for the conservatives and labour, trying to end the deadlock over brexit. theresa may could now ask mps to vote on the best way forward, as both sides blame each other for the collapse of negotiations. in particular, we haven't been able to overcome the fact that there isn't a common position in labour about whether they want to deliver brexit or hold a second referendum which could reverse it. the differences within the conservative party mean it's a government that is negotiating with no authority and no ability that i can see to actually deliver anything. but can parliament deliver a way forward with the house itself split on how best to handle brexit? also on the programme: despite a change in the law, cannabis—based drugs for severe epilepsy have been prescribed to just two children in the uk.

the youngest victim of the manchester arena bombing — now her mum, in herfirst interview, tells us about the moment she realised saffie roussos was dead. i just knew. i thought, if i'm this badly hurt, and she was a tiny eight—year—old, then what chance would she have? and a medicalfirst for britain — keyhole surgery to treat a baby with spina bifida while still in the womb. and coming up in sportsday later in the hour on bbc news: we are at wembley ahead of the 138th fa cup final between watford and the manchester city.

good evening and welcome to the bbc news at six. talks between labour and the conservatives to break the deadlock over brexit have ended without a deal. after weeks of negotiations, the labour leaderjeremy corbyn said they collapsed because of what he called "the increasing weakness and instability of the government." but theresa may blamed divisions in the labour party over whether or not there should be another referendum. mrs may says she'll now consider holding a series of votes for mps to try to agree on a way forward. here's our deputy political editorjohn pienaar. jeremy corbyn always looked more likely to back away from mrs may's brexit plan than bail her out and today, sure enough, faint hopes of a cross—party compromise finally died. these talks have now reached what i believe to be a natural conclusion. the prime minister has announced the date she is leaving. there have been increasing noises off stage by conservative cabinet ministers and others who don't agree with much of the talks, or any of the discussions we are holding,

so we are concluding the talks. so no comfort here for a prime minister on borrowed time. helping her was hardly mr corbyn‘s priority, anyway. what a time to promote the tories' faltering euro election campaign. no cheering crowds. not many there in bristol for her stock message. next thursday, we will be holding european elections. the conservative party did not want to be fighting these. we wanted to be out of the european union. indeed, if parliament had backed our brexit deal, we could already have left the eu. and the breakdown of brexit talks — all labour's fault. we have not been able to overcome the fact there isn't a common position in labour about whether they want to deliver brexit or hold a second referendum which could reverse it. six long weeks of talks. workers' rights, green policy, that was easy. sharing customs rules with the eu — many tory mps hated that — and any deal without a referendum

would have split labour. now these talks are over, ministers will consider testing ideas in parliamentary votes and hope enough mps backed a plan and pass the legislation to deliver brexit in earlyjune. i think it's important that parliament takes a decision and i think that means every mp thinking in their conscience that perhaps they are going to have to accept their second or third preference to find the right compromise. but the pressure‘s intense. those tories who are campaigning at all — and many aren't bothering — expect a bad euro election night next thursday. do you think you are too divisive a character to be tory leader? borisjohnson‘s now declared himself a candidate to succeed mrs may. other potential runners would also like to see brexit delivered first. do you want the top job, mr gove? hello, good morning. i think the most important thing that we all need to do is to focus on the fact that the government

are bringing forward the withdrawal agreement bill, which will enable us to leave the european union. if theresa may's last effort to get brexit passed here ends in failure, the next tory leader may well take office having promised a sharper break from the eu. the ca rd—carrying conservatives who will choose britain's next prime minister are, by and large, brexiteers. senior conservatives are convinced that the chances of britain leaving with no deal are as high now as they have ever been. parliament might oppose that, but constitutional experts say only the government could, at a single stroke, stop it happening. so, to reason made‘s last remaining hope of achieving her mission impossible before she leaves may just be that heightened fear of a no—deal brexit persuades enough tory and labourmps to no—deal brexit persuades enough tory and labour mps to change their minds when the legislation to take britain out is voted on here at westminster at the beginning of next month. stubbornness, duty and a steady diet of faint hope will all feature

