this is bbc news with the latest headlines for viewers in the uk and around the world. more than 2,000 people have been arrested in russia at protests in support of the jailed opposition leader, alexei navalny. mr navalny�*s wife yulia was briefly detained then released. senior doctors in britain call for the maximum 12—week gap between administering the first and second doses of the pfizer coronavirus vaccination to be halved. a curfew has come into force in the netherlands as part of new measures to contain coronavirus. and the american broadcaster and talk show host, larry king, has died at the age of 87.

hello and welcome if you're watching in the uk or around the world. reports from russia say police have detained more than 2,000 people at protests in support of the jailed opposition leader, alexei navalny. large gatherings have been taking place across russia, including the eastern cities of vladivostok and khabarovsk. in the siberian city of yakutsk, protesters braved temperatures of minus 50 degrees. the main demonstration was in the capital, moscow, from where our correspondent steve rosenberg reports. in moscow, you can feel the anger. police had warned people any protests would be broken up, any protester risked arrest. but thousands came to pushkin square to support the kremlin�*s fiercest critic, alexei navalny.

"freedom to navalny," they cried. and, "russia without putin." on her way to the protest, mr navalny�*s wife, yulia, was detained by police. so were hundreds of others for taking part in what the authorities called an unsanctioned gathering. for years, the russian authorities made out that alexei navalny had minimal support across the country, that he was in no way a threat to them, but these scenes of riot police and detentions suggest the kremlin is more worried than they've been letting on. in a direct challenge to vladimir putin, whom he accuses of ordering the nerve agent attack on him, alexei navalny returned to russia last weekend and was arrested for an alleged parole violation. russia isn't investigating his poisoning, it's investigating him. the kremlin denies any involvement in the attack.

there were pro—navalny rallies across russia today. things heated up in vladivostok. in yakutsk, it was —50, but there were protests here too. but the kremlin rarely gives in to pressure, especially from the street. instead of compromise, expect a crackdown. steve rosenberg, bbc news, moscow. i'm joined from mary dejevsky, who worked as the moscow correspondent for the times newspaper from 1988—1992. hello there, mary. seeing people out there in these extreme temperatures, clearly determined to have their say, how dangerous a moment is this for the kremlin and for russia in general? i for the kremlin and for russia in ueneral? ~' ., general? i think for the kremlin, it's probably _ general? i think for the kremlin, it's probably not _ general? i think for the kremlin, it's probably not as _ general? i think for the kremlin, it's probably not as dangerous i general? i think for the kremlin, j it's probably not as dangerous as general? i think for the kremlin, i it's probably not as dangerous as it looks. because although these were very impressive protests from the

point of view of the navalny camp, and they're particularly impressive because they're the sweep right across russia. you got the sense of this huge country, as you are watching this from early morning until mid—afternoon, when it was in st. petersburg. so, it was a real national organisation, coordinated protest. for the kremlin at the moment, i think that probably won't be seen as a huge threat, but if it continues, and if, as navalny and his camp say, they want these demonstrations to happen next week and maybe the week after, then you could be looking at something a bit more destabilising, really. you could be looking at something a bit more destabilising, really.- more destabilising, really. you say that we've had _ more destabilising, really. you say that we've had this _ more destabilising, really. you say that we've had this sort _ more destabilising, really. you say that we've had this sort of- more destabilising, really. you say that we've had this sort of protest| that we've had this sort of protest across the time zones in the way, what has enabled that to happen with fellow this is very, very

interesting— fellow this is very, very interestin: , , �*, ' interesting because it's different from theft cell _ interesting because it's different from theft cell lifetime. - interesting because it's different from theft cell lifetime. that - interesting because it's different| from theft cell lifetime. that was 2012 -- from theft cell lifetime. that was 2012 —— from the last time. they were most concentrated in moscow and st. petersburg. the cosmopolitan places with large numbers of very fragile educated people —— very well educated people. these protests were right across russia in practically every, not as major city, but towns as well. the difference between then and now is the extent of social media, internet access and the fact that there's a new generation of russians who are completely at home with this sort of technology. and navalny himself, when he started his activism, he was a pioneer of using social media for political purposes in russia. in a way, that's been

