this is bbc news. i'm carol walker. the headlines at 11pm: have you lost control of brexit, prime minister? theresa may faces questions as the government's full brexit legal advice is published. she denies misleading parliament over measures to avoid a hard border on the island of ireland. the benefits for patients now as british scientists complete the world's largest gene sequencing project in healthcare. carbon emissions reach an all—time high in 2018, according to a new study, because we're using more coal and buying more cars. a bbc investigation has found that a student from bath set up an extreme neo—nazi group which urged attacks on public figures. four goals but it's still a draw at old trafford, as manchester united fight back from behind and arsenal extend their unbeaten run. and at 11:30pm, we'll be taking an in—depth look at the papers

with our reviewers, the daily telegraph's brexit commissioning editor, asa bennett, and author and journalist rachel shabi. the prime minister has been accused of of misleading mps following the publication of the government's full legal advice on brexit. the document, which ministers were forced to publish after a vote by mps yesterday, includes legal opinion on the so—called backstop — that's the guarantee of no checks on the irish border in the event of no trade deal between the uk and the eu. the attorney general, in his legal opinion, warns that despite the intention to make the backstop temporary, it could endure indefinitely, and he warns that the uk could be involved in protracted

and repeating rounds of negotiations with brussels. political editor laura kuenssberg has this report. grimly carrying on. after three defeats in parliament yesterday, now a legal mess, on the most contentious part of the brexit compromise, that so—called backstop. have you lost control of brexit, prime minister? after number ten was forced to publish its private lawyer's advice on how northern ireland would be more tangled up with the eu than the rest of the country. questions to the prime minister. we have seen the facts that the government tried to hide. we have seen the facts that the government tried to hide. mr speaker, this government is giving northern ireland permanent membership of the single market and the customs union. the prime minister has been misleading the house, inadvertently or otherwise. a serious charge to lay around here. the prime minister says there is nothing new.

there is indeed no unilateral right to pull out of the backstop. what i have also said is it is not the intention of either party that the backstop should a — be used in the first place or b — if it is used, to be anything other than temporary. but there was more. those northern irish mps who were meant to be the prime minister's friends sounding more and more like her enemies. does the prime minister agree that at this last moment that the entire premise of the backstop has been based on a false assertion? yet the legal advice spells out in more gory detail what the government had tried to gloss. the attorney general writes that the so—called backstop will apply differently in great britain to northern ireland, two parts of the uk with separate rules. and that the european courts will continue to have jurisdiction over northern ireland. the legal advice also states this relationship would endure

indefinitely until another agreement takes its place. that could take a long time. the advice does make clear, though, that neither side wants it to happen. it is not a comfortable resting place for the eu either. the prime minister is trying to persuade people to vote for her deal. what this document shows is the weaknesses of her deal, and she didn't want to tell people what they were. and remember, unhappiness over the backstop is what makes the overall backdrop for the government so gloomy. dozens of tories loudly swearing they will reject the brexit compromise because of it. well, it shows the very predatory nature of the eu's claim to northern ireland. it's very extraordinary that there will be a different relationship between northern ireland and the eu. is it realistic to imagine you can get rid of the backstop now? of course it's possible to get rid of it.

it's not essential for the negotiations. is there any way you can see yourself voting for this as it stands? no. there's no point in having a mishmash of remain and leave when the result is so bad. if it's that bad, is there any point in leaving? let's throw the deal out. as for whether this deal is better than remain, i'd have to admit, it's a pretty finely balanced question. it might feel like it but this is not a rerun of the referendum. in less than a week, mps will vote not on in or out, but on the prime minister's compromise, and there is a minority ready to grin and bear it. i think people should be thinking carefully before they vote it down because we would be in unprecedented territory and i think mps have got to rise to this occasion, step up to the plate and sort it out, to show we can do that without having to spend too many more months arguing about it. this could move fast, but right now, there's no sign of enough support

