this was all about, tomorrow will be a good day, and being hopeful. and no reason to sit and mourn for too long. get on with it. and make a good job of it. he couldn't have said it better himself, could he? thanks for lending him to us for the last ten months. thank you. and there are of course many exciting things to come and we look forward to sharing them with you. that was hannah ingram—moore speaking tojohn maguire. time for a look at the weather. here's louise lear. hi, simon. last week it was all about the cold, bitterly cold feel across the country but this week it is about mild but wet, but i have found a glimpse of sunshine, as you can see. look at this stunning photograph from causeway head in sterling, and there is some decent, dry weather for sterling, and there is some decent, dry weatherfor some out sterling, and there is some decent, dry weather for some out there but not for all with a weak weather front across the south coast producing rain and i can relate to this muddy walking paths at the moment as well. it is a cold front

thatis moment as well. it is a cold front that is easing the way but the tail end will return later this afternoon, but here is the window of fine weather for many, squally showers to the north—west and accompanied by gusts of wind in excess of 60 miles an hour plus in places, but the fine weather across eastern scotland and down into northern england and north wales and the midlands accompanied by a milder field comic ii or 12 degrees, so get out and enjoy it if you can because the emphasis tonight is more wet weather to push up from the south, gradually moving north and some of it will be heavy across north wales and northern ireland in southern scotland as well, perhaps a few scattered showers in the east but here it stays largely dry, cloudy, but very mild through the night and overnight lows of only six up to nine celsius, so yes, the front has to sweep through and it will sweep through quite quickly because all of the isobars behind it, so blustery winds across the country meaning we have an hour or two of wet weather

moving its way steadily west to east, but if you time your outdoor fresh air you might be lucky and see a window of fine, sunny weather before squally showers driving along the west facing coast, particularly in the far north—west near the low pressure. not quite as warm tomorrow, between six and nine cold front introduces something a little less mild but as we move into friday, all change again, and other low moves in again bringing south—westerly winds mild weather but it will be very windy with gale force gusts on exposed coasts and force gusts on exposed coasts and for some it will be very wet as well. rainfall totals are going to top up in a few places, between two and four inches of rain at least so we need to keep a close eye on that is a good bring a localised flooding. it never really gets to the east where it stays mild and largely dry but it's just the beginning of this conveyor belt of moisture that will run up from the south west as we move into the weekend and that is going to bring yet more wet weather with it. it

will continue to bring a milder theme but it means a saturday stays unsettled. however, we could see warm and springlike weather into the south—east by sunday afternoon. a reminder of our top story. the world's first study in which people will be deliberately infected with coronavirus will begin in the uk within a month. human viral challenge models, because they directly inoculate volunteers, are able to establish whether the vaccines are working extremely quickly. much less volunteers involved — therefore, much quicker responses to determine if the vaccines are working. that's all from the bbc news at one, so it's goodbye from me, and on bbc one we nowjoin the bbc�*s news teams where you are. good afternoon.

it's 1:33pm, and here's your latest sports news. i'm 0lly foster at the bbc sport centre. the semi—final line up is complete at the australian open. 20—time grand slam winner rafael nadal is out after an epic five set quarter—final against stefanos tsitsipas. the spaniard, who has reached five finals in melbourne, winning it once back in 2009, looked to be cruising after taking the first two sets easily 6—3, 6—2. but the greek fifth seed turned it around for only his second career win against nadal. the match lasting just over four hours at almost midnight. tsitsipas is into a third grand slam semi—final, he reached the last four in this tournament two years ago. next up for tsitsipas is daniil medvedev, he beat fellow—russian andrey rublev in straight sets — world number four medvedev has matched his best performance at a grand slam. he also reached the semi—finals at the us open last year. world number one ash barty said it was "heartbreaking" to be knocked out today —

