this is bbc news: i'm david eades with the latest headlines for viewers in the uk and around the world. a blunt warning from the us vice president on a visit to central america — don't come to the united states because you won't get in. i want to be clear, to the folks in this region who think about making the dangerous trek to the united states—mexico border, do not come. the first new treatment for alzheimer's for nearly twenty years has been approved by us regulators. this will give hope to the people who have not had any hope for a very long time. there are patients and participants in my trials who were desperate to find something that will help. a dramatic fall in applications from asians to study at american universities

is put down to an increase in racist attacks. and — countdown to another stratospheric rise for amazon founderjeff bezos. this time he prepares for takeoff on a sight—seeing tour into space. hello and welcome. the us vice president, kamala harris, who's visiting guatemala, has urged its citizens not to come to the united states. this is herfirst stop on a regional tour aimed at tackling the undocumented mass migration to america right at the source. ms harris and the biden administration are pledging $310 million in immediate humanitarian aid. in addition, there will be long—term investments worth $4 billion to boost development and security across the region.

and it's notjust money — last week the us said it would send 1.5 million vaccines doses to guatemala and mexico. but consider this: one us aid study looking into programmes in guatemala found that from 2006 to 2011, incomes rose less in places that got us funding, than in similar areas that received nothing. and the numbers heading north keep growing. in april, us border agents encountered nearly 180,000 migrants at the border — that's a 20 year high. i want to emphasise that the goal of our work is to help what islands find hope at home. is to help guatemalans find hope at home. at the same time, i wanted to be clear to folks in this region who are thinking about making that dangerous trek to the united states— mexico border, do not come.

0ur correspondent will grant joins me now from mexico city. i suppose it is not a surprising statement but it is very long. it surprising statement but it is very long-— surprising statement but it is very long. it is very blunt and it is not a _ very long. it is very blunt and it is not a surprise, _ very long. it is very blunt and it is not a surprise, no - it is not a surprise, no because we heard the secretary of state make it in costa rica a few days prior. ultimately it is the basic tenant of the message from the wyden administration, albeit with the subtlety of don't come because we are going to commit to try and make conditions better here. the problem they face of course is that that has been said by subsequent government administrations in washington including the 0bama administration, for example, and none of those commitments and none of those commitments and incentives have really made and incentives have really made a great difference to the flow of migration north and of course these particular funds come not necessarily with the caveat that certainly with the

push to anticorruption efforts and so on which makes the relationship with the governments in question more difficult. ,, ., ., difficult. she also said that the only people _ difficult. she also said that the only people who - difficult. she also said that| the only people who benefit other toyotas, she put it, and the messages to individuals do not head up to the us border because they will not get in. but the money is therefore a reason, isn't it? and one those reasons is that the governments of mexico and what are my love will find out in the course of her trip will be expected to do something to slow this down, if not stop it. something to slow this down, if not step it— not stop it. absolutely. and i think we know _ not stop it. absolutely. and i think we know that _ not stop it. absolutely. and i think we know that they - not stop it. absolutely. and i think we know that they have been pushing those governments hard to employ police, military, to stop the flow of migrants from even leaving the borders of their own country full this is notjust outright humanitarian aid, it is a package, $4 billion overfour years and one of those things would be bolstering security forces. security forces would

be expected to disarm and tackle the international drug organisations and criminal organisations and criminal organisations that run the drug routes north and the people trafficking routes north but it would also be to stop, for example, the caravans of people we have seen trying to leave who have been stopped from doing so with water cannon and teargas and so on. this is much more than simply an altruistic measure by the biden administration.- measure by the biden administration. ., ~ , ., , administration. thank you very much. a controversial new treatment for alzheimer's has been approved by regulators in the us. aducanumab targets the underlying cause of the disease rather than just easing symptoms. patient groups have campaigned for its approval — but it's a contentious decision — some experts and the fda's independent advisory committee opposed its approval. our medical editor fergus walsh reports. this is an historic moment in the battle against alzheimer's. for the first time, a drug has been

