after losing family members to breast and ovarian cancer. charley was a carrier and given up to an 87% risk of breast cancer. annie wasn't but was told she had a 50% chance. as a result, both had masectomies. 87% is pretty high, so to me, ijust wanted to get rid of them as soon as i could. had the risk been a bit lower, i would have maybe thought twice about it and been a bit calmer about the situation and perhaps gone for regular screening, as opposed to such drastic surgery. i always thought that they would kill me, so ijust wanted them off. so, it was all to do with that mindset, really. no, it is a big operation and it is something that is life—changing. the women's chances of developing breast cancer could have been much lower, but it was not possible to tell. this research could make a huge difference to the choices made by women with a family history of breast cancer. scientists here believe it could cut

the number of patients having risk—reducing surgery by a third. the more that we learn about the genetic components behind the increased risk of developing breast cancer in women who have got a family history of the disease, the better that they can make choices about their health so that hopefully in the future, fewer people will be diagnosed with breast cancer. the new test is likely to be available on the nhs in manchester in around six months for women at high risk. they want it to be available eventually for all women and also hope they can extend their work to understand how all our genes affect our chances of developing other cancers. jenny walrond, bbc news, manchester. now with news of lewis hamilton's win injapan and the rest of the day's sport let's cross to lizzie greenwood—hughes at the bbc sport centre... thank you. lewis hamilton is on the verge of winning his fourth formula 1 world championship. he eased to

victory in the japanese grand prix while his nearest rival sebastien vettel was forced to retire. patrick geary reports. one man and his mercedes. a tender moment between lewis hamilton and the car that might carry him to a fourth world title. they started as so often in front, his main rivaljust behind him. that was as close as sebastien vettel would get as hamilton sped off, that'll lost power, his car developed problems at the wrong time. spark plugs with the issue, that might that sebastien vettel reversed out of the title race. he was left to channel his hopes through others in particular max verstappen, the next big star. he beat hamilton in the last grand prix and chased him in the final stages, hamilton lost speed but never composure. he knows just hamilton lost speed but never composure. he knowsjust what hamilton lost speed but never composure. he knows just what is neededin composure. he knows just what is needed in the last lap. beautiful work. at the end of august, hamilton

was behind sebastien vettel but now he may be a race away from becoming britain's most successful driver, thatis britain's most successful driver, that is some overtake. patrick geary, bbc news. hamilton's lead is 59 points with four races to go which means he could take the title at the next grand prix in the usa if he wins and sebastien vettel fails to finish higher. scotland are leading to the media 1—0 in their crucial world cup qualifier. leigh griffiths scored the all—important goal after just griffiths scored the all—important goal afterjust half griffiths scored the all—important goal after just half an griffiths scored the all—important goal afterjust half an hour. the second half has just kicked off and scotla nd second half has just kicked off and scotland must win to guarantee a play—off place. it would be scotland's first major football tournament for 20 years. northern ireland play later and they need a draw in norway to reach the play—offs. england who have already qualified for the world cup were also winning i—0 and they have kicked off the second half against lithuania. harry kane putting away a penalty to score his seventh goal in

his past six internationals, gareth southgate has given debuts to harry winks and harry maguire as well. here is confirmation of those half time and the other game in group letter f. that is significant for scotla nd letter f. that is significant for scotland because if they do not win, slovakia could overtake them in second place. saracens are top of the rugby union premiership after a victory over wasps. jamie george scored a hat—trick of tries as saracens looked comfortable throughout the win in north london. it is the fourth defeat in a row for wasps. england have won the netball open championship for the second yearin open championship for the second year ina open championship for the second year in a row beating wales 72—52 com plete year in a row beating wales 72—52 complete a year in a row beating wales 72—52 com plete a clea n year in a row beating wales 72—52 complete a clean sweep in the tournament that features all four home nations and one international side. northern ireland came second after edging past scotland by one goal. that is it from me. the bbc

sport website has much more including how to rail hatton became the first player to win back—to—back alfred dunhill links championships. back to you,. there's more throughout the evening on the bbc news channel, hello. this is bbc news. theresa may has insisted she's determined to continue as prime minister, despite moves by conservative rebels to force her to resign. mrs may told the sunday times that she was "pretty resilient" and had the full support of her ministers. but the former conservative deputy prime minister, lord heseltine, told me the current situation for the prime minister is unsustainable — and that we could see a general election much sooner than anticipated. i think there is a deep division in the conservative party that has been there for some time, but it has now erupted in public gaze and the brexit agenda is going to dominate the next couple