prominently in theresa may's still to be written political epitaph. and a bit about the uk and its future place in the world, that is still being written. thank you, john pienaar, at westminster. there have been renewed calls for better access to cannabis—based medicines for children with severe epilepsy. the law was changed last year to allow doctors to prescribe unlicensed drugs containing cannabis. but the bbc has learned that only two children are getting the medicine on the nhs. our medical correspondent fergus walsh looks at the contrasting experience of two families. sophia and indie—rose have the same rare form of epilepsy and used to suffer life—threatening seizures nearly every week, until being treated with cannabis—based medicines. sophia's mum danielle, on the left, gets her prescription on the nhs. but indie—rose's parents, on the right, smuggle the same drugs into the uk. tannine and anthony have come to a pharmacy in the netherlands to pick up two cannabis medicines prescribed by a dutch doctor.

this cost us today £1200 and will give us approximately a months worth of oil for indie. how long could that continue? it can't. this will be the last time that we can afford to come here. the cannabis oils made at the dutch pharmacy have two key ingredients. cbd — cannabidiol — known to reduce seizures. and thc, the psychoactive compound in cannabis. nhs specialists are worried about its effects on the brain. when the law was changed last year, it was meant to put a stop to families coming to the netherlands and smuggling cannabis—based medicines back into the uk. it has not worked. that's because uk specialists are still reluctant to prescribe the dutch cannabis oils, as they have not been through the same stringent clinical trials as nhs medicines. 2a hours later, tannine and anthony land back in the uk.

so you made it? what does it feel like having to do that run, because you are breaking the law? myself, for sure, i am really anxious every single time i go, and especially when i come back. back home in suffolk, tannine prepares the cannabis oil. have your medicine? she says it has made a dramatic difference, cutting the frequency and severity of five—year—old indie—rose's seizures and making her more alert. her seizures controlled her life effectively, so she was so tired all the time from having seizures and sedative medications, that she really didn't do anything at all. when she has the cannabis medicine, the whole picture changes. the impact on everyone makes life worth living. in belfast, danielle has also seen huge improvements in seven—year—old sophia, who used to be blue—lighted to hospital nearly every week with life—threatening prolonged seizures.

compared to a weekly occurrence, to not needing an ambulance in nine months, to us it is like a miracle. we are very, very fortunate to get it through the nhs. it's just we know a lot of other families out there are either hearing no, or that the trust won't fund it. nhs doctors who treat children with severe epilepsy say safety concerns are a key reason why they are refusing to prescribe the dutch cannabis oils. first and foremost, we want to do no harm. there's no question we have a whole multitude of children who are resistant to our standard medications. but we need to look at making sure we are not going to make them any worse and make sure that we are giving an appropriate product. we want to do trials in order to look into this, but we don't feel we can just prescribe it without having more of a knowledge base. there is a new cbd medicine made by a british company from these cannabis plants that has gone

through clinical trials. around 80 children are on the drug, but sophia and indie—rose's parents want to stay on the unlicensed dutch cannabis oils, which also contain thc, saying if they work, why change things? fergus walsh, bbc news. the inquests into the eight people who died in the london bridge attacks in 2017 have heard how a young nurse was killed after rushing to the aid of one of the victims. kirsty boden, who was 28 and from australia, had told herfriends, "i'm a nurse, i have to help." she was stabbed to death as she tried to save a waiter, who also died. new figures show that 100 people have been fatally stabbed so far this year, amid a rise in serious knife crime in england and wales over the last five years. 83 of the victims were men and 17 were women. police have brought charges in 85 of the 100 cases,

