tonight at ten, theresa may agrees to set a timetable for her departure from downing street, after the next vote on her brexit plans. sources say if she loses in early june, she'll resign. it follows talks today with senior conservatives. she and i will meet to agree a timetable for the election of a new leader of the conservative party. the former foreign secretary boris johnson says he'll be running. also tonight... the french waiter stabbed to death by the london bridge attackers. a nurse tells how she was trying to help him when she was attacked. as the probation service goes back into public ownership, the man who pushed part privatisation defends his decision. it's disappointing that this has not worked.

it did lead to a reduction in reoffending... screaming and shouting. in yemen, saudi coalition airstrikes target rebel positions in the capital sanaa, killing six people. and making cancer a chronic, not a fatal disease. scientists say that could become a reality in the next decade. and coming up on sportsday on bbc news... defending champion brooks koepka puts on a superb display to make the early running on day one of the us pga championship. good evening. theresa may has agreed to set a timetable for her departure

from number ten after mps vote on her plans to leave the european union in three week's time. she's expected to resign if she loses the vote. the agreement follows talks between mrs may and senior conservatives, led by sir graham brady, who said they had a "frank" discussion. the former foreign secretary, borisjohnson, today confirmed he'll stand for the leadership. here's our political editor, laura kuenssberg. a police escort no protection from reality. theresa may has tried and tried to keep notjust the trappings, but a slippery grip on power. but her party's agonies over europe and gridlock behind those gates mean her time is officially nearly up. the formality of the announcement no disguise for what the prime minister had to agree. we have agreed to meet to decide the timetable for the election of a new leader of the conservative party as soon

as the second reading has occurred, and that will take place regardless of what the vote is on the second reading, whether it passes or whether it fails to pass. not leaving for the last time yet, but in plain english, if theresa may can't persuade reluctant mps to back her brexit deal injune, the door will close on her time in office. it's out of the question she could stay if she loses, one cabinet minister told me. and in the unlikely event ministers could still win it, she'd likely resign injuly. who could be next? he won't say. can you confirm that you'll run for the leadership? it's a lovely, sunny day. it's lovely to see you here. she won't say. are you ready to declare today? but in the latest you—could—not—make—it—up moment, today happened to be the day when, guess who, finally admitted

to a business conference that he would definitely take part in a race. i'm going to go for it, of course i'm going to go for it... applause. boris inaudible. um, i—i don't think... i don't think that's... i don't think... i—i don't think that is, uh, any particular secret to—to anybody. soon this whole place will be a frenzy over who's next, who will be our next prime minister. we can't know that yet, but we can be sure another tory leader's time in office has been cut short by the party's decades—old disputes. witham in essex should feeljust like home for tories. but listen to the fury of committed conservatives driven to distraction because we're still the eu. because we're still in the eu. they're so fed up, and i think we are top of their fed up list at the moment, as we are ourselves. i was a huge fan of her when she was home secretary. i thought she did a greatjob. i warmed to her when she

first became leader. not quite so warm now. there are conservative voters out there that are refusing to vote conservative now that have done so their whole lives. we're talking 30, 40 years. we want out, as soon as. it's absolutely stagnated the country on other big issues. this is the great sadness to all of us conservatives, because we are all leader orientated, but when you get a rum leader, you've got a rum leader. that's it. with brexit farfrom resolved, a new resident here will still be confronted with many of the same old problems. but perhaps even by the end ofjuly, a different politician will call this place home. laura, night after night we have talked about this in recent months, to reason may is stepping down. it seems to be our as close to knowing when that might be as ever. that's right, and it still had to be

definitive about the date but it's a big moment when the prime minister has finally agreed that on the night of her next big brexit vote in the first week ofjune, she will at that point agree a timetable that will ultimately lead to someone else moving into downing street. it is highly likely at that moment, if she loses that big vote, as most people in westminster expect, she will at that point, within a matter of days, at the beginning of next month say, yes, i resign, and there begins the hunt for a successor. there are still some slim hopes inside number ten that there is still a way of winning and the european elections might provide a shock to the system that could suddenly get mps behind the brexit deal, but it is now extremely likely that we might see a new prime minister by the end of july, perhaps even, or more likely in the autumn, with a conservative leadership contest, with all sorts of runners and riders taking place over the summer period. i think we are in very short order going to see

