this is bbc news. the headlines at eight. remembering the victims of the grenfell tower fire — emotional tributes are paid to six of the 72 people who died, as the public inquiry into the tragedy opens. i hate night time because it brings silence and that brings tears of sadness. there's a gaping hole in our hearts that can never be filled — and it hurts, it really hurts. we can't imagine a time when it will hurt any less. ken livingstone resigns from the labour party — the former london mayor was due to face a fresh hearing into allegations of anti—semitism. in the united states mike pompeo says his country will impose the strongest sanctions in history on to

as they set out on alternative to the iran nuclear deal. announcing the iran nuclear deal. announcing the gary raghav faces pressed charges injuly the gary raghav faces pressed charges in july —— the gary raghav faces pressed charges injuly —— in iran. also in the next hour: capturing a magical moment — kensington palace shares photographs from this weekend's royal wedding. the duke and duchess of sussex thank everyone who took part in celebrations, as three official portraits featuring the newly—weds are released. good evening and welcome to bbc news. relatives of those killed in the grenfell tower fire have been remembering their loved ones at the start of the public inquiry into the disaster. the first victim to be commemorated was logan gomes, who was stillborn in hospital shortly after his pregnant mother escaped from the blaze. 72 people died after flames engulfed the block of flats

in west london lastjune. our special correspondent lucy manning has been listening to their stories. so many killed, so many lives cut short, none more so than logan gomes, not even born, when he died. after g re nfell. his family shared pictures with the enquiry. he looked like he was just sleeping. and basically, at that moment, we felt like our hearts had broken. but at least we were able to hold him. and to be with him.

the joy of the baby shower, choosing a name, the nursery, all destroyed. you never know what you are made of until you are broken. mohamed neda fled the taliban in afghanistan, he came to britain and started a chauffeuring business, his final message to his family from inside the tower played to the room. his wife's tribute read out by her solicitor.

so sad that my beloved husband will not be with us for the wedding, and will not be there to see and hold his grandchildren, and share in thejoy of becoming a grandparent. those hopes and our dreams have been shattered. he was my husband, he was my best friend, i miss him so much. he will always be the love of my life. denis murphy had lived in grenfell tower for more than 20 years, he had three big loves, family, friends, and chelsea, not always in that order, his sister said. he was the linchpin of our family, and touched the lives of so many people. once you had met denis

you would never forget his warmth, wit, cheeky smile and love of life. there is a gaping hole in our hearts that can never be filled and it hurts, it really hurts. a short but poignant tribute to 69—year—old joseph daniels, made by his son. the events of that night took his life and all trace of his existence in this world, he never stood a chance of getting out. it should never have happened. mother and daughter, mary mendy, and khadija saye died together, mary was remembered as strong and hard—working. khadija saye, a photographer, lauded for her talent, the family solicitor read the tribute. for every birthday, christmas and new year, two empty chairs, but they will forever own a position in our hearts. then the enquiry heard

khadija saye's own words about the future she would never have. one of my friends said, you are an artist, and i said, iam, now! it'll be quite an emotional moment to actually say, khadija, you have done it! the tower is now largely covered up, the grenfell families are desperate for the truth to be exposed. the people will be extremely angry about that. it gets worse. we have discovered the insulation on g re nfell discovered the insulation on grenfell had never been tested for tower blocks. panorama understands the product that passed the safety test contained extra fire retardant. we think a more flammable version

was then sold for public use. well, words fail me. this is absolutely mind blowing. this material is all over the place. the insulation that burned out of control on grenfell should never have been there. but celotex targeted the grenfell refurb and specifically offered their untested insulation. we have been advised that the company's behaviour could amount to corporate manslaughter. celotex say they can't comment because they are cooperating with the police investigation and the public enquiry. but they haven't denied panorama's allegations. richard bilton, bbc news. so an indication of

where the a little earlier my colleague ben brown spoke to the area dean of kensington, mark o'donoghue, who offered his support to many of the families. listening to the tributes from families and friends, colleagues, is always a helpful part of the process of grieving and remembering and looking back with thanksgiving for their loved ones. today, we had heartfelt, harrowing tributes, the ones that particular stuck in my mind works marcio gomes remembering his son, public enquiry might public go. but the focus will be on the survivors. marcio gomes talking about the dreams that he had for his son to support benfica and liverpool, and all the dreams that people have their children and their love

that they have their parents, and listening to denis murphy's sister talk about his love for his family, his friends and chelsea football club, obviously not in that order, she said. and just being really struck that he were people whose lives had been ripped apart, who lost the linchpins of their community, and their families, but at the same time, able to talk about them at the very start of this inquiry. i think it is key that the focus right at the start is on the victims, and their families and friends, are able to talk. and will that reassure the community. this inquiry has been controversial among some in the community. what are your thoughts about the inquiry, your hopes for it? the inquiry is a necessary step, but it will only be a sufficient step if it gets to truth. if it achieves justice. grenfell united said this morning, it is part of the long road to truth and justice, and it will only, only if it gets