repaid. navalny himself is imprisoned, these protests happened and were projected to the outside world all thanks to social media. you mentioned navalny as called for protest again. do you think we could see happening across russia what happened in belarus with those weekly protests against president lukashenko? i weekly protests against president lukashenko?— lukashenko? i think there are several things _ lukashenko? i think there are several things to _ lukashenko? i think there are several things to say - lukashenko? i think there are several things to say about. lukashenko? i think there are i several things to say about that. one thing is we may. it is also very cold in russia. as steve rosenberg was saying, it's particularly cold right across russia. it is quite difficult to keep up protests on the sale they were today —— on the scale. the other thing, i suppose, is that when you look at what's

happened in belarus, even though those protests were very, very well patronised, huge numbers of people turned out. nonetheless, all these months later, lukashenko is still in power and he is not made many concessions. it would be very, very interesting to see from now on i will the kremlin plays this —— how the kremlin play this. his popularity at a national level was much lower, and he'd been the beneficiary of a rigged council, if not a rigged election. hooton is in a much stronger position —— back to

the uk prime minister borisjohnson has confirmed in a tweet that he has spoken to president biden on a telephone call. he said... here in the uk, senior doctors have called for the i2—week gap between administering the first and second doses of the pfizer coronavirus vaccine to be halved. the british government chose to extend the maximum wait from three to 12 weeks, claiming it could saves lives by allowing more people to receive a firstjab more quickly. in a private letter to england's chief medical officer, which has been seen by the bbc, the doctors' union, the bma, called the delay "difficult to justify". our health correspondent anna collinson reports. it's the largest vaccination programme in british history and, to many, so far, it's been a success. but there are calls for the pfizer/biontech second dose to be given more quickly. the manufacturers have no data to back up the i2—week delay and some senior doctors want it reduced to six weeks.

that would still allow many more people to have a first dose compared to a three—week interval, but at least it will be in keeping with international best practice guidance. there is no other nation internationally that has adopted a i2—week delay. health officials have called extending the gap to 12 weeks a public health decision. the government says the current system is under review but believes it is the right thing to do. it enables people to get the first jab as quickly as possible and the high level of protection that one jab alone provides to them, and then of course, those individuals will be invited back for their second jab within 12 weeks. questions are also being asked about the more infectious variants. vaccines are still expected to be effective, but early evidence suggests it may be more deadly, though more research is needed. the question about then - whether it's more dangerous

in terms of mortality i think - is still open, but there is evidence that it is more dangerous. but on the other hand, - this is a very dangerous virus so it's not a game—changer, it's a very bad thing - that's slightly worse. we can expect more reminders to stay at home and to keep our distance for weeks and maybe months to come. anna collinson, bbc news. a curfew has come into force in the netherlands as part of further measures to contain the coronavirus. the �*stay at home order�* runs from 9 o'clock at night to 4.30 in the morning. anyone outdoors will need a valid work reason, or it must be an emergency. anna holligan reports from the hague. this is the toughest measure that the dutch politicians have introduced, which is a reflection of how this is designed to end social gatherings. since the bars and restaurants close, there's been a real increase.

exceptions to this rule exist, so you can go out if there's an emergency or if you have a work valid reason. also, if you're attending the funeral or court proceedings or travelling into or out of the country. and the one other exception that exists is you can have one of these — a dog on a lead, and actually there are reports there's been a real increase in the number of people who are signing up to offer to walk people's dogs as a way to try to get round these curfew rules. on top of this, the flight ban has just come into force, so this is affecting flights from areas considered to be high risk where the new strains of the virus were first detected and are spreading rapidly, so no more planes for at least a month from the uk, south africa and south american countries. that will be at least a month or until they've changed the legislation here so that they can make the ten—day quarantine rule obligatory for anyone arriving in the country. italy is accusing pfizer

and astrazeneca of serious contract violations, after the drugmakers said they wouldn't be able to deliver the agreed amount of coronavirus vaccine on time. prime minister giuseppe conte, says the delays are unacceptable, prime minister giuseppe conte says the delays are unacceptable, and doing enormous damage to italy and other european countries. he says the government will use all legal means to make sure the companies meet their obligations. the two companies say production problems have forced them to more than halve the amount of doses they can deliver. the us coronavirus immunisation programme has been thrown a curve ball by pfizer. it says six doses of vaccine can be extracted from every vial supplied to pharmacies, rather than the five previously announced. the new york times says the us drugmaker now plans to provide fewer vials to meet its commitment to supply 200 million doses by the end ofjuly. pfizer says its contracts worldwide have always been based on doses, not vials. i'm joined from columbus ohio by dr mike gannio.