approved which tackles notjust the symptoms but the underlying cause of this devastating disease. aducanumab is not yet licensed in the uk and available only as part of a clinical trial — like here, at the national hospitalfor neurology, in central london. aldo ceresa, who's 68, was diagnosed with alzheimer's ten years ago and had to stop working as a surgeon. he receives aducanumab every month, via infusion, and is certain it's helped him. i felt that i wasn't getting so mixed up. my cognitive tests were improving quite markedly. two years ago, aducanumab was written off as a failure and the trial aldo was taking part in was abandoned. but the manufacturers, biogen, analysed more data and concluded those

on the highest doses had better cognition, memory and language. this is the brain of someone with early alzheimer's. the red areas show a build—up of amyloid, a protein which can form toxic deposits. this is the same individual after a year of aducanumab — significant amounts of amyloid have been cleared. so, this drug was approved on the basis of this drop in amyloid that you are seeing here. the doctor who is leading the clinical trials of aducanumab in the uk is delighted. this is a pivotal moment for the alzheimer's research community. this will give hope to the people who haven't had any hope for a very long time. there's patients and participants in my trials who are desperate to find something that helps. in recent years, over 100 promising alzheimer's drugs have flopped,

so to now have a medicine that can potentially slow the disease is a huge moment and will encourage scientists to redouble their efforts and find even better treatments. aldo has been back on aducanumab for six months and says he's already beginning to feel the benefits. i've noticed that i'm getting less confused. although it's still there, it's not quite as bad. and i'm just feeling that bit more confident now. aducanumab is suitable only for those with mild alzheimer's, when damage to brain function is still limited. it could take more than a year before uk regulators decide whether to approve the drug. if they do, demand here will be enormous. the us government says it has managed to recover $2.3 million worth of cryptocurrency, which had been paid to the hackers who shut down a major fuel pipeline last month.

the ransomware attack last month led to massive shortages at gas stations and sparked panic—buying. it had been hacked by a group called darkside, believed to be based in russia 0ur north america correspondent, peter bowes, joins me now.(0s dtl) joins me now. it is some of the ransom money but it is a breakthrough.— ransom money but it is a breakthrough. the justice department _ breakthrough. the justice department is _ breakthrough. the justice i department is characterising this as turning the tables on cyber hackers and a lot of it was going on behind—the—scenes. 0ne was going on behind—the—scenes. one month ago when all this was an holding, turning the tables by retrieving, as you said, a few million dollars from the almost $4.5 million that they see as a major success and i think also holding it as an example to other companies

around america, a stern warning that if they find themselves in a miller position, the first thing they should do is alert the justice department, thing they should do is alert thejustice department, call thejustice department, call the fbi and they can work together to try and initially solve the problem and this was a huge problem, as you said, for the eastern united states, this pipeline carries about 45% of all the aviation fuel, diesel, gas that americans use and it crippled part of the country for a good part of a week. initially retrieving ransom money if it is paid. if they get their money back they can feel bullish about what they are doing there. however there is still a part. not all there is still a part. not all the money. it was an intensive investigation that takes a lot of time and money in itself. is there enough there to feel that there enough there to feel that there is any disincentive to hackers in what they have been

doing? that is the lingering question, isn't it? if you just do the straightforward mouth, they will still have profited by about $2 million and of course there is no chance of this group based in russia, no chance of them saying american justice. there is no extradition treaty that will see these people in an american court. so is it a deterrent or perhaps this criminal gang are they contemplating something like this in the future, and weighing the possibility they may not get all of the money that they had hoped for, that they had wanted to get from holding a company ransom? so i think thejury is holding a company ransom? so i think the jury is out on the it is simply a stern warning that the justice department is simply a stern warning that thejustice department is sending out to other gangs or maybe this gang again if they contemplate similar action, that they are onto it. and we know that president biden will meet president putin next week. this is one of the issues that

