this is bbc news with the latest headlines for viewers in the uk and around the world. a warning from the us vice president on a visit to central america, don't come to the united states. the first new treatment for alzheimer's for nearly 20 years has been approved by us regulators. this will give hope to the people who haven't had any hope for a very long time. those patients and participants in my trials were desperate to find something that helps. a dramatic fall in applications from asians to study at american universities is put down to an increase in racist attacks. and, next month, this rocket will take the world's richest man, on a sight—seeing tour in space.

the us vice president, kamala harris, who's visiting guatemala, has urged its citizens not to come to the united states. this is herfirst stop on a regional tour aimed at tackling the undocumented mass migration to america right at the source. ms harris and the biden administration are pledging 310 million dollars in immediate humanitarian aid. in addition, there will be long term investments worth four—billion dollars to boost development and security across the region. and it's notjust money, last week the us said it would send 1.5 million vaccines doses to guatemala and mexico. but consider this: one us aid study

looking into programmes in guatemala found that from 2006 to 2011, incomes rose less in places that got us funding, than in similarareas that received nothing. and the numbers heading north keep growing. in april, us border agents encountered nearly 180,000 migrants at the border — that's a 20 year high. i want to emphasise the goal of our work is to help guatemalans find hope at home. at the same time, i want to be clear to folks in this region who are thinking about making a dangerous trek to the united states mexico border, do not come. 0ur correspondent will grant has been following developments from mexico city, which is where the vice president is heading next. he says there's no guarantee the aid

promised will help migrants stay in these countries. there is a lot of discussion of anti—corruption of anti—corruption efforts being taken, taking place in guatemala and in the countries of central america more generally to make sure the funds of the recipient and are not as kamala harris put it, into corrupt hands. it was interesting to watch the president alejandro giammattei become very defensive when he was questioned about his demonstration's record in terms of corruption, he said his administration had not meddled with anti—graft prosecutors. it is a lot of money and the record of these countries and the the trust of the population in the politicians is very low and a very poor. so it is an extremely difficult thing for the administration to do properly if it intends to put this large amount of money in with the intention of incentives and jobs and so on to make sure that

people do not head north. i'm joined now by ariel ruiz o, policy analyst at the migration policy institute in california. thank you for being with us. kamala harris is don't come. it is not as simple as that. do you think she will have any success on this mission?— will have any success on this mission? ., ~ , ., ., ., mission? thank you for having me. the success — mission? thank you for having me. the success for _ mission? thank you for having me. the success for the _ mission? thank you for having me. the success for the mission - mission? thank you for having me. the success for the mission to - the success for the mission to guatemala and afterward for mexico is really going to be measured by the way in the outcome of after her visit. the key point in guatemala is to build enough political motivation and also set of structural systematic structures or political cooperation to make sure the future plans for their development and assistance but also for migration management in mexico and guatemala actually goes through. that is what will be the main stream stick care me think about migration in central america. there is a lot of different barriers in the way. one of them is

includes trying to understand the depth of the problems. when targeting better us assistance you can try to get to some of the focus and some of the populations that are most likely to migrate. quite and some of the populations that are most likely to migrate.— most likely to migrate. quite a lot of money being — most likely to migrate. quite a lot of money being offered _ most likely to migrate. quite a lot of money being offered to - most likely to migrate. quite a lot of money being offered to but - most likely to migrate. quite a lot. of money being offered to but money actually the answer here do you think we shallow well, what money alone is not the answer of course but the problem that come afterwards may be telling to shift. to but the problem that come afterwards may be telling to shift.— may be telling to shift. to shift the flow of _ may be telling to shift. to shift the flow of migration _ may be telling to shift. to shift the flow of migration from - may be telling to shift. to shift i the flow of migration from certain populations. and potentially for example with a women or children in specific rural areas in guatemala, those programmes could be quite helpful and beneficial in the more that we do in the united states but also in the region together to make the essence of course much ability you can define and have some irregular migration flows in the meantime. in total, research are shown for development to really increase migration over the long—term it will have to be several years before that will happen so i think we had to set our standards

and expectations for the beginning to talk about particular groups in particular targeted areas. briefly, what are the _ particular targeted areas. briefly, what are the key _ particular targeted areas. briefly, what are the key factors - particular targeted areas. briefly, what are the key factors that - particular targeted areas. briefly, what are the key factors that are | what are the key factors that are driving these migrants? in guatemala, the factors driving these migrants? i�*i guatemala, the factors are poverty, malnutrition, insecurity and corruption. in el salvador, it tends to be more gang violence and more with political instability but overall the number one factor for most places is a violence and insecurity, especially in places of the country that often have protection like they do in the urban settings. protection like they do in the urban settinas. ,., ., protection like they do in the urban settinus, ,., ., ., protection like they do in the urban settinas. ., ., ~ ., . ~ settings. good to talk to you. thank ou for settings. good to talk to you. thank you for that — settings. good to talk to you. thank you for that analysis. _ a controversial new treatment for alzheimer's has been approved by regulators in the us.

