this is bbc news with the latest headlines for viewers in the uk and around the world. i'm tim willcox. the first vaccine trials for coronavirus are under way across europe. two uk volunteers are injected in what's described as a scientific landmark. president trump offers hope to americans as they head towards the summer, by saying the latest research sunlight and heat helps kill the virus. and a warning of a second wave: the world health organisation tells the bbc countriues in south east asia need to get used to a "new way of living" and the royals leading the applause for britain's carers and key workers.

hello and welcome to audiences in the uk and around the world. we're covering all the latest coronavirus developments here in britain and globally. the first human trial in europe of a coronavirus vaccine has begun here in the uk, marking a highly significant moment in the scientific response to the pandemic. this afternoon two volunteers were injected with that potential vaccine, the first of more than 800 adults aged between 18 and 55 years old who've been recruited for the study. the scientists behind it say they are already working with manufacturers to produce

millions of doses later this year, should it be found to work. our medical correspondent fergus walsh has this special report. this could change everything. a vaccine against coronavirus. a way out for all of us. ok, so a little scratch. the first volunteer to receive it was elisa granato, a microbiologist. she's 32 today. i'm a scientist, so of course i want to try and support science, the scientific process whenever i can, and since i don't study viruses i felt a bit useless these days, so i felt like this was an easy way for me to support the cause, yeah, and that's why i'm here, and i'm excited. half those on the trial will get the coronavirus vaccine, half a different jab. the volunteers don't know which one they have received. i am just basically going to sit here and incubate this thing, and hopefully provide some good follow up data, and we'll see, and hopefully it works.

what would normally take years has been done in three months, by scientists at oxford university. around 80 groups world wide are developing coronavirus vaccines. a few others, in the us and china, have also started human trials. there's no guarantee any of them will succeed. personally, i am very optimistic it's going to work. formally, we are testing it in an efficacy study. there's absolutely no suggestion we are going to start using this vaccine in a wider population before we have demonstrated it actually works and stops getting people infected with coronavirus. so how does the vaccine work? scientists have taken the genes for the spike protein on the surface of coronavirus, and put them into a harmless virus. this forms the vaccine. after it's injected, the vaccine enters cells, which start to produce the coronavirus spike protein. this prompts the immune system to produce antibodies,

and activate killer t—cells which should recognise the coronavirus in future, and destroy it, preventing infection. the scientists will only know how effective the vaccine is if lots of volunteers are exposed to coronavirus. well, at this moment we are chasing the end of this current epidemic wave, and of course, if we don't catch that, we won't be able to tell whether the vaccine works in the next few months, but we do expect that there will be more cases in the future, because this virus hasn't gone away. why not simply infect people with coronavirus after they have had the vaccine, then you would know? at this moment, it would be very difficult to do that with a disease which potentially has quite a high fatality, so i think if we reached a point where we had some treatments for the disease and we could guarantee the safety of volunteers, that would be a very good way of testing the vaccine.

the vaccine is stored in this freezer, at minus 80 degrees. rarely has a medical trial had so much riding on it, for so many people. it is hard to overstate just how important this vaccine could be. if—and it isa big if— it proves to be safe and effective, it would represent science giving us the solution to the coronavirus pandemic. well, i think everybody agrees it is the only way we are going to get out of the lockdown, the social distancing, and really be able to still have people protected as they go about their daily lives. edward, a cancer researcher was next up. there is a theoretical risk the vaccine could make a coronavirus infection worse, but the team here think that highly unlikely, and the volunteers will be carefully monitored. it seems like the right thing

to do, to ensure that we can, you know, combat this disease and get over it a lot faster. do you have any concerns at all about safety? i think you can neverfully exclude any potential risk, but i think you have to, i guess, walk in faith in these things. you have to trust in what they, that the work is being done as best they can, and know that the cause is important. the oxford team are hoping to have a million doses of vaccine ready by september, with a huge scale up in manufacturing after that. it is not clear, though, who would be prioritised to get the vaccine first, and for now, we have to wait and see if it works. let's get some of the day's other news. european union leaders have agreed to work together towards establishing a fund to help economies recover from the coronavirus pandemic. the head of the european commission, ursula von der leyen, said it would mobilise a trillion euros' worth

of investment, and would require greater contributions to the eu's budget. the world health organization is warning that up to half of all covid—i9 deaths in europe could have been among care home residents. its regional director for europe, hans kluge, said there was a ‘deeply concerning picture' emerging of the impact covid—i9 is having on those in care, labelling the fatalities an ‘unimaginable human tragedy‘. the bundesliga says it hopes to resume matches on the ninth of may, becoming the first major european football league to restart after the coronavirus outbreak stopped matches. the proposal — which would need to be ok‘ed by the german government— would involve matches taking place behind closed doors, and those taking part be rigorously tested for covid—i9. vietnam has started to ease lockdown across much of the country after reporting no new coronavirus cases for a week.

