tonight at ten: for the first time in nearly 20 years, a new treatment for alzheimer's is approved by us regulators. the treatment targets the underlying cause of alzheimer's rather than the symptoms, and regulators in the uk will now consider its potential. while some scientists warn the drug will only have marginal benefits, those involved in the trials say it's very promising. this will give hope to the people that haven't had any hope for a very long time. there's patients and participants in my trails who are desperate to find something that helps. we'll be asking how soon the new drug could be available to patients in the uk. also tonight... in wales, anyone over 18 can book a covid vaccination from next week and in england, the over—25s can book from tomorrow.

we report fom portugal, where british tourists are rushing to get home before the new quarantine rules apply. we the new quarantine rules apply. only came because green we only came because it was on the green list, the words of more than one british tourist today. tonight, many have made it home but others have stayed on, knowing it will mean quarantine. suspending the england bowler ollie robinson for racist and sexits comments made nine years ago was "over the top" according to the prime minister. and, next month, this rocket will take the world's richest man on a sight—seeing tour in space. and coming up in sport on the bbc news channel: world number one novak djokovic survives a scare to join rafa nadal in the quarterfinals of the french open.

good evening. for the first time in nearly 20 years, a new treatment for alzheimer's disease — the most common form of dementia — has been approved by regulators in the united states. the decision raises the prospect of the drug, called aducanumab, also being approved here in the uk. the treatment for mild forms of alzheimer's targets the underlying cause of the disease, rather than its symptoms. but scientific opinion is divided — both here and in the us. some say it's a milestone for millions living with alzheimer's, others warn the drug will only have marginal benefits. our medical editor fergus walsh has more details. this is an historic moment in the battle against alzheimer's. for the first time, a drug has been approved which tackles notjust the symptoms but the underlying cause of this devastating disease. aducanumab is not yet licensed

in the uk and available only as part of a clinical trial — like here, at the national hospital for neurology, in central london. aldo ceresa, who's 68, was diagnosed with alzheimer's ten years ago and had to stop working as a surgeon. he receives aducanumab every month, via infusion, and is certain it's helped him. i felt that i wasn't getting so mixed up. my cognitive tests were improving quite markedly. two years ago, aducanumab was written off as a failure and the trial aldo was taking part in was abandoned. but the manufacturers, biogen, analysed more data and concluded those on the highest doses had better cognition, memory and language. this is the brain of someone with early alzheimer's. the red areas show a build—up

of amyloid, a protein which can form toxic deposits. this is the same individual after a year of aducanumab — significant amounts of amyloid have been cleared. so, this drug was approved on the basis of this drop in amyloid that you are seeing here. the doctor who is leading the clinical trials of aducanumab in the uk is delighted. this is a pivotal moment for the alzheimer's research community. this will give hope to the people who haven't had any hope for a very long time. there's patients and participants in my trials who are desperate to find something that helps. in recent years, over 100 promising alzheimer's drugs have flopped, so to now have a medicine that can potentially slow the disease is a huge moment and will encourage scientists to redouble their efforts and find even better treatments. aldo has been back on aducanumab

for six months and says he's already beginning to feel the benefits. i've noticed that i'm getting less confused. although it's still there, it's not quite as bad. and i'm just feeling that bit more confident now. aducanumab is suitable only for those with mild alzheimer's, when damage to brain function is still limited. it could take more than a year before uk regulators decide whether to approve the drug. if they do, demand here will be enormous. fergus is with me now. not all scientists are agreed on the potential. how do you read it? this is not a miracle _ potential. how do you read it? ti 3 is not a miracle drug, it potential. how do you read it? ti 1 is not a miracle drug, it is not potential. how do you read it? t1i1 is not a miracle drug, it is not a cure for alzheimer's but it is the first treatment that tackles the underlying mechanism behind this disease which can rob people of their identity and that alone makes

this a landmark moment. thejury is still out on this drug. some doctors remain sceptical and us regulators have said everyone there who received it will need to be part of an ongoing trial and they have said they will pull approval in a few years if it fails to live up to the improvements in cognition the manufacturers are promising. here in the uk, patient groups reckon 100,000 people with early alzheimer's could benefit and they will be pressing regulators for a decision here but that is likely, for at least another year it will take. the likely cost is £35,000 per patient per year and approval would likely be limited to those who had had specialist brain scans to confirm the diagnosis. 500,000 people roughly live with alzheimer's in the uk. it won't help those with moderate or advanced disease but despite all the caveats, i think this is a day of hope and a moment for cautious celebration. {lila

