news people think they are perhaps they knew it to the crisis, but it is very easy to bash, and rightly in many cases, when money is misspent or wasted, the ethiopian spice girls, wires and british taxpayers money, going to that. but it is important to cover the attempts to help people facing starvation. important to cover the attempts to help people facing starvationi important to cover the attempts to help people facing starvation. i am so help people facing starvation. i am so old i can remember the ethiopian crisis... you are not the only one! and british people are the most generous in the world, they are fantastic when it comes to situation fantastic when it comes to situatiggl this. but what worries you is like this. but what worries you is you are giving money to somebody who will put it straight in a swiss bank and it is not getting to account, and it is not getting to the tragic stories of this little girl who died, and does social media say that we get fatigue? the ft, trump calls for aesthetically

pleasing wall, this is the wall that will be built between america and mexico. what does aesthetically pleasing mean? i'm hoping that david hockney and banksy will go around their with their paint, and there can bea their with their paint, and there can be a mirror to donald so he can check his hair. it is a lovely idea that there will be less aesthetically pleasing wall. that is what it is all about(!) but there is a requirement for it to be built with american materials. yes, and it says here, only aesthetically pleasing colours and textures on the us side. it can be ugly concrete for the mexicans to look at. mexican was; '. the mexicans to look at. mexican balsiszis firms being the mexicans to look at. mexican luigi; firms being asked to builders' firms being asked to examine their conscience and not reply when asked to build it. we

will be back at half past 11 with another look at the pages with lucy and eve. and you can see the papers seven days a week on our website. there is something coming up next, it is meet the author. we know more about our genes than seemed possible only a few weeks ago, and the pace of research seems faster than ever. there's so much of the ethical problems that genetic discoveries are forcing us to confront. siddhartha mukherjee, who is a cancer doctor he wrote written what he calls: an intimate history of the gene. and it takes us form that history,

starting in a monastery garden 150 years ago, into a future where we are going to have to deal with the consequences of what we're beginning to learn about how we're made up and what makes us function. welcome this is a comprehensive history f? rza 15,5; 7:7;i3sizsaarcifis-srzeh— — ,,, and its implications, but it's also a deeply personal story, isn't it? yes, it is. you know, this book begins with an exploration of my own family and in particular a history of schizophrenia and bipolar really the book begins with the question, why? why me? am i susceptible? are my children susceptible?

and what happens, what do i do with that knowledge. let's trace the story from this monastery garden. yes. because it is quite remarkable. here's a chap playing around in his garden, and he makes a discovery, and it really is one of the landmark i would say it is one of the most important discoveries in modern science and we know very little about it. you know, we are taught about mendle, about greta mendle, we are taught about him in some kind of abstract way. he was a monk, in a garden, et cetera, yet from that little plot alone emanates virtually all of modern biology. you know, you can trace a line from that plot. all he could see in contradistinction to his priors across the biological world and it was moving like units. in a kind of, almost as if particles were moving. he didn't know what the physicalform was, what the chemical form was. no—one had even heard at that time, made the connections between dna and genes. and even the word, gene,

mendle didn't know. it was coined afterwards. if we race forward 150 years. we are all aware that the pace of this exploration speeded up in a way that, you know, whether you were born in the early 19705, would have been inconceivable. well, what can we do now? we can read, we can read the sequence of a genome. your genome, my genome, and the cost is plummeting. was about $3 billion—odd, now you can sequence, not the whole genome but the active part of the genome for about $1000. you could then, therefore, potentially sequence the genome of an unborn child. you see, this is the question that our children will be facing: should have i a genome sequenced? should i have the genome of my unborn child sequenced? should i do it even before i conceive? before implantation?

what you're talking about is a power that's produced by these discoveries... yes. which we have, and which human way, of a kind we have never known before? i mean the power is asjohn solsten, the great scientist, once said, what happens when a machine begins to decipher the own language of its construction? what if a machine could write its own manual? that's where we are now. we are machines that are learning to read and write our own manuals of instruction. you know, genes are not destiny. there's chance, there's environment. genes are a kind of constraint that place a constraint on chance and destiny. so i don't want to say that genes equal you. no. but what is important is that it is impossible to think about you without at least paying very, very serious attention to genes. of course, the moment we get on to this subject, people begin to think, in a nightmarish way, about, people who talked about eugenics in the earlier and middle years of the 20th century,

and you deal with this here, and in a way, that's the horror of where these things can lead? i do think that the gene is the defining idea of this new century. it is the most important and potentially the most dangerous the capacity to control genetics, either throughwhatrwescheosef= how we choose to read and write genomes is absolutely of importance. so i don't think we will go back to a state mandated eugenics project. ijust think it is very unlikely. but eugenics will become personal. you will make a decision about what kind of, in a very broad sense, about what to do about your unborn child's genome. so either we look away, or we confront, what i think is the most important and most dangerous idea of the 24st centurys= it seems to me we need a much wider conversation about this, much like the conversation that occurred when we learned to open up the energy and the atom, and the broader conversation is, who have experienced devastating genetic illnesses.