she was looking to be the first home winner in 43 years. she raced through the first set of her quarterfinal against karolina muchova, taking it 6—1. her czech opponent complained of dizziness and called for a medical timeout, and that was the turning point for the 25th seed. when she returned, she dominated the rest of the match, taking the next two sets 6—3, 6—2. she'll face americanjennifer brady in the last 4, for barty defeat was hard to comprehend. i have played a lot of matches where there have been medical time—outs, i have taken them myself before. that should not be a massive turning point in the match. i was disappointed today that i let it become a turning point but i am experienced enough now to be able to deal with that, but it is a disappointment today without a doubt but we learn and we move on. i think it was a bit of the heat, i was feeling dizzy at some points,

really lost and almost fainting, so ijust ask for help. the doctor checked my pressure, temperature and everything, yeah, heat, i think was the main one. the england cricket captainjoe root says he didn't express himself clearly when telling the media yesterday that moeen ali had "chosen" to return home and miss the rest of the test series against india. he says the initial plan had always been to stand moeen down for the last two tests as part of their rotation policy but because he had played so little cricket, missing the sri lanaka series with coronavirus, he was given the option to stay on. he says he fully supports moeen�*s decision to spend time with his family. japan's 0lympics minister seiko hashimoto is the preferred candidate to take over as president of the tokyo 0lympics organising committee. it follows the resignation of yoshiro mori after

he made sexist comments. hashimoto was born in 1964, the last time tokyo hosted the games, and she was named after the olympic flame. she competed in four winter olympics as a speed skater and three summer games as a cyclist. she's also been minister for women's empowerment since 2019. the two—time 0lympic triathlon champion alistair brownlee says it'll take a bit of luck for the delayed tokyo games to go ahead this summer but he believes the organisers are right to continue with their preparations. it was terrible when the pandemic really— it was terrible when the pandemic really started _ it was terrible when the pandemic really started in _ it was terrible when the pandemic really started in earnest. - really started in earnest. midsummer, _ really started in earnest. | midsummer, premiership really started in earnest. - midsummer, premiership football really started in earnest. _ midsummer, premiership football was back on. _ midsummer, premiership football was back on. so _ midsummer, premiership football was back on, so things _ midsummer, premiership football was back on, so things changed _ midsummer, premiership football was back on, so things changed both - back on, so things changed both ways _ back on, so things changed both ways i— back on, so things changed both ways i don't _ back on, so things changed both ways. idon't think— back on, so things changed both ways. i don't think it _ back on, so things changed both ways. i don't think it would - back on, so things changed both ways. i don't think it would be . ways. idon't think it would be right— ways. i don't think it would be right to — ways. i don't think it would be right to call _ ways. i don't think it would be right to call it _ ways. i don't think it would be right to call it off _ ways. i don't think it would be right to call it off now. - ways. i don't think it would be right to call it off now. i - ways. i don't think it would be right to call it off now. i thinkl right to call it off now. i think the organising _ right to call it off now. i think the organising authorities - right to call it off now. i think the organising authorities in. right to call it off now. i think- the organising authorities in tokyo are doing — the organising authorities in tokyo are doing absolutely _ the organising authorities in tokyo are doing absolutely the _ the organising authorities in tokyo are doing absolutely the right - are doing absolutely the right thing — are doing absolutely the right thing they— are doing absolutely the right thing. they have _ are doing absolutely the right thing. they have to _ are doing absolutely the right thing. they have to organise i are doing absolutely the right. thing. they have to organise like are doing absolutely the right - thing. they have to organise like it is on _ thing. they have to organise like it is on and _ thing. they have to organise like it is on and keep— thing. they have to organise like it is on and keep going _ thing. they have to organise like it is on and keep going and - thing. they have to organise like it is on and keep going and keep- thing. they have to organise like it. is on and keep going and keep going, and h0pefuiiy— is on and keep going and keep going,

