this is bbc news, the headlines at 11. self—isolating but showing no symptoms of coronavirus — the prime minister borisjohnson is under orders from nhs track and trace after meeting an mp who later tested positive. the former us president, barack obama, tells the bbc that america is more divided today, than when he first ran for office 12 years ago. scientists behind the first covid vaccine to be successful in early trials say its full impact will be felt next year — but warn of a hard winter ahead. the side effects of statins could be down to patient anxiety and have nothing to do with what's in them according to a new study.

good evening. the prime minister borisjohnson is self—isolating after coming into contact with an mp who has since tested positive for covid—19. downing street says mrjohnson is well and does not have any symptoms of the virus. our political correspondent nick eardley has more. borisjohnson was contacted today by the test and trace programme in the uk and told that he had come into contact with someone who has tested positive. my understanding is he had a meeting with a group of conservative mps on thursday. since that meeting, one of those mps, lee anderson, developed symptoms and has subsequently tested positive. borisjohnson was contacted as a result. it is a pretty big deal. he will have to stay at home for the next ten days, it means he will not be able to be in parliament. i'm told he will be working from downing street. he does still intend

on communicating with the country. it is a big week for borisjohnson. he is trying to reset his government after some faction fighting in his office over the last few days. there are conversations taking part with the parliamentary authorities in the uk to see whether he can still contribute to the commons. but i think it is fair to say this couldn't have come at a worse time for boris johnson. it is also worth bearing in mind, he was extremely ill with coronavirus early in the year. but we also don't know exactly what getting the virus means for your future immunity. he doesn't have any symptoms right now. i am told he is absolutely fine and is feeling well, but under the test and trace programme in the uk, he has to self—isolate. earlier i spoke to jack blanchard, the uk political editor of the politico website — about the potential impact this might have. it never rains but it pours for this prime minister, doesn't it?

you have to feel sorry for him. he had a big planning downing street. they've been dreaming up over the weekend for a big relaunch after the chaos we've seen in number 10 over the last few days. he had a big speech planned, he was planning to go and meet with groups of mps who have been unhappy. obviously, prime minister's questions on wednesday in the house of commons and other events as well. and instead, he's going to find himself locked back in his home for another well, we guess about ten days at an absolutely critical time for him. i mean, imagine the look on his face when the call comes through from test and trace on a sunday telling him he's got to stay in for ten days. he must‘ve been pretty upset. well, of course cynics out there will say, "well, "this serves him quite well," because he has not got to face the music with all of those backbench mps in particular who were rather unhappy with the way things were being run undeercummings. no, i think he will be very frustrated. and don't forget as well we're in an absolutely critical moment

of the brexit negotiations. you know, maybe borisjohnson might have wanted some sort of face—to—face meeting over the next week and a half with counterparts in europe. well, that's not going to be possible either but of course it's really important that as prime minister, he sets absolutely the best example that he can to the country and even though we would hope that having had the illness once, he is less likely to be susceptible, we don't know that. and so obviously, he's going to have to do his duty. the mp that was in contact who has tested positive is lee anderson. how many other contacts do we know who are going to be affected? well, that's a really good question. as we understand it, there were other mps at this meeting as well and as i understand it, a whatsapp message has been flying around between mps wondering who else among them is going to need to be contacted and of course than staff members, key aides as well. to be contacted and of course then staff members, key aides as well. so, yeah, the problem as we know all too well with this illness is that once it catches in one area, it can spread very quickly between people close to that person.

a lot of speculation though and questions as to what immunity might the prime minister have. obviously, the vaccine is not ready. wouldn't the immunity that hopefully he has give him some protection? it sparks a lot of conversations and a lot of confusion. yeah, but we just don't know enough about the virus to be sure. what we know about other viruses of this type is that it would normally confer some sort of immunity but of course you don't know how much and you don't know how long for. so, i would be optimistic that borisjohnson is unlikely to come down badly with the illness a second time that you can't time but you can't take any chances. and of course there is also the issue of asymptomatic spread. he could pass it onto somebody else. so it's essential that he does do his duty and home but i think we will still be seeing a fair amount of borisjohnson this week. ijust think we will be seeing him speaking to the nation just as i am from a small room in his flat rather than from the despatch box.