what one former cabinet minister described to me as a series of prancing show ponies competing for the big rosette. yet again we see the big rosette. yet again we see the conservative party's agonies over their splits in europe, claiming the career of yet another one of their leaders. and there is nothing straightforward about whoever is next. the unresolved problems and conflicts over brexit will be a very real inheritance for whoever out of the many people who wa nts whoever out of the many people who wants thejob, whoever out of the many people who wants the job, is lucky enough to win it. laura kuenssberg, thank you. a nurse who was stabbed in the neck by one of the london bridge attackers in 2017 has told an inquest how she was trying to help a man who'd been fatally injured. helen kennett was off duty at a restaurant with her mother and sister when three men began randomly stabbing people. daniel sandford has more. sirens. just after 10:07pm onjune 3rd, 2017, a van crashed into railings after fatally injuring two

pedestrians on london bridge. just below, in the boro bistro, waiter alexandre pigea rd reacted to the noise and rushed outside. he headed for these steps that lead up to the street. then his colleagues heard the sound of people screaming, and he ran back through the arch holding a gash in his neck. off duty nurse helen kennett was in the bistro with her sister and mother celebrating her birthday. she stepped forward to help the wounded waiter. then she realised that alexandre was being held by a man with a knife.

alexandre died from multiple knife wounds just outside the bistro where he worked. other witnesses saw this young australian nurse, kirsty boden, being stabbed on the ground just metres away. she also died. in less than two minutes, the attackers had stabbed five people to death around the boro bistro, and others like helen kennett were lucky to have survived. daniel sandford, bbc news, at the old bailey. tensions over trade between the trump administration and beijing have escalated, with the us confirming sanctions will take effect tomorrow on the chinese technology giant huawei. washington has effectively blocked the company doing business in the us, over fears shared by other countries that it poses a risk to national security. huawei is a global leader in 56, superfast wireless technology, which will link everything from our phones to driverless cars

to domestic appliances. the firm is already operating or planning services aross much of the world, but here, the government is divided on whether to allow huawei to provide equipment for the uk's new 56 systems. we'll have reports from china and our security correspondent, but first nick bryant in washington. the global battle is under way over sg, the global battle is under way over 56, the next—generation wireless technology. superfast networks connecting our phones, workplaces, cars, connecting our phones, workplaces, cars , every connecting our phones, workplaces, cars, every aspect of our lives. it's pitted against each other at the two countries that will likely shake the rest of this century, america and china. here in washington the fight has produced that rare thing. bipartisan agreements on the threat posed to us national security if the chinese technology giant huawei is ever allowed to run the american networks. huawei is definitely a bad

actor. i think it sends a strong message and help shore up the integrity of our infrastructure. from the trump administration has come a double—barrelled assault. not only is it stopping the company from establishing a foothold in the united states, it is threatening to block american companies from supplying essential components to huawei, such as conductors and optical cables. that'll make it hard for the company to operate anywhere. coming in the middle of an angry trade war with china, the trump administration's attempts to cripple huawei make this look increasingly like a commercial cold war. so what's the in beijing? china is rattled. technology is at the heart of what once looked like an unstoppable economic rise. and it's all suddenly under threat. cutting one of its prized companies off from the us supply chain would bea

off from the us supply chain would be a massive blow. translation: we are against other countries unilateral sanctions that impose measures. we urge the us to stop this practice. huawei, which had yet another new product launch in beijing this week has repeatedly said it would never allow its equipment to be used for spying. translation: it's the us that's undermining trust, it claims. the problem for huawei is that it's much easier to say it's not a pawn of the chinese government than it is to actually prove it. and this latest escalation from america is clearly meant as a signal notjust to china but to the rest of the world to take its warning seriously. here in britain, gchq, one of the national