aducanumab targets the underlying cause of the disease rather than just easing symptoms. patient groups have campaigned for its approval — but it's a contentious decision — some experts and the fda's independent advisory committee opposed its approval. our medical editor fergus walsh reports. this is an historic moment in the battle against alzheimer's. for the first time, a drug has been approved which tackles notjust the symptoms but the underlying cause of this devastating disease. aducanumab is not yet licensed in the uk and available only as part of a clinical trial — like here, at the national hospital for neurology, in central london. aldo ceresa, who's 68, was diagnosed with alzheimer's ten years ago and had to stop working as a surgeon. he receives aducanumab every month, via infusion, and is certain it's helped him. i felt that i wasn't getting so mixed up.

my cognitive tests were improving quite markedly. two years ago, aducanumab was written off as a failure and the trial aldo was taking part in was abandoned. but the manufacturers, biogen, analysed more data and concluded those on the highest doses had better cognition, memory and language. this is the brain of someone with early alzheimer's. the red areas show a build—up of amyloid, a protein which can form toxic deposits. this is the same individual after a year of aducanumab — significant amounts of amyloid have been cleared. so, this drug was approved on the basis of this drop in amyloid that you are seeing here. the doctor who is leading the clinical trials of aducanumab in the uk is delighted. this is a pivotal moment for the alzheimer's research community. this will give hope to the people who haven't had any hope for a very long time.

there's patients and participants in my trials who are desperate to find something that helps. in recent years, over 100 promising alzheimer's drugs have flopped, so to now have a medicine that can potentially slow the disease is a huge moment and will encourage scientists to redouble their efforts and find even better treatments. aldo has been back on aducanumab for six months and says he's already beginning to feel the benefits. i've noticed that i'm getting less confused. although it's still there, it's not quite as bad. and i'm just feeling that bit more confident now. aducanumab is suitable only for those with mild alzheimer's, when damage to brain function is still limited. it could take more than a year before uk regulators decide whether to approve the drug. if they do, demand

here will be enormous. let's bring in dr howard fillit in new york. he's the founding executive director and chief science officer at the alzheimer's drug discovery foundation. aducanumab has had quite a chequered history but how excited are you by this news today? we history but how excited are you by this news today?— this news today? we are very excited. this _ this news today? we are very excited. this really _ this news today? we are very excited. this really is - this news today? we are very excited. this really is a - this news today? we are very - excited. this really is a landmark decision in a breakthrough for our field. aducanumab isjust the decision in a breakthrough for our field. aducanumab is just the first target for drugs for alzheimer's disease and i'm certain it will be the first of many new drugs that will come on the market in the coming years for this disease. there is an incremental benefit here but we need to keep going and find more drugs and ultimately get to a world of combination therapy like we have for cancer and other chronic diseases of old age. put for cancer and other chronic diseases of old age.- for cancer and other chronic diseases of old age. put it into historical context _ diseases of old age. put it into historical context for _ diseases of old age. put it into historical context for us - diseases of old age. put it into i historical context for us because actually alzheimer's is a disease we haven't known about for that long

for it, for that many years, so in a sense we are trying to catch up, aren't we in terms of drugs to deal with the? . aren't we in terms of drugs to deal with the? , ., , .,. , with the? yes, that is exactly ri . ht. with the? yes, that is exactly right- the _ with the? yes, that is exactly right. the cancer _ with the? yes, that is exactly right. the cancer trestle - with the? yes, that is exactly i right. the cancer trestle started with the? yes, that is exactly - right. the cancer trestle started in 1902 in the uk and we had cancer drugs on the market for many decades but alzheimer's has a cause of senility in all age wasn't really recognised until 1970 by some pathologist working in london. the research on alzheimer's really didn't start until 1980 basically and in that sense we are right on time because it takes about 35 years for a basic research finding to ultimately translate into new drug so we are kind of right on time but just historically delayed. the so we are kind of right on time but just historically delayed.— just historically delayed. the child was as i mentioned _ just historically delayed. the child was as i mentioned a _ just historically delayed. the child was as i mentioned a little - just historically delayed. the child was as i mentioned a little bit - was as i mentioned a little bit controversial. do you have any concerns at all about this decision to approve a? == concerns at all about this decision to approve a?— to approve a? -- the trial was controversial. _ to approve a? -- the trial was controversial. in _ to approve a? -- the trial was controversial. in science - to approve a? -- the trial was controversial. in science and i to approve a? -- the trial was i controversial. in science and the fda regulatory environment, regulators often have to make decisions in the face of