to the truth and only if it serves to rebuild the trust of the community, between the community about for years that they were not listened to, for years they were marginalised and neglected, and often felt unwanted in kensington, and if it enables that trust to be rebuilt between them and those in authority, both locally and nationally, then it will have achieved something. that hope is at a lower ebb, and it has been for months. every day of this inquiry, my hope and prayer is that that trust and confidence will be rebuilt. as there has been so much anger in the community. do you sense that the community almost one—year on is beginning to heal? let's remember, in the days immediately after the fire, you and i met, and you and i will know that yes there was anger, there was shock and grief, but there was also stunning compassion, people were giving up time and energy and supplies and resources to stand with that community, shoulder to shoulder,

and what we saw in those early days is something that we need to keep remembering. that london at its best, kensington at its best, is when it comes together when it comes together and stand together. that is a slow process. but it is a vital one. and this story will be covered by the newspapers tomorrow. and we'll find out how this story — and many others — are covered in tomorrow's front pages. our guestsjoining me tonight are the political commentator, lance price, and the deputy political editor at the sunday times, caroline wheeler. ken livingstone has announced he's resigning from the labour party. the former mayor of london has been suspended for two years over allegations of anti—semitism.

he was facing a fresh disciplinary hearing this week. earlier mr livingstone spoke to bbc london's political editor tim donovan. i decided that rather than this drag on for another two years, it's better for the labour party if ijust resign. i can go back to campaigning on issues like the environment, supporting jeremy's economic plans and all of that. but if i was to stay in and fight this my lawyers say it could take two years or more. so you are accepting you were going to lose, in other words you are jumping before you were pushed? i was tipped off at the weekend some of the right—wingers on the labour national executive committee were planning to raise this again at tomorrow's meeting. and all the does is just distract attention from jeremy's leadership of the party. and the options he is giving britain. you haven't worried about that and that disruption over the last couple of years. you have been causing a lot of distraction, haven't you? i have worried about that, i mean this is absolutely ridiculous.

the police don't take two years to solve a murder but the labour party has allowed this to drag on under the previous general secretary. i think it is all going to get sorted out a lot quicker under the new general secretary. do you accept, and it looks increasingly that the leadership thought this as well, that you were going to be found wanting in this second disciplinary hearing and you were going to end up being expelled? the second disciplinary hearing, it is simply says i was on press tv but if you go and listen to the interview i was defending the jewish community from some of the lies and smears about them. we can cross to westminster and talk to our political correspondent eleanor garnier. ken livingstone labour remarks about

hitler and said that he was just making historic arguments. but he made the comments time and again and became the subject of an investigation. we understand that the case was to be discussed at the labour governing body tomorrow although ken livingstone is saying he was not pushed, he had decided to go for the process drag on and on for top what is interesting is in his statement he has continued to reject accusations that in any way he had been guilty of anti—semitism oi’ he had been guilty of anti—semitism or had brought the party into disrepute. is that he was sorry, he acknowledged that some of his comments had caused offence within the jewish community and comments had caused offence within thejewish community and he said that he was truly sorry for that. some labour mps are extremely happy to see the back of him because this case has been one of the most high—profile cases of allegations of anti—semitism that the party has been dealing with in the past couple

of years. one of the main campaigners, one backbench mp said tonight, good riddance. another key campaigner against anti—semitism and said that he was pleased to see the back of him and said we must now make clear that he will never be welcome to attend and his vocal supporters should follow him out of the door. one of the key things about this is jeremy corbyn the door. one of the key things about this isjeremy corbyn will now no longer have to face questions about his key friend of his, a very old friend and ally, as he deals with the issue that has been engulfed in the party, jeremy corbyn at least can note that this issue with ken livingstone has gone away. but there are mps and those in the jewish community who still want more to be done and the other cases that still need to be sorted to get sorted swiftly. we can speak to the labour mp tulip siddiq. let's just show the viewers the

message you put out a few hours ago after the announcement of the resignation. you said you are glad to see the back of him but does this end the controversy within the labour party about anti—semitism? no, of course it's one resignation is not going to end the controversy there is about anti—semitism in the labour party but what i will say is it is symbolic. it used we have got rid of someone who caused such an offence to the jewish rid of someone who caused such an offence to thejewish community and not just the jewish community but also friends of the jewish not just the jewish community but also friends of thejewish community and to us as mps. today i'm in my constituency which has a large jewish contingency and these are constituents of families were murdered in the holocaust and the comments made by ken livingstone