30 of which were in london. but knife injuries are actually down in the capital by 10% on last year. in the west midlands, there have been eight deaths due to knives since january, and the police and crime commissioner has now declared an emergency, as our home affairs correspondent tom symonds reports from birmingham. this is what a knife can do to a child's arm in a second. jack, he's14, was robbed and stabbed by strangers in a park in dudley. how many is it, jack? 14. he was very close to having an artery cut, wasn't he? and that would have been very, very serious. yes, really. he was... he'sjust so lucky. if that had gone through his stomach as well, again, he wouldn't be here. we've got to do something. we've got to stop it. we really have got to stop it. it's wrong. there you go. the 100 fatal knife attacks this year are concentrated in big cities. the west midlands has eight. that's a high number, given its population. a 19—year—old was stabbed

right here in birmingham. thankfully, he survived. the blood is still here on the steps. when you talk to the police and experts about this, you get all sorts of answers. drugs, social media, children excluded from school. but what about austerity? in 2009, a training session for gang mediators who tried to intervene when rivals in birmingham were trying to kill each other. the murder rate fell. but in 2012, the scheme was scrapped. it hurts in here. and it wasn't. .. the fact that something that was working so well was just literally thrown away. so, they stopped it because of funding? i thought they felt it was job done, but the catalyst for that was austerity. and of course, it wasn'tjob done, so they're having to reintroduce gang mediation. lack of cash is also hampering the police,

even in priority violent crime. unquestionably, in some cases of violence, the investigation won't move at the same pace as it would have done in the past. and pace is important. pace is hugely important, so we prioritise these things hugely, but sometimes that competing demand means the resourcing isn't always adequate. there was a stabbing just down the road by the shop. at this primary school in coventry, a new approach. the children... so, we're going to do a scenario. teach each other to deal with conflict. you tell satnam, and he says he's going to take a knife into school to protect himself. the idea is, it makes them more resilient before they head to secondary school, more able to say no to peer pressure. if it starts like a big like argument, it might start getting like other people involved. this is what's sometimes called a public health approach to violence. in other words, immunising children to a disease which may be spreading.

it's got the appearance that those people who are inclined to violence are actually becoming more violent than they were previously. someone has to clean the blood from the streets. much harder to find ways of preventing the bloodshed. tom symonds, bbc news, birmingham. and you can find more information on the background and court dates of all 100 cases on the bbc news website. just head to bbc.co.uk/news. the time is 18:14pm. our top story this evening: weeks of talks have ended in failure for labour and the conservatives trying to end the deadlock over brexit. coming up: on their way to wembley — watford fans prepare for tomorrow's fa cup final after 35 years.

coming up, ahead of the fa cup final, manchester city and watford. two years ago next week, saffie roussos, who was eight years old, was the youngest person to die in the attack on a concert at the manchester arena. her mother lisa was also very badly injured and was in a coma for six weeks. but, after extensive surgery and rehabilitation, she's now preparing to walk the route of the great manchester run this weekend, to raise money for a new charity in her daughter's memory. she's given her first broadcast interview alongside her husband andrew, to our correspondentjudith moritz. i remember... leaving, and saffie had got my hand, this hand, and she was pulling, jumping about. and the next minute,

i just hit the floor with a thud. ijust remember lying there and trying to move. i was just paralysed. i couldn't even move a finger, i couldn't move at all. and i could blink. ijust kept thinking to myself, keep your eyes open. and when somebody finally spoke to me and started moving me, they asked me my name. and ijust said saffie. that's all i could get out. i wanted to say, will you just go and find saffie? i must have gone again, because the next time, i remember them cutting myjeans off. and that was the last thing i remembered until i woke up, how many weeks later? six weeks. six weeks later. what happened at that point? andrew was with you. andrew was with me, and i can remember thinking, well, why has he not mentioned saffie? and i knew. i just knew. i thought, if i'm this badly hurt,

and she was a tiny eight—year—old, then what chance would she have? like an intuition? yeah. did you ask the question? i said, she's gone, isn't she? it's a painful moment. i can't talk about her. because it's so raw, and it's two years on. i know that. it makes no difference at all, does it? no, it doesn't. still like yesterday? i feel like we are stuck in 2017. yeah, you do, you feel like this. it's amazing how these two years have gone by, but when sometimes we talk amongst each other, you're stuck in 2017. and for you, over the last two years, balancing your bereavement, your loss, with your recovery, how have those two

things been possible? ifelt like i needed to be strong, and i needed to be the best i could be before i could deal with the loss of saffie. i had to learn to walk again. those first few steps round the ward, ifelt like i'd run a marathon, didn't i? i was out of breath, sweating. it was only about five steps. the hand, i think the progress is a lot slower with the hand. coming to manchester, taking part in the run in manchester, how will that feel, do you think, being back here? i know it's going to be emotional. but it's a good thing. and we need it, don't we? something good's got to come out of something so awful. it's got to. judith moritz talking to the parents of saffie roussos.

