hello, this is bbc news. the headlines: a leaked document appears to reveal plans to reverse reforms made to the nhs in england by the coalition government in 2012,

which saw the private sector given a greater role. the chairman of the vaccines taskforce says he's confident the uk will be able to offer coronavirus jabs to everyone over 50 by may. thousands of people take to the streets in myanmar to protest against the military coup and to demand the release of aung san suu kyi. president biden says donald trump is "dangerous" and wants him to lose access to intelligence briefings normally given to former presidents. i just think that there is no need to have that intelligence briefing. what value is giving him an intelligence briefing? what impact does he have at all, other than the fact he might slip and say something? and tens of thousands of farmers block major highways across india as they continue their protests against new agricultural laws.

now on bbc news... click, is looking at �*bioprinting' — literally printing replacement parts of the body to help treat disease and illness. this week, bioprinting cells, talking to strangers, and perfecting your posture. welcome to click — hope you are doing 0k. you probably don't want to hear this, but we are now almost coming up on a year of video calls, zoom meetings, and teams chats. in that respect, at least, i think

the world has adapted quite well. unsurprisingly, a lot of innovators have lept to the chance to invent a whole range of video call accessories. and my good friend lara lewington is wearing one now. can you spot it? what could possibly be? these are the periphery smart earrings. not only do they help you get your top half dressed up for a video call, but they also provide sound directly into your ear from behind the earring, and there is a microphone just here, as well. it means you can make phone calls or video calls and communicate through these. i'm no expert — i would say they are a little on the big side, but they do match your frock. almost, and they come in different designs. but, as you say, they chunky and could do with being made smaller. the idea is not bad. and talking about not—bad ideas, how about this? what's that?

this went viral a month or two ago. it turns out one of the most awkward parts of a video meeting is trying to leave it. i don't know if you have been there, but everybody waves, and with their other hand they hit the leave meeting button, then it turns out that you haven't left the meeting, and then you need to click to confirm that you want to leave. this inspired one creative technologist to create the zoomout. to leave a meeting, i pull this... he's gone. you know when you're talking to somebody and you say goodbye in person, and then you end up walking in the same direction? i hate that. exactly. it's like that, but every hour, when you're doing calls all day. you are trying to leave and you say goodbye, and you're fumbling for the leave button.

this is brian moore, who created the zoomout. of course we had to make our own. so stephen beckett downloaded the plans that brian put on github, got handy with his sd printer, and here's is the result. here you go. a pull cord connected to a bluetooth—enabled circuit board that sends an instruction to your computer to end the call. simple and effective. it's a race. one, two, three, go. i guess these days, as well, you don'tjust have to make these things for yourself, you can share them with the world on the internet so you can go viral with these things. i feel really good comedians, they make a joke about something that everybody thinks is just something that they experience, but then because they laugh at it because, well, everybody experiences it. the same thing goes with this. i didn't think that many people would — this is certainly something that i experience.

it turns out that millions of people who watched this felt the same way. i never know — i'll make something and put it out in the world, and one person will see it, and then sometimes, i will make it, and put it on the web, see what happens, and suddenly blows up and i'm like "wow, i can't believe it." it just struck a chord, no pun intended. what are some of the other crazy things that you have built? i have built a scooter that is powered by screaming. it's powered by anger. it was for angry birds. it was a scooter with a microphone on it. the throttle didn't work unless you screamed. so, the louder you screamed, the faster it went. something i am working on that i have not mentioned is this polaroid. when you take a photo of somebody, it actually prints out a reverse image recognition photo of them off the internet, which is terrifying. it's a really scary thing. i tried taking a photo of my wife

and i printed out a photo i had taken of her seven years ago, because it was on the internet somewhere. brian, can you keep these dumb projects coming, please, because they're brilliant? i can try. it's all i've got in covid. i'm doing is sitting here at home and making these things. good, you're back. iam. now we're going to talk about stem cells. stem cells grow from one type of cell into any type of cell in the human body. but, for researchers, controlling that process is proving difficult. but now, one company in cambridge claims to be able to reprogram stem cells to produce any other type of human cell in large quantities. it's part of a growing trend to bioprint elements of the body. the ability to repair damaged cells and tissue in the body is the focus of the field

of regenerative medicine. over the years, we have seen bioink to print tissues, sd—printed body parts, and even a company growing bones from a person's own stem cells. innovations around stem cells, the building blocks of our bodies, offer exciting potential. typically, these cells are extracted from a blood or skin sample in small amounts, but one company is working on producing any type of human cell in industrial quantities. hello, how are you? hi. thank you for having us in your lab. this is one of our molecular biology labs, and here we create what is called gene cassettes, and we create — we engineer cells, essentially. here at bit.bio in cambridge, an interdisciplinary team has created a new technology called optimised inducible overexpression.