and h0pefuiiy they— is on and keep going and keep going, and hopefully they got _ is on and keep going and keep going, and hopefully they got to _ is on and keep going and keep going, and hopefully they got to have - is on and keep going and keep going, and hopefully they got to have a - is on and keep going and keep going, and hopefully they got to have a bit l and hopefully they got to have a bit of luck _ and hopefully they got to have a bit of luck what — and hopefully they got to have a bit of luck. what i'm _ and hopefully they got to have a bit of luck. what i'm saying _ and hopefully they got to have a bit of luck. what i'm saying is, - of luck. what i'm saying is, unfortunately _ of luck. what i'm saying is, unfortunately there - of luck. what i'm saying is, unfortunately there is - of luck. what i'm saying is, unfortunately there is a - of luck. what i'm saying is, i unfortunately there is a little of luck. what i'm saying is, - unfortunately there is a little bit of luck_ unfortunately there is a little bit of luck in — unfortunately there is a little bit of luck in there _ unfortunately there is a little bit of luck in there that _ unfortunately there is a little bit of luck in there that they - unfortunately there is a little bit of luck in there that they need. i steven gerard says that he has been let down by the five of his players who have had to self—isolate after breaking lockdown rules. they attended a party in glasgow that was broken up by police in the early hours of sunday morning. all have been fined but are also likely to receive bans by the sfa. more on that on the bbc sport website. let's get more now on the news that the world's first coronavirus human challenge study — which involves deliberately exposing participants to the virus — will begin in the uk in the next few weeks. earlier my colleague victoria derbyshire spoke to dr andrew catchpole — chief scientific officer at hvivo, the clinical company involved in the study which has pioneered viral human challenge models. he explained why these kind of trials are important. this is going to be a really

important tool, actually, to help us fight the pandemic. it's already quite clear that the current wave of vaccines that are being rolled out very successfully now are, whilst they are wonderful, not going to be the answer to eradicating this virus. it's clear that we are seeing variants emerge with the virus as it continues to transmit globally, but as that happens eventually they will be a variant which pops up which is able then to evade the current vaccines. new vaccines will be needed. so, in such a scenario, we are going to need a way of testing these new vaccines to be sure that they can work against these new variant viruses. and human viral challenge models, because they directly inoculate volunteers, are able to establish whether the vaccines are working extremely quickly. much less volunteers involved, therefore much quicker responses to determine

if the vaccines are working. right, does this mean the vaccines we have already weren't tested on humans? no, so there are two different ways of doing this. traditionally, vaccines can be tested with filtras, and what we mean by that is we give everyone the vaccine, then they are asked to go and live their normal lives in the community. when that happens, the way that we determine if the vaccine is working or not is purely down to random chance, whether those individuals become exposed to the virus. of those that are exposed to the virus, we can then determine if the vaccine has worked or not by comparing against placebo versus vaccines. so this has worked traditionally for vaccines for many years. the problem with it is it takes many thousands of people to be vaccinated, because of course those people would actually become exposed to the virus. you can't tell if the vaccine is working. so in a scenario where you have got different versions of the virus circulating, you need very quick, very clear

answer — does this vaccine work against this specific virus? the only way to do that is in these challenge studies, and the difference here is, we control the virus because it is an experimental virus. we have made a medical grade version of the virus and we administer this in very small, safe doses to the volunteers to then determine specifically if the vaccine is working against that strain of the virus. so, what kind of people are you looking for? safety is of course our absolutely first priority on this, and because of that these trials will only be conducted on the demographic of the population that are considered the absolutely lowest possible risk of any severe outcome, and that of course is the younger demographic of 18—30—year—olds, non—smoking 18—30—year—olds. are there any risks? there is a risk with any clinical trial, of course there are. but we have worked extremely hard and across a very multidisciplinary collaborative effort with the uk

