the prime minister's plan to break the brexit deadlock as she prepares for a major speech in italy tomorrow. theresa may is planning to propose a post—brexit transitional deal of up to two years — it could cost the uk £18 billion. a show of unity from the foreign secretary and chancellor, after a marathon cabinet meeting to discuss the plans. but the final brexit bill is likely to be higher. the eu says still major uncertainty over the uk's approach to brexit. also on the programme: almost 48 hours after the earthquake in mexico, rescuers say none of the children trapped in their school is alive. the women who took this epilepsy drug during pregnancy — calls for a public inquiry after thousands of children were left with autism and learning difficulties. why did it take for me to have four children before somebody finally sort of said, that child looks like it's got sodium valproate syndrome. cancelled flights —

but now ryanair‘s pilots are being asked to change their holiday plans because of a rota crisis. the lawyer mark loonie on a major step forward in the campaign for justice of the yazidi victims of so—called is. this is the story of a search for a dragon. and the man who's spent his life searching for the natural wonders of this world — we speak to sir david attenborough. and coming up in sportsday on bbc news, who knew what and when? the fa asked questions about why they appointed mark sampson to run the england women's team in the first place. good evening. theresa may will propose a transitional deal for the uk of up two years in order to secure a smooth exit from the european union. it is thought the plan could cost britain £18 billion. but the final brexit bill is likely to be higher.

the prime minister is expected to make the offer in a key speech on brexit in italy tomorrow. theresa may also wants continued access to the single market during that transition time and for britain to be able to negotiate its own trade deals. from florence, our political editor laura kuenssberg reports. this city might be an escape from westminster, yet the trickiness of our departure from the eu is no easier in a foreign language. and here on mainland europe, as at home, threats to theresa may lurk in many different corners. before packing her bags, she had to try to get her cabinet onside. after two and a half hours, an oh so natural display. look, we all smile and agree. is this your new best friend? very united, very good, all behind the speech.

mr cairns, will eu leaders like what they hear in florence? you'll have to wait and see. we don't have to wait for all the detail, though, the prime minister is expected to say for the first time explicitly the uk will seek a transition deal that could be up to two years long, after we leave the eu. she's likely to signal, too, she might be ready to offer 20 billion euros so that no other cou ntry loses out from brexit. but after we leave the prime minister will make clear again she wants a bespoke trade arrangement, not a model based on any other. remember in the referendum leavers promised we would get money back. but after a visit to number ten, this prominent eurosceptic sounds completely on board with paying, if only for a couple of years. we're leaving a big hole in their finances if we just leave. and if the european union is going to deal constructively with us and reach a sensible agreement,

well, then there are reasonable political and diplomatic reasons why we should help them. but in a transition the eu's top negotiator has been firm we have to pay and play by their rules. saying there are still big uncertainties around our approach. in government circles, though, there is hope this speech can unlock the eu impasse, that is why the plans have been carefully kept under wraps. and i have the british prime minister on the phone this afternoon, don't tell the public, because the public will not be told. but no more secrets on this speech tomorrow on how decades of membership, ties of money, of politics, will start to be phased out. there is much still for britain to decide, though, for the eu to discuss. this is still the overture before we finally depart. laura joins us now from florence. a

big speech tomorrow. how much do we know exactly about what the prime minister will say? i understand that theresa may will have a pretty strong message actually to the rest of the eu, basically saying it's not just britain but also them right across the continent have a responsibility basically to crack on, to get on with it. and while it's not that surprising that she is going to, for the first time, explicitly acknowledged there will bea explicitly acknowledged there will be a transition period, it is significant, coming from her lips, because it does mean that number ten is acknowledging publicly that there could be for five years after the referendum a long period of time where we are still paying into the eu and still playing by many of their rules. now of course that's what businesses desperate for, they wa nt to what businesses desperate for, they want to have that time so we don't suddenly crash out, so new systems can be set to minimise disruption, but politically, for many people who