a neo—nazi who planned to murder the labour mp rosie cooper has been jailed for life with a minimum of 20 years. jack renshaw, who's 23, also admitted threatening to kill a police officer who was investigating him for child sex offences. for the first time in the uk, doctors have used keyhole surgery to treat a baby with spina bifida while still in the womb. surgeons at king's college hospital in london say the spinal procedure isn't a cure, but could mean a child might be able to walk. 0ur health correspondent james gallagher has the story. meet baby jaxson. he had pioneering spinal surgery before he was even born. his mum sherrie was told that without an operation, jaxson may never have moved his legs. so they had surgery, while jaxson was still a tiny foetus in her womb. it was a very high risk pregnancy from the start, anyway. through being told i couldn't have

babies and everything, so any decision we have had to make, i've made it purely for the fact that he is meant to be here. he has fought every day. these routine pregnancy scans found jaxson had spina bifida. his spine and spinal cord were not developing properly, which could lead to paralysis and other problems later in life. surgery reduces the risk. we are operating on very delicate structures. the foetus nerves, and that they are exposed, the foetus itself is very small and we are operating on the foetus inside the womb. so obviously it's a very delicate operation. surgeons operated when sherrie was 27 weeks pregnant. a tiny camera and surgical tools were used to correct the spinal defect by delicately pushing the baby's nerve tissues back into place. spina bifida cannot be completely cured, but surgery in the womb can be the difference between a child

learning to walk or not. jaxson is still being looked after in neonatal intensive care, but he is doing well and should be ready to go home soon. james gallagher, bbc news. voters go to the polls next week in the european parliamentary elections, and while brexit will be a key issue for many across the uk, in scotland, there are other priorities too. as a single nation—wide constituency, six meps represent the country. 0ur scotland editor sarah smith has been to falkirk, to find out what's uppermost, on voters minds. the falkirk wheel is a landmark that connects the forth and clyde canals in central scotland, where a significant majority of scots voted to stay in the european union. but don't assume people here will vote along the same lines as they did in the brexit referendum. you say you voted remain in the eu referendum, so are you tempted to vote for a party that advocates

remaining in the eu? not in the least. not now. it's done. i want to respect the democratic vote of the british people. do you want to vote for a party who you think are going to make that happen and swiftly? i really don't know. perhaps. the snp are hoping to appeal to all the voters in scotland who want to stay in the eu. they say a vote for them is a vote to stop brexit. it's a pretty clear message. but they are also arguing for another referendum on scottish independence. so how much of a problem does that pose for any remainers who don't want their vote in this election to be interpreted as support for an independent scotland? the political combat is over what kind of scotland these karate kids will grow up in. next week's election will allow their parents and grandparents to send a message about the future they want. the snp say people should vote for

them if they want to stop brexit. what do you think of a political message like that? no, if it's another devious way of actually trying to get another vote on independence, then, no, i don't agree with that. have you decided how you are voting in the eu elections? i have and it will be the same as what i did last time, which was to stay in the eu, just like the majority of scotland. if the snp do well, will that be seen as a sign that support for independence is rising? i think again it is a separate issue, but i would say we are 50—50 in terms of independence. arguments that a vote for the snp is also a vote for independence may not carry many voters who think this election is about brexit. on which the results may show scotland thinking quite differently from the rest of the uk. sarah smith, bbc news, falkirk. manchester city's footballers are hoping to make history tomorrow, by becoming the first english side to win all three domestic trophies in one season.

