this is bbc news — welcome if you're watching here in the uk or around the globe. our top stories: the flagship of russia's black sea fleet has sunk, after an explosion on wednesday. ukraine claims it hit the moskva with missiles, but russia says the ship sank after a fire. in an exclusive bbc interview in his war bunker, ukraine's president says continuing attacks from russia are damaging chances of a peace deal bucha is in this process closing these possibilities. bucha, borodyanka, mariupol. so i don't have, you know, it's not about me, it's more about russia. the first asylum seekers could be flown from the uk to rwanda in weeks, according to the british

government. the scheme aims to deter people crossing the english channel, but critics say it is inhumane more than 340 people are now known to have died in the south african province of kwazulu—natal, in the worst flooding there in decades. it's hoped new research, mapping the genetic code of brain tumours, could lead to more accurate diagnoses and potentially better treatments. joe root has stepped down as england test captain after his side's defeat by the west indies. appointed in 2017, he holds the record for the highest number of matches and wins as captain. the russian defence ministry says it has warned it'll intensify attacks

around kyiv after accusing ukraine of targeting russian border towns. earlier moscow confirmed a warship in its black sea fleet had sunk. ukraine claims to have hit the moskva with cruise missiles, while russia says it went down in rough seas following an explosion on board. russia confirmed the cruiser had sunk but said it went down in rough seas as it was towed to port after a fire caused its ammunition to explode. the scourge of the black sea now buried at the bottom of it. but how the moskva got there is still disputed. ukraine says it hit the ship with cruise missiles launched from the coast. russia would only admit there had been an explosion on board and it then sank in bad weather. if the ukrainians were responsible it would be the biggest warship to be sunk by enemy action

since the second world war. this is a tremendous victory for ukraine, even if they didn't directly contribute to the sinking. and it's an enormous defeat for russia because it indicates that the russian armed forces simply aren't up to snuff in terms of modern military capabilities. perhaps not, but it does beg the question how will russia react? these were air raid sirens heard overnight in the western city of lviv for the first time in several days. and there were reports of powerful explosions in the capital kyiv. in his latest video message, president zelensky made reference to the fate of the moskva. he praised the ukrainian people, those who stopped the advance of endless columns of russian equipment, those who proved that russian planes were defenceless, and those who proved that russian ships can only go to the bottom of the sea.

but in the east of the country, invading troops continue their operations. the ukrainian government fears their main goal now is to destroy the donbas region. russia may have sustained a heavy defeat, but it is still very much in this war. tim allman, bbc news. our correspondent in moscow, jenny hill, told me what the russians are saying about the ship's sinking. the statement from the authorities says that the ship sank while it was being towed back to port in stormy seas. they say that it had suffered significant damage inparticular to the hull following a fire and explosion of ammunition on board. interestingly, this morning, state television has not dwelt on the topic beyond citing that particular statement from the authorities. the statement came too late to make it into the paper editions of the morning newspapers but the online editions are starting now to include a little bit more

in the way of commentary. some are talking about what could have caused the fire? they are very much sticking to the script from the authorities and noting that perhaps this ship, some a0 years old, of course, had rather outdated and inefficient firefighting systems on board. very much sticking to the kremlin�*s script. certainly, no official response to the suggestion from ukraine that its missiles were responsible for sinking the ship. speaking about scripts, obviously very different script throughout this work from the ukrainian side, from the russian side, from kyiv and from moscow, what is the latest the russian defence ministry are saying about the war in general? we have actually had another update this morning, they say that moscow plans to increase the frequency and the scale of strikes on facilities in kyiv in retaliation for what it says are ukrainian

attacks on russian territory. this has been building for the last couple of days. it follows a similar threat a couple of nights ago. it is difficult to know whether the actual number of reported attacks from ukraine into the regions in russia which border the country have increased in recent days or whether the russian authorities, i suspect this is probably the case, are now talking about them with more frequency. many of these attacks as we put it, are not verified, it is difficult to get independent verification of what is happening there. the russian authorities are talking about ukrainian strikes on russian soil and yesterday officials in one region said that low—flying ukrainian military helicopters had conducted air strikes in a residential area leaving seven civilians injured and residential buildings damaged. russia is now saying in response to this, it will step up strikes on kyiv. we have to see how that situation