jack blanchard of politico. and we'll be taking a look at the papers with our reviewers giles kenningham and miatta fahnbulleh. that's coming up after the national bulletin with mishal husain. most of the debilitating effects of statins are not caused by the drug, but by people believing it will make them sick, according to a study by imperial college london. the phenomenon is known as the "nocebo effect" and may account for 90% of the ill health associated with the drugs. earlier i spoke to one of the co—authors of the study, dr howard jones — and asked him to explain more about the nocebo effect. as people now, the nocebo effect is where you take a drug where you think it will help you and even if it is just think it will help you and even if it isjust a think it will help you and even if it is just a shepherd tablet, you truly do feel a lot better. —— the placebo effect. the nocebo effect is the opposite and we wondered with statins that this could be a problem because when people pick up their newspaper and the point they learned to expect that statins will give them aches and pains and we wonder whether if we gave them sugar tablet

we can give them makes them pains. and what did you find? 50 we and what did you find? so we actually ran a child for a third of the year where people were taking nothing but then for two thirds of the year they took a statin or sebo and they did know which was which. and we found the people were much worse when people took sense but they felt 90% is better when they took sugar tablets. so, what are the complaints that people have about statins and what is causing the symptoms even though they are not caused by the drug? so, the most common thing we think of when we think of statin side effects or muscle aches and pains and 60% of oui’ muscle aches and pains and 60% of our people in the trial were with that but we let anyone in whose side effects were so bad they had to stop the tablet so we tried to be as representative as possible of the general population. with regards to where it comes from, it is iiro good question. we do not understand the placebo effect and our understanding of the nocebo effect is even worse. but what is interesting is why our

statins so bad for causing people nocebo symptoms because people tolerate a lot of other problems so much better and it probably is because people are being conditioned by the media to expect to feel worse on them. what we don't want people thinking is that we think patients are making it up or that they should not be believed. our patients were really suffering in the trial. 71 times and our trial people had to stop their tablets because their symptoms were so bad. they were not making it up. but what's interesting is the amount of time they had to stop the tablets was very similar between whether they were taking statins or whether they were just taking sugar tablets.

the prime minister is self—isolating, after coming into contact with a conservative mp who has covid. lee anderson had a half—hour meeting with borisjohnson and later tested positive — the prime minister says he has no symptoms and will continue working from home. it comes after a dramatic few days in downing street, and at a tense time in the brexit trade talks. also tonight: scientists behind the first promising covid vaccine say a hard winter lies ahead, but life should return to normal towards the end of next year. ba rack obama tells the bbc his successor president trump is partly responsible for polarisation in america today. we are very divided right now, certainly more than we were when i first ran for office in 2007, and more divided than we were four years ago.

that is where all the kids out there who dream the impossible! a seventh world championship title — lewis hamilton is now the most successful formula 1 driver ever. i have kept a list of the insults against des 0'connor. a consumate entertainer — for six decades. des 0'connor has died at the age of 88. good evening. the prime minister borisjohnson is self—isolating in downing street, after being contacted by nhs test and trace and told he had come into contact with a positive covid case. last week, he spent more than half an hour in a meeting

with the conservative mp lee anderson, who later tested positive for the virus. in the last hour, mrjohnson has said he has no symptoms, but is following the rules, and will be leading the government's pandemic response from home. here's our political correspondent, nick eardley. this is boris johnson this is borisjohnson on thursday with the conservative mp lee anderson. they were part of a small group who held talks in downing street for just over half an group who held talks in downing street forjust over half an hour. since then, mr anderson has tested positive for coronavirus, and earlier today the prime minister was told to self—isolate by nhs test on trays. the prime minister wrote to tory mps tonight. the good news is that nhs test and trace continues to improve. the bad news is that i've been pinged. it doesn't matter that we we re been pinged. it doesn't matter that we were all following the guidance and socially distancing. it doesn't matter that i feel fine, better than ever, or that my body is bursting

