this is bbc news with the latest headlines for viewers in the uk and around the world. i'm lewis vaughan jones. a scientific landmark — two uk volunteers are injected as the first vaccine trials for coronavirus in europe get underway. american lawmakers pass another relief bill worth m80 billion for small businesses and overwhelmed hospitals. gun sales are up, as americans worry about personal safety in a time of crisis. and the royals leading the applause for britain's carers and key workers.

hello and welcome to audiences in the uk and around the world. we're covering all the latest coronavirus developments here in britain and globally. the first human vaccine trial has occurred in europe. two volu nteers has occurred in europe. two volunteers were injected. the first of more than 800 adults who have been recruited for the study. scientists behind say they are working with manufacture and to manufacture billions of doses should it be found to work. this could change everything, a

vaccine against coronavirus. a way out for all of us. the first volunteered to receive it was a microbiologist. she is 32 today. i am a scientist so i wa nt to today. i am a scientist so i want to support the scientific process wherever i can and sense i do not study viruses are felt a bit useless so i thought it was an easy way to support the cause. half will get the coronavirus vaccine, half a different jab. get the coronavirus vaccine, half a differentjab. the volu nteers half a differentjab. the volunteers do not know which ones they have received. volunteers do not know which ones they have receivedlj volunteers do not know which ones they have received. i will sit here and incubate this thing and hopefully provide good follow—up data and hopefully it works. what would normally take years, has been donein normally take years, has been done in three months by scientists at oxford university. around 80 groups worldwide are developing coronavirus vaccines. a few others in the us and china have also started human trials. there is no guarantee any of

them will succeed. personally, iam very them will succeed. personally, i am very optimistic it is going to work formally. we are testing in an efficacy study and if there is absolutely no suggestion began to use this vaccine in a wider relation before demonstrating it actually works and stops getting people infected with coronavirus. so how does the vaccine work? scientists have taken the gene from the spike protein on the surface of coronavirus and put it into a harmless virus. after it is injected, the vaccine enters itself which start to produce the coronavirus protein which prompts the immune system to produce antibodies and activate killer t cells which will recognise the virus in future and destroyed, preventing infection. the scientists will only know how effective the vaccine is if lots of volu nteers vaccine is if lots of volunteers are exposed to coronavirus. at this moment we

are chasing the end of this current epidemic wave and, of course, if we do not catch that, we will not be able to tell whether the vaccine works in the next few months. but we do expect there will be more cases in the future because this virus has not gone away. why not simply infect people with coronavirus after they have had the vaccine, then you will know? at this moment it would be difficult to do that with the disease which has potentially a high fatality. if we reached a point where we had some treatment for the disease and we could guarantee the safety of volunteers, that would be a very good way of testing the vaccine. the vaccine is stored in this freezer at —80 degrees. rarely has a medical trial had so much riding on it for so many people. it is hard to overstate just how important this vaccine could be, if — it is a big if —

it proved to be safe and effective. it would represent science giving us of the solution to the coronavirus of pandemic. i think everybody agrees it is the only way we're going to get out of the lockdown, social distancing and really be able to steal have people protected as they go about their daily life. edward, about their daily life. edward, a cancer researcher was next up. there is a theoretical risk of the vaccine could make a coronavirus infection worse but the team here thinks that highly unlikely and that volu nteers highly unlikely and that volunteers will be carefully monitored. it seems like the right thing to do to ensure that we can combat this disease and get over it a lot faster. do you have any concerns about safety? you can never fully exclude any potential risk but you have to walk in faith in these things and trust in the

work that has been done, best they can, and know that their cause is important. the oxford tea m cause is important. the oxford team are hoping to have a million doses of vaccine ready by tamba, with a huge scallop in manufacturing after that. __by in manufacturing after that. ——by september stop —— with a huge scale up. now we just have to wait and see if it works. let's cross to atlanta, georgia now and talk to dr patrice harris, who's president of the american medical association. we have heard" a bit of detail about the vaccine potential. let's look at the united states, big restrictions in place. some states now starting to ease those, specifically georgia reopening many shops. what is your reaction to that?