vaccine task force, imperial college london, university of southampton, the royal free, and hvivo's expertise to design this trial to absolutely minimise the risks. there are a number of things we are doing to minimise risks. we have spoken briefly about making sure we only enrolled participants who have very low likelihood of any severe outcome. also, we are using a very controlled, very small amount of the virus, and we are only going to be administering the amount of virus until we achieve infection. so the smallest amount of virus. and, additionally, as soon as we have established that they are infected, which will be tested by swabs, then we will be administering antivirals, purely as a pre—emptive measure to minimise risk. and you will require them obviously to, what, effectively isolate for two weeks after this virus has been injected into them? how much will you pay them for doing that, forgiving up theirtime? yes, that's right. we will require them to isolate. actually, it's one of

the benefits of doing these challenge studies, is because you conduct the study in a very controlled medical setting — this will be conducted in the royal free hospital in a specially designed wing of that hospital and that isn't in normal general use — so the individual volunteers will be in their own individual rooms with ensuite bathrooms and have dedicated research medics and nursing staff all the clock around so we can monitor them extremely closely. this means we can determine very accurately as soon as they are starting to have infection because we will be taking swabs multiple times a day. to enable it to be possible, they will need to be in this unit for approximately two weeks. �* , ., this unit for approximately two weeks. �* i. _ this unit for approximately two weeks. �* , ., _ as weeks. and will you pay them? as with all clinical _ weeks. and will you pay them? as with all clinical trials, _ weeks. and will you pay them? as with all clinical trials, we - weeks. and will you pay them? as with all clinical trials, we don't - with all clinical trials, we don't pay them as such, but of course volunteers should be compensated for their time. volunteers should be compensated for theirtime. so, yes, we will absolutely be compensating them for their time. the values are always

agreed with the independent ethics research body. for this trial, its approximately four and a half thousand pounds, because they are giving up two weeks of their time to be in this isolation unit, and then they will be required to come back to the facility for regular checkups for up to a year. you to the facility for regular checkups for up to a year-— for up to a year. you want 90 --eole. for up to a year. you want 90 people- that— for up to a year. you want 90 people. that sounds - for up to a year. you want 90 | people. that sounds relatively small. is that fair?— small. is that fair? yes, it is meant to — small. is that fair? yes, it is meant to be _ small. is that fair? yes, it is meant to be small, - small. is that fair? yes, it is meant to be small, and - small. is that fair? yes, it is meant to be small, and it i small. is that fair? yes, it is meant to be small, and it is| small. is that fair? yes, it is - meant to be small, and it is one of the key benefits of doing challenge studies. for example, a comparison for a typical vaccine study, we can have about 100 people. 100 people with a placebo, 100 people with a vaccine. you compare that with what you need to do in the field, and you need tens of thousands. of course, we are giving the virus to everyone on this trial. you need very much less volunteers. we are still

looking for volunteers. they can volunteer via the website. the headlines on bbc news... the world's first human trials — where people will be deliberately infected with covid—19 — are given the go—ahead in the uk. cautious and prudent — the prime minister says he won't be pushed into lifting lockdown restrictions too early. the united nations says it will raise the detention of princess latifa, the daughter of dubai's ruler, with the united arab emirates. the uk says it, too, is concerned. nicola sturgeon has told msps that the latest coronavirus figures show death numbers falling across scotland. speaking at first ministers questions she said the statistics give the "first hard evidence" of the positive impact

of vaccination. now, every death from covid is deeply regrettable, and for that reason it never feels quite right to talk about encouraging news in the context of the mrs report. however, there are aspects of today's report that really do bear some emphasis, because they give us, i think, the first hard evidence of the positive impact of vaccination. deaths overall have fallen now for three consecutive weeks. deaths that occurred in hospitals have fallen over that three—week period by 11%, and deaths occurring in people's own homes or in other non—institutional settings have fallen by 29%. however, deaths in care homes, which were the early focus of the vaccination programme, have fallen by 62%. in fact, with the exception of one week at the end of august when there were only two covid deaths recorded over all, care homes accounted for a smaller proportion of overall covid deaths last week than at any time since march of last year. and i think that is positive news given the toll that the virus has taken on our care homes. more generally, the age breakdown of the