with only 200 and 68 confirmed infections — and no deaths — the communist government‘s strategy for containing the virus among almost 100 million people has been one of the most effective anywhere in the world. president trump says he‘ll sign into law another huge financial relief bill — worth almost 500 billion dollars, aimed at small businesses and hospitals. it pushes the country‘s total spending repsonse to the crisis to almost three trillion dollars. but how much help will it be the record 26 million americans who‘ve so far lost their jobs because of the pandemic? nada tawfik reports from washington. let us pray. these are days of great political, social, and economic stress in our nation... lawmakers in the house keep a safe distance even as they move closer to pushing through a fourth coronavirus relief bill.

a m84 billion package that mostly boosts the small business loan programme that quickly ran out of money last week, and also funds for hospitals and testing plans. our nation faces a deadly virus, a battered economy, and nearly 50,000 deaths. this is really very, very, very sad day. but will the new measures be enough? 4.4 million more americans have joined the ranks of the unemployed last week alone. 26 million in total since late march. the surge ofjobless claims is overwhelming federal and state systems. viran ra nasinghe owns a karate studio in maryland. he‘s applied for a pay cheque protection programme loan three times but has heard nothing. i think the most frustrating part is it seems that the people who are needing it

the most are not getting it and big businesses, it seems like they‘re the ones getting it. we have customers, and clients, and students that paid for their classes who are all asking for refunds. and, you know, we have to give them their refunds. the pain of relentless job losses has intensified the debate over when to lift state lockdowns. according to a recent cbs poll, health concerns still take precedence over economic ones by a wide margin. 70% of americans say the country‘s top priority should be staying home. even if restrictions were lifted, very few say they would definitely return to public places regardless of what happens with the outbreak. soon, that might be put to the test as cities and states across the country consider easing restrictions in the days and weeks to come. nada tawfik, bbc news. in the last few minutes president trump has given his daily coronavirus press briefing at the white house — where he‘s offered some hope to americans as they head towards the summer, by saying the latest research shows sunlight and heat has

a powerful effect on killing the virus. he‘s also said that america is leading the way in how to properly lift lockdowns. states are starting to open up now and it is very exciting to see. very awe—inspiring. we are coming out of it and we are coming out of it and we are coming out of it and we are coming out of it well. and we are coming out of it well. and we a re really coming out of it well. and we are really happy the governors have been doing a really good job working with us and it is really pretty impressive to see. i have spoken to numerous leaders of countries over the last 48 hours and they are saying we are leading the way. so many different ways. let‘s get more on that and other lines coming out of the white house and speak to our north america correspondent david willis. interesting because mike pence spoke after the president and he doesn‘t normally come out with such a bold statements but even he was saying we might be seeing the end of the pandemic in the states by early summer. he was. president trump had said before that that social

distancing guidelines might well remain in place until the summer, but he tested research which he says suggest that the virus does not do well in the heat and in the sunlight, loss and thrives in colder and weather. he drew on an expert from the department of homeland security to advance that theory. president trump has made the point at rallies in the past several weeks ago when the past several weeks ago when the coronavirus was not at his height that this would all be over by the summer. now he seems to have got some sort of scientific evidence to back that up and as you say, the vice president mike pence unprompted also made the point that by the summer time, this country could be as he put it ina much country could be as he put it in a much better place. and politically, that will be hugely important for the president and this election year. the jobless numbers just

escalating. absolutely. and another 4 million added to the jobless role and that puts it at 26.5 million in the last five weeks. now, the house of representatives is expected to pass a bill providing more fun as you mention in your introduction about 500 billion oi’ introduction about 500 billion or $0 introduction about 500 billion or so additionalfunding introduction about 500 billion or so additional funding for small businesses to basically encourage them to retain staff rather than laying them off. this very uncertain time. the house of representatives have reconvened today and exercising social distancing of its own committee members wearing masks, and they are to vote to approve that and on a bipartisan line tonight and it will be on the presidents death for signing tomorrow. all part ofa $3 for signing tomorrow. all part of a $3 trillion similar effect. —— president‘s desk

tomorrow. briefly, more states now releasing their lifting of the lockdown measured. absolutely. georgia in particular announcing that it is lifting restrictions on spas, beauty parlors, tattoo parlors and so on to the chagrin of president trump, who was a supporter of the republican governor of florida, brian kemp, mr trent with that briefing that is just concluded think i want people in georgia to be safe, i don‘t want things to be safe, i don‘t want things to flare up and i‘m not happy about the lifting of those restrictions and he added i‘m not happy with brian kemp. thank you. stay with us on bbc news, still to come. the weekly national applause for britain‘s carers and key workers — as people come out onto the streets to say thank you.