with antibodies. the rules are the rules and they are there to stop the spread of the disease. mrjohnson will now work from here while he self isolates. he plans to continue to communicate with the public, and his team are exploring ways he could ta ke his team are exploring ways he could take part in parliamentary proceedings remotely, but he won't be able to leave his flat in downing street for another ten days. the prime minister has of course had the virus already. good afternoon. this was back in april, when he was released from intensive care, but a previous positive result is not an exemption under the test and trace rules. i understand others who are at the meeting had been told to self—isolate too. number ten is said to bea self—isolate too. number ten is said to be a covid—secure workplace, but insiders say it is not possible to remove all risk. the timing is far from idealfor the prime minister, who was planning to be out and about this week, trying to move his government on, after days of headlines about infighting and his tea m headlines about infighting and his team and some very public departures. and nick is in downing street now.

let's talk more about the impact of this, given the timing, just after all those changes in downing street? yeah, michelle, what abbott and her plan for the next week, they might not be calling a reset for the government, but it certainly sounds a lot like one. before borisjohnson was told to self—isolate, his diary was told to self—isolate, his diary was jam—packed. he had talks with the chancellor pencilled in to make some big spending decisions. he was due to hold talks with the scientist about how to live to lock down in england on 2nd of december, he was due to make big decisions about brexit, and he was also supposed to meet many tory mps who have been frustrated at how number ten has been working, and are hoping that things might now change. i've got to say borisjohnson things might now change. i've got to say boris johnson is things might now change. i've got to say borisjohnson is striking a defiant tone in messages to tory mps, telling them tonight that self isolation won't change any of those plans, and that he is more confident than ever that lockdown in england

will be lifted in a few weeks' time, but at a time when the prime minister wanted to be out and about on the front foot, the timing was farfrom ideal. on the front foot, the timing was far from ideal. nick eardley in downing street, thank you. one of the scientists behind the first covid vaccine to emerge successfully from early clinical trials says it won't start to make a significant difference until next summer. professor ugur sahin, whose company biontech developed the vaccine with the pharmaceutical giant pfizer, told the bbc today this would be a hard winter, but normal life should be resuming this time next year. he also believes the vaccine will reduce the spread of infection, as well as disease. our health correspondent sophie hutchinson reports. tiny vials of the new biontech/pfizer vaccine, which hold the world's hope for an end to the pandemic. but today, one of its creators, from the husband—and—wife team, warned there were still many months to get through. this winter will be hard.

we will not have a big impact on the infection numbers with our vaccine this winter. the bigger impact will happen until summer. the summer will help us anyway, because the infection rate will go down in the summer, and what is absolutely essential is that we get a high vaccination rate before autumn and winter next year. there are still many unknowns about this new vaccine. how long does immunity from it last? its creators say you might need a jab every year, every two years or every five years — it is just too early to tell. and how effective is it in older people? up to 40% of those who took part in this trial that has been deemed so successful were older people, and we should get more data on them in the next few weeks. and will it stop transmission from one person to another? well, its creators again say it seems to have been so successful at reducing illness in people that they are very hopeful that it

could have a big impact on transmission too. i am very confident that transmission between people will be reduced by such a highly effective vaccine, maybe not 90% but maybe 50%, but we should not forget that even that could result in a dramatic reduction in the pandemic‘s spread. but we will not know for sure until we see the data in a few months. others have sounded a note of caution about the possibility the virus could mutate, and that any successful vaccine needs to be able to adapt at speed. we mustn't take our eye off the ball. the virus is an rna virus and is highly likely to change and we need to keep a watchful eye out for that and be able to respond if necessary. but there is genuine excitement about the vaccine, which will be given to those who live and work in care homes as a priority.

