welcome to bbc news, broadcasting to viewers in north america and around the globe. my name is mike embley. our top stories: senatorjohn mccain's body arrives at andrews air force base in maryland. he'll now lie in state at the us congress before burial in annapolis. after two days of violence, more far—right protests stoke fears in eastern germany. migrants say racism is on the rise. more venezuelan migrants cross into brazil, but the brazilian president now says that closing the border would be "unthinkable". and new hope for children with a severe muscle wasting condition. researchers discover that gene editing will correct it in dogs. hello.

family, friends and political rivals have been remembering senatorjohn mccain at his memorial service in arizona. the republican presidential candidate, vietnam veteran and former prisoner of war died from brain cancer last saturday. he will now lie in state at the us congress, in washington, this weekend, before burial at the us naval academy in annapolis, maryland. former vice president, joe biden, a democrat of course, was prominent among those leading the tributes. from washington, laura trevelyan. the streets were lined in phoenix, arizona as people turned out to bid farewell to the man who served his adopted state with such distinction. # amazing grace...# as his grieving family watched, an honour guard carried john mccain into the baptist church where his funeral began with a much—loved traditional hymn. # that saved a wretch like me...# members of the public, arizona dignitaries

and nationalfigures from both political parties were there. the speakers were eclectic, showing john mccain's extraordinary life. i'm black, he was white. a star arizona football player reflected on the bond he had with his senator. he didn'tjudge individuals based on the colour of their skin, their gender, their backgrounds, their political affiliations or their bank accounts. he valued them on the merits of their character and the contents of their hearts. navajo musicians performed, underscoring john mccain's close relationship with arizona's native tribes. my name's joe biden. i'm a democrat. and i lovejohn mccain. john mccain wanted former vice—presidentjoe biden to speak and he delivered a pointed tribute to his beloved friend.

john's story is the american story. not hyperbole. it sounds like it. it's the american story. grounded in respect and decency. basic fairness. the intolerance for the abuse of power. # and now the end is near...# the final musical tribute spoke to the maverick figure john mccain was, one who never hesitated to switch political positions to put the national interest first. now he's left his beloved arizona for the last time, making a finaljourney to washington, dc where he'll lie in state before a memorial service on saturday. laura trevelyan, bbc news, washington. just an update on the. —— on that. the casket carrying the late senator has now arrived at andrews air force

base in maryland. he will lie in state at the us congress ahead of a funeral service at washington's national cathedral on saturday. former presidents george w bush and barack obama, each of whom defeated mccain in their races for the white house, will offer their tributes to their political rival and personalfriend. let's get some of the day's other news. at least four people have been killed in a collision betweeen a bus and a truck on a freeway in new mexico, according to local police. around 50 people were on the bus, travelling from st louis to los angeles. canada and the us have resumed talks on a new trade deal to replace the nafta treaty. president trump has set friday as a deadline. according to canada's foreign minister, there is goodwill on both sides, but a lot of work still to be done. president trump has claimed he's already done a deal with mexico. president trump has threatened to pull the us out

of the world trade organisation if it doesn't, in his words, "shape up". the president has frequently criticised the international trade body, claiming it disadvantages the us. french prosecutors are investigating allegations that the actor, gerard depardieu, raped and sexually assaulted a young woman. media reports say a complaint was lodged on monday by a 22—year—old actress. she says the 69—year—old assaulted her on two occasions this month at his paris home. through his lawyer, he's denied the allegations. around 2,000 far—right, anti—immigrant protestors have demonstrated in the city of chemnitz in eastern germany, for the third time this week. tensions have been raised by the killing of a german man early on sunday, blamed on an iraqi and a syrian immigrant, who are now in custody. the bbc‘sjenny hill reports. it is not what angela merkel wanted.

extremists on the streets, nazi slogans in the air. "lugenpresse", they shout — lying press. this city is caught between grief and anger. this is where a german man fatally stabbed by, it is believed, by a syrian and an iraqi man in a street fight at the weekend. even the police admit they have been overwhelmed by the subsequent violence. it has horrified germany, terrified chemnitz‘s migrant population. abdul told us he was attacked on sunday. translation: a group of 15 men abused us, then beat us. i ran, but one punched me in the stomach. i fell and he took his foot and stepped on the side of my face. and mara told us she locked herself and her children in theirflat

for two days, too afraid, she said, to leave. but she is frightened too. "go down to town", she says, "see what happens to you as a woman!" there is only one person here speaking up for migrants. "open your eyes, wake up", they tell her. tense times then, for this troubled city. local politicians tonight appealed for calm, but few here trust them to keep chemnitz safe. angela merkel wanted to put the migrant crisis behind her. chemnitz may not let her. brazil's president is now saying it would be "unthinkable"