where despicable. so i'm glad that he has resigned but i will say that he has resigned but i will say that he should have been expelled. he should have been expelled a long time ago and i hope the labour party ta kes time ago and i hope the labour party takes note that there is no place for people like him in the party. it should not have taken him to resign on its own terms, we should have expeued on its own terms, we should have expelled him and done that a long time ago. and does that not then leave a sour taste because he has been allowed to look at least coming he can portray it this way, he says he can portray it this way, he says he rejects all the allegations against him and is not anti—semitic, does not believe that he brought the party into disrepute but that this is lasting too long and he will go. and the reaction from jeremy corbyn to that resignation was look, this is rather sad but it is the right thing. it looks like quite chummy relationship and that leaves the labour party with a bit of a problem. well what ken livingstone

is saying about not bringing the party into disrepute is rubbish, a all the silly things and stupid things and offensive things that he has said that is probably the stupidest in terms of of course he has brought the party into digital feud. just because he was once a good mayor of london does not mean you are allowed to make such offensive comments about the community. —— into disrepute. and do not forget in 2010 he went to tower hamlets and campaigned for the independent candidate in the mayoral race rather than support the labour candidate. but would not be accepted from anyone else and so why are we making exceptions for powerful men who used to be a former mayor. you wrote to jeremy corbyn who used to be a former mayor. you wrote tojeremy corbyn over a year ago basically saying look ken livingstone needs to go, you need to get rid of him. clearly you do not believe jeremy corbyn get rid of him. clearly you do not believejeremy corbyn reacted to this in the right way. how does he 110w this in the right way. how does he now build a new relationship with

the jewish community and now build a new relationship with thejewish community and people in your constituency? jeremy corbyn when i have had a conversation with him, he has listened carefully when i've said about the fact that people are concerned about the anti—semitic elements within labour party and i would say the labour party as a whole is not anti—semitic about there are elements and we have to act quickly to make sure we get rid of them so would that we send a clear message that we will not put up clear message that we will not put up with this and not put up with people being anti—semitic. there's no place in the labour party for who are anti—semitic racist or whatever but no doubt a lot ofjewish members especially in my area felt very upset and offended by a party that they had supported for years. jeremy said to me over and again that there isa said to me over and again that there is a due process and it has to take place but we did see calls for ken livingstone to go and finally we had to use this as a springboard to make

sure that we win back the hearts and minds of the jewish sure that we win back the hearts and minds of thejewish community and get rid of anyone who makes anti—semitic comments because we are party proud of our diversity and proud of the fact that we welcome eve ryo ne proud of the fact that we welcome everyone from every community. if we do not demonstrate that and we're not the party that we wanted to be 70i not the party that we wanted to be 70 i think i livingstone, his resignation is a good thing but againi resignation is a good thing but again i say we should have expelled him a long time ago and it should not have taken two years. thank you very much forjoining us. sport now...and for a full round up, from the bbc sport centre, here's ben mundy.. and, we're starting with some news out of arsenal in the last half an hour.

the club are set to appoint unai emery as their new manager. the spaniard will replace arsene wenger after his 22 years in charge at the emirates. our sports correspondent david ornstein is right across this developing story.. well the interviewed a number of candidates and spoke to even more. i'm told the unanimous choice to be the next manager is the former psg manager unai emry. he led seville to three europa league titles. that is the competition that arsenal have been competing in. it was expected that the new captain would be arteta but it is going to be unai emry and we expect a press conference later in the week to confirm that. so they've gone for experience? just looking at reaction to this.

lots of arsenal fans seemingly underwhelmed. they have the choice to go with a lot of experience. someone younger that arteta was spoken to, but they've gone with unai emry, proven in european competition, comes from a huge club in ps6 for the 46 years a huge club in psg for the 46 years old so still has youth on his side for the known for getting the best out of his players and working with restrict the budget in spain as well which he also will have at arsenal. but his english is not said to be perfect, he is not fluent but he will be the new arsenal manager and quite a seismic shock to many people. there will be people underwhelmed all who thought that arteta have the job

underwhelmed all who thought that arteta have thejob but underwhelmed all who thought that arteta have the job but it will be unai emry as the new arsenal manager to be confirmed later this week. thank you. breaking news there and much more on the bbc sports website. i will have much more for you at half past ten. the us secretary of state mike pompeo has said america will impose the strongest sanctions in history on iran, following president trump's withdrawal from the nuclear deal. mr pompeo used a speech to set out twelve us demands to iran's leadership, including pulling all its forces out of syria and ending support for rebels in yemen. we will continue to work with allies to counter the destabilising activities in the region. block their financing of terror and address iran's proliferation of missiles and other advanced weapons systems that threaten peace and stability. we will also ensure iran has no path to a nuclear weapon. not now, not ever.