develops but certainly it seems to be an escalating one. there are very different narratives in russia and ukraine about what happened with the moskva cruiser. from ukraine, here's our correspondent danjohnson. to ordinary ukrainians it doesn't matter too much whether the russians admit it was caused by ukrainian missiles. the fact that the moskva now sits at the bottom of the black sea is victory enough for them. it had already become a symbol of fun, really, and of ukrainian resistance after the opening stages of the invasion when it was told by ukrainian soldiers where to go, where to get off as at first approached that ukrainian island. it has become a symbol of ukrainian resistance used on posters, t—shirts, it even appeared on ukrainian postage stamps. there are billboards around town in places like lviv, souvenirs sold with that message on it. it has become a meme. that fact it is now

at the bottom of the sea only adds to that sort of morale—boosting propaganda message. i think it will be the sort of attack that if it is proven, the ukrainians will try to repeat it because it shows they have potentially found a weakness in russia's marine defences. in terms of morale, the other side of the coin from ukraine's point of view is what is going on in mariupol and fears that the russians may take control of that city pretty soon. what is the latest from there? yes, there have been fears that the sinking of the ship may mean further attacks launched by the russians perhaps in retaliation. we are not sure if it has happened. there have been explosions reportedn a few cities overnight. we know the situation in mariupol keeps going from desperate to dire. this morning, the officials in the city believe russian forces are exhuming bodies that had been buried in the yards of some of the residential blocks there.

the city council believes russians will not allow the residents to bury any more people who have been killed in the bombardment of that city. each residential yard now has a supervisor enforcing that. they believe that mobile crematoria are being used to burn the bodies of civilians, essentially, the claim is that russia is doing everything it can to cover up any potential evidence of war crimes that have been committed in mariupol. the battle for the city goes on, russia has claimed a couple of times now it had completed the takeover of the city but ukraine says there are still pockets of resistance holding out. no doubt the situation is desperate, not only for the people in mariupol, but the governor of luhansk this morning said people should do everything they can to evacuate from that region as well in expectation that the conflict really will intensify in the east of ukraine. i'm joined now by mark] grove — senior lecturer in maritime strategy at the britannia royal naval

college. thank you forjoining us. how big a blow do you think it is to the russian navy that the flagship of the black sea fleet has sunk and we do not know exactly why. they said it was a fire out a ammunition explosion and ukraine is saying they hit it with missiles. it is explosion and ukraine is saying they hit it with missiles.— hit it with missiles. it is an enormous _ hit it with missiles. it is an enormous blow. _ hit it with missiles. it is an enormous blow. it - hit it with missiles. it is an enormous blow. it is - hit it with missiles. it is an enormous blow. it is the i hit it with missiles. it is an - enormous blow. it is the black sea fleet, the flagship, and because of the titanic significance it has had during the last 50 days, it is a huge blow. it is also an enormous blow in terms of the russian surface fleet. it is the largest or one of the three largest vessels that they have. it is very old. but the russians are not capable of building anything larger than the 5000 tonne

frigate. much is expected of these albeit old but large ships so to lose this vessel is of enormous significance. lose this vessel is of enormous significance-— lose this vessel is of enormous significance. from the ukrainian oint of significance. from the ukrainian point of view. — significance. from the ukrainian point of view, if _ significance. from the ukrainian point of view, if they _ significance. from the ukrainian point of view, if they hit - significance. from the ukrainian point of view, if they hit it - significance. from the ukrainian point of view, if they hit it with l significance. from the ukrainian| point of view, if they hit it with a missile, or more than one, how big a victory and morale booster is it for them and how difficult is it to sink a ship like this although it took some time for it to sink obviously? in terms of the military effect, it is huge because it means that the russian navy now is going to be very low to get within 150 miles which is the range of the missile. 150 miles of the coast. as long as the ukrainians can provide targeting information for those missiles. as far as the slaver is concerned, it is an old ship, its firefighting systems are not going to be of the

latest. it's air defence systems, particularly for dealing with low flying missiles are not particularly modern but the biggest problem with design of the slava, as your viewers will note from some of the photographs, its superstructure is actually aligned with its main armament and 16 large anti—ship missiles, each one of those missiles had almost one tonne of high explosive in its warhead. you are encasing —— increasing your superstructure in high explosive. if it were to hit one of those missiles, the old—fashioned warheads have old—fashioned high explosive, known insensitive. they are very likely to explode. it means that the ship is actually very easily disabled and in this case, quite

