that they've been submitted to use given that's not just the but around it and the nets, they are allowed to use the work as well. it allows them to handle the still perfect . i'm going to be in need of the government. you know, the n g o is have really looked at the social side of this vehicle. they say we're going to do this. i was just thinking of themselves and the quit a note about the fishing community and asking, what are those families going to live on? now the mexican government announced that the no fishing area will be enlarged. evict treats of the scientists a further lifeline to the bi. keep the an a problem for fishermen. you say they're already struggling. don't homan out to zeta simply pay mexico to enter that uses should soon be even best to connect it off to the latest last off. 22 stall and look into that fast. lots of noise from cape canaveral in florida. they'll be important to know a little bit to join the space 6 many satellite network 11 was best intimate

worldwide. the hello again. i'm elizabeth ronda mendoza with the headlines on challenges here on us. president joe biden is headed for 10 donnell street where he can meet you. k prime minister virtue. so nack laser on monday, had a key nato summit this week. biden's trip to europe will be dominated by the gathering in virginia and, but shown solidarity with ukraine. 6 people have been killed in an attack, and another ended at a kindergarten in china. the incident took place and long donald province move of hong kong. a 25 year old suspect has been taken into custody for questioning. tennessee, as president, has rejected allegations that his government, as most recent black african migraines, as hundreds, remain stranded at the border with libya. they were detained by security forces

following anti migrant protests. but you, what it says to dawn is on the brink of a full scale of 7 pool and the conflict could, the stabilize, the entire region is strong. something to port itself of the capital. as the sudanese army and rapid support, power military forces continued to fight or tuesday march the 28th anniversary of the strep and its a genocide. bosnian serb forces killed $8327.00, mostly less than men and boys taken shelter in a un safe haven in the small town. in sarajevo, capital of bosnia and herzegovina, hundreds lined the streets as a trunk carrying says he, constance of newly identified victims, past new york states has on federalist because of heavy rain homeowner's recorded video is tons of water publish the properties. and so much cons, a southern japan has seen some of the heaviest rain ever recorded that the stream

is coming up basically out of teams. does the un fits the purpose was like many critics sites, just pump solutions doesn't get anywhere near enough done to the amount of money that is put into it. hard hitting in to be this. do you think look to their lives on washington enough for money to go on its own and built it's on thoughts providing on for centuries, people have been taken care of are. so i have every confidence that future generations will do it as well via the story on told to how does era the high end. funny. okay. sad to watch and the stream that is a wholesale to say you a and biotech research that is dedicated to i have a slowing of stuff in aging. what would you like for me like if we didn't age, is that even at the co? but we have a panel of experts, so that's kind of what scientists you are going to be here to answer your questions

and your concerns. you can put your comments right here in the comment section on each time from the age of point 76 for every 3 years, a year by age 277. that is to get like october, november, december, free. for the most i do age, the progress is to reimburse the agent that has happened so that i can be to stay in biological age. we all know how much money that our bank account we don't how much we way we know how many social media followers. yeah, but we don't know our speed of aging. but how fast are you a unit? if you had an aging point, like your bank account would, you spend a certain way is if we have asian points, we have an a bank account, then society could shift instead of us saying we're going to be a martyr or wealth or status or whatever would it change and that balance a little more be about 2 minutes and we become an excess about when he becomes this b. c. acknowledge that was brian johnson. he has, he's 45 years old,

but he really wants to achieve apply logical buddies of 18 years old. is it possible to stop aging or with this aging? joining us to discuss this, we have mingo, as a physician, scientists and directors, the aging center, the university of california, los angeles, with us from bell, great stub yet pizza fetish of founder and chief science officer. at jarrett, i am joining us from berlin. andrew, still scientists right to an over the age this the new science of getting older without getting old. is that possible? i'm good. always chasing somebody that actually is it possible web phone? we live a certain amount of time with age of, with fortunate enough to live long enough and then we die. how can you disrupt? i think the most important message i want people to come away with tonight is this isn't science fiction that can sound like science fiction. and i think the best way to demonstrate that is, well, let's think about what i think is best if you're

