. if you're a human being, your risk of death doubles about every 8 years. this is because of the increasing risk of diseases like cancer and heart disease and stroke, leaving killers in the modern world. so that means that maybe at the age of $37.00

i've got i won a 1000 shots dying this year. and i quite like those odds. but unfortunately carry on doubling and definitely and doubling a number, it can eventually get very big very quickly. so if i'm lucky enough to live into my ninety's, i'm lucky enough that we haven't made any breakthroughs, nation biology, and the intervening time my risk of death and one of those years will be one in 6 months of life and death that the roll, the dice on so it is to, to stick all definition of agent is doubling of mortality right? to every 8 years. that's one way of understanding the aging process. but if we look around the animal kingdom there on the most, he's risk of death. it doesn't change them out. a whole day, all around, almost like tortoises, certain kinds of paste, certain kinds of liquids like solemn on this. these are capable of living, but they apparently don't get old. they can literally get older without getting old . and so i think there's no reason biologically continentals of physics while we couldn't apply the same types to watch to we age name, that's certain questions that come up in this conversation, but we don't use the all sky house we just accepted. what do we age?

what is the scientific reason for humans aging? well, there are many ways. it's just that, oh, come, come right back to me. i'm going to get, let me go 1st and you guys, 2nd fax. this me? yes. so there are multiple reasons that we would potentially when it gets aged. so one is biological reasons. so there are machinery in our body, no longer works well, because we pay attention to for taylor t. so from a lucian already standpoint to we humans as a speech, these are the most important it's activities of life to propagate. after certain propagation that are there is no strong evolutionary drive to keep us. wow, because historically we live you roughly about 30 years to forty's and then we

pass because then the resources can be said for you to your generation. however, right now life has changed due to technology advancement. we have the resources to support more people. so this is sort of a philosophical argument as well as biological argument. so, so usually we have a strong agree that we could reverse aging because this is obviously reverse aging or expand live is a long dream over several centuries. but we, in the past, we failed. but however, when i was a ph. d student at university of california, san francisco, one of my favorite professors cynthia, came in, wanted to expand, extend the life spam starting from a little worm known as c elegans. so these worms lived for 2 weeks

and then what she did is she asked if she could extend the life span of these worms when she introduced gene mutations. as you could imagine, i was skeptical at 1st. however, shockingly, she did it, she and other colleagues of the other scientific field found that she and they were able to double the worms, maximum life span. interesting, they, this extension is full for life span and how span not only do squirm flip twice as long the 2 weeks old worms, which would have been dead now appear useful and robust with robust movement. so and then install that would normally lead to brain, degenerative disease no longer did so. so then that would be the equivalent of a 160 years old in schumann. yes. right. it would be a really but healthy. well,

let me bring in pizza for one low, and i'll come back to guess. this is free to own on twitter. and i want you to understand what he's mission is coming over here to twitter on a mission to significantly extend huffy human life span. sadie is really important the, the, the was, it jumped out to me was healthy human life. i pay the what do you want to add also, so 1st of all, i will probably close out of option less thumb is increasing the depo a life changing. of course, um i do a 1000 years ago. okay. probably expandable after 30 years old. but now it takes 30 to 40 years old. just social nice or way addition to your typical so homework professions, find 40 years old when houses or when you're starting to, to, to, to decrease, excuse by apply or the last or how many peers. all right, almost doubling. it's not because too much decided to come along for all my life fun is because of to call gen social changes. it takes longer for us to develop,

to socialize, and that's why i would g somehow combine it in such a way that we do like our development on waste time. but we're life amount of things. just knowledge of groups that are a life, some even more. so you're asking about vision. important things here is that humans too much company page can be young can for you, or they can be open for help with this plan with them that is age. so age is kind of normal, so nobody, you know, develop stops, the gymnast agencies like that. but if you have diseases, you'll have medical interventions. so i think the data context that there's a cutting right now is that people start to get aging prior dakota until the disease and what we're going to do, everyone is to so aging before does it stop purchasing us? they bought some features that phone, facebook, we are a function regular, so i thought we were unfortunately, so she is a back, a moment, easiest, most mostly in physics, as colton. topic is mostly not the deductible, is where they have to go to my uncle bill,

