thousands of people are gathering on the streets in myanmar for a second day to protest against the military coup. in the main city yangon, crowds are chanting slogans against military dictatorship and in support of democracy, calling for the release of detained leader aung san suu kyi. pharmaceutical company, astrazeneca, says a small trial suggests the coronavirus vaccine it's developed with oxford university, does not appear to offer much protection against mild or moderate disease, caused by the south africa variant. but the firm believes the jab would protect against severe disease. thousands of indian farmers brought some of the country's major roads to a standstill to show their opposition to new agriculture reforms, which they say would leave them out of pocket. dozens were arrested with more than 50,000 members of the security services being deployed for the protests.

now on bbc news, click. this week, bioprinting cells, talking to strangers, and perfecting your posture. welcome to click — hope you are doing 0k. you probably don't want to hear this, but we are now almost coming up on a year of video calls, zoom meetings, and teams chats. in that respect, at least, i think the world has adapted quite well. unsurprisingly, a lot of innovators have lept to the chance to invent a whole range of video call

accessories. and my good friend lara lewington is wearing one now. can you spot it? what could possibly be? these are the periphery smart earrings. not only do they help you get your top half dressed up for a video call, but they also provide sound directly into your ear from behind the earring, and there is a microphone just here, as well. it means you can make phone calls or video calls and communicate through these. i'm no expert — i would say they are a little on the big side, but they do match your frock. almost, and they come in different designs. but, as you say, they chunky and could do with being made smaller. the idea is not bad. and talking about not—bad ideas, how about this? what's that? this went viral a month or two ago. it turns out one of the most awkward parts of a video meeting is trying to leave it. i don't know if you have been

there, but everybody waves, and with their other hand they hit the leave meeting button, then it turns out that you haven't left the meeting, and then you need to click to confirm that you want to leave. this inspired one creative technologist to create the zoomout. to leave a meeting, i pull this... he's gone. you know when you're talking to somebody and you say goodbye in person, and then you end up walking in the same direction? i hate that. exactly. it's like that, but every hour, when you're doing calls all day. you are trying to leave and you say goodbye, and you're fumbling for the leave button. this is brian moore, who created the zoomout. of course we had to make our own. so stephen beckett downloaded the plans that brian put on github, got handy

with the printer, and here is the result. here you go. a pull cord connected to a circuit board that sends a message to your computer to end the call. simple and effective. it's a race. one, two, three, go. you don'tjust have to make these things for yourself, you can share them with the world on the internet so you can go viral with these things. i feel really good comedians, they make a joke about something that everybody thinks isjust something that they experience, but then because they love it because, well, everybody experiences it. the same thing goes with this. i didn't think that many people would — this is certainly something that i experience. it turns out that millions of people who watched this felt the same way. i never know — i'll make something and put it out in the world, and one person

will see it, and then sometimes, i will make it, and put it on the web, see what happens, and suddenly blows up and i'm like "wow, i can't believe it." it just struck a chord, no pun intended. what are some of the other crazy things that you have built? i have built a scooter that is powered by screaming. it's powered by anger. it was for angry birds. it's a scooter with a microphone on it. it didn't work unless you screamed. the lourder you screamed, the faster it went. something i am working on that i have not mentioned is this polaroid. when you take a photo of somebody, it actually prints out a reverse image recognition photo of them of the internet, which is terrifying. it's a really scary thing. i tried taking a photo of my wife and i printed out a photo i had taken of her seven years ago, because it was on the

internet somewhere. brian, can you keep these dumb projects coming, please? i can try. with covid—19, all i'm doing is sitting at home and making these things. good, you're back. iam. now we're going to talk about stem cells. stem cells grow from one type of cell into any type of cell in the human body. for researchers, controlling that process is proving difficult. but now one company in cambridge claims to be able to reprogram stem cells to produce any other type of human cell in large quantities. it is part of a growing trend to bioprint elements of the body. the ability to repair damaged cells and tissue in the body is the focus of the field of regenerative medicine. over the years, we have seen bioink to print tissue, and bones being grown from a person's own stem cells.