ten million doses should be here by the end of the year. sophie hutchinson, bbc news. let's take a look at the latest figures released on coronavirus. another 24,962 new infections were recorded in the latest 24—hour period, which means an average of 25,329 new cases per day in the last week. there were an average of 1,656 hospital admissions per day in the week to last wednesday. another 168 deaths were reported today — that's people who died within 28 days of a positive covid—19 test. it means an average of 413 deaths per day in the last week. the total number of uk deaths is now 51,934. the former us president barack obama has told the bbc that america is more divided today than it was when he was elected twelve years ago. he said his successor donald trump was partly responsible,

because he had actively fanned division for his political purposes. 0ur diplomatic correspondent, james landale, reports. so help me god. congratulations, mr president. the election of america's first black president was seen by many as a watershed moment, a step towards ending historic divisions that had scarred the united states. but barack obama now believes those divides are deepening. divisions notjust of race, but also inequality. we are very divided right now, certainly more than we were when i first ran for office in 2007 and more divided than we were four years ago, when donald trump first won the presidency. some of that is attributable to our current president, who actively fanned division, because he felt it was good for his politics, but it preceded him and it will outlast him.

in part, he says, that's because some americans feel they've lost their grip on the ladder of economic advancement and can be persuaded it's someone else's fault. resentments fanned, he says, by conspiracy—fuelled social media. crazy conspiracy theories, and what some have called truth decay, right, where facts don't matter. that has contributed enormously to these divisions. and, oh, yes, he believes the current president has played his part. what's been interesting, obviously, and sad during this election, is that that kind of lack of fidelity to the truth has consequences when it's being promoted by the most powerful elected official in the country. fixing that truth decay,

he suggests, will take time and potentially better regulation of the internet and the media. i think at some point it's going to require a combination of regulation and standards within industries to get us back to the point where we at least recognise a common set of facts, before we start arguing about what we should do about those facts. talk about our bromance! as a new president prepares for his first term, his predecessor is mulling the legacy he left his country. mr obama says the us was better off after his eight years in office, but he accepts deep fault lines in american culture remain. james landale, bbc news. and you can see the full interview in a special programme — barack obama talks to david 0lusoga — this wednesday on bbc one at 7:30pm. the prince of wales and the duchess of cornwall have become the first members of the royal family

to attend germany's annual remembrance of victims of war and dictatorship, and in a speech at the german parliament, the prince said the bonds between the uk and germany would endure after brexit. 0ur correspondent damien mcguinness reports from berlin. a day of remembering the victims of war, but also a reminder of the miracle of reconciliation between two countries who were once enemies. this is the first time that a member of the royal family has come for this commemoration. the meaning of this national day of mourning has evolved over the years. for the nazis, it was about glorifying war, but for modern germany, it's about pursuing peace and remembering all victims of oppression. a message echoed by the wreath of poppies laid here by prince charles. today's visit comes at a crucial time for the uk's relationship with its near neighbours. in a speech in the german

parliament building, at times speaking in german, prince charles said that although the uk has chosen a future outside the european union, britain and germany will remain close. wir werden immer freunde, partner und verbundete sein. "we will always be friends, partners and allies," he said, and called on the two countries to reaffirm their bond for the years ahead. the parliament building was damaged by the allies in the second world war, but it was later redesigned by a british architect, a fitting place to talk about how war can be replaced by friendship. damien mcguinness, bbc news, berlin. tributes have been paid to one of britain's best known entertainers, des 0'connor, who has died at the age of 88. the comedian, singer and television star had a career spanning six decades, from the morecambe and wise show to countdown, and more. today, he was remembered as a consummate professional

and one of the old school. 0ur arts correspondent david sillito looks back at his life. i have kept a list of the insults against des 0'connor... des 0'connor was in the 70s famous, a star, and on morecambe and wise, the butt of hundreds of gags. but the singer and comedian took it all with good grace. number one, eric: i've just heard some good news. ernie: what good news? eric: des 0'connor‘s got a sore throat. laughter. nothing seemed to dent that clean cut, deep tanned optimism. numbertwo, ernie: des 0'connor is a self—made man. eric: i think it's very nice of him to take the blame. laughter. # be sure it's true when you say i love you, love you, # love you # he recorded more than 30 albums, in a career that took him from butlins to las vegas to countdown. he was the ultimate professional, and that's why he worked from his time as a redcoat back in the 1950s until