it enables the precise reprogramming of entire cultures of stem cells into any cell type on a vast scale. founder and neurosurgeon mark kotter is combining the fields of coding and biology to enable a deeper understanding of the genetic engineering of a cell. we have, sort of, taken a slightly different angle on biology. when we look back over the last 30 years, it seems like you can look at biology a little bit like a software. and that means that there is a possibility to, you know, reprogram, reboot a cell with a new programme. and our technology allows us to do this extremely efficiently. and that has really opened a completely new way of thinking about manufacturing and precision engineering of cells. we keep them in incubators here,

as all other cells that are grown outside the body. they need certain oxygen level, carbon dioxide, and temperature. and when — once we make the — design the cell type, we can actually freeze them in small test tubes, in tubes, and you can send them to the customer in a frozen format. these cells could then be used for patient therapies, but also to study rare diseases or discover new medicines. the golden standard in the field is to use primary cells, which are isolated from human organs — but, as you can imagine, the difficulty there is that the donors are very scarce, so it is very difficult to get these primary cell types. and so, bit.bio aims to bring a new gold standard to the field. we can create mature cell types that behave like primary human cells that you would find in the body.

using these mature cell types for drug testing could yield much better results and eliminate the need to test on animals. every disease, every condition, it starts with a problem at the cell level. it is the cells that actually go wrong. if you want to create medication, drugs, then you need to understand what is happening in order to be able to design the right drugs. and i'lljust pull out an example. for example, alzheimer's disease, you know, there has been a lot of effort to create drugs. unfortunately, so far, they haven't been very successful. traditional drug discovery, we would use animal models and cells to model, you know, a condition like alzheimer's. but the problem is that mice don't get alzheimer's, so you have to do something

to the mice so that they then sort of present with something that looks like alzheimer's, and then you create a drug to treat the thing that you have created. and so, here, that's where we bring a unique solution. we can create human brain cells that actually are affected by alzheimer's. what this allows you to do is then use, you know, target your research and your drug discovery against the actual condition. having access to millions of high—quality human cells could help advance other technologies. a team in south korea have developed this bioprinter, which can help heal diabetic foot ulcers. a photo of the ulcer is uploaded to the machine which prints a patch the exact size of the ulcer with biomaterials. this helps with the healing of ulcers which could lead to amputation. this and many more technologies could benefit from the manufacture

of human cells on an industrial scale and could maximise the capabilities of regenerative medicine. hello and welcome to the week in tech. it was the week amazon founder jeff bezos announced he was stepping down as chief executive. he will become executive chairman, and will be replaced as ceo by andy jassy. the latest starter prototype by elon musk�*s spacex met with an explosive landing. spacex said the test flight provided valuable data. and call of duty: warzone has banned more than 60,000 accounts in one day for cheating. publisher activision says it was enhancing its own anti—cheat software. ai—powered traffic cameras in australia could soon be getting an upgrade. existing cameras detect offences like mobile phone use. now, instead of being hit with a fine, drivers will be warned by a roadside display.

continuing the road theme, swiss researches have developed a computer vision system to allow motorcyclists to take bends more safely. using cameras and a display, it calculates the optimal trajectory and speed through a curve. and finally, everyone�*s favourite — and/or terrifying — robot dog now has an arm. spot, developed by boston dynamics, can now perform tasks like tidying up, opening doors, and writing massive messages in chalk. it can now also be operated remotely. good boy. i've been working home comment from home now for almost a year, and it's safe to say i've done a lot of slouching. and i started getting worried i might be doing myself some harm. i've also been bombarded with instagram ads for this gadget that makes you sit up straight,

so i thought i'd give it a go. this is the upright go 2, and you wear itjust at the top of your back. it comes with sticky pads so you can literallyjust stick it to your skin, or you can wear it on a neckband, but i preferred the glue. once it's in place, you tap the button twice to calibrate. then, if you lean forward for a few seconds, it will vibrate, reminding you to sit up straight. that's all there is to it. the application records how long you've been slouching, and how long you have been upright. in my first experiment, i actually turned it the vibration off so the app would just record how much i was slouching at my desk. that was hard to do, because once you're conscious you're wearing it, you tend to sit more upright, anyway. but, in my first two—hour stint, i was uprightjust 5% of the time. for the other days, when i was sat at my desk working, i had the vibration switched on. as you would expect, as i leaned forward for a few seconds, it would buzz. there were times where this got a bit annoying, because there are lots of times