a human being your risk of death doubles about every 8 years. this is because of the increasing risk of diseases like cancer and heart disease and stroke, the leading killers in the modern world. as that means that maybe at the age of 37 i've got, i won a 1000 shots dying this year. i'm not quite like those ons, but unfortunately counting on doubling and doubling and doubling a number, it can eventually get very big very quickly. so if i'm lucky enough to live into my ninety's, i'm lucky enough that we haven't made any breakthroughs, nation biology, and the intervening time my risk of death and one of those years will be one in 6 months of life and death of the roll. the dice, i'm sorry, the statistical definition of aging is doubling of mortality, right? every 8 years. that's one way of understanding the aging process. but if we look around the animal kingdom there on the most, he's risk of death. it doesn't change them out a whole day all around a most like tortoises, certain kinds of paste and kinds of liquids like solemn on this. these are capable of living, but they apparently don't get old. they can literally get older without getting old . and so i think there's no reason biologically, according to the laws of physics, while we couldn't apply the same piece to watch to we age name,

that's certain questions that come up in this conversation that we don't need to ask ourselves. we just accepted. what do we age? what is the scientific reason the humans aging? well, there are many ways. it's just that, oh, pick out i'll come, i'll come right back to me. i'm going to get me go 1st and you go 2nd fence. this me? yes. so there are multiple reasons that we would potentially, when it gets aged. so one is biological reasons. so there are machinery in our body, no longer works so well, because we pay attention to for taylor t. so from a lucian already standpoint to we humans as a speech, these are the most important it's activities of life to propagate. after certain propagation that are there is no strong evolutionary drives to keep us.

wow, because historically we live, you roughly about thirty's to forty's and then we pass because then the resources can be said for you to your generation. however, right now life has changed due to technology advancement. we have the resources to support more people. so this is sort of a philosophical argument as well as biological argument. so. so usually we, yeah, i strongly believe that we could reverse aging because this is obviously reverse aging or expand live. yeah. is a long dream over several centuries, but we in the past we failed. but however, when i was a ph. d student at university of california, san francisco, one of my favorite professors, cynthia, came in, wanted to expand,

extend the life spam starting from a little worm known as c elegans. so these worms lived for 2 weeks. and then what she did is she asked if she could extend the life span of these worms when she introduced gene mutations. as you could imagine, i was skeptical at 1st. however, shockingly, she did it, she and other colleagues of the other scientific field found that she and they were able to double the worms, maximum life span. interesting, they, this extension is full for life span and how span not only do squirm flip twice as long the 2 weeks old worms, which would have been dead now appear useful and robust with robust movement. so and then install that would normally leaves

a brain degenerative disease no longer did so. so then that would be the equivalent of a 160 years old in schumann. yes. right. it would be a really but healthy. well, let me put in pizza for one low, and i'll come back to the guest. this is free to own on twitter, and i want you to understand what he's mission is. come over here to twitter on a mission to significantly extend huffy human life span. sadie is really important the, the, the was, it jumped out to me was healthy human life. i pay the what do you want to add also, so 1st of all, i will probably close out of option less thumb is increasing the depo a life changing. of course, um i do a 1000 years ago. okay. probably expandable after 30 years old. but now it takes 30 to 40 years old, just so to socialize a way. additionally, it's in the goal. so how i professions find 40 years old. when houses are we are starting to, to, to, to decrease,

excuse by apply or the last or how many peers our life from almost doubling. it's not because too much decided to come along for all my life fun is because of to call gen social changes. it takes longer for us to develop to socialize, and that's why i would g somehow combine it in such a way that we do like our development on waste time dollar life amount of to use just knowledge of groups that are a life some even more so you're asking about vision, important things here is that humans too much company age can be young for you, or they can result in, sorry what his plan with him that is age. so this is kind of normal. so nobody, you know, develop stops, germs, agencies like that. but if you have diseases, you'll have medical interventions. so i think the data context that there's a cutting right now is that people start to get aged prior. they couldn't solve the disease of what we're going to do. everyone is supposed to so aging before diseases stop purchasing those. the important features that phone facebook, we should be able to select all we, we unfortunately. so she is