of years, with all, in my view, the deteriorating news that it will produce. what does the prime minister do? you have only got to read today's newspapers or yesterday's to realise the present situation is unsustainable. she can either, so to speak, retract and abandon brexit, but the party will not let her do that, so there is only one alternative, to go forward and attack. that seems to me inevitable. it would mean a reshuffle. high—profile, very dangerous, because you create more enemies than you attract by a reshuffle. she will find it extremely difficult to divert the media and the gossip away from brexit. but there are things that she could do. and the housing agenda is one. our failing schools is another. she should get on with the devolution agenda to embrace

the enthusiasm of the whole country and notjust parts of it. she should address the skills shortages. but they have to be done with a determination and with a leadership which is very difficult at the moment for her to produce. she clearly wants... it is the most unenviable position. she clearly wants to get the policy issues front and centre again, rather than the discussion of her leadership. but as you say, the media is reporting it because that is coming from within the conservative party. do you agree with sirjohn major who said today that those seeking to question theresa may's leadership are disloyal and self—absorbed 7 well, i served asjohn‘s deputy for some years. they were there then and it was exactly the same. one has to face up to this, that in democracies, there are people with strong views and there is a certain integrity

in pursuing those views. there are great historic examples of people who have fought the conventional wisdom. but they are there. i do not know any way in which they can be silenced. and i do not know... is she the right person to lead the party at the moment, in your opinion? she is not going to lead the party into the next election and i believe it is much sooner than people are anticipating, i think. two years is about the timescale. but what she could do is to open up the debate about who the leadership should pass to and, of course, as i say, that is a reshuffle and it is a very dangerous policy, but i do not know what choice she has got. there does need to be a focus on the younger generation, the great gap in the tories, in the younger voters, it is very serious.

i think there is a certain boredom about the rather stereotyped arguments over brexit that are continuing. but let's not escape the simple fact, brexit is the overarching issue of our time and it is hugely damaging to the unity of the conservative party. let's explore the point you were making about a reshuffle. you say it brings with it its own dangers. but would that be an opportunity for theresa may to sack borisjohnson? do you think that is what she should do, despite his call yesterday for mps to circle the wagons around her? boris is very flexible in his approaches to these matters. but the serious thing is that quite rightly, in my view, theresa may put three brexiteers in charge of the negotiations. they would never have forgiven her if she had done anything else. all of the gossip is quite clear. she wants to move boris, who has had

very unfortunate effects as a foreign secretary overseas, she has taken away david davis's principal civil servant to put him in number 10 because she wants to do it herself, and liam fox, frankly, is obscure. it has been a disaster, putting the brexiteers in charge. but the fact of the matter is, the insecurity the europeans now see in the domestic situation here makes it hardly worth their time to take the negotiations seriously. so what does theresa may do by taking control of it herself? the split will not go away, the party will not unite, the country won't unite. it simply puts her further and deeper into the difficulties. the deputy first minister of scotland, john swinney, has opened the snp conference in glasgow, saying his party is the only progressive political choice for scottish voters. brexit, and the rights of eu citizens living

and working in scotland, is expected to loom large throughout the three—day event in glasgow. in his address to party members, mr swinney outlined his party's achievements. every conference brings scrutiny of the position of political parties and ours is no different. at this point in ourfirst government back in october, 2008, we were polling about 38%. not bad. but by this point in our second government, we had hit a0%. getting better. but now, ten years into government, what is our most recent polling number? it is 42%. infact... applause. in fact, our lead over our nearest rival is a stonking i7% — five times what it was in 2008 and double what it was in 2012. our party commands that support

because we stay close to the people, we listen to them and we act in the national interest of scotland. applause. in amongst all of the polling, scottish labour has descended into infantile name—calling and the tories have flirted with the cabinet coup against theresa may. labour and tories are not so much locked in a battle for the future of this nation, but in a battle for who can break twitter first. the antics of borisjohnson, labour's leadership contest, theresa may's pas — things have gone from the ridiculous to the bizarre. friends, there is chaos on the left and there is chaos on the right and through it all, the snp government stands firm, a beacon of progressive,

effective government, delivering for all of the people of scotland. the scottish first minister and leader of the snp, nicola sturgeon was on the andrew marr programme this morning. she said that independence is still a target, especially in light of brexit. there are many people in scotland desperately want to see scotland become independent and others will never be convinced and some think dust must settle on brexit. perhaps an element of people a little bit scunnered by big decisions. we had two general elections and the referendum. brexit is likely to be monumental over the whole of the uk. the damage of brexit is likely to be monumental over the whole of the uk.