a year or two ago. in his mid—80s, he was still touring with his one—man show, and with a two—man show withjimmy tarbuck, aged 85, he was still out there, singing, dancing, telling jokes. # loneliness, alone you'll always find me # the son of a dustman from london's east end, he made more than 1,000 appearances at the palladium, and on television he could look back at more than a0 years of chat shows, but the success always came with a touch of self—deprecation. this little old lady came up to me one day at the stage door, she said, mr 0'connor, i have enjoyed your show. she said, here's £5, could you send me your new lp? so i said, well, you can get it for £3 in the shop come you don't have to give me five... she said, well, no, the last time i went in the shop and asked for a des 0'connor lp, the guy said, you're kidding! laughter. as the decades rolled by, he remained an almost ageless fixture in the schedules.

he was never really fashionable, and so never fell out of fashion. it was a career of 60 yea rs of professional, unflappable, good—natu red charm. you have my word. well, that's good enough for me. and when the joke was on him, he was always the first to laugh. laughter des 0'connor, who's died, aged 88. with all the sport now, here's 0lly foster at the bbc sport centre. good evening. lewis hamilton says that winning a seventh world championship is "the pinnacle of his life so far". he won the turkish grand prix in treacherous conditions, to equal michael schumacher‘s record of world championship titles. here's our sports correspondentjoe wilson. lights out and away we go.

when the circuitjust slips, when the tyres won't grip, well, that's when champions win. in turkey, driving was like dancing — on ice. valtteri bottas, theoretically the title rival, spun so often he finished a lap behind lewis hamilton, and max verstappen — exactly. hamilton, through it all, was serene. having started sixth, like this, he took the lead. this victory was its own triumph. lewis hamilton wins the turkish grand prix! thank you so much, everyone, for your support. he's won more races than anyone. he is now a seven—time world champion, the same as michael schumacher, the most titles ever. we dreamed of this when we were young, and when i was young, when we were watching the grand prix

and this is way, way beyond our dreams and i think it's so important for kids out there to hopefully see this and know that don't listen to anyone who tells you you can't achieve something. dream the impossible. and so to lewis, just turned 17. lewis, karting before lockdown in kent. aiming for formula one in a sport still dominated by white competitors and by the wealthy. this lewis has hamilton inspiration. seeing him at the highest level doing what he does best, it really gives me the push to carry on, because seeing that he's made it to the top, itjust shows me that i can do the same thing. he's been the start to the change in the diversity we see in f1. lewis is still making his journey, and it's tough one, but he has a lewis to follow — the man who is statistically simply the best in history. joe wilson, bbc news. dustinjohnson is the new masters champion. the american dominated the final round at augusta, winning by five strokes to claim his second major title.

the world number one also set the record for the lowest total score at the masters, 20—under—par, to claim the green jacket from tiger woods. rory mciroy was tied forfifth, nine shots behind. ray clemence has died at the age of 72. he was an ever—present in the great liverpool team of the 19705 and won 61 england caps. he had been living with advanced prostate cancer, andy swiss reports. when it came to the art of goalkeeping, few could beat ray clemence. commentator: that was a supreme save. in liverpool's all—conquering team of the 19705, clemence was the cornerstone, his courage and composure key to their success. it brought him five league titles, three european cups, and legendary status. even after he moved to tottenham in 1981, the liverpool fans welcomed him back like a hero. a fantastic reception from the kop.

he won the fa cup with spurs, as well as 61 caps with england. only the presence of peter shilton prevented him winning more. he laterjoined england's coaching staff and across football there were few more popular figures. he always had time for people. we all, as keepers, have massive highs and desperate lows. and throughout all of that, whether it was a high or low, you always got the same ray clemence smile. announcer: goalkeeper, ray clemence! but for all his warmth and wisdom, it's for moments like this that ray clemence will be best remembered. what a save! one of england's goalkeeping greats. ray clemence, who has died at the age of 72. england's players paid tribute to clemence in the nations league this evening. they lost 2—0 to belgium. there was a good win for wales, but defeat for northern ireland. sportscene follows the news for viewers in scotland; if you were trying to avoid the scots result, well,