to close the border to venezuelans fleeing political and economic turmoil. michel temer had suggested brazil might start limiting the numbers allowed in. hundreds of thousands of venezuelans have fled their country's problems, and their exodus is threatening to overwhelm neighbouring states. lebo diseko has more. this was not what they had hoped for when they left the chaos of venezuela looking for a better life. sleeping rough on the streets of brazil's border strait of roraima, it's thought that hundreds of venezuelan migrants arrived here every day. the mayor's office says around 3,000 are now homeless. translation: i came to get ahead, to get a job and take things back for my children. but all i have now is exhaustion from sleeping outdoors. the influx of people has strained resources and cause conflicts between locals and newcomers. earlier this month a migrant camp was attacked and set on fire. and yet the people still continue to come. on tuesday, soldiers

were deployed to the states to re—establish law and order. brazil's president, michel temer, says it is for the safety and security of brazilians and venezuela ns alike, but he later caused concern when he suggested brazil might cap the numbers allowed into between 100 and 200 each day. on thursday he clarified, saying the border would remain open. translation: it would be, i repeat, unthinkable to close the borders. i do not understand how people could say that president temer now wants to close the borders. it will not happen, this will not happen. and still, the economic meltdown in venezuela continues unabated, with electricity blackouts, food shortages, and hyperinflation. venezuela's government says the situation is the work of foreign enemies, but one thing is clear. what started as a crisis in just one country is now fast becoming one

for an entire region. a memorial concert is taking place in detroit to honour the life of the singer, aretha franklin who died two weeks ago. among those performing are gladys knight and the four tops. the queen of soul is being laid to rest later in detroit, motown, where she was born and made her name. mary callaghan—lynch was aretha's opera coach for over 20 years, including ahead of a special performance at the 1998 grammys, of nessun dorma. i spoke to her a little earlier. the reason he was able to work with aretha franklin was that luciano pavarotti was having a party in new york city and asked ms franklin to learn the nessun dorma.

she contacted me, i taught her the aria, and i thought that would be it. but because she was in new york and the grammy awards were one week after the party, pavarotti became ill and she stepped in with a few minutes of notice, no rehearsal, and she reallyjust nailed it. she did an incrediblejob. so our relationship continued because she got requests from all over the country to sing with orchestras, so we had to expand her repertoire. and i know you run a charity which brings opera and music to inner—city kids in detroit. it's worth saying, isn't it, she was a board member, it is worth saying she stuck with detroit even when she was very famous, at a time when a lot of people are trying to get out of detroit. she recorded there, she invested there, she opened a club. well, i would like to say she was our queen. she was detroit's queen. because we shared

her with the world. but the truth is, aretha could have lived anywhere. and she chose to live here in the motor city, in detroit, and for us detroiters, that meant the world to us. she was our queen. to a lot of musicians, just after she died, several said her musicianship was underrated. i know that elton john said that she was one of his favourite pianists. and she was a meticulous arranger, apart from that voice. and i don't know if people realise, but aretha franklin could sit down at the piano and play anything. she was extraordinarily musical, she had great instincts, and yes, she was particular about her arrangements. very particular. do you have a particular special memory? well, actually, it is about playing the piano. i was at a concert with her and i was in the dressing room

and condaleeza rice, an accomplished pianist, was playing a mozart concerto. we were talking and she suddenly became quiet and listened and said, "i love that melody." she proceeded to sit down at the piano, listened, and played the mozart as she was listening. it was extraordinary. i don't know if people really realise she was a musical genius. let's talk to someone now who witnessed the concert first—hand. i know everybody knows you as sharnie the hippie. aretha franklin appeals across the generations. she

definitely does, everyone from my great aunt, jermaine nieces and nephews. how was it? what was the feeling they're? nephews. how was it? what was the feeling they‘ re? how nephews. how was it? what was the feeling they're? how did it stand out to you? it was amazing, it was a really great testament to how detroit spirit is, it was a feeling of solidarity and happiness. she's detroit's icon. everybody felt close to her even if you never met her, could fill it in the room. she was a great interpreter of other peoples songs. a whole lot of people today interpreting songs, that is quite a tough gig, matching up to that. interpreting songs, that is quite a tough gig, matching up to thatm is. but because they pick people who are influenced by her they did an amazing job tonight. who stood out for you? lj reynolds stood out for me, definitely. he sung one of her

earlier records and it was amazing. he said he always wanted to perform a song in front of a crowd and he is a song in front of a crowd and he is a decorated singer himself, so do finally get that opportunity was amazing and that was my favourite part. what is it that makes it particularly special for you? -- makes her. she is special because her songs were always my church. a matter what she was singing about, it always felt like her singing. even when i was a kid who knew nothing about being a fool for a man, it was something that sat in my soul because you could hear her soul in everything. thank you for sharing all of that with us. astronauts onboard the international space station are having to deal with a leak, most likely caused by a collision with a fragment from a meteorite. one of the astronauts, germany's alexander gerst, had to plug the hole temporarily with his finger,