for the prime minister's plan. that's why in private, conversations are starting to swirl about the kind of extra promises theresa may may have to make to get this done. but so far, there's nothing firm on the horizon that would really change the equation. after more than two years of argument, there is now an agreement. in less than a week, mps will give their verdict on it. but don't hold your breath for a sudden outbreak of goodwill. laura kuenssberg, bbc news, westminster. well, as the debate at westminster continues until the vote next tuesday, there are a number of uncertainties. will the prime minister's deal get through? could there eventually be a second referendum, or could the uk leave the eu with no deal at all? deputy politcial editor john pienaar looks at what could happen next. despite all the setbacks and all the defeats, theresa may is battling on, standing by her plan for brexit,

maybe against all the odds. but what happens next? let's say mrs may wins. that may look unlikelyjust now, but if parliament approves her plan, britain leaves on schedule on march the 29th, an unexpected triumph for mrs may. at this stage, it seems more probable that she loses. her conservative critics may then try, again, to force a vote of confidence in her. and either way, labour will look at tabling a vote of confidence in the government. that would be hard to win. tories and the dup would have to vote for it. meanwhile, unless mrs may manages to somehow get a better deal in brussels, the uk would be on course to leave the eu with no deal at all. but the idea of what brexiteers sometimes call a clean brexit is just not that simple any more. mps voted yesterday to give themselves power to decide the country's next steps if mrs may is defeated, and there's no majority in parliament for a no—deal brexit. so, what then? there is support, within both main parties, for negotiating a new deal,

outside the eu but close to it — a norway—style brexit, though brexiteers call that brexit in name only, brino, taking eu rules without shaping them, continuing free movement of people in and out of britain. in the end, could parliament simply fail to approve any solution and turn back to the people? well, a general election is one way and it's labour's first choice. it's hard to imagine, but even that can't be entirely ruled out. otherwise, the idea that seemed all but impossible until recently may be gaining ground among mps as a potential way to break the deadlock. campaigners call it a people's vote. to most people, it's the idea of a fresh referendum. john pienaar. our political correspondent nick eardley is at westminster for us. ahead correspondent nick eardley is at westminsterfor us. ahead of that vote, lots of manoeuvring behind—the—scenes. we're hearing new

information about where the dup, which is supposed to be propping up the government, will stand in the coming days. yeah, the dup aren't happy with this deal, it's very hard to see at the moment what could persuade them to vote for it. it seems almost certain, barring some big change that they will vote against the prime minister when it comes to that meaningful vote on tuesday. the big question then is what happens, what do the dup do if there's a call for a no—confidence vote in the prime minister in parliament? we're hearing tonight that the dup have the conservatives privately that they will back the government if there is a no—confidence vote. they don't want to bring down the government at this stage. they would use it to try and get a better deal with brussels somewhere down the line. another question, however, comes if this deal were to get through, looks

extremely likely just now that the pm will get the backing she needs, but if she were to pull that off, it's a lot less clear that the dup would remain on side and it becomes quite feasible them that they remove that support and confidence supply arrangement to keep the government in power —— confidence—and—supply. downing street clearly trying to win over every possible mp. now it seems some senior mps are being called in for briefings on contingency planning? that's right. a number of mps on the privy council office some senior ranking former ministers, some long serving mps and the like, serving privy counsellors in the commons are being invited in invited along —— are being invited along to see some of the no deal planning that's going on. they will be briefed by civil serva nts on. they will be briefed by civil servants for about half an hour on what that looks like. some are

saying that, brexiteers in particular, as an attempt to scare grandees into supporting the prime minister's plan —— seeing. some i've spoken to tonight are less than impressed. they're spoken to tonight are less than impressed. they‘ re getting spoken to tonight are less than impressed. they're getting those invites at 7:30pm for meetings tomorrow, some saying they can't attend at the last minute. it's part ofan attend at the last minute. it's part of an offensive, a charm offensive to might want to call it, or an arm—twisting offensive, some might say, from the government to get last—minute support onto the prime minister's side. we know chief whip julian smith has been doing the rounds tonight. he met with the conservative backbench committee, the 1922, to make appeals to them. then he was with the erg, arch brexiteers, some of the biggest critics of the plan, listening to their concerns and trying to figure out if there was something the government could do to win them back. lots of speculation in the