uncertainty, considering of benefit and was the case here. but it was very clear as you mentioned earlier evidence on the biomarker on impact of the drug and completely removing these amyloid plaques for the brain, so that are thought to cause of the disease in the real question was if you get rid of this amyloid protein for the brain, will people slow their rate of decline and there was clearly some suggestion in the data that this would happen, so the fda could have rejected the drug company could have rejected the drug company could approved it without any restrictions, they took a middle ground in the face of this uncertainty and gave it what is called an x accelerated approval which means that based on the biomarker evidence of the removal of the plaques by this amyloid scan, and whatever clinical evidence they have they have approved the drug condition requiring the company to do another study which is called a

phase for study to prove that efficacy it if they can prove it and that additional fees for study the fda has the right to pull the drug when the market. —— if they cannot prove it. if when the market. -- if they cannot rove it. ., ., , , , prove it. if all goes well, briefly, what could _ prove it. if all goes well, briefly, what could it _ prove it. if all goes well, briefly, what could it mean _ prove it. if all goes well, briefly, what could it mean to _ prove it. if all goes well, briefly, what could it mean to millions i prove it. if all goes well, briefly, j what could it mean to millions of people who suffer from alzheimer's? i think that it is the first and what will be a series of new drugs targeting amyloid, inflammation, but targeting amyloid, inflammation, but targeting amyloid, inflammation, but targeting a whole variety of ways to treat the disease the same way we treat the disease the same way we treat other diseases of ageing old age. but i think it certainly gives people hope and people an option and as your person that interviewed me earlier suggested, some people might even improve and that would be a big benefit. . ~ even improve and that would be a big benefit. ., ~ , ., ., ., benefit. thank you for that pempective. _ benefit. thank you for that perspective, doctor - benefit. thank you for that perspective, doctor philip. let s get some of the day's other news. the us government says it has

recovered 2.3 million dollars worth of cryptocurrency, paid to the hackers who shut down the colonial pipeline's computer systems. investigators seized about 63 bitcoins from the hacker group based in russia. the ransomware attack last month led to massive shortages at gas stations and sparked panic—buying. police in western india say at least 18 people have died after a fire swept through a chemical manufacturing plant near the city of pune. most of those killed are said to be women workers. local media reports said those killed in the incident were trapped following an explosion in a machine. stay with us on bbc news, still to come: concern over the level of covid deaths in india. fears that the number of fatalities in rural areas is far higher than official statistics.

the date the british liberated the falklands and by tonight british troops have begun the task of disarming the enemy. in troops have begun the task of disarming the enemy.- troops have begun the task of disarming the enemy. in the heart of the west german _ disarming the enemy. in the heart of the west german capital, _ disarming the enemy. in the heart of the west german capital, this - disarming the enemy. in the heart of the west german capital, this was i the west german capital, this was gorbachev mania. the crowd practising the man who has raised great hopes for an anti—division of europe. it great hopes for an anti-division of euroe. . . . great hopes for an anti-division of euroe. ., ,, , ., europe. it happened as the plane moved towards _ europe. it happened as the plane moved towards horse _ europe. it happened as the plane moved towards horse cart - europe. it happened as the plane moved towards horse cart parade europe. it happened as the plane i moved towards horse cart parade for the start_ moved towards horse cart parade for the start of— moved towards horse cart parade for the start of trooping the colour. the client — the start of trooping the colour. the client looks worried, but recovers _ the client looks worried, but recovers quickly. as the client looks worried, but recovers quickly.— the client looks worried, but recovers quickly. the client looks worried, but recovers cuickl . �* , ., recovers quickly. as long as the pay to no see recovers quickly. as long as the pay to go see me. _ recovers quickly. as long as the pay to go see me. i— recovers quickly. as long as the pay to go see me, i will— recovers quickly. as long as the pay to go see me, i will get _ recovers quickly. as long as the pay to go see me, i will get out - recovers quickly. as long as the pay to go see me, i will get out there i to go see me, i will get out there and kick— to go see me, i will get out there and kick him _ to go see me, i will get out there and kick him down— to go see me, i will get out there and kick him down the _ to go see me, i will get out there and kick him down the hills. - to go see me, i will get out there and kick him down the hills. but. to go see me, i will get out there | and kick him down the hills. but if ou like and kick him down the hills. but if you like to — and kick him down the hills. but if you like to be _ and kick him down the hills. but if you like to be the _ and kick him down the hills. but if you like to be the first _ and kick him down the hills. but if you like to be the first man - and kick him down the hills. but if you like to be the first man to - you like to be the first man to cross the channel by your own power? it feels pretty neat. it feels marvellous, really.