certainly, as we began to loosen stay—at—home restrictions, we need to do so keeping the signs and evidence in mind. at the ama we recommended listening restrictions only when we have the capacity to test and trace, when we have a good capacity in our medical infrastructure, and certainly when we are able to test more and that is both diagnostic testing and anabolic testing and we are still a way to getting fair and we have great concerns about listening these restrictions to early and we do not want to see a rebound in the number of infections. in the us, the testing regime is not where it needs to be at the moment? we are behind and certainly we are improving but we still need to be able to make sure that the diagnostic

testing is getting particularly to the hot spots, those areas that seem to have the most rate of infections. most hospitalisations and u nfortu nately hospitalisations and unfortunately and tragically most deaths. we are still a way of getting our anabolic testing up. we have made some emergency use but we still need to test those and make sure that those anabolic tests are both sensitive and specific so we believe we have still a way to go to get our testing infrastructure in place. go to get our testing infrastructure in placelj go to get our testing infrastructure in place. i do not know whether you heard the comments from the white house in the regular briefing are just a couple of hours ago, donald trump talking about the effect of sunlight on the virus, of disinfectant on the virus. what you make of those comments? i have to say, i gave

an address last week and i really encourage everyone, from those in elected office to citizens on the street, to make sure that we are led by science and evidence and we need to see whether or not this virus behaves like other viruses. 0ther behaves like other viruses. other viruses, there has been a decrease in the summer with warmer temperatures but we just do not know yet. this is a new virus. it may behave like other viruses, it may not. it does, we could use the time when our weather is warmer to make sure weather is warmer to make sure we are prepared because dr faucihas we are prepared because dr fauci has said we are likely to have a resurgent in the fall. i think we need to wait on a fuel review of the science and evidence to see if warmer weather and humidity help. we will see. thank you for your time and expertise, dr patrice

harris. thank you for having me on. president trump gave his daily coronavirus update to the media at the white house a short time ago and took questions from our north america editor, jon sopel who asked whether the us was in a position to roll out the vaccine being worked by british scientists in oxford if it turned out successful. 0xford, johnson &johnson 0xford, johnson & johnson is working and working together. we have many companies working together on a vaccine. does the scallop production and pharmaceutical companies be able to do that quick fully? —— scale up. we could do it quickly. some of the companies, johnson &johnson quickly. some of the companies, johnson & johnson is quickly. some of the companies, johnson &johnson is one, is scaling up already before having the final answer which saves a lot of time. could you put a timescale? no because then the so—called media, lame

street media will say he set a time. i will say there has been tremendous progress made. you spoke to borisjohnson this week, ijust wonder how he sounded, how he was an when you think you will be back at work? he called me a few days ago. i will tell you, he sounded incredible. i was actually surprised. he was ready to go. iam very surprised. he was ready to go. i am very surprised to tell you this. it is like the old boris. let's get more from our correspondent david willis. lots of things happening. shall we start with the financial stimulus past and on its way to donald trump's desk? $500 billion stimulus package and the total stimulus spending here in the us to nearly $3

trillion. president trump has said he expects to sign it swiftly into law and what this does is it provides forgivable loa ns to does is it provides forgivable loans to companies who do not shed workers from their payroll and keep them on until the crisis abates and that a significant given the figures today, the latest unemployment figures, an additional 4 million americans now out of work and that brings the jobless total to 26.5 million in the last five weeks. now that he rose all the gains of the last few years and in actual fact plunges unemployment back to levels not seen since the great depression of the 1930s. those economic reasons, part of the reasons shirley certain states are going to be easing those restrictions and those lockdown areas but that is not without controversy? it is not without controversy? it is not without controversy and indeed you are

referring particularly to the state of georgia which has announced it is to reopen, as from tomorrow, spas, hair salons, tattoo parlours and so on, much to the chagrin of president trump, despite the fa ct president trump, despite the fact he supported the republican governor's run for office, he was damning today when asked about this move by george's governor. he said i wa nt george's governor. he said i want people in georgia to be safe, do not want things to flareup and i am happy about it, iam flareup and i am happy about it, i am not happy about the governor there, brian kemp, it, i am not happy about the governorthere, brian kemp, on monday, mr kemp wants to go even further and reopening some restau ra nts a nd even further and reopening some restaurants and cinemas in the state of georgia. thank you for bringing us up to speed. stay with us on bbc news, still to come: aboriginal australians

struggle to get fresh food and essential supplies due to the lockdown. we due to the lockdown. speak to a leading aboriginal we speak to a leading aboriginal medical expert. the stars and stripes at half—mast outside columbine high. the school sealed off, the bodies of the dead still inside. i never thought that they would actually go through with it. one of the most successful singer songwriters of all time, the american pop star prince, has died at the age of 57. ijust couldn't believe it, i didn't believe it. he was just here saturday. for millions of americans, the death of richard nixon in a new york hospital has meant conflicting emotions. a national day of mourning next wednesday sitting somehow uneasily with the abiding memories of the shame of watergate.