spy britain, gchq, one of the national spy agencies, has warned of industrial level cyber espionage by china. little wonder then that some like former defence secretary gavin williamson, have raised concerns about a company allegedly too close to chinese state security. today in westminster a major report came out arguing against using huawei. huawei have made a series of claims this week that they don't spy for china, that they are not a high—risk offender and there is no record of poor behaviour, that they are a proud company. what's new in our report is that we show these claims are essentially dubious at best, and inaccurate at worst. for many, that won't be a problem. huawei is a popular global brand and is competitively priced. but can it be trusted? we need to be able to trust in cyber security, whoever it is that provides your network, builds your kit. huawei is an open question right now, because it is compelled by china's security law to work with china's security agencies, that is a

risk. a view in britain's intelligence and community, including mi6, is that there are risks with huawei's technology but those risks can be mitigated. but the problem with mobile phone technology is that it is moving at such a fast pace that a managed risk today could well be a national security threat tomorrow. frank gardner, bbc news in central london. the supervision of all offenders on probation in england and wales is being brought back under public control. the probation service was part—privatised in 2014, by the then justice secretary chris grayling. but the change is said to have cost taxpayers £500 million, and led to a service described as "irredeemably flawed". here's our home editor, mark easton. like the supposedly reformed prisoner who ends up back injail, the government has performed a humiliating u—turn in its probation policy for england and wales. parts of the service privatised just six years ago are to be renationalised. when it comes to offender

management, i recognise that the system isn't working as we wanted it to work. payment by results has not worked. in hertfordshire today, ex—offenders were hard at work as part of their probation programme, but service providers say they've seen the human cost of introducing payment by results into the complicated business of helping people turn their lives around. changing people's behaviour is a complex task, and so, payment results was never likely to work, and it was predictable. and you told them? i think it would be fair to say that the entire criminal justice system told them. the government spending watchdog says the policy's failure has cost taxpayers almost £500 million. instead of cutting reoffending, there have been sharp increases in offenders breaching their probation rules and being recalled to custody. everyone's different and it's all well and good saying, "here's a programme, it's everyone do the same thing and everyone should come out at the end of it." no, it doesn't work like that.

everyone is individual everyone, everyone comes with their own individual problems and stuff like that. chris grayling was the minister who privatised probation management for low and medium risk offenders, refusing to test his plans would work first. i met him at the launch back in 2013. no more money, greater responsibility and businessmen looking to make a profit out of it all — is this really the right way to run probation? it's partnership. what i want to do is capture the best of the public sector, the private sector and the voluntary sector. what we didn't know at the time was that mr grayling had already been warned by internal advisers that his plans were almost certain to fail, with higher risks for the public and poorer outcomes for victims. he went ahead anyway. mr grayling, mr grayling, hello, bbc news... we caught up with mr grayling this evening and he was still defending his decision to privatise. it's disappointing that this has not worked but it did lead to a reduction in reoffending and it also led to more than 40,000 people a year, around 40,000 people a year, getting support from the system which they were not

previously getting. this latest embarrassment, though, comes just a fortnight after the government confirmed mr grayling's cancelled brexit ferry contracts will cost the taxpayer tens of millions of pounds. mark easton, bbc news. four people have been killed in a plane crash three miles south of dubai international airport. three britons and a south african were aboard the uk—registered aircraft. the general civil aviation authority of the united arab emirates, of the united arab emirates has begun an investigation. air strikes from the saudi—led coalition in yemen have targeted the capital sa naa, killing six people. the strikes are said to be in retaliation for drone attacks by houthi rebels on a key oil pipeline inside saudi arabia. forfour years, yemeni government forces backed by riyadh and other countries including the uk and america, have been battling houthi rebels linked to iran. the un says the fighting has caused

a humanitarian disaster for millions of civilians. bbc arabic's special correspondent nawal al—maghafi reports. another tragedy hits the heart of the capital, sanaa. neighbours in a desperate search for survivors. 11 airstrikes in a single morning. one of the most populated residential areas was hit. this little girl, the only survivor in a family of seven. translation: they were sleeping peacefully, a family with their children. it's always the civilians that pay the price. the coalition said these airstrikes were aimed at munitions stores, retaliation for houthi—driven strikes on a key oil pipeline in saudi arabia. independent monitors say despite a decrease in coalition air raids over the last month, the civilian death toll keeps mounting. children cry.