thought they might have been voting to leave the eu and get it over with, acknowledging transition is something that some members of the public might find difficult to stomach. with brexit talks due to begin again next week, what impact could this have on the sticking points? the talks haven'tjust been the sticking point, they've basically been at a brick wall, because the eu hasn't wanted to talk about the future relationship because we wouldn't say that we would pay up. we wouldn't say that we would pay up unless the eu was willing to talk about the future. now, with this offer going on the table, the hope in government circles is that theresa may's intervention will be able to unblock that, and stick it, to start mashing some cracks in that brick wall, but as far as the eu is concerned talking about transition is something that is conjugated in itself and its the same at home as well. there's so much to hammer out and the hope is at least the talks due to start again next week will be able to get going, they will be able

to make some progress, but for some people they are already six months in and we are still in the foothills of all of this. laura kuenssberg in florence, thank you. in mexico city, the authorities say none of the children trapped when their school collapsed in the earthquake on tuesday has survived. rescuers had been in contact with a 13—year—old girl who was sheltering under a table, but they were unable to reach her. now the focus is on rescuing an adult in the school the country's president says there could be people alive in ten collapsed buildings. 273 people are known to have died and thousands more have been injured in the quake. aleem maqbool is there. the rescue effo rts aleem maqbool is there. the rescue efforts became all the more desperate in mexico city. volunteers have on the moments of hope but in all the confusion non—really knew what the ambulances were carrying away. any room of life in the rubble, the call went out for

doctors or more of the soldiers who have been deployed. the focal point became the school, with children and teachers missing. for a time we were given access to the schoolyard with rescue workers, right beside the collapsed three storey building. there was a dramatic moment where it was announced all efforts were now to be focused on a 13—year—old girl they thought they'd made contact with. then, one of the teachers from the school, who has been waiting here for hours, was called forward — what remains of the collapsed building, potentially a familiar voice for a trapped girl to hear. through the night rescuers worked at the site tunnelling through the debris and using specialist rescue cameras to locate those buried. it appeared someone was rescued overnight, but his condition is unknown. much of the news in the past 2a hours has been bad. it believed the body of a teacher was

pulled out. with seemingly all of mexico holding its breath for news from the school, an officialjust came out with a devastating announcement. that while all children have now been pulled from the rubble, there are more —— normal —— no more came out alive. the operation though continues because rescu e rs operation though continues because rescuers say they believe someone who worked at the school is still trapped alive. it's hard to move heavy machinery to move her —— to free her because of the risk of causing further collapse. the work is so delicate says the head of one rescue brigade. we have to do everything by hand, or chisel, with hammer or handsaw. if you don't, you could cause something very serious. volu nteers could cause something very serious. volunteers and experts came together at this school, giving traumatised pa rents, at this school, giving traumatised parents, the school community and a nation hopes that more children would be found alive in stock now though, that has all turned to a sense of grief, even more acute than

before. this time yesterday we were talking about that schoolgirl, we we re talking about that schoolgirl, we were told her name was freed. we we re were told her name was freed. we were told her name was freed. we were told that she was going to be out of the rubble within half an hour. of course, that turned into oui’s hour. of course, that turned into ours and we now know that she was never pulled out alive, but no more children were pulled out alive as well. we have confirmed the other couple of days ago that 11 children had been pulled out of the rubble since the earthquake, but it has remained at 11. i9 since the earthquake, but it has remained at 11. 19 children died in the school will stop just beyond the taped the icing me, and six adults we re taped the icing me, and six adults were killed. the operation does continue, there is thought to be one aduu continue, there is thought to be one adult still trapped in the rubble here, but the operations continue across the city as well. a short while ago the president of mexico, enrique pena nieto released a statement saying he believed there we re statement saying he believed there were people trapped alive in ten buildings across the city but it's because this school became such a symbol of this tragedy that it's really been so heartbreaking for so

many here and across this country that it's now been confirmed that no more children have been found alive. aleem maqbool with the latest in mexico city, thank you. it's a powerful and effective drug that's been prescribed for decades to people with epilepsy and bipolar disorder. but some women who were told to keep taking sodium valproate during pregnancy were devastated to find that it had harmed their children in the womb and they're now calling for a public inquiry. it's estimated that around 20,000 children have been left with physical and mental disabilities in the uk. it comes ahead of a europe—wide drug safety review next week. this special report from our health correspondent, sophie hutchinson. three—year—old alfie has only just learned to walk. he can't speak or point. he has severe learning difficulties caused by the epilepsy medicine which his mum natasha took while pregnant. sodium valproate has been prescribed since the early 1970s, but women say they're still not being told about the risks. there was nothing mentioned about valproate at all.