he's the senior director for pharmacy practice and quality at the american society of health—system pharmacists. hello then, thank you so much for joining us on bbc news. why do you think this confusion has arisen over doses versus files?— doses versus files? good evening, thank ou doses versus files? good evening, thank you for _ doses versus files? good evening, thank you for having _ doses versus files? good evening, thank you for having me _ doses versus files? good evening, thank you for having me on. - doses versus files? good evening, thank you for having me on. it's i doses versus files? good evening, l thank you for having me on. it's not surprising to find out there's this confusion because when these contracts were agreed upon over the summer, there was no perception of what kind of dosage form it would be in. they could be a fivejoe's file, a tentative smile, a prefilled syringe. it makes sense to dispute —— five dose. now that six doses are available in the drug administration has allowed the label of the pfizer vaccine to be updated to that six

dose, it's not surprising to find out the wall 200 million doses instead of by five, the challenge we haveis instead of by five, the challenge we have is to ensure we can get that six dose out of every single file, and currently, that's not always possible with the supplies we have. why should that be the case with willow the sixth dose —— why should that be the case with willow the sixth dose --- why should that be the case with willow the sixth dose -- there are several when _ willow the sixth dose -- there are several when use, _ willow the sixth dose -- there are severalwhen use, you _ willow the sixth dose -- there are severalwhen use, you can - willow the sixth dose -- there are several when use, you can get - willow the sixth dose -- there are several when use, you can get a i several when use, you can get a sixth or possibly seven stoves. in a standard needle and syringe when the needle is corrected to the syringe, there could be up to .08 or more leaders of dead space, and that dead spaceis leaders of dead space, and that dead space is left remaining in the syringe, so it's basically lost now. if you use a device where the needle is affixed to the syringe or it has a special type of plunger, you are

more likely to get a full dose out of that syringe without wasting. when you use the right combination, you can get six, even seven doses out. the way supplies are currently, we usually have available and sometimes the sixth dose may not be possible. sometimes the sixth dose may not be ossible. , , , , , possible. thus must be terribly frustrating- _ possible. thus must be terribly frustrating. it _ possible. thus must be terribly frustrating. it was _ possible. thus must be terribly frustrating. it was very - possible. thus must be terribly frustrating. it was very exciting when we learned _ frustrating. it was very exciting when we learned six _ frustrating. it was very exciting when we learned six doses - frustrating. it was very exciting l when we learned six doses were available. it's been a long year. workers have been superheroes managing our patients, and this vaccine re—energize our process and health care workers. we're excited to in this pandemic, finding out that there is a six spoofs —— to this pandemic. that there is a six spoofs -- to this pandemic.— that there is a six spoofs -- to this pandemic. that there is a six spoofs -- to this andemic. . ~ . ., this pandemic. thank you so much for talkin: to this pandemic. thank you so much for talking to us- — the headlines on bbc news... an estimated 2,000 people have

been arrested in russia at protests in support of the jailed opposition leader, alexei navalny. senior doctors in britain call for the maximum i2—week gap between administering the first and second doses of the pfizer coronavirus vaccination to be halved. a curfew has come into force in the netherlands as part of new measures to contain coronavirus. sport and for a full round up, from the bbc sport centre, here'sjohn watson. (0s they were so close, but in the end outclassed by premier league giants cheltenham town, of league two, conceded three late goals against manchester city. they were leading with ten minutes to go, butjust couldn't hold on to secure what could have been the most famous of fa cup upsets. for a team used to raising the bar,

this would have been a new experience. the surroundings may have been unfamiliar, but manchester city's goal was clear, a void in upstate. john and bob michael was busy. —— cheltenham's goal. cheltenham were holding their own. nothing fancy, no fireworks, inside the stadium anyway. pyrotechnics stop play. maybejust the the stadium anyway. pyrotechnics stop play. maybe just the thing the spark city into life. gabrielle also beat the keeper, but not the post. the mood was about to get worse. this wasn't to get sachar, but this didn't matter. 0ne long throw, a couple of written essays, a moment to ignite this type. —— a couple of ricochets. in a town famed for its horse racing, this 72 places three divisions and strike separating these two teams. but cheltenham

needed to last a course for all city's squad. a type turned in two minutes when gabrielle fired city ahead. to confirm their place in the fifth round, but not without one almighty freight. they might need a drink after this. ben proctor, bbc news. —— ben crouch. holders arsenal are out of the fa cup after a i—nil defeat at southampton. a first—half own goal by gabriel, who turned in kyle walker—peters' cross was all that separated the two sides at st mary's. southampton will now face wolves in the fifth round. to cricket now — and sri lanka had the better of the second day of their second test against england in gaulle after being bowled out for 381 in their first innings. angelo matthews making 100. england's veteran pace bowler james anderson ran the show, with figures of six for a0. england's openers were both out