weeks before, a series of explosions right beside a public school. children's daily routine punctured with the horrors of this conflict. the injured rushed to hospital. in yemen, it's the children who suffer the most. even going to school is dangerous. mothers desperately searching for family among the dead, their worst fears realised. 15 children were killed and over 48 injured. the blast came from a houthi rebel—controlled warehouse beside the school, but it's still unclear what caused the explosion. ali lost his 13—year—old son nasur in the blast. they'd fled to the capital to escape violence in their village. but in yemen, there's no refuge.

translation: i've lost the most important thing in my life. he wasn'tjust my only son, but he was my friend and a brother, he was everything to me. i can't put in words what i have lost. nasur walked to school with his cousin fatima that day. translation: it was fifth period. we heard an explosion and we ran away from the windows. i went to look for my cousin, but then there was a second attack. nasur's classroom now lies empty. another blow to yemen's hope for the future. nawal al—maghafi, bbc news. this time next week, voters will be heading to the polls across the uk, for the european parliament elections. the conservatives are taking a low—key approach to the campaign while labour is focused on policy beyond brexit. the results could see a surge in support for some of the other parties in england,

including newcomers to the political scene like the brexit party and change uk. our correspondent alex forsyth has been out on the campaign trail. i must warn you her report contains flash photography. thank you. nice to meet you. good luck. you've got my vote for this one. good man, very good. for some, these elections have brought welcome attention. without a shadow of a doubt, you've got my vote. stand up to them. i know! nigel farage was on the campaign trail in pontefract on monday. this is what we need, we voted brexit, we voted out. not everyone was completely sold. i feel like he also let us down with the vote out because i don't believe they had a plan in place at that point. but there's clear support. the newly formed brexit party has been targeting leave areas and labour heartlands, tapping into anger at how brexit has been handled. chanting: nigel, nigel! i think they're the best one. i just want a clean break away from the eu totally. thank you, huddersfield.

nigel farage knows how to draw a crowd, but in billing his as the party of brexit, he has been competing against the brand he helped create — ukip — which is campaigning and canvassing in these elections saying it is the authentic party of leave. with its own battlebus, ukip has been out on the road trying to maintain eurosceptic support. yes to europe, no to climate breakdown. but pro—eu voices are pushing to be heard. in norwich earlier this week, the green party was promoting its anti—brexit stance. let me explain... you're not the first person to have made that case. the tories and labour know they are under threat from the smaller parties, which have a clear brexit message. i think they will be better than most people, i'm thinking of voting for them. it seems right for today's world. but there is a battle for those trying to capture the remain vote.

but there is a battle among those trying to capture the remain vote. at bristol university yesterday, the lib dem leader was rallying student supporters. for 50 years, actually, the lib dems have been the party of europe... trying to build on their success in local elections, the party's activists and councillors seem comfortable with a quieter campaign. the lib dems love to knock on doors and actually talk to people and i feel like that's working in our favour because we're actually speaking to them and asking their issues. stop brexit is a very simple message, and i hope it does actually get through to people. they're not the only ones hoping that. change uk, another new party, is seeking its breakthrough moment. in bath today, trying to reason with remainers to win support. the vote is going to be split, it can't be helped. if you compare the academic intelligence or rationed reasoning with the ranting and raving and outright lies, the comparison is stark. this campaign is clearly driven by brexit. whatever the tactics on the trail...