corridors of power about potential tweets here and there to the government's plan to try to win back that support —— adjustments. little concrete tonight, little sense that the tide is in anyway changing. because that vote is getting ever closer, the mounting the prime minister has to climb to win is getting larger and larger —— mountain. the horizon of victory is getting further away. nick eardley, thanks for the latest from westminster. in a world—first, british scientists have completed the largest gene sequencing project in healthcare. 85,000 people took part — people with rare diseases, their family members and patients with cancer. 100,000 genomes were mapped. the genome contains all a person's dna and is the blueprint for life. errors can trigger a vast range of disorders. many of those who took part in project have already benefited from a diagnosis or treatment for their condition. our medical correspondent, fergus walsh, reports. the faces behind the numbers.

these are some of the people who volunteered to have their entire genetic codes sequenced. visiting the laboratories near cambridge where it was done. some are affected by cancer, others by rare diseases. sometimes, what we have to do is go back to the dna sample and do another library preparation... all are helping to improve our understanding of how genes influence our health from cradle to grave. inside, nearly every one of our cells is a copy of our genome. made up of three billion pairs of dna code and 20,000 genes, it is the instruction manual for how our bodies work. sequencing the first human genome took 13 years. now, a genome's worth of dna can be done in 30 minutes. that dramatic acceleration has

enabled scientists here to sequence 100,000 gemones of people affected by rare diseases or cancer. every genome mapped by these machines yields vast amounts of data. so, how is that helping individuals and society? karen carter has contributed two gemones. first, the gene she was born with, then, the dna from her breast tumour, containing the faulty genes that triggered her cancer. by comparing her dna with that of other cancer patients, it may explain why she and several members of her family have developed cancer at a young age. knowledge is power and we need to find ways forward, because once you've had cancer, the worry is always there. good girl. mummy's turn. six—year—old tilly has a rare brain and muscle disorder that used

to cause seizures, meant she lost the ability to walk and made her aggressive around other children, like her brother, arlo. it was not until tilly and mum hannah joined the 100,000 gemone project that scientists were able to compare their dna and finally found the cause of her condition, and an effective medicine. she has been treated now since march and the difference is amazing. her epilepsy is gone. she's developing every day, she's communicating. she's just full of life and she's not violent any more. she can be around her brother without attacking him. the 100,000 genomes project is just the start. the ambition is to sequence a further one million genomes over the next five years, as genomics rapidly becomes embedded in the fabric of healthcare. well, it's transformational in terms of what it means to society and humanity.

the vision is that your health record will eventually have a genomic backbone to it and therefore a more accurate diagnosis or more accurate treatment will be available to you. olivia is three weeks old. it is her generation that has the most to benefit from genomic medicine, as the growth of dna data gives more insights to enable us all to stay healthier longer. fergus walsh, bbc news, cambridge. the head of hs2 and crossrail, sir terry morgan, has announced he's resigning. sir terry has been at the head of crossrail, a new east—west rail link across london, for almost a decade. concerns were raised recently about his dual role with hs2 after crossrail‘s opening was delayed from this month until autumn next year. the home office failed to act on repeated warnings

about how its immigration measures would hit the windrush generation. that's the finding from the government's spending watchdog. the windrush generation are people from caribbean countries who arrived legally after the second world war until 1971. yet the national audit office, accused the home office for failing to protect their rights, and also warned the full scale of the scandal, has still not been established. the headlines on bbc news: the prime minister denies misleading parliament over the government's brexit legal advice, as the full document is published. the benefits for patients now as british scientists complete the world's largest gene sequencing project in healthcare. carbon emissions reach an all—time high in 2018, according to a new study, because we're using more coal and buying more cars. global carbon emissions are set

to hit an all—time high in 2018, according to a new study. researchers at the university of east anglia and the global carbon project, say a projected rise of more than 2% has been driven by a growth in coal use for the second year in a row. a booming global market for cars has also helped drive co2 emissions to a new high. and of course, all this comes as leaders and scientists are in poland to figure out a set of rules for countries to meet the targets agreed in paris. our environment correspondent, matt mcgrath is there. this question of the sport has become the common really interesting. people are using more oil to power their cars, trucks and on their planes. it it is very difficult, even a country like the uk, which has lowered emissions,