theyjust said, keep on the drug. i wasn't aware of any risks. you can do three things from that one. it wasn't untiljulie marjot's fourth child was born that she was told her pills had harmed three of her children. i think shock at first. numb. and then afterwards is laying in bed and just feeling guilty. her seven—year—old daughter, 11—year—old son and 21—year—old daughter have all been affected. as time went by and i had more children, we saw more paediatricians, we saw gps, we saw midwives, we saw all of these health care professionals. why did it take for me to have four children before somebody finally sort of said, well, that child looks like it's got sodium valproate syndrome. valproate medicines are an effective treatment for epilepsy and bipolar disorders, but babies exposed to it in the womb have a 10% risk of physical

abnormalities and 30 to 40% risk of autism, learning disabilities and low iq. warning signs about the danger of the drug emerged as early as the 1980s and increased in the ‘90s, but large studies were slow to follow up. it wasn't until 2005 that patient information leaflets included risks of delayed development in children, and only last year warnings were put on the outside of packets. these are some of the faces of the 20,000 children it's estimated have been harmed by sodium valproate in the uk, and the tens of thousands injured across the world. in france, 1200 families are suing the drug's manufacturer, sanofi. they claim it was aware of the risks and should have warned women. these red files are just some of the cases for the french trials. lawyers here say they give an indication of the huge scale of the harm caused by sodium valproate.

their lawyer showed me a sanofi document from 16 years ago which lists cases of children born to mothers taking valproate who had developmental problems, many of them in the uk. you can see uk, uk, uk everywhere. the french government is supporting the legal action and has also put aside around £9 million to compensate the families. but here, parents like emma friedmann have given up hope of a day in court. her 18—year—old son andy is severely autistic after being harmed by valproate. in 2010 andy's case was part of a class action. 100 families tried to sue sanofi but three weeks before the trial began, legal aid was pulled and the case couldn't go ahead. i believe the children have had justice denied. we need to have a public inquiry into what went on. why were the warnings

ignored with this drug? why wasn't further research done? why weren't we informed? who was responsible? sanofi declined to comment about the legal cases but said: despite being an effective drug, the valproate that natasha took is only meant to be prescribed to women of child—bearing age as a last resort, according to the uk's medicines watchdog. it's said it's kept the drug under constant review and updated warnings, but next week the european medicines watchdog will examine whether those warnings are actually reaching women and protecting children. sophie is with me now. this drug has

been taken by people since the 19705, been taken by people since the 1970s, so many children have been affected but very few people will have heard of it. it's astonishing this is more than four decades old but only last year were warnings put on packets. many say it's as if this tragedy was hidden in plain sight. it's important to stress that for a minority of women this is the only treatment they can take. doctors stress if they have a seizure in pregnancy there are very serious possible consequences. the women say because they weren't told of the risks they didn't have an informed choice to decide whether to have children or not. some even went to their doctors and said could they ta ke their doctors and said could they take the medicine if they were planning a family, and they were wrongly reassured the medicine was safe. now they have children that have irreversible life changing disabilities. now, tonight we've had m essa 9 es disabilities. now, tonight we've had messages from many mothers, one said pa rents were messages from many mothers, one said parents were crying at seeing their

babies on tv and that finally someone had listened. sophie hutchinson, thank you. and the advice if women are concerned about valproate is to consult your doctor. for more information and links to help groups, you can go to the bbc website. the boss of ryanair, michael 0'leary, has admitted that a "significant management failure" has caused the cancellation of 2000 flights in september and october. he told the airline's annual general meeting that pilots were now being told to postpone a week of their holiday untiljanuary. pay rises are also being offered in areas where there are recruitment problems. here's our transport correspondent, richard westcott. under fire for cancelling thousands of flights. michael 0'leary, ryanair‘s boss, admits to a significant management failure, but denies he is feeling the heat. more than 300,000 passengers have had to the company says most will be sorted by