give them hell. i'll do my best, i promise! just stop farage! the outcome will depend on whose message can cut through. alex forsyth, bbc news. scientists say they hope that within the next ten years, drugs will be available that will stop cancer cells becoming resistant to treatment. now that could mean tens of thousands of people will live much longer, with cancer becoming morte of a chronic, than a fatal disease. our medical correspondent fergus walsh has the story. it's been called the survival of the nastiest. it takes just a few rogue cancer cells to adapt and develop resistance to drugs for a tumour to survive and reappear, perhaps years later, with greater force. but scientists are beginning to learn how they may be able to stay one step ahead of the hundreds of cancers which affect us. cancers evolve because their mutated dna is unstable. every time they divide, more genetic errors occur and the disease changes.

so, when drugs are sent to destroy them, this natural selection can mean some cancer cells are able to evolve and survive. scientists here at the institute of cancer research hope to exploit this process of darwinian evolution to herd mutating cancer cells into a state that makes them more vulnerable to particular drugs and perhaps a combination of different treatments. they predict that the new treatments could be available in around ten years which help further extend patients' life expectancy. when we look at it from an evolutionary perspective, what we're saying is, we think we can predict what the cancer is going to do next, and so we know how to treat you next. and therefore, we're turning it into something that you can live with longer instead of something that you die from. it's what really helps me get through cancer, it's my escape. christine was diagnosed with breast cancer seven years ago and found out

last year it had spread to her brain. she knows she can't be cured but is doing well on a new treatment which targets her tumours' ability to spread. at some point, my cancer will develop a resistance to it, it will re—occur, and i will have to be on a new form of treatment. and i think all the new initiatives, all the new researches coming out, hopefully means that by the time that i need that next new treatment, there will be something even more innovative and new available to patients. one in two of us will get cancer. so, advances in our understanding of tumour dna matters to every family. new drugs will cost billions to develop but should ensure more patients survive cancer for longer. fergus walsh, bbc news. that's it. newsnight is getting underway on bbc two. here on bbc one, it's time for the news where you are. have a very good night.

hello and welcome to sportsday.

our main headlines this evening... a solid defence — brooks koepka makes the perfect start as he looks to retain his title at the us pga championship. "i forfeit." nick kyrgios quits the italian open and is fined after another spectacular tantrum. and wembley bound — sunderland hold on to reach the league one play—off final at the expense of portsmouth. hello, good evening. we begin with day one of the second golf major of the year — the us pga championship — which this year takes place on the bethpage black course in new york. it's an extremely testing course which american brooks koepka has,

so far, breezed through. let's speak to us golf journalist alex miceli, who is out on long island. it was it is a fascinating round for brooks koepka, 7—under. what did you make from it? just everything went right for brooks koepka. bogey free, course record, 7—under par, seven birdies. the only thing that did not go right for ms. he had focused on going well on the par fives. go right for ms. he had focused on going well on the parfives. he actually parred both fives. just think if he had actually done well in both those par fives. absolutely. he's had a bit of a challenge from the new zealander danny lee. what did you make of him? we weren't expecting much. i wasn't expecting much. he hasn't played well this year. he probably has never lived up to the expectations of being a former us imager champion. it only ta kes former us imager champion. it only takes four rounds in a major to all

sudden get your name in the headlines. danny lee, one back at 6—under, is very surprising but yet i think when you get into these situations, it's only the first round. danny lee does not have anywhere near the experience brooks koepka has. it will be interesting to see what happens as we progress through the rest of this weekend into the weekend. we expected a lot of the great tiger woods, a 72 from him. you think his hopes are now over eve n him. you think his hopes are now over even though which is the first round? 15 major titles, tiger woods, you realise you can have a bad round ona you realise you can have a bad round on a major as long as you followed up on a major as long as you followed up with three good rounds. i think the double bogey at the beginning, and kind of watching tiger throughout the day, he did not seem like he had much in his tank. he seemed a third chick to some extent, even distant at times when he watched his eyes and where he was focused —— he seemed