which is pretty low century concerns for any most important thing because i can just offer age as someone most of my interests are stopping. i think somebody will stop wages and maybe a few minutes here, something major revolution. i must apologize for now. i have to use all day reliable biotechnology and i'll just will stop agent right now on to the doors about this topic right before she use it. let me just bring in a voice from out poor to community. this is aubrey. the grey, as she talks about what one of our biggest challenges right now as a human race is this is aubrey told us that yeah, more than 100000 people die of aging every day. and they do so after a long period of debilitation and decline. and now vice is the number one problem across the world, even in the poorest countries of the world. because every country has an average life span of at least 50 now. so we absolutely must address it

with that i can say, and i'd like to say, but we're all making progress, but we need to make progress much more rapidly. we're getting some really interesting questions, andrew, on youtube. i can also take on this one. and one of of us as a key part of a healthy life is being able to accept via thanks to ality of death, trying to take away into a tunnel you for being a move tool is a waste of time, a fast. i don't waste of us trying to maybe be a sue, a spiritual, pow wow. rob's and accepting that with me, humans that so treated as like, no, i'm sure you're noting. so i'm going to get this a very quickly to have that conversation with with some of our peers i'm doing. he stopped putting you guys 2nd. yeah, i think that this is a very common question like actually, and i can completely understand where people are coming from when they ask this. but the challenge is that when you're thinking about treating aging, most of us on super interested in and we'll tell it to you and i go over some

generally sweat off and ask about actually what we care about as this, with me mentioned earlier, it's health spine it's about the amount of your life that you can spend free from disease. so gonna come so as a disease essentially caused by the aging process. heart disease is essentially caused by aging. stroke out time is dementia. all of these diseases, the leading candice, the leading causes of suffering as it will be mentioned in the modern world are caused by this process as biology that we call aging. and so we want to tackle the aging process to remove that suffering. and people will live longer because they don't hang on well as a result. and she necessarily think that's a bad thing. i think you know, death is a tragedy. there is, um, you know, you never go to a funeral and say, oh my god on go have they died. it really gave that life, meaning i use it just to so a story that we tell ourselves to try and justify the fact that we do, you know, we do eventually go out and die. and i think that as we, you know, we do have to accept that human beings, but we shouldn't accept the suffering that comes along with it. and that's what aging biologists really care about. basic i had, i was just, uh,

think about the world in which uh, national, just uh can i start the quote on those quote uh, leave for another 10 years more display stories. i ended up in europe another as a forwarding domain. i think today would be fine too much over. it just ends you some time of booking about 1005 extension to well think about the world where steve jobs probably for another 10 years. i think what the agent essentially uh did you say how the most successful or professional uh from us uh, those guys have own change. so the total complete value traditionals, which means. busy agent, uh, think solid commercials for you. what was your flight creepiness from the wall? it's not true. the under the personal decisions also huge economic things. and also guys, look, we don't die. so i'm kind of your wrestling. this is just as much as you would. you'd reason they'll die from jumpstart, as, as much as we used to have as the you're, you're still do, but think about dimension. and then just think what happens if it don't stop agent

kind of what would be the amount of truth on some software at all. let's towards this fantastic african problem that whenever someone dies, a library buttons, i just really captures the fact that, you know, all of this knowledge is wisdom is accumulated in life experience or the social connections. everything just up in smoke. i mean, not really to crystallize is what people are saying or what is human tragedy of aging. and yeah, because of the oil tradition of some traditional societies. well that hopefully you pass that on to the next generation. so your library lives on in a younger generation being let's be very specific about what is being done right now. that is relevant to us aging in terms of drug technologies and research. what he told us about the one getting an extra, like doubling life span. but when not once, so was going to help us write now. hi. oh,

great question. so what i was trying to say is to stop 18 or extend the life span is possible. this work was done 30 years ago. and as my colleagues have already told you about, there is a lot of work that has been done to extend healthy spend in animals. there is no reason to believe that humans, we don't work that way because in many other circumstances, we humans just use the same kind of tool as and more that is to say, right? but what is the actual research that's being done? so we understand that there's certain animals that get older, but they don't age a well, you've managed to double it sliced by. well, what about us right now as an aging population around the world? what is that for us right now? so they are, all right, let me, let me get, let me, let me have a little chat with me and then i'll come back to you. so of course,