theirfinal hurdle — watford, in the fa cup final. joe wilson reports. commentator: under clear blue skies... their finances may be under some scrutiny, but they sure know how to win a trophy. last weekend was the premier league. the league cup has already been lifted. nowjust the fa cup remains. man city are relentless. winning is so addictive, so when you prove it and you taste it, you say, i want more. it is something like, you know, you win, you go to take a shower, so i want to win the next one. of course, manchester city's achievements have rightly been celebrated, but the fa cup is surely about every high street in every every team can dream. what is the fa cup for if not for a club like watford? there's one big team

against a minnow of a team and, if manchester city win, it willjust be another one to chalk up. for watford, it will be a lifetime achievement for them. just got off the plane from new york and just landed and come straight to the club shop and pick up some merchandisers and excited for the game tomorrow. so you've come from the states to be at wembley? absolutely, yeah, iwouldn't miss it for the world. watford have played an fa cup final before. they lost in 1984. many will remember eltonjohn‘s emotions. well, tomorrow's game is really for the next generation. it could be 35 years until get there again. joe wilson, bbc news, watford. time for a look at the weather. here's nick miller. will it be good weather? there is a chance of a shower at wembley and a chance of a shower anywhere. sunshine return to the east of northern ireland after a splash of rain and you can see on the satellite where most of the cloud has been coming in today and look at the cloud waiting in the

wings to the east. even where you have been clear today, tonight expect increasing cloud and there will be rain more substantially across parts of scotland and the odd splash possible just about anywhere. but also dry weather out there. lo cloud and temperatures holding up at 8-10. cloud and temperatures holding up at 8—10. look at the weekend, low pressure is close by. not deep low pressure is close by. not deep low pressure but it is giving cloud and the chance of wet weather at times. the bulk of that tomorrow will be in scotla nd the bulk of that tomorrow will be in scotland and northern ireland with occasional outbreaks of rain. in england and wales, it slowly brightens up. just pick out some showers, some of which can be heavy but plenty of sunny spells around and it will start to feel warmer but cooler feeling in scotland, especially in the west where it has been warned this week. this is sunday. if you start with cloud you

will probably brighten up and if you start sunny, you will see cloud increasing and you can pick out a scattering of showers that could be heavy. but notice temperatures are moving upwards. if you see sunshine it will feel warmer by sunday. to sum up, a lot of cloud around, some warmer, sunny sum up, a lot of cloud around, some warmer, sunny spells. there will be showers but if you are holding out for rain on the garden, it will be hit and miss. that's it. so goodbye from me. now on bbc one, let'sjoin our news teams, where you are.

the headlines of bbc news. cross party breaks or talks collapse. jeremy corbyn pulled the plug on them naming the weakness and instability of the government. the divisions between the conservative party and the government is negotiating with no authority and

knowability that i can see actually deliver. we have not been able to ove i’co iti e deliver. we have not been able to overcome and the fact that there is i'io overcome and the fact that there is 110 common overcome and the fact that there is no common position in labour about whether they want to deliver brexit or hold a second referendum which could reverse it. a police constable tells the inquest into the london bridge attacks have you tried to fight off all three killers armed only with his baton. and you not plans to murder the labour mp rosie cooper is jailed for life at the old bailey. the human cost of the knife crime crisis. 100 lives lost this year and most of the mail and under 30. ina in a moment will be time for sports day but first look at what else is coming up this evening. a man who says he was left feeling suicidal after appearing on the jeremy says he was left feeling suicidal after appearing on thejeremy kyle show says his concerns went unheard. the itv show was cancelled this week. wildfires continue to place across parts of sutherland and

scotland. we will be hearing about latest efforts to contain them. we will be taking a look at tomorrow's front pages. and kate andrews, assisted director of the institute of direct economic affairs. now it's time for sportsday with ali foster at wembley. around this time tomorrow with the 130th cup final will be drawing to a close and whatever the result will be special. the fitzroy that mixes up to the box and lift the trophy right here at the net will be a first for watford, but if the ribbons are blue and vincent company does the honours manchester city will have completed an unprecedented domestic travel. there's an awful lot at stake. welcome to