innovations around stem cells, the building blocks of our bodies, offer exciting potential. typically, these cells are extracted from a blood or skin sample in small amounts, but one company is working on producing any type of human cell in industrial quantities. hello, how are you? thank you for having us in your lab. this is one of our molecular biology labs, and here we create what is called gene cassettes, and we create — engineer cells, essentially. here at bit.bio an interdisciplinary team has created a new technology. it enables the precise reprogramming of entire cultures of stem cells into any cell type on a vast scale. founder and neurosurgeon mark kotter is combining coding and biology to create a new understanding of the genetic

engineering a result. we have taken a different angle on biology. when we look back over the last 30 years, it seems like you can look at biology a little like a software. and that means that there is a possibility to, you know, reprogram, reboot a cell with a new programme. and our technology allows us to do this extremely efficiently. and that has really opened a completely new way of thinking about manufacturing and precision engineering of cells. we keep them in incubators here, as all other cells that are grown outside the body. they need certain oxygen level, carbon dioxide, and temperature.

and when — once we make the — design the cell type, we can actually freeze them in small test tubes, in tubes, and you can send them to the customer in a frozen format. these cells could then be used for patient therapies, but also to study rare diseases or discover new medicines. the golden standard in the field is to use primary cells, which are isolated from human organs. but, as you can imagine, the difficulty there is that the donors are very scarce, so it is very difficult to get these primary cell types. bit.bio aims to bring a new gold standard to the field. we can create more true cell types that behave like primary

human cells that you would find in the body. using these mature cell types for drug testing could yield much better results and eliminate the need to test on animals. every disease, every condition, it starts with a problem at the cell level. it is the cells that actually go wrong. if you want to create medication, drugs, then you need to understand what is happening in order to be able to design the rate drugs. and i willjust pull out an example. for example, alzheimer's disease, you know, there has been a lot of effort to create drugs. unfortunately, so far, they haven't been very successful. traditional drug discovery, we would use animal models and cells to model, you know, a condition like alzheimer's. but the problem is that mice don't get alzheimer's, so you have to do something to the mice so that they then sought to present with something that looks like alzheimer's. then you create a drug to treat the thing that you have created. and so this is where

we bring a unique solution. we can create human brain cells that actually are affected by alzheimer's. what this allows you to do is then use, you know, target your research and drug discovery against the actual condition. having access to millions of high—quality human cells could help advance other technologies. a team in south korea have developed this bioprinter that can help heal diabetic foot ulcers. a photo of the ulcer is uploaded to the machine which matches the size of the ulcer with biomaterials. this helps with the healing of ulcers which, if left untreated, could lead to amputation. this could be aided with the manufacture of human cells on an industrial scale and could maximise the capabilities of regenerative medicine.

hello and welcome to the week in tech. it was the week amazon founder jeff bezos announced he was stepping down as chief executive. he will become executive chairman, and will be replaced by new ceo andy jassy. and the latest rocket prototype from elon musk�*s spacex had an explosive end. spacex said the test flight provided valuable data. and call of duty: warzone has banned more than 60,000 accounts in one day for cheating. publisher activision says it is improving its own anti—cheat software. and traffic cameras in australia could soon get an upgrade. existing cameras detect offences like mobile phone use. now, instead of being hit with a fine, drivers will be warned by a roadside display.

continuing the road theme, swiss researchers have developed a vision system to allow motorcyclists to take bends more safely. using cameras and a display, it calculates the optimal trajectory and speed through a curve. and finally, everybody�*s favourite terrifying robot dog now has an arm. spot, developed by boston dynamics, can now perform tasks like tidying up, opening doors, and writing massive messages in chalk. it can now also be operated remotely. good boy. i've been working from home now for almost a year, and i've done a lot of slouching. and i started getting worried i might be doing myself some harm. i've also been bombarded with instagram ads for this gadget that makes you sit up straight, so i thought i'd give it a go. this is the upright go 2, and you wear it at the top of your back. it comes with sticky pads so that you can stick it

to your skin, or you can wear it on a neckband. i prefer the glue. once it's in place, you tap the button twice to calibrate. then, if you lean forward, it will vibrate, reminding you to sit up straight. that's all there is to it. the application records how long you've been slouching, and how long you have been upright. in my first experiment, i turned the vibration off so it would just record a passive reading of how often i was slouching at my desk. that was hard to do, because once you're conscious you're wearing it, you tend to sit more upright, anyway. but, in my first two—hour stint, i was uprightjust 5% of the time. for the other days, when i was sat at my desk working, i had the vibration switched on. as you would expect, if i leaned forward, it would buzz. there were times where this got a bit annoying, because there are lots of times where you lean forward, even if you're resting on your elbows with a straight back, or you get up to make a coffee, and you're leaning