a moment easiest most mostly in physics is colton. topic is mostly not the deductible, is where they have to go to my uncle bill, which is pretty low century concerns for any most mapleton painters that can just off wage. as someone most managed to stop it, i think somebody will stop waging and maybe a few minutes here, something major revolution. i must apologize for now. i have to use all day reliable by technologies, and i'll just will stop agent right now on to the doors about this topic right before she use it. let me just bring in a voice from out for the community. this is only the grey ad. she talks about what one of the biggest challenges right now as a human race is this is aubrey told us that yeah, more than 100000 people die of aging every day. and they do so after a long period of debilitation and decline. and no rush is the number one problem across the world,

even in the poorest countries of the world. because every country has an average life span of at least 50 now. so we absolutely must address it. with that i can say, and i'd like to say, but we're all making progress, but we need to make progress much more rapidly. we're getting some really interesting questions angel, unusual like an alternate to take on this one. a one of us says a key part of a healthy life is being able to accept via things to while a t of deaf trying to take her away into a tunnel you for being a move to is a waste of time, a best. i don't waste of us trying to maybe be a see a spiritual power rosalyn accepting that with me. humans that subject created is i know i'm sure you're nothing. so i'm going to get this a very, very quickly to have that conversation with, with some of our peers, andrew, he stopped putting you guys 2nd. yeah, i think that this is

a very common question like actually, and i can completely understand where people are coming from when they ask this. but the challenge is that when you're thinking about treating aging, most of us on super interested in and we'll tell it to you and i go over some generally sweat off and ask about actually what we care about is this with me. mentioned earlier, it's health spine, it's about the amount of your life that you can spend free from disease. so when it comes to is a disease essentially caused by the aging process, heart disease is essentially caused by aging, stroke outside of dementia. all of these diseases, the leading candice, the leading causes of suffering as it will be mentioned in the modern world are caused by this process as biology that we call aging. and so we want to tackle the aging process to remove that suffering. and people will live longer because they're not going on well as a result. and i thought she necessarily think that's a bad thing. i think you know, that is a tragedy. there is, um, you know, you never go to a funeral and say, oh my god on go have they died. it really gave that life meaning. is it just a story that we tell ourselves to try and justify the fact that, um, we do, you know, we do eventually go out and die. and i think that as we, you know,

we do have to accept us human beings. but we shouldn't accept the suffering that comes along with it. and that's what aging biologists really care about. basic i had, i was just, uh, think about the world in which uh, national, just uh can i start the quote on those quote uh, leave for another 10 years more display stories. i ended up in europe another as a forwarding domain. i think today would be fine too much over there. justin gmc time of booking about 1005 extension to well think about the world where steve jobs probably for another 10 years. i think what the agent essentially uh, did you face out the most successful or professionals uh, from us uh, those guys have own chunk. so to, to complete video traditionals, which means. busy engine, thanks our was held for you. what was your flight creepiness from the world? it's not true. the under the personal decisions also huge economic things. and also guys, look, we don't die. so i'm kind of your wrestling. this is just as much as you would.

you'd, we'll die from jim, so as, as much as we used to have as the you're, you're still to think about dimension. and then just think what happens if it don't stop agent kind of what would be the amount of truth on some sort of around let's towards this fantastic african problem that whenever someone dies, a library buttons, i just really captures the fact that, you know, all of his knowledge is wisdom is accumulated in life experience or the social connections, everything just up in smoke. i mean, not really to crystallize is what people are saying or what is human tragedy of aging. and yeah, because of the oil, which addition of some traditional societies well that hopefully you pass that on to the next generation. so you will, library lives on the, in a younger generation being let's be very specific about what is being done right now. that is relevant to us aging, in terms of drug technologies and research, what he told us about the one getting an extra, like doubling life span,

but when not once so was going to help us write. now i have a great question. so what i was trying to say is to stop 18 or extend my spend is possible. this work was done 30 years ago. and as my colleagues have already told you about, there is a lot of work that has been done to extend healthy spend in animals. there is no reason to believe that humans, we don't work that way because in many other circumstances, we humans just use the same kind of tools and more. that is to say, right, but what is the actual research that's being done? so we understand that there's certain animals that get older, but they don't age a well, you've managed to double it sliced by. well, what about us right now as an aging population around the world?