this is a day of hope and a moment for cautious celebration.— for cautious celebration. 0k, thank ou ve for cautious celebration. 0k, thank you very much- _ for cautious celebration. 0k, thank you very much. fergus _ for cautious celebration. 0k, thank you very much. fergus walsh, - for cautious celebration. 0k, thank you very much. fergus walsh, our| you very much. fergus walsh, our medical editor. in wales, the first minister mark drakeford has said everyone over the age of 18 will be able to book a coronavirus vaccination from next week — the first home nation to achieve that level of cover. and from tomorrow, anyone aged between 25 and 29 in england will be able to book a vaccination. our health editor, hugh pym, has more details. the welsh government says it'll be the first to reach an important milestone — offering all aged 18 and over a first coronavirus vaccine dose, and that's the aim by next monday. the target for the uk as a whole is for all adults to be offered a firstjab by the end ofjuly. by any standards, this is a remarkable achievement and a tribute to the hard work of all those involved in the programme, to all of those doing the complex work of planning behind the scenes, and to the thousands of people vaccinating and helping to run the clinics across our country. it was welcome news for those in cardiff we spoke to today.

the fact it's opened up to everyone i thinkjust means we can get to a state of normality quicker. i mean, i think that's a good thing, yeah. i imean, there's... i know a lot of students in that, like, age range that, yeah, - definitely need to get it _ because they're out and about a lot. wales is ahead of the other uk nations at the moment for the roll—out of first doses. 86.4% of the adult population have had a firstjab. in england, it'sjust over 76%. in scotland, just under that. and in northern ireland, 74.8% of those aged 18 and over have had the first dose. in england, from tomorrow, those aged 25 and over will be contacted and encouraged to book a jab. there are still concerns about the delta variant, first identified in india. the health secretary said there had been 12,500 cases so far, about 1% have been admitted to hospital, of which just three had received two doses. so, the jabs are working. we have to keep coming forward

to get them and that includes, vitally, that second jab, which we know gives better protection against the delta variant. it's still not clear whether lockdown restrictions will be fully lifted in england onjune 21st. the manager of this bar in manchester says they'll struggle if current rules limiting customers continue. it's going to really restrict our ability to take sufficient cash. we're in the summer now, we need the footfall. we need people in here and we can't get them in, we're not allowed to get the number of people in that they need to take enough money. and there are warnings of serious damage to the hospitality industry if lockdown isn't ended. you're going to have a long covid for the economy if you're not very careful. we've got £2.5 billion of historic rent debt that currently falls due in one hit on the 1stjuly. as surge testing continues in some areas, ministers save more time is needed to assess the data, as the government weighs up

the needs of the economy and keeping the virus in check. hugh pym, bbc news. the latest official figures on the pandemic show that in the past 2a hours, one death was reported, and there have been 5,683 new infections, which means an average of 5,111; new cases per day in the last week, up more than 50% in seven days. more than 127,000 people have received a first dose of the vaccine in the latest 2a hour period, meaning more than 40.4 million people have now had their firstjab, 76.8% of uk adults. while the number of people who've had their second dose of the vaccine in the latest 24—hour period is almost 260 thousand. around 28 million have had both doses, meaning 53% of uk adults are fully vaccinated. thousands of british

holidaymakers have been rushing to get home from portugal before the latest quarantine rules come into force in the early hours of tomorrow morning. anyone who doesn't make it back before 4am will have to quarantine for up to 10 days on their return because portugal has now been taken off the green list and is in the amber category, a decision widely criticised by travel companies and tourists alike. our correspondentjenny hill is in albufeira tonight, and we canjoin her now. yes, for so many, this was the perfect destination. a chance to get away, enjoy some sunshine after a year of lockdowns. this is a phrase we have heard a lot today from british tourists: we only chose portugal because it was on the green list. it's not how they thought their holiday would end. faro airport in the algarve today, a last chance for those who don't want to quarantine to get home. we had to change our flight from wednesday to today

and it cost us £140 each, which is disgusting. for esther and audrey, it's been a stressful weekend. like many, they struggled to secure the test they needed for the flight home. we paid more money getting here than what we actually paid for the holiday. most here thought portugal was a safe bet, until on thursday, the uk government suddenly decided otherwise. a bit of a blow, really, i it came out of nowhere. wejust had to bring ourflight forward by a couple of days. so, we were meant to be coming back on wednesday. i need to go to work. it's not been easy. spent all weekend worrying about how to get back. there are some 45 flights back to britain today. there were more over the weekend, as holiday—makers scrambled to get home in time. it's orderly today but the overwhelming sense is one of disappointment, notjust for those who've had to cut their holidays short but perhaps more so for this country's tourism industry. it's just a few weeks