they are several ways to answer these questions, their potential medication interventions. there are also a lifestyle interventions. so with a common goal to reduce the disease of aging, the burden of disease of aging. so which are heart disease, cancer stroke, dementia frailty, also preserve per process and increased propensity for infection and so on, so forth. right now, the medications potentially that are not necessarily approved or anything and then more work needs to be done. the intriguing, intriguing possibilities are related to animal medication known as met foreman, which is a n t diabetic medication by certain retrospect, to studies in the literature. it appears that it would potentially reduce the propensity to develop heart disease, cancer, and so on, so forth. currently,

there is a large truck back to clinical trials that is being planned on to formally addressed if this medication can be really reversing. h with other studies including medication, no nets from mice in which has being shown to affect aging in animal models. so those are just, are we talking about mice? thing are we talking about next to mice can become, i'm sorry, it was none of these makes no perfect. what can we, i to be formally proven to delay aging in humans. yeah. those are interesting. be that research community following through. all right. piece out. what do we have right now? what are you working on right now to extend a healthy human life span? oh, i just, i wanted to bring up this edition study month,

which is called part of yours is where it was full and the picture can connect us up ration system. so if you don't come to the mice will trap a situation, whether elder of orange to get the younger and the unfortunately, the younger marshes, just molder. so that clearly factors are someplace in practice in my block of mice, at least that could be associated as agent question. do you want control age which i've been using, right. you. busy sense of humor, of blood samples. and we identified the fact that they should have moved from the shop collision naturally stand slash from the mice. and forget to just tell them that you monday or don't have to have a pool that this was for consumers as well. but essentially what impact or engage was a mattress and one big crowd to share of the younger blocked, at least so welcome from from college of co solutions that are going to do what are some crunch, getting stage and produce literate in life. all right, preachers you what to hey, angel is making a face, thought it was a good face or 5 face. articulate your face, andrew guide. there was

a good face. i'm very excited by this stuff because we have literally thousands of ideas on the table. and the way to i often try and write these down is to think about something called the hallmarks of the aging process. i know it's because biologists finally have some really strong ideas for the on, depending. so you not my life cannot biological mechanisms because us to grow old. these changes in our biology that happened as we age on the pin. the whole gamma of age we like to change is not just the cancer with heart disease of the story from the dementia, but also the ring cause the grey had frailty, that incontinence. all of these different things that happened to us as we get older, are fundamentally caused by some collection of biological changes. so to give them a concrete example, one of these hallmarks is accumulation of what i called the semester so semester. it's just a so technical term for old and these are cells i've been speaking with the current of your body for a long time. and as a result they've stopped dividing. yeah, i want to always on task sticker, 100 nation. can you, can i show a few 1000 that? yes. all right, hold tight and that one get these are pick up off the back of this video. this

video came from a bio take organization. they're trying to make a book on drugs to stop senescence. and andrew is just about to explain what some essence is. but next let the animation do that as i've look you may not feeling good as to body agents. it can be an accumulation of malfunctioning so school semester, which is like a link to many common age related disease. as these things have cells and they begin to nod quantities of full protein, causing inflammation, tissue, a differential west of underlying conditions, etc. rate tissue damages disease. so i'm really proud of, i know what significance is and just please continue to select the yes and the animation shows you what's going on inside all of our bodies. all of the time the semester is how it's coming to being. now you might think it's weird why the cells and not potty imaging this talks it comp time with molecules if you now think

excellent. all right, smart truth might be oh that the aging process. the answer is, according to the mean system to assign higher, hey, i'm a dysfunctional, wholesale can you come and, you know, clean me up and then a young person, do you mean system is very effective? it comes in clears out the semester itself is not a problem, but as we get older, the cells accumulate more and more quickly. and also one of the other hallmarks of aging is a reduction in the efficiency of our immune systems. and we've all seen already. you know, tremendously powerful example of this in the last few years when we saw how much older people were much greater is deceptive of di from a disease like carrying a virus because our main system is a week or less able to find that often unfortunately. but the immune system is also i, i could sort of a police force within our own bodies as well clearing out the scent sense house. and this might be a very depressing story, sondra. so we're going to find some cause of aging. but the good news is scientists of also identified something that we can do about it, which is that we can give these things we'll send out electric drugs. these are drugs that kill this and i some cells believe the rest of the sounds that the body intact. and scientists are given these to mice industry. and what they found was they basically made these mice biologically younger. sorry parents a bit longer,