where you lean forward, even if you're resting on your elbows with a straight back, or you get up to make a coffee, and you're leaning over the kettle. at those times, it would be vibrating, telling you you're slouching. for that reason, i didn't wear the device all day every day, but if i knew i was going to do an hour or two stint at my desk — perhaps editing a video — i would put it on. after a while, i did get used to it, and there were times where i completely forgot i was wearing it. at least once i showered with it on — thankfully, it still works. after using it a few times, those stints where i was wearing it, i was managing to get 80—90% of the time upright. now, i'm lucky i have never had serious neck or back pain, but i wonder if there are health benefits to this. the company makes no health claims on its ads on instagram, but it does make some health—related comments on its website. such as... so, i spoke to ashleyjames from the uk's charter society of physiotherapy to ask if there's anything wrong with slouching.

absolutely not. there's nothing wrong with slouching in moderation, just as the same there is nothing wrong with sitting up perfectly straight. what we know is there's no right or wrong position to sit in. there's only positions that are held for too long. i've seen those posts on social media that see if you use your phone too much or we sit it badly in a chair, we're permanently changing the shape of your necks and spine — is that true? yeah, no, there is no good evidence that sitting in any one position will permanently change the position of your spine. the key thing is movement and not to be sat in any one position for too long. what i am hearing is it is absolutely fine for me to work in bed all day? yeah, i mean, everything in moderation, i wouldn't suggest working from the sofa or bed all day, not because it is inherently bad, but because it

would reduce our ability to move regularly, and that might lead to some pain and discomfort. the company told me it doesn't make health claims for its products but its research shows that people do sit up more when they use it. well, no surprise there because it buzzes every time you slouched. one thing i notice is it doesn't because if you lean backwards. so, position like this are not ok, but you can sit really badly backwards in a chair and it will never vibrate. purely from a cosmetic point of view i have really enjoyed wearing this, because i know when i see go shopping, i see my reflection in the shop windows, and i'm always hunched over. but now, when the pandemic is over and i get to go to a positive event, i might wear this to remind myself to sit up straight and keep my shoulders back. that was chris. watching it made me want to sit up straight. it does seem it is more about movement than posture? that was certainly the view from the physiotherapist. as long as you're not spending

all day sitting in one position and moving around a bit more, then that may be comfortable for you. for me that makes sense. i've never been someone who suffers back pain but the times when i have had a sore back, or a sore coccyx has been when i have been on a flight, and haven't realised they had been sitting in the one position. it makes me just want to carry on moving while we're chatting to you, chris. i think that is good advice. maybe do some desk yoga, some dance routines. what i wanted is rather than spending maybe £100 on a posture trainer like this, if you are ready have a smartwatch or fitness tracker, they usually actually tell you, once an hour you can set it to buzz to remind you to move around. i feel that is the same thing. to stand up every hourfor a number of minutes stopping another good thing to do as well, it you moving. chris, thank you for sitting up andpaying attention. now, one of the things we missed in lockdown, some of us probably missing more

than others is meeting new people. now, i don't mean dating, ijust mean for a chat with somebody different, because many of us have been speaking to the same person all week for the last year. i will say nothing. well, i've tried platforms that aim to change the conversation. meet marguerite, who lives in surrey. i have six grown—up children and 18 grandchildren and 15 great—grandchildren. some of them live far away, others are working all day and they cannot always come and visit me. but life can be isolating, especially in these days of lockdown or restrictions. so, one of marguerite�*s daughters went looking for a professional companion for her. now, meet sue, a freelance script writer who lives close to marguerite. it was marguerite�*s name, i think, that first kind of caught my attention. i asked her about her name

and she started telling me her history and then mentioned that she'd once upon a time been a professional ballroom dancer. yeah, i was very interested in her life and she was interested in what i was saying to her. the app was originally launched to provide face—to—face short spells of company from pre—vetted companions for an agreed fee. it may have been the start of a beautifulfriendship, though. during lockdown times, many, like sue and marguerite, have chosen to switch to the apps online meeting space. so, hearing stories is fascinating for me. companions app is the structure. if you go around to help somebody for an hour, and then they say could you just, and can you just, with the app, you're able to have boundaries, i think, and i think