i have a mandate to give people in scotland a choice on the issue. i listen to what people say in terms of the timing of that but let me stress that the case for shaping decisions that shape our future being in our own hands, not the dysfunctional government in westminster, is stronger than ever. our scotland correspondent, james shaw, is following the opening day of the conference in glasgow. it looks as though independence, or a second independence referendum, could be a long way away, even according to people in the snp. nicola sturgeon said she would think about it again next year. leading figures say it should not be considered until after the next scottish elections in 2021. what does the snp — how does it reinvigorate itself? it talks about domestic policy. it compares itself to other parties as a party of government in scotland for the last ten years. it looks at its record, which it

might be possible to attack it, particularly education, that is where the snp have come under fire, but they focus on domestic issues. they will talk about bursaries for teachers to enable them to change mid—career into stem subjects such as maths, and they may talk about increasing tax to provide funding for public services. the headlines on bbc news: theresa may insists she's determined to continue as prime minister, despite moves by conservative rebels to force her to resign. as the snp conference begins, nicola sturgeon says she won't think about the timescale of another independence referendum until brexit becomes clearer. tens of thousands of people show their support for the spanish government, with demonstrations against independence for catalonia. the man arrested after a car crash outside london's natural history

museum yesterday has been released by police, but remains under investigation. the 47—year—old was one of 11 people hurt when his toyota prius mounted the pavement and hit pedestrians. police said the incident was a traffic accident and not terrorism—related. hurricane nate has hit the united states, bringing torrential rain and powerful winds to communities along the southern coast. since making landfall, it has now been downgraded to a tropical storm. but weather experts warn the threat of dangerous storm surges remain. after claiming at least 30 lives in central america, it became the fourth major storm to make landfall in the us this year. anisa kadri reports. as it approached, hurricane nate promised strong winds and torrential rain. it hit the gulf coast of the united states,

causing flooding in parts of mississippi, alabama, florida and louisiana, where people have been ordered to evacuate. although it is weakening, the impact is still being felt. we are still seen wind gusts between 70 and 80 mph. we have water coming up on most of our roadways. about two miles inland. so we've got about seven to ten feet of storm surge. so our first responders are kind of overwhelmed right now. the force of nature has already devastated central america, killing at least 25 people. in nicaragua, honduras and costa rica, where hundreds of thousands of people are reported to be without running water. and scenes like these have become all too familiar in the past few months. after back—to—back hurricanes irma and maria, people in the caribbean have been left without homes, power or clean water. visiting the islands to see the damage, the un secretary—general had a stark message. it is clear, warmer climate means

more hurricanes and more devastating hurricanes, and we need to do everything to stop this. we need to make sure that the paris agreement on climate change is implemented, and more, as the paris agreement is not enough, that enhanced commitments are made by all countries around the world, in order to make sure that we are able to dominate this very dramatic evolution. people in new orleans, who remember the devastation of hurricane katrina 12 years ago, did what they could to prepare themselves for the impact of nate. but early indications are that they have been spared the worst. some americans are seeing nate as a near miss, as it is been downgraded from a hurricane to a tropical storm, but there are still warnings of life—threatening storm surge flooding. the number of women having surgery to prevent breast cancer

could be reduced by a third, according to scientists in manchester who have developed a new genetic test. it looks at looks at genetic variants known to affect the chances of getting breast cancer. the researchers hope that, if successful, the procedure could be rolled out across the nhs. joining me now is drjustine alford from cancer research uk. you tell a small about how this works, about this research. in this study the scientists were building on previous research that looked at women who had a family history of breast cancer and was notjust looking at a broad population of women, it was women with a family history. they looked at small genetic changes to the letters of dna that are common in the population but looking at small changes which have been linked with the risk of developing breast cancer

in people with a family history of the disease and they found by homing in on the disease and they found by homing inona the disease and they found by homing in on a small number of changes, they found they could accurately predict the risk of these women going on to develop breast cancer which is in courage in because at the moment in terms of genetics we only know about genes behind 20 —— 2596. this test is about allowing women and doctors to make a more informed choice about what to do next and whether to have a mastectomy. exactly. there are different options these days for women with a higher risk of developing breast cancer, ranging from taking preventative drugs, having more regular monitoring, mammograms, that kind of thing, ranging from slightly more severe things, so having for instance a

double mastectomy, which is a dramatic thing for many women to do. we wa nt dramatic thing for many women to do. we want to reflect a woman's risk of developing the disease and this research is a step towards getting to that stage. researchers hope that if the test proves successful, to be accurate, it could be rolled out across the nhs. do we have an idea of the timescale? it is difficult to say, this is early research, although it has been done in patients, but it could be years before it ends up with patients because it needs to be proven and proven to be cost—effective and effective at predicting the risk of disease. thank you. let's take a look at some of the other stories making the news this afternoon.