we need to ask peoples, you know, genes have the capacity, the ability to manipulate genes, they can have an incredibly important effects on the biosphere, you can make new kinds of animals and crops. you can make wonderful things like vaccines. you know, virtually all of the new vaccineses that are made today are using genetic technology. you can make new medicines that change the course of devastating illnesses. there's an incredible amount of good that you can use genes for, genetic technologies for. in your profession... yes. things must have changed hugely? i mean, and so much has changed. i'll give you a two examples, you know i see cancer patients, virtually every patient that i see has some aspect of their genetics, their cancer genes, sequenced and analysed and something in that information is used to direct their therapy. it was unthinkable ten years ago.

even ten years ago. we were doing it on small numbers of patients. virtually every patient that comes into my clinic has some aspect, some have their entire genome or the active part of the genome sequence, that is one example. a second example, we are beginning to take immune cells from patients, bring them out, culture them in test tube, genetically engineer them into human beings for leukaemias that were previously absolutely deadly, you can bring out a person's own... i mean think about that for a second, bring out a person's own immune cells, reengineer them, and make them specifically deadly killers to their own cancer, and now inject those cells back, all because, in part, down to genetic technology. what it boils down to is this: our expectations of life what life holds for us are changing extraordinarily fast as a result

of this, as we speak? absolutely. there's no doubt about that. and it will continue to change and in order to contend with it, it's at our doorstep, we cannot open the door without knowing its name, without knowing what its powers are, why schizophrenia in my family? why diabetes in yours? why huntingdon's disease in another person? why breast cancer in yet another family? how do we have the knowledge and the vocabulary? and the consequence of that is that we have to think about it and we have to confront it. absolutely. siddhartha mukherjee, thank you very much. my pleasure, thanks. good evening. we have been watching week good evening. we have been watching

a week weather front slipping its way south, and it extends quite a long way out into the atlantic. [gr]! wgy . i n. inf ‘klifi‘fr' ='" wet [gr]! lggy . i n. inf ‘klifi‘fr' ='" wet here, and there is increasingly wet here, and there is another area of wind and rain that is making its way into the west. in the southern half of the uk, many places holding on to double figures, but it will be turning that bit colder through the day on monday, colder through the day on monday colder throdgh the day on monday windy and quite as quite windy and quite unsettled as well, particularly through the morning. it will be wet and windy through the western side of scotland, the wind getting close to 50 mph so blustery conditions as the 50 mph so blusteryrcenditionsastbeac , ,, cc moves from west to east. quite wind moves from west to east. quite a bit of rain across northern england, down through wales and on towards the south—west, and blustery winds to go with 11535; along the winds to go with that. along the south coast, quite grey and windy, but largely dry, and the south—east

corner should start the day on a note in terms of reasonable note in terms of rainfall. that rain is on the move, moving its way from west east, so it will see wet and windy weather. still some relatively mild temperatures in the south—east, 13, 14 temperatures in the south—east, 13, 1a celsius, but back into single figures in the north and west, and thatis figures in the north and west, and that is the trend as we go through the rest of this week. monday evening, the caldaire moves in, started to see wintry showers getting going across parts of scotland, northern ireland and england as well. the caldaire will slowly creep all parts england as well. the caldaire will slowly creep - all parts as we slowly creep through all parts as we get into tuesday. feeling much set mm particularly in the wind, colder, particularly in the wind, and a good crop of showers around, and a good crop of showers around, and tuesday will start on a cold note with widespread frost and icy patches as well. the wintry showers will be a big feature i the day on will be a big feature of the day on tuesday, some sunshine but also some

wintry showers, many northern and western 3 333 not i wintry showers, many northern and western 5 not just wintry showers, many northern and western 3333 not just over wintry showers, many northern and western 3333 notjust over higher western areas, notjust over higher ground but lower levels at times well. a cold start to wednesday, further flaring? ” " well. a cold start to wednesday, further seiner? showers dotted further wintry showers dotted around, and called again to start thursday. this is bbc news. the headlines at 11pm: another warning over health service funding. a leading nhs executive says many trusts will struggle to meet targets. police arrest a man in east london over the murder of a one—year—old 152375523] 11535 5115321531 gut-15; , ,, , ,, a”, ,, ”7, a row over george osborne's latestjob as editor of the evening standard newspaper. it means the former chancellor has the suffering of the civilians survivors of islamic state now in desperate need of aid. and also in the next hour, the water main in derby that burst with such force it damaged houses and cars. residents said they thought a bomb had gone off as water crashed through their bedroom windows

in the middle of the night.