what is that for us right now? so they are better let me get, let me, let me have a little chat with me and then i'll come back to you. so of course, there are several ways to answer these questions. there a potential medication interventions. there are also a lifestyle interventions. so with a common goal to reduce the disease of aging, the burden of disease of aging. so which are heart disease, cancer stroke, dementia frailty, also preserve per process and increase propensity for infection and so on, so forth. right now, the medications potentially that are not necessarily approved or anything and then more work needs to be done. the intriguing, intriguing possibilities are related to and then medication known as met foreman, which is a n t diabetic medication by certain retrospect,

to studies in the literature. it appears that it would potentially reduce the propensity to develop heart disease, cancer, and so on, so forth. currently, there is a large prospective clinical trials that is being planned on to formally address if this medication can be really reversing. h with other studies including medication. no that's from mice in which has being shown to affect aging in animal models. so those are just, are we talking about mice? mean, are we talking about 2 mice can become no none of these makes no perfect. what can we, i to be formally proven to delay aging in humans. yeah, those are interesting. be that the research community following through. all right, piece out, what do we have right now?

what are you working on right now to extend a healthy human life span? oh, i just, i wanted to bring up this edition i study month, which is called part of yours is where it was full and the picture can connect us up ration system. so if you don't come to the mice, compare frustration whether elder of orange does it to younger. i'm the unfortunately, the younger more she's just molder. so that clearly factors are someplace in practice in my block of mice, at least that could be associated with those aging questions that you don't control age which i've been using for very much. busy sense of humor, of blood samples. and we identified the fact that they should remove from the shop collision naturally stand slash from mice and forget that just television that you monday or don't have to have a pool that this was worth, and humans as well. but essentially what impact or engage was a mattress and one big crowd to share of the younger blocked, at least so welcome from from college of coastal ocean stuff. going to do what are

some french getting stage and produce literate in life? all right, preachers you what to, hey, angel is making a face, thought it was a good face or 5 face, articulate your face under guide. there was a good face. i'm very excited by this stuff because we have literally thousands of ideas on the table. and the way to i often try and write these down is to think about something called the whole marks of the aging process. i know it's because biologists finally have some really strong ideas for the on, depending. so you not my life cannot biological mechanisms because us to grow old. these changes in our biology that happened as we age on the pin. the whole gamma of age we like to change is not just a cancer with heart disease of the story from the dementia, but also the ring cause the grey had a frailty that incontinence. all of these different things that happened to us as we get older are fundamentally caused by some collection of biological changes. so to give them a concrete example, one of these hallmarks is accumulation of what i called the semester so semester is just as a technical term for old. and these are cells. i've been speaking with the current of your body for a long time. and as

a result they've stopped dividing. yeah. and when i still, i'm always on task sticker, 100 lation. can you can i show it if it's out. so next yes. all right, hold tight. and then i'll get, these are pick up off the back of this video. this video came from a bio take organization. they're trying to make a book on drugs to stop senescence. and andrew is just about to explain what some essence is. but next, let the animation do that as i've look you may not feeling good as to body agents, it can be an accumulation of malfunctioning so school semester, which is likely to many common age related disease. as these things have cells and they begin to nods quantities of full protein, causing inflammation, tissue breakdown, a differential west of underlying conditions, etc, right? tissue damages disease. so i'm really proud of, i know what significance is and just please continue to select the yes and the