possibly sunk as a result of missile attack. it is one of the problems with the design of that particular ship. we with the design of that particular shi -. ~ . with the design of that particular shi . _ . ., ., ~' with the design of that particular shi. ~ . . ~' ., ., with the design of that particular shi . _ . ., ., ~' ., ., , ship. we have talked throughout this war about the _ ship. we have talked throughout this war about the land _ ship. we have talked throughout this war about the land conflict, - ship. we have talked throughout this war about the land conflict, the - war about the land conflict, the attack on russian tanks, the success the ukrainians have had there. we have not talked a lot about the naval struggle. this is interesting, strategically, how important is it to have this kind of victory if that is what we are talking about here for the ukrainians? is what we are talking about here forthe ukrainians? in is what we are talking about here for the ukrainians?— is what we are talking about here for the ukrainians? in truth, there are two elements, _ for the ukrainians? in truth, there are two elements, the _ for the ukrainians? in truth, there are two elements, the russians i for the ukrainians? in truth, there i are two elements, the russians have used or attempted to use their naval power in two ways, one is to blockade the ukrainian coastline and we know that the ukrainians are not able to export and import and that is having an enormous effect on world food supplies. that is not going to change. the fact that the

russians were forced off the coastline, will still enable them to maintain that blockade. i think the big issue here is with the threat that the russians have demonstrated that the russians have demonstrated that they appear to have in terms of amphibious landings. in truth, the russian amphibious capability even though it has been reinforced within the black sea, is not incredibly significant. it is not very large scale. russian amphibious tends to use fairly small amphibious landings in concert with an overland ground attack. what we have seen over the last few weeks as the russians mainly what we call demonstrating their ability to land in the vicinity of 0desa, partly to hold ukrainian defenders in the vicinity of 0desa, with the apparent ability

of 0desa, with the apparent ability of the ukrainians to hit russian naval vessels within at least 60 miles, but because i think that is what the slava was act, any attempt at a russian amphibious operation against 0desa is really very, very dangerous and probably out of the question. dangerous and probably out of the cuestion. , , ., question. very interesting to get our question. very interesting to get your thoughts- — ukraine's president volodymyr zelensky says european countries that continue to buy oil from russia are aiding the country's war against them — and they will have blood on their hands. he's urged western leaders to speed up the delivery of military aid to help ukraine. 0ur correspondent clive myrie is in kyiv and he spoke to president voldymyr zelensky about the conflict. first, he gave us his reflection on spending time with the president

very affable, very charming, he knows how to work the media, let's be clear about that. i found him also to be at the same time genuine. he has been an office barely three years, and he has having to deal with a conflagration that has completely swallowed up his country. has killed many of his citizens. and he is having to deal with all that and they say that when the hour comes, the man comes and there has been speculation that a former comedian and actor turns out to be the head of state, he has risen to the head of state, he has risen to the challenge and that has been recognised by his people here and millions of people around the world. he was utterly charming and deeply

concerned about the situation his country is in. i could not begin to imagine the pressure that he is under. he looked tired when i first saw him, emotionally drained, and thatis saw him, emotionally drained, and that is after 50 days of war. we have no idea how long this will go on for. i could absolutely see why he has gained the respect of so many people around the world in his handling of this crisis. i could see him physically tense up when he started talking about war crimes and what russian troops are alleged to have done. he has visited the north—western suburbs behind me here, borodyanka, bucha, he has seen the body bags. i saw his face crumple, i saw him tense up, and it is deeply painfulfor him. i crumple, i saw him tense up, and it is deeply painful for him. i stayed directly, are you going to be able to sit across a negotiating table and talk to the head of state or the

representative of a nation that is alleged to have committed those kinds of atrocities to your people? he told me it would be very, very difficult but he was willing to try, to try to end this crisis. you get a flavour of that in my interview coming up now. for the entirety of the war, he has called this heavily fortified building home in the centre of kyiv. how difficult has it been for you to be here through all this without your family? be here through all this without yourfamily? it be here through all this without your family?— be here through all this without your family? be here through all this without our famil ? , , ., ., your family? it is my “oh. i have to do it and it — your family? it is my “oh. i have to do it and it is h your family? it is my job. i have to do it and it is difficult _ your family? it is my job. i have to do it and it is difficult without - your family? it is my job. i have to do it and it is difficult without my i do it and it is difficult without my family to be anywhere. his do it and it is difficult without my family to be anywhere.— do it and it is difficult without my family to be anywhere. his wife and children are — family to be anywhere. his wife and children are safe _ family to be anywhere. his wife and children are safe at _ family to be anywhere. his wife and children are safe at an _ family to be anywhere. his wife and children are safe at an undisclosedl children are safe at an undisclosed location. his companions, heavily armed troops, sandbags and mines. at