total number of deaths over the last three weeks shows that the largest reduction, a reduction of 45%, was in the over 85 age group — and of course over 80s living in the community for the next priority focus of the programme. so i think it is reasonable to take some heart from this, because it strongly suggests the vaccine programme is having the hoped—for effect of reducing the death toll from the virus. nicola sturgeon also responded to the findings of an audit scotland report which said the scottish government had been inadequately prepared for the pandemic. the report also noted that the government had reacted quickly to prevent the health service being overwhelmed. 0ne one of the key point is this one, i think. it is perhaps one that is not captured fully in the audit scotland report. what we found ourselves dealing with in february, march of this year was not a flu pandemic. and therefore no amount of preparedness for a flu pandemic would have been sufficient in the face of the situation that we

actually encountered. however we had been for flu, actually encountered. however we had been forflu, i became quite became quite clear quite quickly that we were dealing with something of a completed different nature. in fact, if i reflect back on the last ten months, and of course this will be something for proper scrutiny in the fullness of time, i think the more valid criticism of both the scottish government and governments across the western world is that we relied perhaps in the early stages of the pandemic on flu preparations and perhaps had not done enough to prepare for the experiences of sars —type outbreaks. that is one of the key lessons that government certainly across the western world will have to learn, and of course we will have to learn, and of course we will add that to the lesson is that the audit scotland report has for us. let us end this answer where it we started, according to audit scotland the scottish government and the nhs reacted quickly.

one in three adults in wales have now had their first dose of a covid—19 vaccine, according to official figures. but speaking at the welsh government's daily briefing — the minister for mental health and wellbeing said lockdown restrictions would only be eased at a time that is "right for wales". she started the briefing by outlining the latest progress with the vaccine. more than 807,000 people have had their first dose, which is the equivalent to almost one in three of the adult population. and we are really starting to make progress now — on second doses, there was a 80% increase in the number of people who had these yesterday. now, turning to children, the latest coronavirus survey gives a really good insight into how children have been coping with the latest lockdown. i want to thank the children's commissioner, children in wales, and the youth parliament for their work on this

really detailed set of findings. which will help us to continue to shape our response to the pandemic in a sensitive way. more than 20,000 children and young people took part in this second survey. now, the results show that life has been difficult for children of all ages. they spoke about frustration and even anger about the impact of the _ pandemic on their lives. they spoke about missing friends and family members, and about missing out on experiences. teenagers talked about their worries about exams and their futures. almost one in three 17—18—year—olds said they were woried most of the time. loneliness rates are high and not being able to see friends is recorded as having the biggest impact on children's lives, followed by not being able to see other family members and the impact of school and college closures. getting children and young people back to

school is absolutely our priority. on friday, the first minister will be setting out the results of the three—week review of the restrictions. the youngest children across wales will be returning to school next week as part of our phased and flexible approach, and we continue to monitor and plan for a wider return. bbc reporter cathy killick lost both of her parents to covid—19 within six weeks. herfather died on 2nd december and her mother on 12th january. as a reporter who has spoken to those experiencing loss over the years, she has shared her personal story with bbc viewers to help convey what people who have been left bereaved by covid—19 are going through, and how everyday kindnesses can help people get through. a warning, you might find some

of this report upsetting. piano music plays the music you are hearing is something my brother found to play to our mother when she was dying. it happened six weeks after the death of our dad. they both died from covid—19. their names were ted and elizabeth. dad was in the army, a gunner, and my mum was a primary school teacher. they were such lovely parents. they took us camping and helped us out whenever they could. there were four of us in all. i'm the third. i'm doing this in their memory. and also because i know, as a reporter, it is really hard to give a voice to the bereaved. it is easier to find people who are affected

financially by the lockdown. but i know there are hundreds and thousands of people like mejust holed up, really — just sad and grieving loved ones. my dad had dementia and died in his care home after months of very limited visits. he couldn't even see my mum. i think the staff and the carers did everything they could to keep him safe, and they risked their own health to take care of him. i won't have a word said against them. they were unflagging and dedicated. my mum tested positive for covid in a hospital, having had a stroke two days before my dad's funeral. she couldn't go back to the care home because she was covid—positive, and they were covid—free at the time.