the stars & stripes at half mast outside columbine high. the school, sealed off. the bodies of the dead, still inside. i‘d never thought that they‘d actually go through with it. one of the most successful singer songwriters of all time, the american pop star prince, has died at the age of 57. it's hard to believe it, i didn't believe it. we just — he wasjust here saturday. for millions of americans, the death of richard nixon in a new york hospital has meant conflicting emotions. a national day of mourning next wednesday sitting somehow uneasily with the abiding memories of the shame of watergate. and liftoff of the space

shuttle discovery, with the hubble space telescope, our window on the universe. this is bbc news, the latest headlines: the first human trials of a coronavirus vaccine in europe have begun. two uk volunteers were injected today in oxford. president trump says the latest scientific research shows sunlight and heat helps kill the virus. countries that have successfully fought off major covid—i9 epidemics, are being warned to expect second and third waves of outbreaks in the coming months. the world health organization says people living in countries reporting very few cases now, such as china and south korea need to start getting used to a "new way of living" as they continue easing restrictions. the bbc‘s global health

correspondent tulip mazumdar has been speaking to the regional director of the who‘s western pacific region — dr takeshi kasai. this is something that i think that is maybe once in a 100 years, definitely it is like a historical event, and ifeel we are part of that history. this is a region which so far has had relative success in the global fight against covid—i9. i wanted to start responding... dr takeshi kasai is the man leading the who response in its western pacific area. he told me there have been fewer than 140,000 cases there, that is compared to more thani million cases in europe. at the moment, the epicentre is in europe and the united states. but it can come back and then our region could be the next epicentre. but so far, what i can say is the countries

in our regions, let‘s say like singapore, and it is not a country, but hong kong, or korea or taiwan and china, austria, new zealand, they are the ones really, after sars, prepared based on the lessons they had. that the sars epidemic which killed more than 800 people in the early along with another coronavirus virus outbreak, murs in 2015, meant that when covid—19 arrived in the region, many countries were much better prepared for it. but early successes do not mean the virus simply goes away. japan is now seeing a second wave of infections and has declared a state of emergency. in singapore, meanwhile, with migrant workers living in overcrowded dormitories, the country is also seeing a fresh outbreak. a country, who even has a very strong capacity, if we do not pay attention to all of those vulnerable, it can get into those vulnerable. and so it is very important that the countries do pay

attention to those groups. are second, third, fourth waves, are they inevitable? i think it is going to be a long battle. we should anticipate there will be a second, third wave. and to respond to that, i think we need a new way of living. for the individual, i think we need to continue to do our basic precautions and practice such as washing hands, or in case if you have some symptoms, stay home. for the private sector, we want them to find a new way of operations. that can minimise the risk of an infection. and for the government sector, we want them to bring back basic services, such as immunisation, but at the same time to prepare for a large—scale community community outbreak.

tourists are in celebratory mood on the great wall of china as the country where this pandemic started continues to relax restrictions. this remote south pacific island is one ofjust a few places on earth still untouched by covid—19. but as long as the outbreak rages on in the rest of the world, every single country is at risk. though crime is down in america at this time of crisis — gun sales are up, as americans worry abour personal safety. the bbc‘s jane o‘brien has more. first—time buyers lining up outside a store near san francisco. it‘s a scene replicated across the country as americans stock up on what some consider essential items. we want to feel safer. the mentality of some people, theyjust, they get crazy

and desperate, and you never know what‘s going to happen. but as cities remain in lockdown, there‘s been a sharp decline in reported crimes. from chicago to la and in new york, the epicentre of the virus, serious crime has seen a double—digit drop. but 20% of new york‘s police force is also sick — an example of why americans who‘ve never owned a gun now feel they need one. you have a lot of police officers and first responders right now that are ill and are not out on the streets being able to help people protect themselves. so, you look at the violent crime going up, you look at first responders not being there or being able to be there, the first line of defence to protect yourself is your self. the second amendment guarantees the right to bear arms but exercising that right during the pandemic has become dependent on where you live. the federal government says gun stores are essential businesses and should stay open.