cheaply again, at one stage they were 5 for 2. but their captain came to the rescue once more — joe root not out on 67, as england were 98 for 2 at the close. it was a really good effort to keep them under 400. we know now we have a lot of time to try and win this game, but that's what you got to do. got off to a decent start today. we just need a couple guys to go big. and ben ainslie's dreams of becoming the first british skipper, to win sailing's america's cup are still very much alive. his team ineos beat the italians, to win their qualifying competition, so they now go on to take on either italy again, or the usa, next month for the right to face new zealand for the one of sport's oldest trophies in march. straight for the team because we've had a _ straight for the team because we've had a tough start. i'm incredibly

proud _ had a tough start. i'm incredibly proud of— had a tough start. i'm incredibly proud of everyone. that said, we know _ proud of everyone. that said, we know we — proud of everyone. that said, we know we still have a long way to go. just one _ know we still have a long way to go. just one step along the road and now we've _ just one step along the road and now we've got— just one step along the road and now we've got to — just one step along the road and now we've got to focus on winning that. after_ we've got to focus on winning that. after that, — we've got to focus on winning that. after that, the cup. we've got to focus on winning that. afterthat, the cup. 0ne we've got to focus on winning that. after that, the cup. one step at a time _ after that, the cup. one step at a time. , ., , ., _, time. plenty more still to come. that is all— time. plenty more still to come. that is all the _ time. plenty more still to come. that is all the support _ time. plenty more still to come. that is all the support for - time. plenty more still to come. that is all the support for now. i one of the giants of american broadcasting, larry king, has died. he was 87. larry king is best known for hosting a nightly talk show on cnn, which ran for 25 years. he was being treated in hospital after testing positive for covid—19. daniella relph looks back on his life. for more than 60 years, he interviewed everybody who was anybody. tonight, the legendary liza minnelli on marriage. would you marry again? are you nuts? ..0scar winners. .. start spreading the news — the legendary liza minnelli is here. ..presidents. .. tonight, a candid conversation with president george w

and laura bush from the white house. do you ever think you would say, "maybe i was wrong?" the decision to remove saddam hussein was the right decision. | not friends any more! ..if you were in the public eye, you came to the court of larry king. were you with the president at times, intimately, and he would also be conducting affairs of state? the story that he was on the phone, talking to congressmen? er, yes. it's the witching hour, miami beach's midnight flyer programme... born in brooklyn, he rose to fame in his 20s as a discjockey in florida, spoofing his role in this 1960s tv crime series based in miami. hey, creep! from the nation's capital, you're listening to the larry king show. by the 1970s, he was broadcasting his late—night radio show coast to coast... across the united states, this is the larry king show, coast to coast... ..preferring not to prepare too much for an interview and simply letting the conversation unfold. i like spontaneity, that's the kind of broadcaster i am. i'm coming on the air,

saying, "good evening, my guest tonight is..." i have no idea what that question's going to be. in the 1980s, king joined a new 24—hour tv news station, cnn, gently probing everyone from donald trump... rumblings in the trump camp point as far as the presidency. could the manhatten magnate be eyeing the white house or is he just calling a bluff? i have no intention of running for president, but i have a point to get across — we have a great country, but it's not going to be great for long if we continue to lose $200 billion a year. ..to frank sinatra. i tremble every time i walk out from the wing onto the stage i because i keep thinking to myself, "i wonder if it'll be there." - after leaving cnn, those famous braces could be seen, until recently, on larry king now. they go, "cut! "cut! "what is she doing?!" his new talk show was criticised

for being syndicated on the russian—sponsored tv network, rt. people don't expect you to be sitting at certain board... but with guests like 0prah, larry king proved that, even in his 80s, he still had unrivalled pulling power. remembering the us broadcaster and talk show host, larry king, who has died at the age of 87. earlier, i spoke to pat piper, who produced larry king's radio show for ten years and co—wrote several books with him. he was high—maintenanced, but it was good high—maintenanced if that makes sense. as your report noted earlier, he wouldn't prepare for anything. just a quick story, my first day with him, someone had booked frederick forsyth, who had written a 400—page book. and i said, "here you go, you can read it and he'll be on two days or something." larry threw the book back at me and said, "i