since british tourists and hope returned to the algarve after a pandemic year. the uk is portugal's biggest tourism market. so the decision has left this country furious, frustrated and baffled. the algarve is very low in cases. yet in lisbon and maybe porto, but lisbon at the moment, i think there's maybe one area, there's been a little rise but not here. i mean, everybody comes with a negative test, everyone goes home with a negative test, so what is the problem? queueing up for those tests today, alison and herfamily, who'd come to see granny and grandad for the first time in two years. they fly home tomorrow, which means quarantine. yes... quarantine now. six hours after the deadline because we fly at 10:10. how do you feel about that? not happy about it. well, we're both key workers, actually. i'm a paramedic, amy's a care in the community. they need us out there. making the most of it, rob and betty, who found out

portugal was going onto the amber list ten minutes after they'd checked into their algarve hotel. i'm self—employed and i run a business, sojust a bit of panic, really, of what to do. you know there's a risk coming away, itjust... i'd not thought about this risk as much. this country can guarantee sunshine and hospitality but it's no longer sure of its summer season. there are just there arejust a there are just a few hours before that deadline. most of those who were going have now gone. in normal times, this place would be bustling with british tourists. instead tonight, looking around, the streets are deserted, there is barely a sound from bars and restaurants nearby and that is of course way for so many here, this decision has been so many here, this decision has been so distressing. they are telling us they are trying to stay optimistic

and hope the brits will be back but say they really cannot afford another year like 2020. jenny, many thanks for the latest in albufeira. a group of conservative mps have failed in their attempt to defeat the government on its policy of cutting overseas aid. the speaker of the commons ruled that their amendment wasn't within the rules but he called on ministers to show the commons "the respect it deserves" by giving mps a vote on the matter. the government says aid has been cut on a temporary basis because of the financial burden of the pandemic. our diplomatic correspondent james landale is at westminster. just a thought about what options maybe these people have left in terms of may be wanting to change the policy? i terms of may be wanting to change the oli ? ~ , the policy? i think these conservative _ the policy? i think these conservative rebels - the policy? i think these - conservative rebels suffered a tactical defeat today but they also made some strategic gains. they failed in their attempt to get their amendment, the one which going to in

theory verse reverse these aid cuts, because it was too different to the legislation it was supposed to change, but nonetheless i think they won the support of a valuable ally in the form of the speaker of the house of commons, who made it very clear that if the government does not soon bring forward some kind of meaningful, decisive vote on this issue, then he will help the rebels next time engineer won themselves. so, the rebels got a symbolic debate tomorrow, to vent some of their frustration, and i think the chance of a vote sometime in the future. so, for throw, this is a problem postponed, ratherthan so, for throw, this is a problem postponed, rather than avoided entirely. but crucially what mr johnson has done is avoided a potentially embarrassing defeat this week on international aid in the same week that he is hosting the g7 summit. so i think, no 10 will be happy that the problem has been parked for now. the one thing of course that has not changed are the fundamentals of the disagreement, the government believes that cutting aid this year by £4 billion at the time of an economic downturn is not

only the right thing to do for the public finances, it is also popular with the electorate. its opponents believe these cuts are notjust unlawful and immoral but will also result in hundreds of thousands of otherwise avoidable deaths around the world. , . , ., ., otherwise avoidable deaths around the world. �* . , . . . , the world. james landale, many thanks. police in norway say a body which was washed ashore on new year's day has been identified as that of a 15—month—old kurdish—iranian boy who went missing when his family tried to cross the english channel. artin irann ezhad drowned with his mother, father, elder sister and brother as they attempted to reach britain from france. a dna sample was used to establish artin�*s identity. relatives say his remains will be returned to iran. the prime minister says he agrees with the culture secretary that the cricket authorities went "over the top" in suspending the england bowler 0llie robinson for racist and sexist comments he made online nine years ago when he was 18. and tonight, the england

and wales cricket board said it was looking into claims that a second england player had posted offensive material some years ago when he was under the age of 16. 0ur sports correspondent andy swiss has the latest. caught in a cricketing controversy. this was 0llie robinson last week, receiving his first england cap, but barely had he taken the field than a series of tweets emerged, which he'd posted in 2012 and 2013. they were racist and sexist, and robinson apologised. i deeply regret my actions, and i'm ashamed of making such remarks. i was thoughtless and irresponsible, and regardless of my state of mind at the time, my actions were inexcusable. the issue, though, is gathering pace. last night, the england and wales cricket board suspended robinson, pending an investigation, but that's now drawn criticism from the culture secretary, 0liver dowden. he said the tweets were... "offensive and wrong," but added, "they are also a decade old and written by a teenager.