that's quite important. sometimes you can open up to people and not tell your family certain things, which i think is very enlightening. with the lockdown, life is very boring and there are a lot of old people here where i live, and they're very lonely, a lot of them. it has given me a lift in life, which i was stagnating a bit, i think. tell me, the matching up process sounds like online dating? yeah, yeah! gsoh, all that sort of thing. it's all that. lisa, who used to be an advertising exec for amazon uk thought up the idea after a skiing accident left her needing some help around the house. we wanted to create something that is going to be for us. i mean, we need this, we need to look after our parents when we are older and don't want them to go into homes. started to break it down, what technology do we need? what do they have, what don't they have? how do we make it a seamless

journey for everybody? companions isn't the only platform that can help you meet people for a bit of conversation at the moment. quarantine chart launched last year, and the idea is that it randomly puts two people together from anywhere in the world for a i—to—i phone chat. we're about to connect you to someone else, somewhere in the world to talk. hello? hi. how's it going? i am doing pretty well. i'm a film—maker and there was a big film festival two weeks ago, and a lot of my friends went... now, you know, restaurants can see at 25% capacity. _ i'm craving wide space at the moment, so, big mountains, big, big... so, today, ifound out that somebody was at the party had just tested positive... putting it to the test, i did find out a few of the calls i signed up for did not happen,

but i did manage to make a friend in japan. what has been the greatest high for you? mostlyjust reading books. and i'm interested in people. the app matches you with someone who speaks the same language and is awake at the same time. operating via another app called dial up, no personal information is shared and calls are made using data. it has 10,000 users globally, and although they're not pre—vetted, there's a feedback system to report anything untoward. the idea for the app had come from one of its co—creators' own experience of being quarantined. there is a lot of benefit to just, you know, getting out of your own head and listening to somebody else�*s stories, and having someone listen to you. you know, it's just the two of you on the phone, it's not like this group chat room

or anything, it's just the two of you and you're there and you both want to talk and you are listening to each other, so it's very comforting. it helps you feel very connected. meanwhile, our original pairing, sue and marguerite are looking ever stronger. she's got many more stories that i'd love to hear. we might even write a book together, might me, marguerite? i think we are planning on meeting up soon again, are we, marguerite? we sure are. we can talk about the weather. how interesting. i have to say, i've always felt awkward talking to strangers, but how was it for you? it was funny. of all the things i have missed over the past year, it had never occurred to me that i would miss meeting different people from different places. it was a bit awkward to start with but then you settle into the chat. something new for every one to try. looks like we have all tried something new this week, but, anyway, that is it from us for now.

and as ever, you can keep up with the team on social media, find us and you can keep up with the team on social media, find us on youtube, instagram, facebook and twitter on @bbcclick. see you soon! bye— bye! bye— bye. when we get snow across the country it does tend to dominate weather headlines, doesn't it? but i want to point out that for many hit western areas today we've got some lovely sunny spells. this was cumbria just a few hours ago and we have got relatively mild are still in place with temperatures peaking around seven or 8 degrees. but in colder further east and it is this cold air that will dominate the story over

the next few days, originating from the arctic and coming down across scandinavia it is also going to interact with storm dassey which is really going to fog across the far north of europe butjust the tail end of that weather front interacting with that cold air and that could bring wintry precipitation over the next few hours. some showers drifting in off the north sea and clearer skies as we go through the night so that means a cold, icy start first thing on sunday morning. but it is the south—east that will be the cause for concern during the early part of sunday. the met office has issued an amber warning potentially for 5—10 centimetres of snow quite widely, even as much as 20 centimetres plus on higher ground. the yellow he had a note that that snow might drift further north and west so you need to keep abreast of the forecast to see exactly where that

snow is threatening during sunday morning. elsewhere it is going to be a case of sunny spells and scattered showers. particularly where we have got to the snow, blizzard —like conditions and gusts in excess of 50 mph. western areas will continue sunshine to the afternoon and scattered showers. it is going to be a cold day. temperatures, while struggling to climb above freezing, factoring the strength in the direction of the wind, it is really going to feel bitterly cold with more like “1! minus five degrees. into monday the easterly wind drives in showers and an emphasis further north and east as we can see and again temperatures i fetched a struggle for many. it is going to feel bitterly cold indeed. a few have not already got the got the message the early part of the week looks likely stay very cold indeed with further score the wintry showers.

this is bbc news. the headlines at apm. a leaked document appears to reveal plans to reverse reforms made to the nhs in england by the coalition government in 2012, which saw the private sector given a greater role. the chairman of the vaccines task force says he's confident the uk will be able to offer coronavirus jabs to everyone over 50 by may. thousands of people take to the streets in myanmar to protest against the military coup and to demand the release of aung san suu kyi. president biden says donald trump is "dangerous" and wants him to lose access to intelligence briefings normally given to former presidents.