we will apply unprecedented financial pressure on the iranian regime. the leaders in tehran will have no doubt about our seriousness. thanks to our colleagues at the department of treasury, sanctions are going to be back in full effect and new ones will come in. i will work closely with the department for defence and our regional allies to deter iranian aggression. we will ensure freedom of navigation on the waters in the region. we will work to prevent and counter any malign iranian cyber activity. we will track down iranian operatives and their hezbollah proxies operating around the world and we will crush them. joining us now from washington is our state department correspondent barbara plett usher. they are going to rip up the deal and put some pressure on iran. he

took the hardest line possible against iran without actually resorting to military measures. it seems wanting to force iran through economic pressure to make the concessions that the americans feel iran needs to make. it seems to be talking about trying to reconstitute the sanctions regime that existed before the nuclear deal was negotiated and is what helped to bring iran to the table. he has called on allies to help them implement this. because of course although the americans have considerable financial clout even though influence on the global financial system they cannot impose such a sanctions regime on their own, they need the world to help them with that. he did not say how they would be able to convince allies, of course israel and saudi arabia are the regional rivals to iran and bearall on arabia are the regional rivals to iran and bear all on board but much of the rest of the world thinks the iran nuclear deal was the best you

could get and still support it. and of course the europeans are fighting ha rd to of course the europeans are fighting hard to keep going even though the us has pulled out. though not entirely clear how mike pompeo thinks he will be able to assemble the coalition to put this economic pressure on the iranians. and whether there's kind of diplomatic off—road other than complete capitulation. joining me now from hamburg is dr sara bazoobandi, an expert in middle east affairs. thank you forjoining us. that analysis there from barbara is that it is difficult to see how the us can succeed then in mind that the european union wants to keep the nuclear deal going. is that also your analysis? that is correct i think the three european powers involved in this deal have made it clear from the involved in this deal have made it clearfrom the beginning involved in this deal have made it clear from the beginning that they are not going to give in to the united states demand in that

respect. because they support that this was the best deal that was possible to get with iran. but the problem with this even after the support of the european union is that iran would not be able to enjoy the financial benefits of the deal if all the parties involved were on board and specifically the united states. iran has had problems with us dollar transactions in the global financial system and that will continue. most of the big european companies and businesses that were going to enter iranian markets are now going to back off because of the fear of and the risk of a huge financial penalties imposed by the united states treasury. so overall the deal is likely to survive with european partners but it is not going to have that all—inclusive

financial positive result that the remaining government was hoping to receive. i rememberjohn kerry saying if you did not get all of the financial deals in place, and they weren't in place even in the heyday of the deal, if you didn't get all the financial deals as far as the banking system went in place with iran, he feared at some point: might say we're not getting enough out of this. so presumably, if your analysis is right, teheran could actually decide this just isn't working for us? absolutely. i think the initial reaction from the average ordinary iranian citizens, andi average ordinary iranian citizens, and i am not talking about the hardliners, the ordinary citizens, middle—class iranians, who wanted to be connected to the global financial system, they have not had the simplest benefits of a

well—connected financial system that well—connected financial system that we have in the west, like credit cards and cards that underline payments and so on. they were initially supporting the deal because they believe that this is finally the moment that teheran will come out of economic and possibly political isolation after more than four decades. but now even those people are becoming more and more convinced that maybe the hardliners did have a point, to remain very sceptical about this deal, and maybe this after all was not exactly in the best interests, national interests, of iran. sounds like both hardliners in iran and united states perhaps winning the day then. thank you forjoining us from hamburg. bite, a look at the weather here over the next few days. as well as someone sunshine there has been a scattering of thundery downpours across england and wales. it has been all for nothing really.

those showers will tend to fade away later this evening for much of england and wales will be dry clear skies, maybe the odd shower returning to the south—east later. the rain in scotland and northern ireland tends to peter out. still more clout are drifting into the north—east of england. here it will be quite dull and grey and a misty start. that will slowly burn back to the coast. not much rain left by the morning in scotland, what there is will tend to fade away, cloud thinning and breaking in many areas. the sunnier skies across england and wales, away from these developing storms, and in wales later on the sunshine, temperatures getting into the low 20s once again. wednesday sees the cloud continuing to thin and break up in scotland and northern ireland. it should be a warm day, cabbages into —— temperatures in 220 degrees. across the south, top temperatures 24 or 25. this is bbc news — our latest headlines. the public inquiry into