the end of the week. it'll take longer to fix ryanair‘s reputation. i was obviously very angry, but there was nothing i could do. every year i say i'm not going to fly with them again because of the way they treat the staff and the conditions, the pay conditions. the company admits it messed up its holiday rotors to minimise the damage it has offered pilots bonuses worth up to £12,000 if they work extra days. some will have to reschedule some leave. but i've seen a letter supported by many ryanair pilots that says they want to reject all this extra money and they want new contracts instead. they complain about working extremely long hours for example, being called in at the last minute on their days off. they see this as a golden opportunity to improve the conditions at work. they are under a lot of pressure, the schedules changed quite a lot, they often are overworked, frankly. one member of staff rostered today, he has 45 hours and 15 minutes of flying in one week. pilots are in high demand

right now and rivals like norwegian have been poaching ryanair‘s staff. we have 500,000 pilots today and we need another 500,000 in the next 20 years. that is a global crisis. everywhere pilots are needed. and obviously a low—cost carrier who has traditionally, that is why it is low—cost, low salaries, is losing pilots. angry pilots keep telling me this is their big chance to get more secure contracts. but michael 0'leary doesn't have time to back down. if crews do pull together and take action, it could mean more cancelled flights for passengers. richard westcott, bbc news, dublin. facebook has said tonight that it will cooperate with congressional investigators looking at russian influence on last year's presidential election campaign. let's speak to our north america

editor, jon sopel, who's in washington for us. how significant is this? it is significant. after the eu referendum in britain, the phrase that gained currency was posed truth. 0ften that gained currency was posed truth. often in a presidential election last year it felt like we we re election last year it felt like we were going through no truth. social media was awash with advertisements masquerading as serious news stories. they were invariably fake. they were also in favour of donald trump and against hillary clinton, things like hillary clinton sold weapons to islamic state, hillary clinton has had her fbi officer murdered, involved in unmasking the e—mail inquiry. and in a surprise move donald trump gave the backing of pope francis. all of this had an impact because at the end of the election more people were reading the fake news stories than the real news, according to a survey. under

enormous pressure facebook is going to show the transparency it has often talked about and will reveal exactly where the source of those adverts came from, how much the russians paid, where they were all going. this will answer one question from the presidential election, the extent of russian involvement. the question it won't answer is what impact those fake news stories have on the electorate. that will still be hotly contested between trump supporters who will say it had no impactand supporters who will say it had no impact and the hillary clinton supporters who said it changed the election result. thousands of people have taken to the streets of barcelona after police arrested a number of key officials organising a catalan independence referendum in 10 days time. the spanish government says any referendum on a split from spain would be illegal. but tonight the leader of catalonia's regional government said he would defy the ban and push on with the referendum on 0ctober1st. 0ur correspondent, tom burridge, reports from barcelona. they have their own national anthem.

a language, widely spoken. catalans desperate to vote. in a referendum on independence that the region's devolved government plans to hold in just ten days' time. this, a key moment, because the spanish state is now using its power to try and halt the vote. we want democracy, police oppression, spanish oppression, wa nts to oppression, spanish oppression, wants to stop us from voting. moment that will be written in our history books. we're asking for democracy, that's all. human towers, pa rt democracy, that's all. human towers, part of catalonia's distinct

cultural identity. i've watched the pro—independence movement in catalonia in recent years as it was galvanised in the wake of the financial crisis across pain, pressuring the spanish government for a better economic deal for this region, or a scottish style independence referendum. but if spain has its way this is the only ballot box they will be seeing in the coming days. because last night spanish police raided the offices of the catalonian devolved government. tens of thousands swarmed outside of spain's civil guard police seized election material from the spain's civil guard police seized election materialfrom the regional economy ministry. trapped for hours, their vehicles parked amid the protest, the police eventually emerged. huge tension, minimal violence, but spain had made its move. 1a arrested, including senior

cata la n move. 1a arrested, including senior catalan politicians. as he warmed up in the czech republic, the hot political climate back home on the mind of one of spain's biggest stars. i love catalonia, i really feel from spain. so i can imagine correction macro can't imagine being without catalonia and catalonia without catalonia and catalonia without spain. i don't want to see it. but a night the leader of the catalonian government said contingency plans were in place, the referendum would happen. declaration of independence from spain, illegal or not, still on the cards. a brief look at some of the day's other other news stories. president trump has announced new sanctions targeting north korea. he said they would affect individuals and companies that trade there. earlier the south korean president told the un he didn't want to see the collapse of north korea. an inquest into the death