they continue to go up. how does that relate to what is going on here? people here will be supported to see these emissions rise. they will be looking to put the rules of the paris agreement into place, but the paris agreement into place, but the sad truth from the atmosphere is that the countries who signed up to the paris agreement three years ago and not living up to the promises they made back then. —— are not. the bbc has seen evidence that a student from bath has set up an extreme neo—nazi group that suggested prince harry should be shot. andrew dymock is believed to have set up the group, as an affiliate of a us group linked to five deaths already. the bbc team carrying out the investigation obtained extensive evidence of the group discussing its violent ideology. this report by our home affairs correspondent daniel sandford contains some disturbing images from the start. some of the shocking imagery produced by the sonnenkrieg division, the most extreme of britain's new neo—nazi groups. the violent propaganda, the worst of which we are not

showing, includes this picture implying that prince harry should be killed for marrying someone of mixed race. the bbc has infiltrated sonnenkrieg's secret online conversations, reading hundreds of messages including one where the leader of the group, blitz or blitzy, says kill all police officers. after an investigation lasting several months, the bbc has seen evidence that blitz, the founder of the group, is andrew dymock, a 21—year—old student from bath whose father is a professor of dentistry. he based the group's ideology on a group in the us called atomwaffen division. atomwaffen, which organised what it called hate camps, has been linked to five deaths in america. those include the killing of blaze bernstein, a gayjewish student. the man charged with his murder was a suspected atomwaffen member. at their home near los angeles, blaze bernstein's parents told

the bbc that britain should be very wary of atomwaffen spin—offs. this is like a disease. this group is a disease. and the only way to eradicate it is to figure out where it is and root it out. the uk group, the sonnenkrieg division, was set up this year and believes society needs to be destroyed before being rebuilt as a nazi state. one of the unusual things about sonnenkrieg division is that they like to harm teenage girls. we've seen an image, which we have completely blurred, posted by blitzy of what seems to be a teenager in a bedroom at the university. the teenager is naked and has a swastika and runic symbols carved in herflesh. one of the groups main propagandist‘s who made this video, was also only 17 years old, oscar,

according to a source, produced the prince harry poster, we put the evidence from our investigation to him, but he did not respond. andrew dymock said through his lawyer, all the allegations were wholly incorrect and that he was not a member of these groups and any interest he had was associated with his university studies. we went to his home to ask for more detailed explanations of his actions. but he has refused all requests for an interview. world leaders, including president trump and four of his predecessors, have paid their respects at the state funeral of the late president george bush sr, who served as the 41st president of the united states. he died last week at the age of 94 and will buried in his home state of texas tomorrow. the congergation at the national cathedral in washington dc heard tributes to his sense of duty and public service, as our north america editorjon sopel reports. a nation prepares to bid

farewell to the last of the greatest generation, those political leaders who fought in the second world war and then served their country with distinction. the extended bush family looked on as his flag draped coffin was moved to the national cathedral. among the mourners, prince charles, representing the queen, and sirjohn major, prime minister during the first gulf war and close friend of george hw bush. the german chancellor angela merkel had come, ever gratefulfor the role that president bush had played in the reunification of her country. and in the front pew, all of the living former us presidents were there. and of course, the serving president, donald trump, too, who until george hw bush's death had been so disdainful of the bush family. but on this day of national mourning, it was also a rare day of national unity for a divided country.