explosions at a fuel depot in ghana have killed at least seven people and injured more than 30 others. the first blast in the capital, accra, last night sent a giant fireball into the sky, forcing residents to flee. it's understood to have triggered a second explosion and a fire at a nearby petrol station. the sister of the north korean leader, kim jong—un, has been promoted. seen here on the right with her brother, kim yo jong is 28 years old. she's replaced her aunt in the politburo. her promotion is further evidence of the kim family's grip on the north korean regime. close to four tonnes of cocaine has been seized after a ship was intercepted in the atlantic. the spanish authorities acted on intelligence provided by the national crime agency in the uk to intercept the boat between madeira and the azores. the nca says, if sold, the cocaine would have fetched more than £200 million. seven men have been arrested. cuba has been marking the fiftieth

anniversary of the death of the revolutionary leader che guevara. the events took place in santa clara — the city where he led rebels to victory in one of the decisive battles of the cuban revolution. the bbc‘s will grant was there. the ceremony began with che guevara's old friend raul castro laying a white rose at his tomb. followed by an excerpt from the original speech made by fidel castro in 1967, announcing that che guevara had died. it has been a solemn ceremony, although it has a large presence of schoolchildren — there is an an emphasis on youth when one speaks of che guevara in cuba. they have been repeating a slogan — we will be like che. a key part of the cuban education system.

dignitaries, comrades who fought alongside him, members of his family. they will see him as a hero and an example to youth in cuba and around the world. not everybody sees it that way. his critics see him as a man who was bloodthirsty and cruel. but saying that here today is sacrilege for these people. they see him simply as a hero. at 9:30pm, our correspondent looks at che guevara's legacy in cuba in our world. the duke of cambridge and prince harry have been very open about their own experiences with mental health, and set up their charity heads together to encourage people to speak out. now they've announced the next phase of their mission — a £2 million investment fund to help improve the nation's mental health through technology. our royal correspondent sarah campbell has finding out more. in the run—up to the london marathon, the younger royals' focus was almost exclusively centred on heads together —

the campaign they founded and which aims to improve the nation's mental health. in april, thousands took up the challenge to run the 26 miles and, in doing so, helped to raise awareness of an issue that affects millions of people. this has been an unapologetically personal mission, with the princes opening up in a way they hadn't previously. do you think we've made enough of an impact, or a stepping stone into the schools area at a younger age? i think we are making good progress. so, has it worked? in a high—tech suite in imperial college london, prince william was shown survey data that indicates their campaign has encouraged more people, and particularly men, to talk about mental health issues. and evidence from the partner charities which make up heads together suggests a significant impact. the mental health charity mind had its busiest ever day with 58% more calls the day after the marathon. places2be, which focusses on childrens' mental health,

has seen a 148% increase in their downloads to schools. and young minds saw a 15% increase in calls to their parents helpline around the time of the marathon. phase one of the heads together campaign was about starting the conversation on mental health. now it is moving on to phase two, which is about practical solutions to keep the conversation going. starting with a £2 million grant from the royal foundation to fund digital ways to help people cope with mental health issues. digital allows us to open up the timescale that people can access stuff, so a lot of people struggle late at night with their mental health, and it's very difficult for traditional services to stay open. could a digital intervention start working in that space, so there's always someone you can talk to? as well as digital projects, heads together will focus on mental health in schools, workplaces, and the military, with this issue remaining at the very top of the agenda of the royals.

thank you all very much. pleasure. sarah campbell, bbc news. there's only one week to go until the old pound coins are taken out of circulation. from midnight next sunday the round pound will lose its legal tender status and no longer be accepted in shops and restaurants. people have been urged to spend them, bank them, or give them to charity before then. time for a look at the weather, as was the case with saturday, at its best there was nothing really much wrong with sunday as evidenced by our weather watcher in york but in other parts of the british isles there was a lot of cloud. no rain off the suffolk coast, but it was close from the showers further offshore overnight. reinforcing cloud coming in across scotland.

rain through the heart of scotland pushing to the northern isles. cloudy across the british isles and not a cold night and not a cold start to the new week. it will be disappointing across the greater pa rt disappointing across the greater part of scotland first thing. cloud for to be the odd piece of rain. northern ireland, quite a bit of cloud. the odd piece of rain moving in but not amounting to much. the greater part of england and wales starting dry. towards the south—west, cloud sitting low, so watch out for hill fog and there will be drizzle here. that might fade, the cloud trying to lift. you get the sense that although there will be dry weather to start the week across much of the british isles, sunshine will be patchy across the greater part of england,

maybe wales, northern england, parts of scotla nd maybe wales, northern england, parts of scotland faring better. cloudy in northern ireland to finish the day. northern ireland to finish the day. no great issues with the weather for the match between wales and the republic of ireland on monday. on tuesday, weak weather fronts tumbledown across england and wales bringing the prospect of rain. things brighten up nicely until we bring in the next set of weather fronts. that will spoil the latter pa rt fronts. that will spoil the latter part of the afternoon through northern ireland and western scotland. they have more about them, you will notice the isobars. the wind is a feature of wednesday. if you are anywhere near the front, you will see quite a bit of rain. wet and windy in the middle of the week. once we get through that, towards the end of the week, things could be warmer, especially in the south.