the teenager is now a man and has rightly apologised. the ecb has gone over the top by suspending him and should think again." a spokesman for the prime minister said he supported that view, and so do some within the sport. the correct way forward here was not to suspend, but to say, "ok, right, let's learn from this. let's make you learn from this." make him do, you know, the equivalent of community service. go out there amongst county cricketers, cricketers of any ilk, and spread the word that social media is not a thing to be abused, and these are things not to say. standing up against any form of discrimination... - but the timing of this could not be more sensitive. before last week's match, robinson and his team—mates wore shirts with anti—discrimination messages and many believe as well as education, there has to be a sanction. if you're 18 and 19, you're still an adult, and even as a youngster, i think you know the right and wrong. do you think a ban is over the top?

i think it is really important that it is a zero—tolerance stance on racism, and that if you are sending a tweet which is racist or sexist, you know, that there should be sanctions. and if that be a ban, that's what needs to happen. it has emerged tonight that as well as robinson, the ecb are investigating claims that a second, unnamed player also posted material some time ago. a man who raped and murdered two schoolgirls in the 1980s is set to be released after serving more than 30 years in prison. the parole board says colin pitchfork, who was jailed for life after killing lynda mann a man who raped and murdered two schoolgirls in the 1980s is set to be released after serving more than 30 years in prison. the parole board says colin pitchfork, who was jailed for life after killing lynda mann and dawn ashworth, should be freed.

he was the first man to be convicted of murder on the basis of dna evidence. thejustice secretary is taking legal advice about the decision. our legal correspondent dominic casciani is here. clearly strong feelings about the decision, is thejustice secretary hoping to reverse it? well, he's not saying so tonight, because his options are colin pitchfork finished the punishment element in 2016 and since then he is saying that he is safe to be released under a license in the community. and during his hearing in march, experts look at 1100 pages of evidence, from psychologists, police officers, probation officers who will be managing him, and the conclusion reached by the parole board, which is a judge—led process, was that because he has completed all sorts of offending behaviour programmes, that he has educated himself, he has taken steps to rehabilitate himself, he could be safely managed, and that is the key thing, because the legal test for the parole board is that it cannot release someone unless it is sure that they can be managed safely in

the community. now clearly there is a lot of shock about this because the nature of the crime at the time. one of the families tonight said they want to appeal but the options are limited, robert buckland has got 21 days to ask the parole board to think again but he has to show that their decision was absolutely irrational. so, he tonight has said, thoughts are with the family, but emphasising the independence of the scheme. interestingly, of course, parliament sets the law on sentencing, and the government is asking mps to change the law around child killers. what that means in practice is that a future colin pitchfork may go to jail knowing they will never taste freedom. thank ou ve they will never taste freedom. thank you very much. _ they will never taste freedom. thank you very much, dominic— they will never taste freedom. thank you very much, dominic casciani. - at least 50 people died and more than 100 were injured when two trains collided in pakistan. the crash happened in the southern province of sindh after a train travelling from karachi derailed, pushing carriages onto an adjoining track where they were hit by a train coming in the other direction. 0ur correspondent secunder kermani reports. a baby lifted to safety

amidst the chaos. standing on top of an overturned carriage, passengers desperately try to help others clamber free. a train travelling from the city of karachi came off the tracks in the early hours of the morning. then, another, going in the opposite direction, ploughed into it. translation: that's our carriage over there. we were getting down. the children were, too. then the other train slammed into us, right into our carriage. i don't know what happened after that. my wife, my daughter and my friend all died. some of the injured remained trapped by the wreckage, whilst helicopters helped carry others away. many of the most critical patients have been brought to this hospital, including six—year—old zuneira. both her legs are fractured,

both her parents are still missing. "it's the government's incompetence," says this relative. "they need to ensure drivers and railway staff are properly trained." accidents in pakistan are common. this is at least the fourth major rail disaster in this part of the country alone in the past two years. officials in prime minister imran khan's government have blamed their predecessors. he's promised to conduct a comprehensive investigation into railway safety in the country. the majority of those travelling on pakistan's railways come from poorer backgrounds. they're the ones paying the awful price for years of neglect. secunder kermani, bbc news, rahim yar khan. let's take a look at some of today's other news. kent county council has started legal action against the home office, accusing the government of refusing to deal with the problem of unaccompanied child migrants