over the kettle. at those times, it would be vibrating, telling you are slouching. for that reason, i did not wear it all day every day. but if i knew i was going to do an hour or two stint at my desk — perhaps editing a video — i would put it on. i did get used to it, and there were times where i completely forgot i was wearing it. at least once i showered with it on. thankfully, it still works. after using it a few times, those stints where i was wearing it, i was managing to get 80—90% of the time upright. i'm lucky i have never had serious neck or back pain, but i wonder if there are health benefits to this. the company makes no health claims on its ads on instagram, but it does make health related comments on its website. so, i spoke to ashleyjames from the uk's charter society of physiotherapy to ask if there is anything wrong with slouching. absolutely not. just as the same there is nothing wrong with sitting up perfectly straight. what we know is there is no right or wrong position to sit in. there are only positions

that are held for too long. i've seen those posts on social media that see if you use your phone too much or use it badly in a chair, you are permanently changing the shape of your necks and spine, is that true? yeah, no, there is no good evidence that sitting in any one position will permanently change the position of your spine. the key thing is movement and not to be sucked in any one position for too long. what i am hearing is it is fine for me to work in bed all day? in moderation, i wouldn't suggest it, not because it is inherently bad, but because it would reduce our ability to move regularly, and that might lead to some pain and discomfort stopping the company told me it doesn't make health claims for its products but its research shows that people do sit up more when they use it. no surprise there because it buzzes every time you slouched. one thing i notice is it doesn't because if you lean backwards. position like this

are not ok but you can sit really badly back in a chair and it will never vibrate. from my point of view i have enjoyed wearing this, i see in the shops with the mirrors, i see myself stepping over. but now, when the pandemic is over and i get to go to a positive event, i might wear this to remind myself to sit up straight and keep my shoulders back. that was chris. and this is chris. watching it made me want to sit up straight. it does seem it is more about movement than posture ? that was certainly the view from the physiotherapist. as long as you're not spending all day sitting in one position and moving around a bit more, then that may be comfortable for you. that make sense to be over never been someone who suffers back pain but the time i have had a sore back, a sore coccyx has been when i have been on a flight, and haven't realised they had been sitting

in the one position. it makes me want to carry on moving. i think that is good advice? maybe do some desk yoga, some dance routines. what i wanted is rather than spending maybe £100 on a posture trainer like this, if you are ready have a smartwatch or fitness tracker, they usually tell you about how you can set its above to get up and move around. i feel that is the same thing. to stand up every hourfor a number of minutes stopping another good thing to do as well, it you moving. chris, thank you for setting up and paying attention. now, one of the things we missed in lockdown, some of us probably missing more than others is meeting new people. now, i don't mean dating, ijust mean for a chat with somebody different, because many of us have been speaking to the same person all week for the last year.

i will say nothing. well, i've tried platforms that aim to change the conversation. meet marguerite, who lives in surrey. i have six grown—up children and 18 grandchildren and 15 great—grandchildren. some of them live far away, others are working old day and they cannot always come and visit me. but life can be isolating, especially in these days of lockdown or restrictions. so, one of marguerite's daughters went looking for a professional companion for harris. now, meet sue, a freelance script writer who lives close to marguerite. it was marguerite's name that kind of caught my attention. i asked her about her name and she started telling me her history and mentioned that she had once upon a time been a professional ballroom dancer. yeah, i was very interested in her life and she was interested in what i was saying to her.

the application was originally launched to provide face—to—face short spells of company from vetted companions for an agreed fee. it may have been the start of a beautiful friendship, though? during lockdown times, many like sue and marguerite have chosen to switch to the app was mcelnay meeting space. one of my hobbies is writing. so, hearing stories is fascinating for me. i love it. and one thing i like about the whole sort of companions app is the structure. if you go around to help somebody, and then they say could you just, and can you just, with the app, you are able to have boundaries, i think, and that's quite important. sometimes you can open up to people and not tell your family certain things, which i think is very enlightening. and there are lots of people here where i live,

they are very lonely, lots of them. it has given me a lift in life. which i was stagnating a bit, ithink. the matching up process sounds like online dating? yeah, yeah! it is all about. lisa, who used to be an advertising exec for amazon uk thought up the idea after a skiing accident. we wanted to create something that is going to be for. we need this, we need to look after our parents when we are older. started to break it down, what technology do we need? what do they have, what don't they have? how do we make it a seamlessjourney for everybody? companions is not the only platform that can help you meet people for a bit of conversation at the moment.