they say he will raise with them. at least 40 people have been killed and dozens were injured after two trains collided in southern pakistan. the crash happened when a train came off its track and careered into the path of another travelling in the opposite direction. secunder kermani has this report, and a warning, some viewers may find some elements of it distressing. a baby lifted to safety amidst the chaos. standing on top of an overturned carriage, passengers desperately try to help others clamber free. a train travelling from the city of karachi came off the tracks in the early hours of the morning. then, another, going in the opposite direction, ploughed into it. translation: that's our carriage over there. - we were getting down. the children were, too. then the other train slammed into us, right

into our carriage. i don't know what happened after that. my wife, my daughter and my friend all died. some of the injured remained trapped by the wreckage, whilst helicopters helped carry others away. many of the most critical patients have been brought to this hospital, including six—year—old zuneira. both her legs are fractured, both her parents are still missing. "it's the government's incompetence," says this relative. "they need to ensure drivers and railway staff are properly trained." accidents in pakistan are common. this is at least the fourth major rail disaster in this part of the country alone in the past two years. officials in prime minister imran khan's government have blamed their predecessors. he's promised to conduct a comprehensive investigation into railway safety in the country. the majority of those travelling on pakistan's railways come from poorer backgrounds.

they're the ones paying the awful price for years of neglect. secunder kermani, bbc news, rahim yar khan. stay with us here on bbc news. coming up in a moment, office politics. why employees at apple are resisting plans to return to the office. the day the british liberated the falklands. and by tonight, british troops had begun the task of disarming the enemy. in the heart of the west german capital, this was gorby—mania at its height. the crowd packed to see the man who, for them, has raised great hopes for an end to the division of europe. it happened as the queen moved

towards horse guards parade for the start of trooping the colour. gunshots the queen looks worried but recovers quickly. as long as they'll pay to go and see me. _ i'll get out there _ and kick 'em down the hills. what does it like to be the first man to cross the channel by your own power? it feels pretty neat. it feel marvellous, really. this is bbc news. the latest headlines: the us vice president, kamala harris, has warned guatemalans against coming to the united states, saying they would be turned back at the border. the first new treatment for alzheimer's for nearly twenty years, has been approved by us regulators. with the new academic yearjust months away, universities are sifting through applications to offer places.

last year, the us recorded a drop in student visa applications, and this year the number has fallen even further. as sarah toms reports, the pandemic is partly to blame but many students also worry about rising violence against people of asian descent. singapore student dai xiang rong has always dreamed of studying in the usa. he worked hard and got a coveted place at yale university to take computer science and economics. but the 19—year—old has had second thoughts. for a lot of people, especially asians like myself and my friends, you have seen the recent news of anti—asian racism and attacks, especially in the us and other countries. it's quite a deterrent to our dreams to pursue english education

to pursue an international education and it might be because of the pandemic, but beyond that i think there was some sort of racism that was already ingrained in a lot of people's minds. foreign student enrolment at us universities has dropped 16% between the autumn of 2019 and 2020. the stats on new international students look even grimmer, with a 43% drop. health concerns are a major reason as the us has been hit hard by covid. but racism and violence against ethnic asians are also causing many applicants to pause. some people directly blame the anti—china rhetoric of former us president donald trump. kung flu...kung flu. (crowd cheering). attacks against asians in the us, including the murders of six women in atlanta, have sent shock waves through asia. many asian students are still very willing to study abroad despite of the racism, so what they do is they tend to segregate, and they tend to segregate

in the ethnic communities, so this will to some extent intensify the racism. for universities, foreign students like these ones here in singapore bring in plenty of money by paying higher tuition fees. beyond money, they also bring diversity, fresh ideas, and connections for the future. many experts believe western countries risk losing their competitive edge if foreign students feel unwelcome. missing out on all of that will have repercussions for not only universities but entire economies. as for xiang rong, he is willing to take the risk to pursue his dreams. to pursue his dream. sarah toms, bbc news, singapore let's get some of the day's other news: police in canada have arrested a man accused of killing four members of a muslim family with his pick—up truck. the police say it was a premeditated attack. the victims haven't been named,