but the hodgepodge of existing controls in different states has become more pronounced with the power of individual governors to impose emergency restrictions. in the united states, we have the freedom of assembly, we have the second amendment freedom, freedom of religion... they can‘tjust shut down and shred the constitution because of a virus. attorney andrew couture is suing the state of massachusetts where the governor has ordered the closure of gun stores as part of measures to control the spread of the coronavirus. this is nothing more than an attempt to bankrupt every gun store in massachusetts so when we can finally get through this critical time in our nation‘s history or the world‘s history, let‘s face it, that they would not be able to open. americans have already given up significant freedoms, many protected by the constitution. who has the authority to order

such restrictions and enforce them is an ongoing political and legal debate. on loud-hailer: it is a government that is out of control! and it is notjust gun rights. across the country, americans have begun protesting against restrictions they say are creating more harm than the virus itself. ultimately, such measures will only work for as long as the citizens themselves agree to them. jane o‘brien, bbc news. the duke and duchess of cambridge — and their children have led the uk in the weekly national applause for britain‘s carers and key workers. jon kay reports. applause. standing together... while standing apart. another thursday night... in the uk. it is a little tiny thing i can do, to you know, make some noise, just to say thank you. every week. every week? yes. not missed one? not yet. and we won't.

on this street, like so many others, it is personal. sarah, at number11, is on the front line. she‘s a health care assistant at the birmingham hospital trust, that has had more than 600 covid—19 deaths. does this help you get through? yes, massively, 100% helps me. every thursday. it is like a release. it is a release. i come out and they are all clapping, it is another week coming to an end. just amazing. just fantastic, i can‘t believe it. 0h... at precisely 8.00, for the fifth week in a row, it felt like the whole of the uk erupted.

8,000 miles from home, members of the british antarctic surveyjoined in. in the middle east, divers from hms ledbury clapped and washed their hands at the same time. in the skies above wiltshire, the pilot of a light aircraft plotted his flight path to spell out his gratitude. while on the ground, the social distancing red arrows. from bin collectors in norfolk, to the royal family. back in the midlands, sarah and her husband gary, who is a delivery driver have moved into a caravan on the drive. see you soon, we love you loads. so they don‘t put sarah‘s mum at risk. gwen is 83. clapping for her daughter, and for thousands of others, and she will be saying thank you again, next week. jon kay, bbc news.

well done. that is it from us. back with headlines in a minute. hello. many places across the uk had gently skies from dawn till dusk on thursday. in actual fact, parts of the southeast saw highs of 24 degrees, 75 fahrenheit and is probably going to be the warmest day this week. slightly different story coming in across east and england. in across eastern england. a breeze from the north sea and a little more cloud here at temperatures struggle at a ten or 11 degrees. we start our day on friday with cloud across parts of eastern england, stretching and as far as the east midlands may be but as we go through the day, that should melt away and dry and settle. just an outside chance later on in the afternoon of an isolated shower across the southwest.

we should see temperatures peaking at 22 degrees and may and may be 20 degrees into western scotland as well. as we go through the evening, we keep clear skies are most any risk of an isolated shower across higher ground in southwest england continues. going into the weekend, it looks likely to stay largely fine and dry. just that little bit cooler and we increase the risk of showers as we go through the second half of the weekend. we start off on saturday with very open isobars, light winds across the country in this little fellow here may just introduce more cloud and eventually the risk of further showers. going to the day on saturday, we could have a little more cloud to start off with along the east coast and that melts away, a lot of sunshine coming through. saturday should stay dry, and pleasantly warm out there with highs of nine to 21 degrees. moving out of saturday into sunday, that when the front will just creep

towards the northwest of scotland and enhance the risk of showers. a slow and subtle change of the story for the second half of the weekend. the potential for showers and cooler field developing is the one swings around to a northerly in the showers may well just creep into northwest england and north wales by the end of the day on sunday. ahead of it, it stays pleasantly warm with 22 degrees behind it and somewhat cooler conditions, ten to 14. but the dry story is set to continue for the remainder of april as you can see, dry settle and sunny butjust that little bit cooler right across the country. take care.

this is bbc news, the headlines. the first human trials of a coronavirus vaccine in europe have begun. hundreds of volunteers will get the vaccine — two of them were injected today in oxford. scientists say they are already working with manufacturers to produce millions of doses later this year. president trump has offered some hope to americans as they head towards the summer, by saying the latest research shows sunlight and heat has a powerful effect on killing the virus. he‘s also said that america is leading the way in how to properly lift lockdowns. and president trump says he‘ll sign into law another huge financial relief bill — worth almost 500 billion dollars, aimed at small businesses and hospitals. another 4.4 million americans have filed for unemployment benefits in the past week.

now on bbc news.