the grenfell tower fire has opened with tributes to the 72 people who died — the inquiry chair called it the worst tragedy to hit london since world war ii. ken livingstone is to resign from the labour party, the former london mayor is currently suspended over allegations of anti—semitism, which he denies. us secretary of state mike pompeo has vowed that tehran will face the "strongest sanctions in history", as he set out an alternative to the iran nuclear deal. nazanin zaghari—ratcliffe, the british womanjailed in iran, has been warned to expect to be convicted of a fresh charge of spreading propaganda in the country. in a moment, understanding the causes of childhood leukaemia, we'll hear more about research into preventing the disease. let's get more now on the news that relatives of people

who died in the grenfell tower fire, have spoken of their loss, on the first day of the public inquiry into the tragedy. tributes were paid to the 72 people who perished. our community affairs correspondent, adina campbell, reports now from the first day of the public inquiry into the grenfell fire tragedy. pretty much everyone inside the room behind me has been moved to tears on several occasions today. we have been hearing some very heartbreaking, dignified, poignant accou nts heartbreaking, dignified, poignant a ccou nts of heartbreaking, dignified, poignant accounts of the victims of those who died in last year's fire. the district was logan gomez, we heard from his marcio gomez. he showed pictures of the nursery he had got ready for the arrival of his son, his son logan was stillborn shortly after the fire, and the exchange between him and his wife inside that

building today was really, really powerful indeed. we heard about the football tea m powerful indeed. we heard about the football team he was hoping his son would support, and he was also talking about how strong his wife was after they lost their son. we also heard about khadijah saye, she was a young artist who had taken pa rt was a young artist who had taken part ina was a young artist who had taken part in a bbc documentary. she was a very talented artist, who had showcased some of her work in italy. many people were moved to tears when they saw just how talented and many people were moved to tears when they sawjust how talented and how her life was cut short in the fire as well. come the 4th ofjune, the enquiry will return to what happened in the lead up to the fire, the fa cts in the lead up to the fire, the facts surrounding the tragedy. we will be hearing from the emergency services, the response by those services, the response by those services and also finding out about how the fire started. but certainly over the next two weeks or so, the focus will be on the victims of the fire and the bereaved families, and of course the survivors. an awful lot more from the enquiry

over the next few weeks, of course. more now on ken livingstone resigning from the labour party. the former mayor of london has been suspended for two years over allegations of anti—semitism. he was facing a fresh disciplinary hearing this week. jenny manson from jewish voice for labour, who argued mr livingstone has not said anything anti—semitic, gave her reaction to his resignation. i am saddened for ken, iam resignation. i am saddened for ken, i am relieved for him a little bit because i think he has probably had enough and his friends and family have had enough, i am sorry the labour party has had such a bad period of accepting accusations without evidence and allowing them to be beefed up into real hatred, but i am optimistic, withjennie formby the general secretary, and if mr crombie and jenny corbyn —— mr corbyn and jenny colby orton formby

work together, then they can get on with the job of opposition. people say he has jumped with the job of opposition. people say he hasjumped before he was pushed, there was a likelihood he would have been forced to resign from the party. there was some talking on that, even chakra bathy made a similar which i was surprised by. natural hope —— naturaljustice we hope will prevail and i don't think an enquiry would have any easier time than the one which heard my evidence and other witnesses's, infinding my evidence and other witnesses's, in finding certainly that he was not anti—semitic, that was never suggested, but bringing the party into disrepute, that is something we have to be careful about how it is administered. the jailed british—iranian woman nazanin zaghari—ratcliffe has again appeared in court in tehran, and been told to expect another conviction. she's already serving a five year sentence for plotting to topple the iranian regime, a charge she denies. the 39—year—old was detained in april 2016 at tehran airport while travelling back to the uk with her daughter. our diplomatic correspondent

paul adams explains more. it is not entirely clear how new these charges are. when she was initially jailed these charges are. when she was initiallyjailed in 2016, the charge was secret membership of an organisation planning to bring down the iranian state. last october, she faced what seemed at the time to be a new case, also involving the spreading of propaganda. a 200 page file that was then presented. that was at roughly the time when boris johnson made his unfortunate intervention, suggesting to mps that she might have been involved in some way with politics in iran. then of course he got very intimately involved and he went to iran over christmas. and the case seemed to just sort of fizzle out. now it

seems as though it is back. when i spoke to her husband, richard ratcliffe, earlier, his suspicion is, he can't be certain, it is not at all clear, is that this case from last october seems to have come back, with thejudge last october seems to have come back, with the judge saying nazanin zaghari—ratcliffe can expect to be convicted and sentenced. he did give heran convicted and sentenced. he did give her an opportunity to speak in the course of the hearing on saturday to stop she said at the time i have never been involved in overthrowing the regime and i do think the government here needs to reform, but i have never been involved in any attem pts i have never been involved in any atte m pts to i have never been involved in any attempts to change the regime, and she plea for clemency on two grounds, one that she would love to attend her daughter's fourth birthday, which falls on the 11th of june, and secondly, as she says, this year i am turning 40, i might only have a slim chance to continue developing a family and that is something clearly that she and richard would dearly love to be of