india's second covid—19 wave initially ravaged cities but it soon reached rural parts of the country. many died due to poor or no access to good health care. most of them were not even able to get a covid test done. now experts believe that the number of deaths in rural india is much higher than official statistics. the bbc vikas pandey and anshul verma visited two villages in the northern indian state of uttar pradesh to investigate alleged under—reporting of covid—19 deaths. the visuals you are seeing are from the northern indian city. local say these are the graves of people who died of a covid in april.

when crematoriums ran out of space, people just buried their dead by the river. we are driving to some villages in uttar pradesh to see how covid has devastated rural india and how hunters of dead in the hundreds of dead in the area went unreported. first let's talk about here. officials say that seeing shallow graves is not an uncommon sight because many hindu communities follow the practice of burying their dead by the river. but people and journalists we have spoke to told us that the numbers are much higher this year. our first stop is a village just barely 100 km from the national capital of delhi.

and it has reported dozens of dead. so you we are going to talk to people in the village and also members of the village council. we are going to speak to two people. on a single day, they lost their mother and elder brother to covid.

after hearing those heartbreaking stories in the village, we are now going to another place and we have been told similar things happened there. dozens of people died without getting a covid test done or getting a hospital bed.

people in the villages we visited and many others want officials to acknowledge these missing covid deaths. they believe that those who struggled to get a hospital bed or oxygen or even a covid test deserve some dignity in death. police in london, ontario, say that five family members who were run over by a driver on sunday night were targeted because they were muslim. four members of the family died from their injuries. only a nine—year—old boy survived. officials say the attack was pre—planned and premeditated. police have detained a 20—year—old in connection with the attack. with the new academic yearjust months away,

universities are sifting through applications to offer places. last year, the us recorded a drop in student visa applications — and this year the number has fallen even further. as sarah toms reports, the pandemic is partly to blame but many students also worry about rising violence against people of asian descent. singapore student has always dreamed of studying in the usa. he worked hard and got a coveted place at yale university to take computer science and economics. but the 19—year—old has had second thoughts. for a and economics. but the 19-year-old has had second thoughts.— has had second thoughts. for a lot of --eole, has had second thoughts. for a lot of people, especially _ has had second thoughts. for a lot of people, especially asians - has had second thoughts. for a lot of people, especially asians like i of people, especially asians like myself and my friends, you have seen the recent news of anti—asian racism and attacks especially in the us and other countries. it would be quite a deterrent to our dreams to pursue english education and it might be

because of the pandemic, but beyond that i think there was some sort of racism that was already ingrained in a lot of people's minds.— a lot of people's minds. foreign student enrolment _ a lot of people's minds. foreign student enrolment at _ a lot of people's minds. foreign student enrolment at ufc - student enrolment at ufc universities has dropped 16% between the autumn of 2019 and 2020. the stats are new international students look even grimmer, with a 43% drop. health concerns are a major reason as the us has been hit hard by covid—19. i racism and violence against ethnic asians are also causing many applicants to pause. some people directly blame the anti—china rhetoric of former us president donald trump. congo flu. attacks against asians in the us, including the murders of six women including the murders of six women in atlanta has sent shock waves through asia. in atlanta has sent shock waves through asia-— in atlanta has sent shock waves throu~h asia. , a . , , through asia. many asian students are still waiting _ through asia. many asian students are still waiting to _ through asia. many asian students are still waiting to study _ through asia. many asian students are still waiting to study abroad i

are still waiting to study abroad and despite the racism, so what they do is they tend to segregate and they tend to segregate in the ethnic communities of this will to some extent intensify the racism. the universities. — extent intensify the racism. the universities, foreign students like these ones here in singapore, bringing plenty of money by paying higher tuition fees. where your money, they also bring real diversity, fresh ideas, and connections for the future. many experts believe western countries risk losing their competitive edge if foreign students feel unwelcome. missing out on all of that will have repercussions for not only universities but entire economies. as for dai xiang r0ng come he is willing to take the risks to pursue his dreams. the founder of amazon, jeff bezos, says he and his brother will travel into space next month on his rocket company's first sub—orbital sightseeing trip.