of the moors murderer — ian brady — has found that he died of natural causes. the 79—year—old died at ashworth secure unit in merseyside in may. the inquest heard brady frequently removed his feeding tube while on hunger strike, and did so a few days before his death but this was not a contributory factor. a 17—year —old has been arrested in thornton heath in south london by police investigating last week's attack on a london underground train — in which 30 people were injured. meanwhile a 21—year—old man, thought to be yahyah farroukh, has been released with police taking no further action against him. greenpeace protestors claim they've forced a cargo ship carrying volkswagen diesel cars to turn around in the thames estuary. campaigners who managed to get on board demanded that what they called "toxic cars" were taken back to germany. activists say they also scaled fences at sheerness in kent where thousands more vw cars are waiting to be distributed. the united nations is to launch an investigation into

the massacre of yazidis — a minority religious community in iraq — by so—called islamic state. the security council voted unanimously to set up a unit which will gather evidence of crimes by is. the international lawyer, amal clooney, who has campaigned to raise awareness of the genocide of yazidis, was at the un in new york, along with a yazidi who was captured but managed to escape. they've both been speaking to our correspondent lyse doucet. fleeing the savagery of so—called islamic state. this is iraq three years ago, in the mountains of sinjar. thousands of yazidis were slaughtered. thousands of women and young girls seized and kept as sex slaves. 24—year—old nadia was one of them. many in herfamily were killed by is. for the past year she and lawyer amal clooney have been pushing for an investigation into what the un calls genocide. nadia murad, what does it mean

for you today, for the yazidis? it's a big day for us. ever since my community was subjugated by isis, we've dreamt about it. we want to see justice for the victims and to bring the perpetrators to trial. amal clooney, how big a step forward is this in legal terms? it's a huge step, lyse, it's really a milestone for the victims of isis, like nadia. what happened today is that the council has voted to establish an international investigation to collect evidence of isis crimes. so for the first time the un is saying to isis terrorists that if they commit genocide, crimes against humanity and war crimes, they will be held to account in a court of law. how hard is it going to be to collect the evidence? you've been warning evidence was disappearing and witnesses were disappearing. exactly why we've been saying this is urgent, witnesses are becoming dispersed all over the globe. they are sometimes more reluctant to give evidence after a long time.

medical evidence disappears. mass graves have been contaminated. it was urgent for the council to ta ke it was urgent for the council to take this action. they can do it. will this horrible chapter ever really be over for the yazidis given all that's happened ?|j really be over for the yazidis given all that's happened? i went to visit my family home a few months ago, it was completely destroyed. isis had left nothing behind. it's going to be hard to forget but at least working now to bring those criminals tojustice. at least working now to bring those criminals to justice. at least that's something. tiny victory. on the battlefields of iraq and syria, is's monstrous caliphate is grumbling. defeat is only a matter of time. justice will take far longer. and those who survived will never forget. lyse doucet, bbc news, new york. the former conservative mp, sir teddy taylor, has died at the age of 80.

sir teddy opposed the uk's entry into the european union, and was one of a group of tory mps who attempted to frustrate john major's negotiation of the maastrict treaty. sir teddy represented constituencies in glasgow and southend for a0 years, before retiring in 2005. for more than half a century sir david attenborough has brought us a world of creatures and cultures that millions had never seen before. his major bbc television series was zoo quest which began in 195a. sir david has been talking to our arts editor, will gompertz about his work in the early day — and how things have changed since then. let me take you back to the mid—1950s... this is the story of a search for a dragon. ..when a young david attenborough took his first tentative steps as a natural history programme maker. as he circled us, flicking out his great yellow tongue, savouring the smell of the goat's

flesh, he looked almost as though he had walked out of some prehistoric age. gosh, look at that. now here we are, 60 years later at london zoo. in the dragon house, named after the man who has become quite possibly the most respected broadcaster on planet earth. david, the world and television has changed a lot since you first encountered one of those. yes. hugely. yes, when i encountered that, there were two networks in britain only. the bottom of the ferry grated on the white coral sand... i went to bali in 1956. i only saw one other european all the time i was in bali, which was several weeks, a couple of weeks. and we filmed dancing, and it was just marvellous.