unity there may have been, warmth, there wasn't. the body language as chilly as the december day outside. the eulogy was delivered by his son, the former president george w bush. it was pitch perfect, mixing humour and pathos. i said, "dad, i love you and you've been a wonderful father". and the last words he would ever say on earth were, "i love you, too". to us, he was close to perfect. but not totally perfect. his short game was lousy. chuckles. he wasn't exactly fred astaire on the dance floor. the man couldn't stomach vegetables. chuckles. especially broccoli. and by the way, he passed these genetic defects onto us. and finally, an emotional farewell from a son to his father. so through our tears, let us know the blessings

of knowing and loving you, a great and noble man, the best father a son or daughter could have. and in our grief, let us smile, knowing that dad is hugging robin and holding mum's hand again. as president, george hw bush had said he wanted to see a kinder, gentler nation, something not at the forefront in 2018. the end of an era indeed. john sopel, bbc news, washington. lets return to brexit, and as the prime minister engages in a second day of debate hoping to convince mps to back her brexit withdrawal deal, has she done enough to convince the electorate? nina warhurst has been on a 400 mile tour of the north west of england talking to voters about whether they support the deal, and if they've changed their minds on how they voted two years ago. she starts in barrow,

in furness, cumbria. bis b is for barrow, in furness, with 60% voted leave. unemployment is higher than average, and economy boosted wide building submarines means that those who do work, too well. quick show of hands, who voted leave ? well. quick show of hands, who voted leave? and who voted remain? of these golfers, those who voted remain did so because there kids told them to. as for the leaders, they say barrow is better off without european rules constricting trade. they have no regrets. my name is barbara, i am trade. they have no regrets. my name is barbara, iam lady trade. they have no regrets. my name is barbara, i am lady captain and i voted leave. my name is simon and i voted leave. my name is simon and i voted remain. you describe it as a protracted process, to europe regret

voting leave and would you vote differently? no, iwouldn't. ijust didn't think it would take as long. you still want out? would you like another referendum ? you still want out? would you like another referendum? no. when do we start voting? i think theresa may is doing as well as any body else could possibly do. i suspect everybody knows that. barrow's mp has not written off theresa may's deal, but he wants the plans put to the public. barrow‘s about lovers, they say if that happens, the outcome will be different. i voted remain. people slowly, slowly understand if we leave the european union, we lose the laws of money and work. do you think it barrow would vote again,

would it be different? yes. barrow's population is dwindling and people here are less likely to have received a further education and is likely to be in full—time work in the north—west average. likely to be in full—time work in the north-west average. my name is max, iam the north-west average. my name is max, i am unemployed and i voted leave. i personally feel that the people from abroad are better looked after then the people that live in this country and our uk citizens. instead of bringing all these people in from abroad, hopefully they will invest in the young generation like myself. it was written that barrow wanted, but what we don't know is the sort of brexit that barrow will get. —— it was brexit that barrow wanted. now it's time for a look at the weather for the week ahead with matt taylor. the temperature in aviemore on

wednesday afternoon did not beyond -2. wednesday afternoon did not beyond —2. elsewhere, mild and windy and albert story that dominates. atla ntic albert story that dominates. atlantic wind pushing its way in, yet more waterfront springing early rain across northern scotland and northern ireland. heavy burst in particular. not too much in the high ground. across england and wales, many will start right but a pretty wet day across the north—west of england and across the likes of slavonia. only a few spots of light rain. you were see tempertaures above where they should be the time of year. northern scotland, 12, 13 degrees higher than wednesday. stays mild into thursday night but by friday morning we see a more potent area of low pressure pushing its way in behind at bank of rain. that will target northern scotland particulate, with wind gusts 60, 70, made 80 mph was. brain into the west with blizzards on the heels. further

south, starting work across the south—east before things brighten up. it will be a windy day across the board and even on this western coast we could see wind top ft, 60 mph, bringing frequent showers. one 01’ mph, bringing frequent showers. one or two reaching eastwards but they will stay dry. the blizzards continue across the scottish hills. that ships off into the northern seat to friday night but with a sting in its tail, still pretty lively and destructive wind across scotla nd lively and destructive wind across scotland to take us into the start of the weekend. slowly improving. ryton, chilly start elsewhere across the country but through saturday it looks like cloud, outbreaks of rain will spread its way in from the west topics some of the south and east may stay dry, mainly in scotland dry and bright into the afternoon across the board it will fill chillier than the board it will fill chillier than the next few days. mild air tied in this weather system across the south to