a third seat on the spacecraft is being auctioned off. 0ur science correspondent rebecca morelle reports. heading to the edge of space. this is the new shepard rocket. so far, it's only flown with mannequins. now it's ready for its first real passengers, and jeff bezos, who owns the spacecraft, has announced he will be on board, along with his brother. it changes your relationship with this planet, with humanity. it's one earth. i want to go on this flight because it's a thing i've wanted to do all my life. the rocket system will reach 100 kilometres above the earth, where passengers will experience about three minutes of weightlessness, and see the blackness of space and earth's covered horizon. and earth's curved horizon. in the future, anyone will be able to take a ride for around £150,000 a ticket. and it's not the only company to test if space tourism is commercially viable. sir richard branson�*s virgin galactic space plane is expected to carry paying customers by the end of the year.

spacex. separation confirmed. and seats on elon musk�*s spacex capsule cost millions to go into low earth orbit. for now, these trips are only for the super wealthy, but experts say prices should drop. for the young people today particularly, it will become a reality that they could save up some money and choose to go to space, not every day, but it could be something that you could choose to spend a chunk of your savings on, and experience a few minutes of weightlessness. landing gear deployed. the new shepard flight is due to take place injuly. the capsule carrying jeff bezos and his brother will descend back to earth with parachutes, marking the start of a new era in space tourism. rebecca morelle, bbc news. you are watching bbc news.

hello there. it's been a warm start to the new week. quite a bit of cloud around on monday, but i think for today, it's looking sunnier across the board. it's going to stay warm for the rest of this week, and in fact, we're going to start to import some tropical air across the country, so it's going to feel quite humid. there will be further patchy cloud and rain across northern and western areas as low pressure will always be nearby. the setup into tuesday, higher pressure to the south, lower pressure to the northwest, so it does mean we'll start off rather grey for much of scotland and northern ireland through this morning with some patchy, light rain and drizzle. but conditions will start to improve for northern ireland — skies brightening up here and across northeast scotland. elsewhere, after a bit of early cloud and miss, it's going to be a sunny day, and it's going to feel warmer with more sunshine around. we could see 25 degrees

across southeast england, 22 or 23 for the northeast of scotland. there could be just the odd shower here and there, but most places will be dry. now, as we head through tuesday night, we'll see further cloud returning to scotland and northern ireland. patchy rain here, some coastal fog, too. further south, it is dry with clear skies and we'll start to see some humid air being imported from the southwest, so everywhere staying in low teens celsius. wednesday will have high pressure to the south, lower pressure to the northwest with these weather fronts, and the limitation of these pressures will draw up this warm and humid airfrom the tropics, so it really will be quite noticeable on wednesday. again, rather grey across parts of scotland and northern ireland, perhaps western england and wales. best of the sunshine further south and east. could see a little bit of light rain and drizzle over western areas, but it's going to feel warm, particularly when you factor in the humidity. could see highs of 26 degrees on wednesday in the sunshine. if you add the humidity to that, it's going to feel even warmer than the temperatures suggest. thursday's another warm and humid day.

perhaps a bit more cloud across the board. patchy rain for northwestern parts of scotland and northern ireland. bit more cloud for england and wales, but some sunny spells here and there. most places across england and wales should stay dry, but it'll be a bit breezier across the board. windier in the far northwest of scotland, where we'll have most of the rain. but you can see it is another warm day. low to mid 20s celsius for england and wales. factor in the humidity, of course, it's going to feel warmer than that, and nights are also going to be warm and muggy. could see something a little bit fresher across scotland, northern ireland on friday. otherwise, it's going to remain warm with some sunshine into the weekend.

this is bbc news.

the headlines: the us vice—president, kamala harris, who's visiting guatemala, has urged its citizens not to come to the united states. she said the trip was extremely dangerous and would mainly benefit people smugglers. regulators in the united states have approved the first new treatment for alzheimer's for nearly 20 years. the drug aducanumab targets the underlying cause of the disease and is suitable only for those with mild alzheimer's. at least a0 people have been killed in a collision between two express trains in southern pakistan. specialist equipment was deployed to help rescue passengers who became trapped in the tangled wreckage. and when you own the company, you get to go first. the founder of amazon, jeff bezos, will travel into space next month on his company's inaugural sightseeing trip.