crossing the english channel in small boats. the home office insists it is encouraging other local authorities to play their part. the council says that within just a couple of days, they may no longer have the resources to accept new unaccompanied children seeking asylum. electric scooter rental schemes have been rolled out in six london boroughs today as part of a trial to assess the risks and benefits of the vehicles. more than 30 towns and cities across the uk are taking part in the government trials. critics have raised concerns about safety, while supporters say e—scooters offer a greener alternative to cars and buses for people who don't want to cycle. the leader of boko haram, the nigerian militant group, has killed himself, according to rival islamist militants, who said he blew himself up. abubakar shekau was reported dead last month, but there have been false reports of his death in the past. neither boko haram nor the nigerian government have confirmed the latest report.

michaela coel was the big winner at the baftas last night, winning best actress, as well as awards for writing and directing her drama i may destroy you. she then dedicated her prize to ita o'brien, who worked on the programme as intimacy co—ordinator, a role which exists to support actors in any intimate action on set. our correspondent chi chi izunda has been speaking to ita o'brien about her work and how it's changing the world of film—making. i may destroy you was one of the most talked about tv shows of 2020. and the bafta goes to... ..michaela coel. bafta's best actress winner michaela coel thanked intimacy coordinator, ita o'brien.

thank you for your existence in our industry, for making the space safe, for creating physical, emotional and professional boundaries so that we can make work about exploitation, loss of respect, about abuse of power without being exploited or abused in the process. her bravery in the subject matter in drawing from her own personal experience, the beautiful investigation of all forms of consent, so brave. i was so proud to be able to be on the production and then for her to endorse the work in that way was just mind blowing. but what is an intimacy coordinator? an intimacy coordinator would be going, great, this is what's wanted. are you ok? it says they kiss, are you ok to kiss lip to lip? is it a yes, is it a no? if it's a yes, great. we were fine with that moment of lip to lip connection. if it's a no, we look at ok, what is the core principle of this moment? what other body parts can we use? is itjust placing a hand on a cheek, is it falling forehead to forehead? intimacy coordinators

are a fairly new role on set. how have you been received by the community and the industry? there are productions that have then been told that they have to have an intimacy coordinator and we are there to tick box and those productions are the challenging ones where i'm told, don't speak to the director and, you know, check in with the actors and stand back and do nothing. that the aspect of putting in place an agreement and consent of clear choreography has not been understood. but that understanding was made on productions like normal people, gentlemanjack and sex education, which all had intimacy coordinators. the film and tv charity says recent accusations of historic sexual abuse and bullying have seen an increase to its helpline from people within the industry asking for help but they also say things are changing. where there hasn't historically been a lot of support to report these sorts of incidents, it's a really difficult thing. so i think the fact that more people

are now coming out as allies, as being active bystanders to support women and anyone really who's experienced this sort of behaviour in the industry, i do feel as though the tide is beginning to turn that also is beginning to turn but also recognise that we've got a long way to go. when filming intimate scenes, boundaries need to be respected, and with pioneering roles like intimacy coordinators on sets, there is hope that their presence will make cast and crew members more comfortable making award—winning programming. chi chi izunda, bbc news. the founder of amazon, jeff bezos, says he and his brother will travel into space next month on his rocket company's first sub—orbital sightseeing trip. the world's richest man has scheduled the journey for 20th july. a third seat on the space—craft is being auctioned and the current bid stands at almost $3 million. our science correspondent rebecca morelle reports. heading to the edge of space.

this is the new shepard rocket. so far, it's only flown with mannequins. now, it's ready for its first real passengers, and jeff bezos, who owns the spacecraft, has announced he will be on board, along with his brother. it changes your relationship with this planet, with humanity. it's one earth. i want to go on this flight because it's a thing i've wanted to do all my life. the rocket system will reach 100 kilometres above the earth, where passengers will experience about three minutes of weightlessness, and see the blackness of space and earth's covered horizon. in the future, anyone will be able to take a ride for around £150,000 a ticket. and it's not the only company to test if space tourism is commercially viable. sir richard branson�*s virgin galactic space plane is expected to carry paying customers by the end of the year. dragon spacex, separation confirmed. and seats on elon musk�*s spacex capsule cost millions to go into low earth orbit.

for now, these trips are only for the super wealthy, but experts say prices should drop.