which i guess is a good start if you're trying to start on the aging process, but not stretching out the frailty at the end of life. these animals that they get us disease, they get less cardiovascular disease. so that comes to the fuel, cataracts, of that, less frail and a healthy a. so if you stick them on a treadmill and then the mice and this time you must always treatments or using the experiment can run further in foster on this treadmill, often by taking the drug that appears to slide on cognitive aging. and frankly, it's worth doing a web search, or some of these are some pictures of these animals because you do not have to be an expert to see that the animals that have this, in essence, how treatment i just looked fantastic. because take effect on this gray effect upon skin based this looks like how do we, or fantastic looking mice running around. all right, i and i want to bring in the voice of charles brenda because we've been talking about how are we able to look at as was anti aging. what is that out there? and charles wanted to make this point. let's bring him in and then we can talk about it personally. aging is it normally process required to convert fertilize

a to a mature reproductively capable. adult agent is not a disease. you're going to age better with good nutrition being mentally and physically active. and basically falling mob suffice, you can age worse by whole reading, drinking smoking, taking non prescribed drugs being violent situations. unfortunately, there's an incentive structure in science that has rewarded height in the anti aging space. and it is not at all clear that one can directly target the aging process as a drug approach, despite what's your viewers may have heard. so is that it tells contradicting evident we've been talking about the trucks con, help us just, i'm just going to get you to do to also read it briefly cuz i've got some questions as well for my view as me. but yes,

what charles has been mentioning is a very good point in the sense there are some pharmacological interventions, but most probably more importantly would be lifestyle interventions. and so what i'm seeing here is about certain diet, certain size activities, not no talk sense, including smokes, better, sleep, a good amount of stress, but not bad stress. yeah, social functions and so on and so forth. okay. my, i mean, as long as i've got some questions for my views and they really came to, to what you could just read in spots and thoughts. this one nice for you piece and again, very quickly on youtube. how much will this cost? is this kind of technology available only for the wealthy pizza instant reaction go ahead as well. it did not the. busy cost to launch the cost you a customer in the customer, then they don't customers think about that. quite honestly, for 20 years, 10 years is required to do your clinical trials. 10 years plus these will be

a genetic buck with no cost. okay. all right, this one i know 1st question andrea, what are the possible psychological and emotional effects of living? don't go on. definitely bolton, anxiety, depression, this one is going to andrew, i'm just going to say 30 seconds the whole time 100. i think this is so he just dramatically ever played actually because we think it's going to be this huge transformation of the human condition. but i just want you to think about how you conduct your everyday life. how many of your plans are predicated on the fact you're going to die in 20 or 30, or 40 years in the future? people to obviously cited for time and i've got pension, i think mostly we live, i live some day today. if we happen to be healthier for longer, our friends and family were healthier for longer. this would be a fantastic thing. we've just carry on living our lives as we do now. and i bridge and get this idea of getting bored holes much water. all right, you made me so here's my, me saw piece of we are out of time, but it's over us from was conversation i so much more to talk about much more research to take and really appreciate you. being peter and you and view as on

youtube, for your excellent questions, i'll say next time, take care of your body, the, the the, the, the account zone. how does the gun do you subscribe symbol? you said what the discount. so it's a full, the 50 percent wants to say every day you've already made plans to make an

appointment to subscribe. today. he's probably the code summit 2023 plus the stripe or the tub. the tub in the what the voted to the working class of his hometown and the 12 foot building legend added tons and introduces this piano looked at how one of a time seek this dog buys funds, research and saw you as, as many goes against it least for pulling a lead football rebels on, i'll use the how do you think of control information controlling the narrative to dominating the media? how does the narrative can pull public opinion and kind of norma spite? it might not be the most important story about china of today,

but that's what the big piece attention to. how is citizenship listen replacing the story. the listening post, i fixed the media. you don't cover the news because of the way the news is covered . the for you, as president obama in arrives in the u. k, as he thinks is criticism from nation members or the he's plans just in class to bones to ukraine. the hello, i'm emily anglin. this is l g 0 live from jo. how so coming up soon? as he is president denies racism in dealing with my friends as hundreds of black.