mission control: and lift-off of the space shuttle discovery with the hubble space telescope, our window on the universe. this is bbc news. the latest headlines: the first human trials of a coronavirus vaccine in europe have started. two uk volunteers were injected in oxford. american lawmakers pass another relief bill worth $480 billion dollars for small businesses and overwhelmed hospitals. australia's lockdown looks to be paying off, with most states reporting either no daily cases or rises in the single—digits. but indigenous leaders remain concerned about how the restrictions are impacting their communities. many aboriginal australians are already dealing with poor housing and a lack of health facilities. some of the more remote towns are now struggling to get access to fresh food and essential supplies due

to the lockdown. let's talk to dr kris rallah—baker, who is the president of the australian indigenous doctors' association. thanks very much for being with us. so why are certain communities in australia, do you feel, potentially more vulnerable here? thanks for having me on. so the issues that impact on indigenous australians, particularly what we call the social determinants of health, which you mentioned, overcrowding within housing and access to means, they, as well as the higher level of chronic disease burden, they're impacting potentially on indigenous communities at a high who rate their nonindigenous in the covid—i9 crisis if it was to get into those communities. do you feel that needs to be done? well,

there's been a co—ordinated response led by and large by the indigenous pig bodies in australia and the government has been responsive to that —— peak bodies. as you mentioned earlier in the bulletin australia has managed to flatten the curve at this point and we are holding steady at the moment. as we are aware, at any time the covid crisis could emerge in australia and we're certainly not past it and so are communities need to remain prepared and vigilant. and how live is the issue of racism, particularly around this issue of coronavirus? so the australian indigenous doctors association, which i'm president, has had to deal with a number of situations where our members have reported active racism in the system at active racism in the system at a local level. impressively, that has been fed up through the appropriate systems and has been addressed, but it's something that we are aware of

and that we are certainly acting on when it comes to our attention. just finally and briefly, on a human level, i suppose, how scared and how worried are people in those communities? there is a lot of fear in the communities. and the messaging from the peak bodies has been to be aware but not alarmed. it is a difficult situation. a lot of aboriginal and torres straight islander people in this country are fea rful of people in this country are fearful of the mainstream medical system and hospitals themselves for historic reasons. and so there is not only a fear of the system, but a fear of the virus too. so there is a lot of fear but we are trying to, as best we can, get clear messaging out there and assure people that if they follow the guidelines and they will be best protected. ok, we will be best protected. ok, we will get that message loud and clear. dr kris rallah—baker, thank you for your time. thanks to having me. thank you. though crime is down in america at this time of crisis, gun sales are up as americans worry about personal safety.

the fbi did 3.7 million background checks for gun purchases in march and on march 20 a record was set for the most checks ever conducted in a single day. the bbc‘s jane 0'brien has more. first—time buyers lining up outside a store near san francisco. it's a scene replicated across the country as americans stock up on what some consider essential items. we want to feel safer. the mentality of some people, theyjust, they get crazy and desperate, and you never know what's going to happen. but as cities remain in lockdown, there's been a sharp decline in reported crimes. from chicago to la and in new york, the epicentre of the virus, serious crime has seen a double—digit drop. but 20% of new york's police force is also sick — an example of why americans who've never owned a gun now feel they need one.

you have a lot of police officers and first responders right now that are ill and are not out on the streets being able to help people protect themselves. so, you look at the violent crime going up, you look at first responders not being there or being able to be there, the first line of defence to protect yourself is your self. the second amendment guarantees the right to bear arms but exercising that right during the pandemic has become dependent on where you live. the federal government says gun stores are essential businesses and should stay open. but the hodgepodge of existing controls in different states has become more pronounced with the power of individual governors to impose emergency restrictions. in the united states, we have the freedom of assembly, we have the second amendment freedom, freedom of religion...

you know, they can't just shut down and shred the constitution because of a virus. attorney andrew couture is suing the state of massachusetts where the governor has ordered the closure of gun stores as part of measures to control the spread of the coronavirus. this is nothing more than an attempt to bankrupt every gun store in massachusetts so when we can finally get through this critical time in our nation's history or the world's history, let's face it, that they would not be able to open. americans have already given up significant freedoms, many protected by the constitution. who has the authority to order such restrictions and enforce them is an ongoing political and legal debate. on loud-hailer: it is a government that is out of control! and it is notjust gun rights. across the country, americans have begun protesting against restrictions they say are creating more harm than the virus itself. ultimately, such measures will only work for as long as the citizens themselves agree to them. jane 0'brien, bbc news.

at least six people are now known to have died after a series of tornadoes ripped through several southern us stays leaving a trail of destruction behind them. richard preston has this report. in southern 0klahoma, near to the state border with texas, this terrifying sight. at least two people were killed as tornadoes swept through marshall county. is that one for real? in texas itself, a trail of destruction in pope county, about 70 miles north of houston. came back here and my home's not there. the second worst storm that went through. the first one eye lost everything. they lost everything. they lost everything i word for. i woke up everything i word for. i woke up this morning thinking it was a really bad dream but it really wasn't. it came in so quick all you heard was the noise and saw a big debris field and knew it was coming.