so she came home here with me, with fantastic help from the district nursing team, and we gave her palliative care. i am so grateful to that team of nurses. they let me be with my mum, which i know she wanted. and they were outstanding. 0utstanding. 0n the morning my mum died, two young carers came to change her nightdress, which was difficult because she was hooked up to a syringe. they were so young, working at seven in the morning until ten at night. and they looked after my mum with such incredible tenderness and delicacy. it was a really beautiful thing to see. and i want to say that when we talk

about protecting the nhs, it is not an institution or a building, it is people, it is those young girls. this virus exploits us. it exploits our selfishness. and it exploits the love we feel for people and how we want to be with them. and i can't wait for it to be over. but that's only going to happen with kindness and support for the people around us, because that truly is the best of us. the best of what makes us human. and if you, or someone you know has

been affected by the issues raised in that report contact the bbc action line. 0ne one of the most moving pieces of television for a long time. now it's time for a look at the weather with louise lear. hello there. last week's cold, crisp winter story a distant memory now as we've replaced the theme with something certainly milder but wetter. now, so far, we have seen a weather front easing away, just clipping the far south—east with more rain to return into the south—west later, and scattering of showers into the north—west. sandwiched in between the two, though, there is some drier, sunnier moments to be found, as you can see by this weather watcher picture sent in from 0xfordshire. actually, that is going to be the story for the remainder of the day. we keep the risk of some heavier rain pushing into the south coast later on this afternoon. gusting winds of 70 mph, and a scattering of showers into the far north—west.

sandwiched in between the two — double digits, sunny spells. but as we go through the night, it's this rain down to the south that is going to drive its way slowly northwards. it will bring some heavy rain along west—facing coasts and into northern ireland and scotland. perhaps staying dry in eastern england. here it will be a relatively mild start to our thursday morning. for thursday, we have got this area of low pressure causing some issues. it will bring a spell of rain for a couple of hours as it drifts its way steadily eastwards, and it stays pretty unsettled closest to the low into the far north—west. it's going to be a wet start out to the west, the weather front gradually drifting its way eastwards, so eventually we will see rain into eastern england and south—east england. brighter but fresher behind — a scattering of showers or longer spells continue to the north—west of scotland. but we might see a cooler story for some on thursday. 7—9c quite widely across the country. that slightly cooler theme is not going to last very long. the next low pressure

is winding its way up, with that mild south—westerly flow returning. there will be some heavy, persistent rain expected along west—facing coasts, accompanied by gale force gusts of winds. rainfall totals will really start to tot up. 2—4 inches in some places through friday and saturday. that could cause some issues. we don't think those fronts are going to impact across eastern england at the moment, here staying largely fine and dry. you can see, like a conveyor belt of moisture moving up from the south—west, staying with us for the start of the weekend. a level of uncertainty just where those fronts are likely to be sitting, but we expect them to impact out to the west on saturday. warmer and drier on sunday.

this is bbc news, i'm simon mccoy — the headlines at 2: the world's first human trials where people will be deliberately infected with covid—19 are given the go—ahead in the uk. because they directly inoculate volunteers, they're able to establish whether the vaccine's working extremely quickly. much less volunteers involved, therefore much quicker responses to determine if the vaccines are working. we'll be talking to one of the 18—year—olds volunteering in the trials. also this afternoon: cautious and prudent — the prime minister says he won't be pushed into lifting lockdown restrictions in england too early. we'll be setting out what we can on monday, the 22nd, about the way ahead. it will be based firmly on a cautious and prudent approach to coming out lockdown, in such a way as to be irreversible.