to do. some developing news this evening. a man has died following a stabbing in north london this evening. the metropolitan police say the incident happened at around 6.30 tonight on upper street in islington. officers and london ambulance service attended the scene to see a man suffering from stab wounds. no arrests have so far been made. a leading scientist believes he has found the cause of the most common cancer in children. he says that coming into contact with too few microbes early in life can leave a child vulnerable to a type of leukaemia. our health correspondent james gallagher has more. hugo has a cancerous immune system. he was diagnosed with acute lymphoblastic leukaemia when he was two and the disease means he has difficulty walking. he's now in his third year of chemotherapy. it's all he's ever known, but yes, certainly the early part of his treatment was really gruelling. all the side effects you'd expect, vomiting, hair loss, tiredness, lack of appetite.

hugo's type of leukaemia is more common in affluent societies, but the reason why has been hotly debated. now scientists think they have the answer. it starts with a genetic mutation in the womb, and then in the first year of life, a lack of exposure to microbes fails to train the immune system correctly. so if there is an infection in childhood, the immune system malfunctions and it can lead to leukaemia. part of the problem is how sterile and germfree our lives have become. but the researchers say using bacteria may prevent the disease. if all of our conclusions are correct, it should be preventable by exposing young infants to benign bacteria which primes the immune system adequately. coming into contact with beneficial bacteria is complicated, playing with other children, having older siblings, going to nursery and being breast—fed all play a major role. it's notjust about embracing dirt.

i think you have to let the toy which drops on the ground go and just sort of say, well, that's that and not get too caught up on it. ijust believe sometimes it's good to have some germs around, probably it's better for the immune system. this study adds to growing recognition that bacteria are vital for our health and well—being. failing to train the immune system has been linked to diseases like type one diabetes, to allergies and now leukaemia. but this is absolutely not about blaming parents. it's an acknowledgement that the progress we are making as a society and in medicine comes at a price. james gallagher, bbc news. i'm joined by professor mel greaves from the institute of cancer research who has complied the research. he is the man from the report. thank you for coming in. where didi you

first start thinking that there could be something in the amount of microbes that we ingest in early life that could be linked? quite a long while ago, about 30 years ago, and the observation was that this type of cancer in children more less tracks with affluence, and there have been suggestions for many years that infection might have something to do with leukaemia, but tracking of afflu e nce to do with leukaemia, but tracking of affluence didn't make sense, so i inverted the problem. i thought maybe it is lack of infection. so we set about a whole series of investigations to look at patterns of infection in children and made a discovery that whilst infection seems to trigger disease, this only happens in children who have been under to infections in the first year of life. so those are the microbes which do what in early life? i think the public tends to think that microbes are the enemy but the vast majority, are innocuous, and many bacteria are very good for us, our bodies are

full of benign bacteria that help digestion. it turns out the benign bacteria are very important for priming the human immune system and the absence of that priming, the immune system is poorly regulated and later in life when children get infections, they are badly regulated and can trigger leukaemia. so the underlying problem seems to be a deficit of infections of common microbes, mainly bacteria, in the first year of life. does this suggest a fairly simple cure?m doesin suggest a fairly simple cure?m does in principle, the bottom line for us is that it is probably preve nta ble for us is that it is probably preventable in most cases, and what we think would be possible, if we could reconstitute what is missing, which is a microbial experience, for example by giving probiotics in some form. you wouldn't want to give any that are dangerous, but if we are right about this, what the immune system needs, that historically it has used the nine innocuous

infections to do this, then indeed from you are absolutely right, it should be possible to introduce those in infants, that would be safe and secure, maybe all, and it should prime the system in a way that would be protected. does your research show whether in the majority of cases childhood leukaemia is caused because of this? the computation is that childhood acute leukaemia is a mixture of different cancers and mac cancer which we are confident this is the explanation constitutes about 7596, is the explanation constitutes about 75%, so not all but a substantial fraction. what then are the real world from now, people always ask the cure and when is the moment, but is this the moment that people should say, right, i am is this the moment that people should say, right, iam not is this the moment that people should say, right, i am not going to have a house so clean? are we at that point now, or is more research needed? i think we are at that point. it will take a while to

translate these findings into some form of intervention along the lines we we re form of intervention along the lines we were just discussing, but in the meantime parents will ask the for sure what can i do to minimise the risk? if we look at the factors linked to risk, the factors are if you attend a daycare, you are protected because of exposure to the children, if you have prolonged breast—feeding, you are protected, if you're down the birth order, you have more siblings, you're protected. what it looks like that contact protected. what it looks like that co nta ct of protected. what it looks like that contact of young children is very important, social contacts, they are generally protected. so the advice would be don't worry too much about mild infections, encourage social contacts because they by and large will give your infant the kind of microbial experience they need to train your immune system. fascinating and you quite rightly seemed genuinely excited about this, to let's hope the research continues to let's hope the research continues to prove positive results. thank you. there's been further disruption to rail services across england.