before it could be covered with sealant and tape. engineers on the ground are now working on a more durable repair, but they say the crew is in no real danger. stay with us on bbc news. still to come: new hope to children with a severe muscle wasting condition. researchers have found that gene editing will correct it in dogs. she received the nobel peace prize for her work with the poor and the dying in india's slums. the head of the catholic church said mother teresa was a wonderful example of how to help people in need. we have to identify the bodies then arrange the coffins and take them back home. parents are waiting and wives are waiting, so... hostages appeared, some carried, some running, trying to escape

the nightmare behind them. britain lost princess today, described by all to whom she reached out as irreplaceable. an early—morning car crash in a paris underpass ended a life with more than its share of pain and courage, warmth and compassion. this is bbc world news, the latest headlines: senatorjohn mccain's body arrives at andrews air force base in maryland. he's set to lie in state in washington before being laid to rest. earlier, i spoke to our

corresponent, chris buckler in washington. he told me how senator mccain had meticulously planned his own funeral. of course, he knew that he was suffering from this brain cancer that ultimately claimed his life and he spent a lot of time planning his own funeral service. what we have seen today is, in arizona, he was involved in really ensuring that he had a service which he wanted, in the state he represented the 35 yea rs the state he represented the 35 years inside congress. —— for 35. now his body has made the final journey to washington, and indeed it isa journey to washington, and indeed it is a journey he made so many times during his life. he arrived atjoint base andrews a short time ago, where there was a ceremony with military members standing by, as his widow and their children arrived and were greeted by the defence retreat, james mattis. —— defence secretary.

again, a moment which is being looked upon in washington to remember a man who is remembered fondly by politicians on both sides. again, here in washington, he is going to be given the honour of lying in state at the us capitol. that has happened with only a dozen senators before. it gives you a sense of the high regard thatjohn mccain was really respected in, in terms of the capitol building itself. you talk about both sides, and the respect in which he was held, chris. he made it very plain that he wanted was entered in this series of ceremonies his vision of the united states. political rivals, you say, have been paying tribute, but noticeably no invitation to the current president or to his presidential running mate, sarah pailin? and i think there will be a lot of focus on those who have not been invited. it must be remembered, john mccain, offer all these political tributes, was also a man who did have a little enemies. he was somebody who always advocated a

muscularforeign policy, was somebody who always advocated a muscular foreign policy, which sometimes, particularly anti—war campaigners, really felt he was a man who was not on their side. there is that danger and sometimes thinking ofjohn mccain is a man who represented everyone. that is not the case. certainly when it comes to the case. certainly when it comes to the current president, donald trump, andindeed the current president, donald trump, and indeed his running mate, sarah pailin, that idea of him not inviting them is going to be something that is perhaps overshadowing some of the events that take place, particularly at the washington national cathedral, which will take place on saturday. now, if you listen to president trump, he has been someone who has been very critical ofjohn mccain. he has, for example, questioned whether he should be regarded as a war hero, famously making those statements that frankly a war hero is not somebody who is captured, asjohn mccain of course was, during the more. the president has been careful with what he said and perhaps some of the events of this week, in which we have seen the flag raised and lowered to half—mast on a couple of occasions at the white house, have

not necessarily shown the president in the best light. on the other hand, we have had a comment from sarah palin in which she talked aboutjohn mccain as being a maverick, a fighter and a friend. perhaps, although she has not been invited, they will have fond memories of each other. scientists in london and texas believe they've made a significant step towards an effective treatment for the fatal muscle—wasting disorder, duchenne muscular dystrophy. using the technique known as gene editing, researchers found they could correct the dna of a small group of dogs with the condition. this from our medical correspondent fergus walsh. part beagle, part king charles spaniel, these young dogs all have duchenne muscular dystrophy. the condition mostly affects males in both dogs and humans, and it gets progressively worse as they age. now look at the contrast with these females, who carry the faulty gene but are unaffected. the dogs are part of a groundbreaking project published in the journal science involving the royal veterinary college and the university of texas. this research involved

editing the dogs' genome, the recipe book for life. a faulty gene in the dna causes their disease, duchenne muscular dystrophy. the gene editing system known as crispr was injected into the dogs. it scans the genome, making a single cut at a precise point. this prompted a natural repair and enabled the dogs to produce the dystophin protein which is crucial for muscle strength. these dogs normally do not produce any dystophin protein or effectively no dystophin protein. and by modifying the dna in their muscle cells and their heart we have gone from effectively zero, to up to 92% levels of protein, and that is widely predicted to be life—changing in human beings if we can get to that amount. you have to press that. and that really could be