it kind of disdain for a second and reformed and came right back down. really scary. thousands across texas and nobler —— 0klahoma were left without power. dozens were injured. emergency crews working round—the—clock in search of survivors. weeks of extreme weather have killed more than 20 people across four southern us states. richard preston, bbc news. the duke and duchess of cambridge and their children have led the uk in the weekly national applause for britain's carers and key workers. it's the fifth week in a row that people have come out on the streets all over britain to say thank you, as jon kay reports. applause. standing together... ..while standing apart. another thursday night... ..in the uk. it is a little tiny thing i can do, to you know, make some noise, just to say thank you. every week. every week? yes. not missed one? not yet. and we won't. on this street, like so many

others, it is personal. sarah, at number", is on the front line. she's a healthcare assistant at the birmingham hospital trust, that has had more than 600 covid—i9 deaths. does this help you get through? yes, massively, 100% helps me. every thursday. it is like a release. it is a release. i come out and they are all clapping, it is another week coming to an end. just amazing. just fantastic, i can't believe it. 0h... at precisely 8:00, for the fifth week in a row, it felt like the whole of the uk erupted. # let it shine, let it shine... 8,000 miles from home, members of the british antarctic surveyjoined in.

in the middle east, divers from hms ledbury clapped and washed their hands at the same time. in the skies above wiltshire, the pilot of a light aircraft plotted his flight path to spell out his gratitude. while on the ground, the social distancing red arrows. from bin collectors in norfolk, to the royal family. back in the midlands, sarah and her husband gary, who is a delivery driver have moved into a caravan on the drive. see you soon, we love you loads. so they don't put sarah's mum at risk. gwen is 83. clapping for her daughter, and for thousands of others, and she will be saying thank you again, next week. jon kay, bbc news.

that's it. i'm lewis vaughan jones. this is bbc news. bye— bye. hello there. many places across the uk had clear skies from dawn till dusk on thursday. in actual fact parts of the southeast saw highs of 2a degrees, 75 fahrenheit, and is probably going to be the warmest day this week. a slightly different story, however, coming in across eastern england, with a breeze from the north sea and a little more cloud here, temperature struggled at around ten or ii degrees. we start our day on friday with cloud across parts of eastern england, stretching in as faras of eastern england, stretching in as far as the east midlands, maybe. but as we go through the day they should melt away, dry, settle, sunny for many. just an outside chance later on in the afternoon for an isolated shower, perhaps across the south—west. we should see temperatures peaking at 22

degrees, you might see 20 degrees, you might see 20 degrees into western scotland as well. now as we go through the evening we keep clear skies swimmers. the risk of an isolated joel cross higher ground of south wales and south—west england continues, but as we go into the weekend it looks likely to stay largely fine and dry. it will be just that little bit cooler and we increase the risk of some showers as we go through the second half of the weekend. but we start off on saturday with very, very open isobars, light winds across the country. this little fellow here mightjust introduce some more cloud and eventually the risk of further showers. so as we go through the day on saturday we could have a little more cloud to start with along the east coast. that melts away. lots of sunshine coming through. without the consent of the far north—west but saturday should stay dry and pleasantly warm out there with highs of 9— 2i degrees. now as we move out of saturday into sunday, that weather front will just creep towards the north—west of scotla nd towards the north—west of scotland and enhance the risk of some showers as we go through the day. so a slow and

su btle through the day. so a slow and subtle change of this story for the second half of the weekend. so the potential for some showers and cool the field to develop as the wind swing round toa develop as the wind swing round to a northerly. though showers may creep into north—west england and north wales by the end of the day on sunday. but ahead of it is as pleasantly warm with 22 degrees, behind it somewhat cooler conditions, 10-14 in somewhat cooler conditions, 10—14 in the far north of scotland. but the dry story is set to continue for the remainder of april, as you can see, dry, settle, and sunny, but just that little see, dry, settle, and sunny, butjust that little bit see, dry, settle, and sunny, but just that little bit taller right across the country. take care.

this is bbc news, the headlines: the first human trials of a coronavirus vaccine in europe have begun. hundreds of volunteers will get the vaccine — two of them were injected today in oxford. scientists say they are already working with manufacturers to produce millions of doses later this year. american lawmakers pass another relief bill worth $480 billion for small businesses and overwhelmed hospitals. as new figures put the jobless total at 26.5 million, it's hoped employers will be encouraged to keep staff on their payroll. president trump has offered some hope to americans as they head towards the summer, by saying the latest research shows sunlight and heat has a powerful effect on killing the virus. he's also said that america is leading the way in how to properly lift lockdowns. now on bbc news, click.