have no need to read the book." and i thought, "0k." and he said, "the audience hasn't read the book, why should i read the book?" and i thought, "i'm dealing with a genius or i'm dealing with the laziest person on earth." i was dealing with a genius. were you? but was that maddening for you or did you actuallyjust come to respect it and thought, "this is the way larry works"? yeah, idid. another quick story, we were in los angeles doing the live show, which it was. there was, as you know happens, a cancelled guest. i got tom petty, who was going to go out on tour, the rock and roller, to come in. larry's watching tv, he was looking at the baltimore orioles losing. he's focused on baseball, he's going to be live on the air on 360 radio stations in three minutes, so that's kind of what you're dealing with. so, i give him the list, i say,

"here's what we're doing tonight," and he goes, "who the hell is tom petty?" and i said, "well, he's in a rock and roll band going on tour." "good, all i need to know." and he did an hour interview and it was fun, and petty came up to me later and said, "that was a great interview, i was answering questions i never thought about." and i thought, "man, if you only knew." laughter. so, i guess that means he really listened to his interviewees, because otherwise, how else would you sustain an hour? that is exactly right. it was a conversation, and he's naturally curious anyway. he used to say, "i don't learn when i'm talking." and i thought that's really deep, but that's how he operated. so, what sort of character was he off the air? piper there. the chinese city of wuhan is marking the first anniversary of its coronavirus lockdown with little celebration, even though life has largely returned to normal.

an exhibition in the city where the virus was first detected praises the ruling communist party's efforts to control the outbreak. now it's time for a look at the weather with nick miller. hello. there have been a few wintry showers around today. some of us have seen a bit more snow, but many places stay dry, had a bit of sunshine, but it's a cold weekend. there's a widespread frost on the way tonight. and after the showers fade away from north—west england, the midlands and east anglia, it could be icy, there will be a few fog patches developing. icy patches still, with the wintry showers towards the north and west of scotland, and a new area of rain, sleet and snow heading to south—west england, wales and southern parts of northern ireland. we'll start sunday with that widespread frost. icy patches, fog around in some spots, too. and a focus will be on this next area of sleet and snow, then, that will push into more of wales, towards the south and west midlands, southern areas of northern ireland, eventually feeding into parts of south—east england as the day goes on.

and where you see at snow, you could see a light covering to low levels of a few centimetres, but more to higher ground. so certainly turning difficult on roads and pavements. again, also affecting southern areas of northern ireland. northern counties of northern england into scotland will see the lion's share of sunday's sunshine. but there will be further wintry showers around northern and western scotland. some rain into the afternoon heading into parts of the northern isles. so as we go on deep into the day, then, notice how this area of snow doesn't move very much, so if you are within that, this is where you are most likely to get that few centimetres, even at lower levels, with more to any higher ground. could be some fog patches that linger into parts of the north midlands, east anglia and southern areas of northern england. so anywhere where any fog lingers or you see that snow will be particularly cold, barely above freezing. any of that snow will gradually fade, then, as we go through the evening. again, turning icy behind that. and again, we have these showers affecting parts of scotland, northern ireland and northern england deeper into sunday night. it will be icy in places with a few

centimetres of snow possible in a few spots, too, with another widespread frost as monday begins. a few of those wintry showers will sink further southwards through england and wales. as we go on through monday, there will be some sunny spells around at times, too. and temperatures edging up mainly to around four or 5 degrees. a little bit higher in south—west england, where we will see weather fronts coming in from the atlantic tuesday, wednesday, indeed, for the rest of the week. that does mean it'll be turning wetter and windier once again, but it will also be turning milder, too. temperatures heading up quite a bit from midweek.

hello, this is bbc news.

the headlines: more than 2000 people have been arrested across russia during a clampdown on protests called by the jailed opposition leader alexei navaly. mr navalny�*s wife yulia was arrested, then released. senior doctors in britain call for the maximum 12 week gap between administering the first and second doses of the pfizer coronavirus vaccionation to be halved. a curfew will come into force in the netherlands tonight — as part of new measures to contain coronavirus. residents in wuhan have been marking the first anniversary of the coronavirus lockdown which saw the chinese city sealed off for more than two months. 12 months on and life in wuhan has returned to normal. the american broadcaster larry king has died at the age of eighty—seven. he had been receiving treatment for covid—nineteen in los angeles. in a career spanning six decades, larry king interviewed many of the world's most famous people.

now on bbc news...