but the oldest was 74 and the youngest 15 years old. a 9—year—old boy survived. police in western india say at least 18 people have died after a fire swept through a chemical manufacturing plant near the city of pune. most of those killed are said to be women workers. local media reports said those killed in the incident were trapped following an explosion in a machine. airline bosses have called for a uk—us travel corridor to be opened up. nearly all uk passengers are currently banned from travelling to the us, while any us travellers are required to quarantine in the uk. the airlines say travel between the countries, which have some of the highest levels of vaccination in the world, is "essential to igniting economic recovery". when will you be ready to go back into the office, if at all? different companies are working out different arrangements. apple's ceo tim cook has said

workers will need to return later in the year and come in three times a week. in an all—staff memo last week, the apple boss made the case for going back, writing: "i know i'm not alone in missing the hum of activity, the energy, creativity and collaboration of our in—person meetings and the sense of community we've all built." but some workers are pushing back as they weigh up the advantages and disadvantages of trekking back into work. we can now speak to lauren goode, who's a senior writer at wired. she joins us from silicon valley in california, where apple has its headquaterrs. i guess every company is trying to work out the best approach to work out the best approach to take and this in some respects apple has gone middle ground. why the kickback? fix, lat

ground. why the kickback? a lot of e es ground. why the kickback? a lot of eyes are _ ground. why the kickback? a lot of eyes are on — ground. why the kickback? a lot of eyes are on silicon _ ground. why the kickback? lot of eyes are on silicon valley to see what the big tech companies decide about going back to work. on the one hand of the scale, facebook and twitter, essentially telling employees you can work from home even after the pandemic and. and some other companies like google and apple that they expect them to be in the office at least a few days a week. google, after announcing a policy like that scaled it back after feedback from employees. apple seems determined to have people spend some time a week in the office. starting in the fall. some of the employees are not quite happy about that. they have started a petition now to have more of their opinions considered. what is the difference _ opinions considered. what is the difference between - opinions considered. what is the difference between a - opinions considered. what is| the difference between a spot to fight and twitter and let's

say, apple. —— spotify. to fight and twitter and let's say, apple. -- spotify. some companies — say, apple. -- spotify. some companies say, _ say, apple. -- spotify. some companies say, woke - say, apple. -- spotify. some companies say, woke from i say, apple. -- spotify. some - companies say, woke from home. some companies expect more than half employees will work from home and that the past is gone. software companies, the work they do, it may be easier to do some of the work remotely. apple is a hardware company, it is famously secretive so when you're talking about building physical products, prototypes, sharing designs, the windowless rooms where top—secret products will be developed, a lot of that might require more collaboration in person than simply making outside the

office. apple makes a lot of software as well but it makes it harder and it probably needs some people into the office for that. ~ , ., , that. we will see how it pans out. that. we will see how it pans out- tim _ that. we will see how it pans out. tim cook _ that. we will see how it pans out. tim cook has _ that. we will see how it pans out. tim cook has a - that. we will see how it pans out. tim cook has a point - that. we will see how it pans i out. tim cook has a point about collaboration, creativity tended to come from the office. thank you very much indeed. thanks for having me. the founder of amazon, jeff bezos, says he and his brother will travel into space next month, on his rocket company's first sub—orbital sightseeing trip. a third seat on the spacecraft is being auctioned off. 0ur science correspondent rebecca morelle reports. heading to the edge of space. this is the new shepard rocket. so far, it's only flown with mannequins. now it's ready for its first real passengers, and jeff bezos, who owns the spacecraft, has announced he will be on board, along with his brother. it changes your relationship with this planet, with humanity. it's one earth. i want to go on this flight

because it's a thing i've wanted to do all my life. the rocket system will reach 100 kilometres above the earth, where passengers will experience about three minutes of weightlessness, and see the blackness of space and earth's covered horizon. in the future, anyone will be able to take a ride for around £150,000 a ticket. and it's not the only company to test if space tourism is commercially viable. sir richard branson�*s virgin galactic space plane is expected to carry paying customers by the end of the year. mission control: spacex. separation confirmed. and seats on elon musk�*s spacex capsule cost millions to go into low earth orbit. for now, these trips are only for the super wealthy, but experts say prices should drop. for the young people today particularly, it will become a reality that they could save up some money and choose to go to space, not every day, but it could be something that you could choose to spend a chunk of your savings on,