a big overhaul of train timetables has led to delays and cancellations for a second day. danny savage has been at manchester piccadilly railway station. the main provider of commuter services here in the north—west of england is northern rail. something like 90% of their services have been affected by the new timetable that has come into effect, although they do say that means 1300 new services have been added per week. however, from a shower this morning, they we re from a shower this morning, they were quickly dubbed the northern fail on social media because of the frustrations of passengers who were turning up for some of them services that were on the new timetable, which had been cancelled on day one. other passengers at bolton said most of the scheduled rush—hour services failed to turn up, they were cancelled, and the few that did arrive were severely overcrowded, with people complaining of being crushed inside the carriages. stu d e nts crushed inside the carriages. students going to their gcse exams we re students going to their gcse exams were late as well, some of them complaining that they were missing

train services, they would be late to school and had to be taken by car, some of them, to make sure they got there in time. northern rail blame this on a shortage of drivers on their network, but combined with the new timetable, it created if you like the perfect storm this morning for problems with commuters in this pa rt for problems with commuters in this part of the country. andy burnham, mayor of greater manchester, said the situation was appalling and is calling on the transport secretary to intervene. will it get better tomorrow morning? we willjust have tomorrow morning? we willjust have to wait and see. that wasn'tjust in the north—west of england where there were issues, there were some problems in the south—east where the largest above commuters are travelling in and out of the capital on the thames link services, such as southern rail, gatwick express and thames link. they put on 400 extra trains per day but there were a number of cancellations and delays again this morning with frustrations in the south—east corner of england but i think the feeling down there is that it was not quite as bad as they thought it would be today. and they thought it would be today. and the situation seemed to improve as

the situation seemed to improve as the day went on. the main worry i think going on with all these changes is will it get better for commuters, especially in the north—west of england ? tomorrow marks one year since 22 people were killed by a suicide bomber, at an ariana grande concert at manchester arena. eight—year—old saffie roussos was the youngest victim of the attack. as the anniversary of her death approaches, her father has told the bbc that he wants her life to be remembered with a special concert. judith moritz has been hearing from andrew roussos , as well as from others affected by the tragedy. losing your eight—year—old child is, it's changed life for ever. it'll never be ok again. at night i couldn't sleep, like crowds, loud noises, ijust hated. this experience has brought us all together. it's the psychological part that's been the hardest, i think. devastation caused in seconds has changed lives for ever.

children traumatised, survivors recovering, families broken. like that of little saffie roussos, the youngest child to die. her parents are still reeling. how has this year been? dreadful. you know, having a child that young and losing her in such a way, we'll never be ok. it's not something that time passes and you can pick up the pieces and move on. you start forgetting bits and i dread that. i dread not feeling saffie's touch, not feeling saffie's presence. i want to celebrate my daughter. she loved music. andrew wants the music industry to help him stage a benefit concert at old trafford because there's no specific state funding for terror victims. this concert‘s for us. this concert‘s not for us.

i want it to be there to support victims of future attacks. we are all really shocked at the lack of support from our government. so there's no government support? nothing. you're turning to charity? yes. when it happened, it wasjust a really scary experience. 11—year—old ava wasn't directly caught in the blast, but still struggled emotionally afterwards. she's one of hundreds of traumatised children to be supported by the warrington peace centre. we have been talking about different coping techniques. it's like always good experiences coming here. it's helped a lot? yeah. ava and her mum have also found solace in music. the manchester survivor's choir is giving them strength. everyone singing here survived the bomb. singing together with other people who understand what you're going through, is a positive message instead of seeing the negative in the world.

it's not just about the choir. the people here know how it felt so that makes a big difference. the choir have agreed to perform in the city centre for tomorrow's anniversary, although they know that'll be difficult. that is a common theme, we are struggling going into crowds and busy places. with each other, hopefully we'll all do it and that will be just remarkable. 12 months on, the memories are fresh, the pain still raw. but manchester is healing. judith moritz, bbc news. gina haspel has been sworn in as the first female director of the cia. ms haspel faced stiff opposition over her links to the cia's past use of interrogation techniques, such as waterboarding. president trump attended the ceremony at the cia headquarters.