the start of the war, they walked around in the dark, afraid of russian shelling.— around in the dark, afraid of russian shellinu. ~ ., _, , russian shelling. like our country. it is auoin russian shelling. like our country. it is going through _ russian shelling. like our country. it is going through the _ russian shelling. like our country. it is going through the dark. - russian shelling. like our country. it is going through the dark. to - russian shelling. like our country. | it is going through the dark. to the victory. i hope so. then, as we enter the situation room, the president receives a text. it is emmanuel — president receives a text. it is emmanuel macron? _ president receives a text. it is emmanuel macron? we - president receives a text. it is emmanuel macron? we have| emmanuel macron? we have connections. _ emmanuel macron? we have connections. he _ emmanuel macron? we have connections. he has - emmanuel macron? we have connections. he has droppedi emmanuel macron? we have - connections. he has dropped you a messaue. connections. he has dropped you a message- i — connections. he has dropped you a message- i can _ connections. he has dropped you a message. i can see _ connections. he has dropped you a message. i can see it. _ connections. he has dropped you a message. i can see it. yes, - connections. he has dropped you a message. i can see it. yes, ijustl message. i can see it. yes, i 'ust tried to reach fl message. i can see it. yes, i 'ust tried to reach you. i message. i can see it. yes, i 'ust tried to reach you. we �* message. i can see it. yes, ijust| tried to reach you. we are holding u . tried to reach you. we are holding up emmanuel _ tried to reach you. we are holding up emmanuel macron? _ tried to reach you. we are holding up emmanuel macron? i- tried to reach you. we are holding up emmanuel macron? i can - tried to reach you. we are holding up emmanuel macron? i can see i tried to reach you. we are holding i up emmanuel macron? i can see the code for paris. up emmanuel macron? i can see the code for paria— up emmanuel macron? i can see the code for paris._ a i code for paris. yes, that is true. a few minutes _ code for paris. yes, that is true. a few minutes later, _ code for paris. yes, that is true. a few minutes later, he _ code for paris. yes, that is true. a few minutes later, he returns, - code for paris. yes, that is true. a few minutes later, he returns, his| few minutes later, he returns, his preoccupation a renewed russian military onslaught about to begin in the east. are you getting the right

weapons you need from the west? we weapons you need from the west? - need weapons today so we can fight. we cannot wait until some country decides to give us or sell as weapons. some have still not decided on this and we cannot wait for two or three weeks or a month. the united states, the united kingdom and some european countries are helping, but we need it sooner. we need it now. is it enough? we do not think so. the priority word is sooner. the priority worked as quickly. the priority word is now. he has been cut off from his people, his citizens suffering from unimaginable horrors at the hands of a ruthless adversary. he is full of hate for the russian troops and their leaders, gradually limiting their leaders, gradually limiting the scope for peace talks. how do you sit across the to try and stop the war? how you do that? ? bucha is

in this process. closing the possibilities. bucha, bodyenka, mariupol. i don't have, you know, it is not about me. it is more about russia. they will not have so many chances. in the long period to speak with us. and what of those european countries, despite other sanctions, still sending billions to russia in oil and gas revenues? we still sending billions to russia in oil and gas revenues?— still sending billions to russia in oil and gas revenues? we do not understand _ oil and gas revenues? we do not understand how _ oil and gas revenues? we do not understand how you _ oil and gas revenues? we do not understand how you can - oil and gas revenues? we do not understand how you can make i oil and gas revenues? we do not - understand how you can make money out of blood. unfortunately, some european countries have done this. before the war began, i spoke to angela merkel and said if a full—scale invasion of ukraine happens, they will go further into

poland and after that, they will be on your borders of germany. if that happened, would you say to your people, it's fine, its business, it'sjust people, it's fine, its business, it's just business? and? people, it's fine, its business, it'sjust business? and? how do people, it's fine, its business, it's just business? and? how do you maintain hope in the future given everything that has happened? it is not hope, it is certainty. that everything that has happened? it is not hope, it is certainty.— not hope, it is certainty. that you will win? yes, _ not hope, it is certainty. that you will win? yes, of— not hope, it is certainty. that you will win? yes, of course. - not hope, it is certainty. that you will win? yes, of course. thank i not hope, it is certainty. that you i will win? yes, of course. thank you very much. plans to send some asylum seekers who arrive in the uk to live in rwanda have been described as "absolutely chilling" by charities and politicians. britain's home secretary priti patel — who travelled to rwandan capital kigali to sign the deal — said the "vast majority" of those arriving in the uk "illegally" would be considered for relocation to rwanda. the government says the system would reduce people—smuggling and discourage people from trying to reach britain in small boats. but the united nations' refugee