animation shows you what's going on inside all of our bodies. all of the time the semester is how it's coming to being mnemonic, it's weird why the cells not potty imaging this talks it comp time with molecules if you now think excellent. all right, smart truth might be oh that the aging process. the answer is, according to the mean system to assign higher, hey, i'm a dysfunctional, wholesale can you come and, you know, clean me up and then a young person, do you mean system is very effective? it comes in, clears out the sinister cells. there's no problem as we get older, the cells accumulate more and more quickly. and also one of the other hallmarks of aging is a reduction in the efficiency of our immune systems. and we've all seen already, you know, tremendously powerful example of this in the last few years when we saw how much older people were much crisis, deceptive of di from a disease like carrying a virus. because our main system is a week or less able to find that off unfortunately. but the immune system is also i, i could sort of a police force within our own bodies as well clearing out the scent sense house. and this might be a very depressing story. sondra so identified some cause of aging. but the good news is scientists have also identified something that we can do about it. which is that we can give these things called the senate electric trucks,

these and drugs that killed us and i some cells believe the rest of the sounds of the body intact uncertainty. so given these to mice industry and what they found was they basically made these mice biological younger site a little bit longer, which i guess is a good start if you're trying to site on the aging process, but not stretching out the frailty at the end of life, these animals that they get us disease, they get less cardiovascular disease. like i said, i comes to like a few cataracts that less frail to help you. so if you stick them on a treadmill and then the mice and this time, you must always trick when we start using the experiment can run further in foster on this treadmill, often by taking the drug that appears to slide on cognitive aging. and frankly, it's worth doing a web search, or some of these are some pictures of these animals because you do not have to be an expert to see that the animals i've had this in essence how treatment i just looked fantastic. because take effect on this great physical part of the skin based this looks like how do we order, fantastic looking mice running around. all right, i and i want to bring in the voice of charles brenda because we've been talking about how are we able to look at as was anti aging. what is the outset and charles

we need to make this point. let's bring him in. and then we can talk about it personally. aging is it normally process required to convert fertilize a to a mature reproductively capable. adult agent is not a disease. you're going to eat better with good nutrition being mentally and physically active. and basically falling mob suffice. you can age worse by over eating, drinking smoking, taking non prescribed drugs being violent situations. unfortunately, there's an incentive structure in science that has rewarded height in the anti aging space. and it is not at all clear that one can directly target the aging process as a drug approach, despite what's your viewers may have heard. so is that it tells contradicting evident we've been talking about the trucks con, help us just,

i'm just going to get you to do to also read it briefly cuz i've got some questions as well for my view as me. but yes, what charles has been mentioning is a very good point in the sense there are some pharmacological interventions, but most probably more importantly would be lifestyle interventions. and so which, pressing here is about certain diet, certain ties, activities, not no talk sense including smokes, better, sleep, a good amount of stress, but not bad stress. yeah. social functions and so on. and so for okay, nice or i mean as long as i think some questions for my views and they really came to talk because you've read in spots and thoughts. this one is for you piece. and again, very quickly on youtube, how much will this cost is this kind of technology available only for the wealthy pizza incident reaction go as, as well it did not. busy cost a lot,

the cost you'll have to make the customer spending on customers. think about that quite honestly, for 20 years. 20 years is required to do your clinical trial since 20 s plus. these will be a genetic buck with no cost. okay. all right, this one i know 1st question, andrew, what are the possible psychological and emotional effects of living longer on? definitely bulletin anxiety depression. this one is going to, i'm just going to say 30 seconds the whole time 100. i think this is so he just dramatically ever played actually because we think it's going to be this huge transformation of the human condition. but i just want you to think about how you conduct to your everyday life. how many of your plans are predicated on the front? you're going to die in 20 or 30, or 40 years in the future. people to obviously site for time and i've got pension, i think mostly we live, i live some day today. if we happen to be healthier for longer, our friends and family were healthier for longer. this would be a fantastic thing. we've just carry on living our lives as we do now. and i bridge, i think this idea are getting bored holes much water. all right, you made me so here's my me saw piece of we are out of time,

but it's over us from our conversation as so much more to talk about much more research to take and really appreciate you making pizza, andrew, and view as on egypt for your excellent questions, i'll say next time, take care of everybody. the the growing up in greece means taking action. welcome to generation change a playful series. it takes to understand,

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