i would not be standing before you today if not for the remarkable courage and dedication displayed by generations of oss and agency women, in rolls both large and small, who challenged stereotypes, broke down barriers and open doors for the rest of us. people in hawaii have been given fresh warnings about toxic fumes from a major volcanic eruption which began in early may. the fumes are produced when molten rock flows into the ocean. one person has been seriously injured by lava, which was thrown into the air, and residents near mount kilawea are being advised to move to safety. the lava has also blocked part of a coastal road, cutting off a key escape route for residents. the duke and duchess of sussex have released official portraits from their wedding. in a message released with the photographs, the couple said they felt "lucky" to share their day with their

guests, and also with those watching around the world. the pictures were taken by photographer alexi lubomirski, as nicholas witchell reports. there were certainly no shortage of photographs being taken on saturday, as the carriage procession made its way through windsor, and up the long walk, it seemed as though everyone was holding up a mobile phone to take a snap. but it was after harry and meghan had reached the end of the procession and made their way into the comparative calm of windsor castle that the official wedding pictures were taken by photographer alexi lubomirski. the first of the three photographs released by kensington palace is a group shot of the couple, their close family, and the bridesmaids and page boys. standing to the couple's left is meghan's mother, doria ragland, who made such a deep impression at the wedding with her poise and dignity. the queen and the duke of edinburgh are seated in front of prince charles and the duchess of cornwall. among the bridesmaids and page boys,

prince george is smiling broadly, princess charlotte is sitting on her mother's lap. the second picture shows harry and meghan in a more relaxed pose with their young attendants. george has an even bigger smile. charlotte is sitting on the floor holding one of the bouquets. the third photo is a black—and—white portrait of the bride and groom relaxing and looking very happy on the east terrace of windsor castle. so, what do people make of the pictures? to see a woman of colour in the royal family, which inherently has been white, that acceptance does mean it's a step forward. the commonwealth history, our history and a bit of history in the making. it's nice to see philip there as well. for the queen, visiting the chelsea flower show this evening, the wedding and the positive

reaction to its images of diversity will surely be a matter of relief. she knows the family's younger generation is stepping forward now and it seems well—equipped for the future. nicholas witchel, bbc news. time for a look at the weather... we have the best of the weather over the weekend for the royal wedding, beautiful blue skies. over this week, well, it is not completely blue skies, there will still be someone sunshine around but we have the threat of some thunderstorms. it will always be cool on the east coast with an easterly breeze. we had some thunderstorms today actually, the odd one actually around the london area, a beautiful picture, that. also this line of rain in the west of the uk, moving away, let's focus on the storms earlier. the areas of blue show the downpours we have had. the worst of them have been more towards the west country, up into the west midlands.

those are continuing to fade away and overnight it will become dry across the bulk of england and wales, maybe catching a few more showers in the south—east corner later in the night, the rain continuing to fade away from northern ireland and much of scotla nd northern ireland and much of scotland but there will be a lot of cloud, low cloud as well, that will drift into the north—east of england, temperatures eight to 10 degrees. tuesday will warm up very quickly in the sunshine, still the threat of the odd shower, in the south—east, with a bit more clout, though most cloud will be in the north—east of england and eastern scotland, very low cloud, some patchy fog as well, and also for the western side of northern ireland, a much better day than today. the cloud will thin and break across many parts of england and northern ireland but will stay cool and grey in eastern scotland and the north—east of england. here may be a few more showers late in the day across southern england perhaps into wales, similar sort of areas we had today, large parts of england and wales warm with some sunshine,

temperatures into the low 20s. very warm at the chelsea flower show it again, just the chance of some storms, the risk probably greater on thursday. high—pressure sort of dominating most of the uk, the northern half in particular looks like it will remain dry, and with that high pressure building, so we are tending to thin out a lot of that cloud, more sunshine and warmth in scotland and northern ireland. the risk of catching a shower in the south reduced on wednesday, it may stay across the other side of the most channel. you can see the heat growing across wales, southern england, 25 degrees possible, a warmer day with more sunshine for scotla nd warmer day with more sunshine for scotland and northern ireland. away from those northsea coasts. quite a few more showers, some heavy and thundery pushing northwards on thursday but the showers fade away on friday. hello, i'm ros atkins, this is outside source. the us secretary of state says america is imposing the "strongest

sanctions in history" on iran. the iranians regime should know this is just the the iranians regime should know this isjust the beginning. on the first day of the inquiry into the grenfell towerfire, moving tributes have been paid to the victims — including a baby who was stillborn after his parents escaped. at that moment... we felt our hearts had broken. this is the kilauea volcano in hawaii, spewing out lava — there are now fresh warnings over toxic fumes as the molten rock flows into the ocean.