life—changing for felix. he's six and his muscles are already beginning to weaken. early treatment is vital for him because time is running out. the prognosis for the duchenne kids is very, very bad. they deteriorate very quickly from the age of sort of seven and eight, and normally lose the ability to walk by the time they are 10, ii, 12. and then it's a very rapid decline from then. we trade in hope. so, you know, to hear about something like this is absolutely fantastic. these animals are all descended from one dog, whose owners brought it to the vet with the muscle wasting condition. and scientists found it had the same gene defect as in humans. these dogs are playing a key role in the search for an effective treatment for duchenne muscular dystrophy. a devastating illness. but longer term studies are needed to show whether it actually improves muscle strength and is safe. only then would it be tested on humans.

it is early days, but this research could ultimately benefit both humans and dogs, affected by one of the most severe of all genetic conditions. one of russia's best—known singers, the baritone iosif kobzon, has died of cancer. he sang for stalin at the age of nine, and became a superstar in the soviet union, his career continuing through the 1970s and 80s. he was sometimes known as the soviet frank sinatra. the russian foreign ministry described him as "a human continent." hugely patriotic, seen by some as a propagandist, he was a prominent supporter of president putin and his annexation of crimea. a blimp of the london mayor, sadiq khan, wearing a yellow bikini, is to fly over westminster on saturday. it's in response to the infamous donald tump baby balloon,

which the mayor allowed to be flown during the president'sjuly visit. mr khan says that people are welcome to spend their day looking at him in a two—piece, but that yellow isn't really his colour. now if you're a bit of an adrenalin junkie, and you're based in london, and finally, a baby mandrill has gone on show at the bronx zoo in new york. the infant primate was born at the start ofjuly, the first mandrill to be born there in more than five years. they're one of the largest monkey species, but are classified as "vulnerable. " hello.

well, friday is not looking too bad at all across most of the uk. for the next couple of days will probably bring a little bit of cloud, a little bit of rain, not an awful lot. it is in fact going to be mostly dry for a lot of us and crucially, the temperatures will be rising. so while meteorological summer is coming to an end and friday is the last day of meteorological summer, and the ist of september, it is autumn, technically, according to meteorologists. this is the forecast for the early hours of friday, a lot of clear weather out there, temperatures will be around 12 degrees at 5am on friday, a bit chilly in newcastle and edinburgh. we are talking about six, there will be a hint of autumn first thing on friday morning. some sunshine around and a beautiful start to the day. there is a weather front approaching, you can see thatjust to the west of our neighbourhood. that will encroach on to northern ireland and maybe the isles of scilly later in the day, bringing a few spots of rain but nothing more than that. for most of us it is a dry day.

i wouldn't rule out a shower in the south—east, so just a brief few spots of rain, that's pretty much it. temperatures will be typically around 20 degrees or so. friday is not a bad day. saturday, there is a weather front just stuck to the north—west of us. that means a little bit of cloud and rainfall. scotland, maybe the irish sea. we are not talking about an awful lot. if you squint you can see a little bit here just off lancashire and cumbria and south—western parts of scotland, maybe central parts of scotland, getting a few spots of light rain, possibly northern ireland. that's pretty much it. if anything, it will just be thicker cloud. central and eastern areas looking fine. if you've got plans on saturday, much of england is looking dry, and warming up as well, temperatures in the low 20s. saturday into sunday, we start to see warmer air coming out of france. this is high pressure here, low pressure there. when we get this sort of setup,

this kind of pattern, anything that comes from the west is going to get stuck, and then it sort of slides off to the north—west. so this is where we could see a little bit of rain during the course of sunday, but by the time we get to the afternoon i think the weather fronts will be stuck in the north—west, whereas many central, eastern and southern areas will remain dry. the winds will be light across the uk. that means those temperatures on saturday, or sunday rather, are going to be climbing. on sunday we could be talking about 25 degrees in the south—east. into the low 20s even further north. that's it from me. bye— bye. this is bbc news. the headlines: senatorjohn mccain's body has arrived at andrews air force base in maryland. the arrival came on what would have been his 82nd birthday. earlier, friends, family and political leaders attended his funeral in his adopted state of arizona. he'll now lie in state at the us capitol before being laid to rest. there's been another

anti—immigrant demonstration in the city of chemnitz in eastern germany, after the killing of a german citizen on sunday. police are investigating cases of violence and demonstrators accused of giving the banned hitler salute. brazil's president is now saying it would be "unthinkable" to close the border to venezuelans fleeing political and economic turmoil. michel temer had suggested brazil might start limiting the numbers allowed in. hundreds of thousands of venezuelans have fled their country's problems, and their exodus is threatening to overwhelm neighbouring states. now on bbc news, it's time for hardtalk.