and experience a few minutes of weightlessness. landing gear deployed. the new shepard flight is due to take place injuly. the capsule carrying jeff bezos and his brother will descend back to earth with parachutes, marking the start of a new era in space tourism. rebecca morelle, bbc news. there is or was a pet dog missing somewhere or other and usually it is probably the case that will be found in a nearby park or the neighbour was back backyard however it is not always the case and here is the proof of it. the group of russian sailors going through the arctic, found this little champion, lost on a chunk of seaice champion, lost on a chunk of sea ice that had begun to drift out to sea. the pup was rescued, brought on board. they found the honour in a nearby

village saying the dog had been missing for the best part of a week. that's — the owner. how many lives to dogs have? they need a few! thanks for watching. hello there. it's been a warm start to the new week. quite a bit of cloud around on monday, but i think for today, it's looking sunnier across the board. it's going to stay warm for the rest of this week, and in fact, we're going to start to import some tropical air across the country, so it's going to feel quite humid. there will be further patchy cloud and rain across northern and western areas as low pressure will always be nearby. the setup into tuesday, higher pressure to the south, lower pressure to the northwest, so it does mean we'll start off rather grey for much of scotland and northern ireland through this morning with some patchy, light rain and drizzle. but conditions will start to improve for northern ireland — skies brightening up here and across northeast scotland. elsewhere, after a bit of early cloud and mist, elsewhere, after a bit of early cloud and mist,

it's going to be a sunny day, and it's going to feel warmer with more sunshine around. we could see 25 degrees across southeast england, 22 or 23 for the northeast of scotland. there could be just the odd shower here and there, but most places will be dry. now, as we head through tuesday night, we'll see further cloud returning to scotland and northern ireland. patchy rain here, some coastal fog, too. further south, it is dry with clear skies and we'll start to see some humid air being imported from the southwest, so everywhere staying in low teens celsius. wednesday will have high pressure to the south, lower pressure to the northwest with these weather fronts, and the limitation of these pressures will draw up this warm and humid airfrom the tropics, so it really will be quite noticeable on wednesday. again, rather grey across parts of scotland and northern ireland, perhaps western england and wales. best of the sunshine further south and east. could see a little bit of light rain and drizzle over western areas, but it's going to feel warm, particularly when you factor in the humidity. could see highs of 26 degrees on wednesday in the sunshine. if you add the humidity to that, it's going to feel even warmer than the temperatures suggest. thursday's another warm and humid day. perhaps a bit more cloud across the board.

patchy rain for northwestern parts of scotland and northern ireland. bit more cloud for england and wales, but some sunny spells here and there. most places across england and wales should stay dry, but it'll be a bit breezier across the board. windier in the far northwest of scotland, where we'll have most of the rain. but you can see it is another warm day. low to mid 20s celsius for england and wales. factor in the humidity, of course, it's going to feel warmer than that, and nights are also going to be warm and muggy. could see something a little bit fresher across scotland, northern ireland on friday. otherwise, it's going to remain warm with some sunshine into the weekend.

this is bbc news — the headlines. the us vice president kamala harris has warned guatemalans against coming to the united states — saying they would be turned back at the border. speaking during a visit to guatemala, she said the trip north was extremely dangerous and would mainly benefit people smugglers. the first new treatment for alzheimer's for nearly twenty years has been approved by regulators in the united states. aducanumab targets the underlying cause of alzheimer's. the drug, given as a monthly infusion, targets amyloid — a protein that builds up in the brains of alzheimer's patients. the us government says it's managed to recover more than $2 million worth of cryptocurrency which had been paid to hackers who shut down a major fuel pipeline last month. the colonial pipeline was hacked by a group called 'darkside' which the us justice department believes is based in russia.

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