quarantine chat launched last year and the idea is that it randomly puts two people together from anywhere in the world for a i—to—i phone chat. we are about to connect to someone else, somewhere in the world? hello? hi. how's it going? i am doing pretty well. there was a big film festival two weeks ago, and a lot of my friends went... i'm out the restaurant, we are at 25% - capacity. i'm craving wide space at the moment, so, big mountains, and so on... i found somebody was at the party who had just tested positive... putting it to the test, if you have the calls i signed up for did not happen, but i did manage to make a friend injapan. what has been the greatest high for you? mostlyjust reading books. and i'm interested in people.

the app matches you with someone who speaks the same language and is awake at the time, operating via another app called dial up, no personal information is shared and calls are made using data. it has 10,000 users globally, and although they are not pre—vetted, there is a feedback system to report anything untoward. the idea for the app had come from one of its co—creators' own experience of being quarantined. there is a lot of benefit to just getting out of your own head and listening to somebody else's stories, and having someone listen to you. it is just the two of you on the phone, not a group chat room or anything, it is just the two of you and you both want to talk and you are listening to each other, there is very comforting. it helps you feel very connected.

meanwhile, our original pairing, sue and marguerite are looking ever stronger. so many more stories that i would love to hear, we might even write a book together, temperament? i think we are planning on meeting up soon again, are we, marguerite? we sure are. we can talk about the weather. how interesting. i've always felt good talking to strangers, but how was it for you? it was funny. of all the things i have missed over the past year, it had never occurred to me that i would miss meeting people from different laces. it was pressing. awkward to start with but then you settle into the chart. something new for every one to try. looks like we have all tried something new this that is it from us for now. and as ever, you can keep up with the team on social

media, find as are you can keep up with the team on social media, find us on youtube, instagram, facebook and twitter on @bbcclick. see you soon! bye— bye! bye— bye. hello there. it has been called the beast from the east two and during sunday strengthening easterly wind will bring in colder air and we will have snow falling widely. the focus of the snow has been in scotland and it is still snowing here now but the emphasis changes towards the south—east of england where we are closer to storm darcy, bringing thicker cloud and added moisture, which is bumping into that really cold air that we can trace all the way back to the baltic sea and towards the arctic. we will find snow falling by the morning in the south—east and east anglia. it might be slippery elsewhere, further north there will be snow showers coming

in off the north sea. let's focus on the heaviest snow, where we have the amber snow warning from the met office, it covers parts of suffolk, essex and kent. widely five to ten centimetres, more perhaps in some places and there will be blizzards and drifting as well with the winds continuing to strengthen. notjust knowing here, it will be snowing widely across the south—east of england and east anglia. further north, snow showers coming in off the north sea across scotland, northern england, northern wales, one or two for northern ireland, drier towards the south—west and parts of the midlands as well. the winds will be strong, perhaps gale force around the north sea coasts and it will make it feel cold. temperatures will be lower than saturday, so maybe two or three degrees at best. add on the strength of the wind and it will feel much colder, typically minus four or even minus five degrees. that run of cold easterly winds continue for the start of next week. the cold air coming over

the slightly warmer north sea generates the cloud which generates the showers, which will be snow. those will stream their way in across england, heading towards wales, lots of snow showers coming into scotland as well. drier for northern ireland. we shouldn't see the heavy falls of snow perhaps in the south—east of england but it will be very cold here. temperatures below freezing all day with that covering of snow and of course, because we have the strong winds, it will feel much colder in the wind as well. we are likely to find more snow showers, for eastern parts of the uk during tuesday. and by the middle part of the week, it may be a bit drier, not as windy but it is still going to be cold.

this is bbc news with the latest headlines for viewers in the uk and around the world. thousands gather for a second day in myanmar�*s main city to condemn the military coup and demand the release of leader aung sann suu kyi. astrazeneca confirms a trial does suggest the oxford vaccine has only limited effectiveness against the south africa variant, but says it still offers protection. in india, thousands of farmers block roads across the country in a protest that sees the deployment of 50,000 police officers. 0ne guest on a lonely lighthouse, sweden's film festival takes social distancing to the extreme. we speak to the woman who won a ticket to 70 solitary

screenings.