agency said people fleeing conflict and persecution deserved compassion and empathy — and should not be traded like commodities. earlier i spoke to our political correspondent — jonathan blake — and began by asking him whether we've got any more details on how the scheme will work. in terms of the timescale the government wants to work to, the prime minister said yesterday when he announced the policy that he did not expect it to be in place overnight and that was taken as an assumption and an acknowledgement that it would take some time to get this in place. but we heard from the downing street head of policy last night saying it would be a matter of weeks, if not, a small number of months when the first flights take people arriving in the uk relocating them to rwanda, to attempt to claim asylum there. that, i have to say, seems an ambitious target given the logistical and possible legal hurdles the government

will have to overcome to get this policy up and running which the prime minister himself acknowledged yesterday. there are still questions about how it is going to work, not least about the amount of money it is going to cost. the home office minister has said this morning that he could not put a cost on it, it will depend on the numbers of people involved, those who end up going to rwanda and their individual circumstances. he said the government had little other option available to it to stop the problem of people crossing the channel in small boats trying to reach the uk. we have to get this under control. it is completely unacceptable and unsustainable to have thousands of people making these dangerous crossing, the channel, for example, as we move forward. and that is why doing this in this way will help us to stop that. it is one intervention amongst many but it should mean that not only are people not risking their lives, but we are also getting under control some of these costs.

for example, we are spending nearly £5 million a day at the moment accommodating people and hotels. i think your viewers at home would say that's unsustainable and not acceptable. 0pposition parties were quick to criticise these plans by the government, calling them immoral, unworkable, and the lib dems said they were destined to failure. labour said they would be extortionate in terms of the amount of money they would cost. some criticism is coming the government's way from its own party, the conservative mp and international development secretary andrew mitchell has spoken out against the plan. the problem with this scheme they have announced is that i do not think it will work, it is not practical, it is being condemned by the church and civil society, it is immoral and above all for conservative advocates it is incredibly expensive. the costs are eye watering, sending people 6,000 miles into central africa... that is not the majority view

among conservative mps. those i have heard from are positive about the plan. they accept there are limitations but they think it will go down well with conservative and potential conservative voters. for all the criticism coming the government's way, it does them no harm to attempt to talk tough on immigration, it is safe territory as borisjohnson would see it for his government and his party at a time when, given the fine he has received as a result of breaking lockdown rules during the pandemic and further recriminations over partygate, he will be all too keen to talk about something else. it's set to be a busy bank holiday weekend across the uk as people take their first easter holiday in three years due to the pandemic. 0ne place that's predicted to be busy is the port of dover — where p&0 ferry services to and from calais are still suspended. our correspondent —

simonjones — has been in dover today and sent us the latest. iam i am currently on the outskirts of dover on the a20, lori is already queueing this morning. camera around, you can see the front of the of the queue. the idea of the system it keeps lorries out of the town centre so it does not get blocked up. periodically, lorries are allowed to proceed towards the port. it shows you the amount of freight waiting to get across the channel. also part of the m20 in kent has been closed, that can also stack lorries. the big issue at the moment is that p&0 ferries are running no services at all from the port of dover to calais. it has been like that for the past month or so after p&0 ferries sacked 800 of its staff with the aim of replacing them with

cheaper agency staff. it has tried to do that but this week, two of p&0 ferries here in doverfailed to do that but this week, two of p&0 ferries here in dover failed safety inspections by the maritime and coastguard safety agency so they have not been able to proceed. these queues have become more common since the start ofjanuary queues have become more common since the start of january with increased checks post—brexit as well as problems here, it is going to be a busy day on the roads over all. the aa think that 27 million journeys will be taken by vehicles over the easter weekend period. 0bviously, fuel prices going up, some people may decide to stay closer to home. the advice is to check before you set out. ., ., ., . �* �* the advice is to check before you set out. ., . ., . �* �* , tensions are high in occupied eastjerusalem as christians, jews and muslims prepare to celebrate easter, passover and ramadan at the same time. there have been clashes between israeli forces and palestinian demonstrators at al aqsa mosque. tear gas has been fired and reports

suggest more than 90 palestinians and three israeli policemen were injured. brain tumours are the most common cancer killer in people under a0. but treatments have barely changed in years and research into the condition has been very limited. the issue was highlighted recently by the death of the singer tom parker at the age of 33. now, brain tumour patients at addenbrooke's hospital in cambridge are having their cancer genomes — the entire dna — sequenced. the aim is that tumour mapping will lead to more accurate diagnosis. a warning — this report from our medical editor fergus walsh contains images of brain surgery. i've got a rough idea of what is going to happen. i'm going to be partially awake or i could be woken up during the surgery. daniel is just 34. he is on his way to theatre

for brain surgery. i think that is the bit that i'm most scared about, being awake and having someone screwing around in my head. daniel has a large brain tumour, the round white area at the top of the scan. to begin with, daniel is fully anaesthetised while surgeons remove part of his skull. but once his brain is exposed, he is woken up and must be kept awake. daniel, how are you feeling? just have to be a bit careful towards the back because that is the part of your brain that moves the right hand side of your body. before removing each piece of tumour, surgeons need to be sure it won't affect daniel's speech or his ability to move his body. going to show you some i pictures now, daniel, 0k? i want you to just say what you see. so at each step, the team checks his responses.

well done. part of daniel's tumour will be sent for whole genome sequencing. its entire dna will be mapped. what that means is essentially we are looking at the abnormalities in the genes that we think because the tumour in the first place. so we are really able to drill down into the molecular problems in the tumour. daniel's diagnosis, his future, rests on what they find in these tubes. dna sequencing used to take months, now it can be done in days at these labs near cambridge, of us biotech firm. not only does it speed up diagnosis, but reveals what is driving the growth of a patient�*s cancer. nothing can prepare a patient or a family for the nuclear bomb that detonates at the centre of your world when you receive a diagnosis. jess lost her mother to brain cancer in 2018.

the former labour cabinet member spent her last months campaigning for more funding and research into the condition. bring cancer is the biggest cancer killer of children brain cancer is the biggest cancer killer of children and people under a0 in the uk. yet treatment options have not changed in decades. because this is low—grade... just two weeks after the surgery, daniel returns with his brother to receive his results. this is a diagnosis that is treatable. but it is not a curable condition. 0k? so this is something that will be life limiting. about 50% of people survive for about 15 years or more. but i think it is important that you understand this isn't something that is going to go away. i don't know what to say. you don't have to say anything. the next 15 years of my life.

he has gone 2—0 to them. a few weeks later, ijoined daniel to watch his local football team. the quality of finishing it is shocking. he used to play in goal, now he gives advice from the touchline. life is very short, so i want to make the most of it. i just want to get the treatment i can to prolong my life. about six weeks of radiotherapy, five days a week. more than 200 brain tumour patients are taking part in the research with the hope it may eventually yield new, personalised treatments which improve outcomes. joining me now is dr richard mair who is a consultant neurosurgeon at cambridge university hospitals who is leading the minderoo precision brain tumour programme.

thank you so much for being with us, it is incredibly exciting work you are doing. explain why it is so revolutionary, white is so different and what hope it brings us. goad and what hope it brings us. good morninu. and what hope it brings us. good morning- i _ and what hope it brings us. good morning. ithink— and what hope it brings us. good morning. i think really _ and what hope it brings us. good morning. i think really what - and what hope it brings us. (limo. morning. i think really what this gives us, as you say, is hope for the patients, and really what we are doing is a paradigms shift in both how we diagnose and potentially treat these patients. so, previously, what we have done is we had taken tissue from surgery, looked down a microscope in the pathology labs and said it looks like whatever type of tumour it looked like. now, what we are able to do with these new technologies that have become much more available is send the samples off for really in detail analysis, using both what is called dna sequencing, so looking at the genetic code of the cells in the cancer, but also rna sequence which is looking at really, it is a stepping stone from their dna to the

protein and how the cancer cells behave. so by getting all of that information, we get a much clearer picture notjust what information, we get a much clearer picture not just what the cancer information, we get a much clearer picture notjust what the cancer is but also how best to treat it. and what that means is that we can identify that within what would be previously a catchall term of glioblastoma, the most common primary malignant rain cancer, there are different subtypes and maybe those different subtypes are different diseases, and treating them all in the same weight may not be the best way to go about things. we had in that report a suggestion that may be that whole area has been under and certainly underfunded in the past, do you agree with that? because it is, as we were hearing, the biggest cancer killing of under a0s. the biggest cancer killing of under a05. i the biggest cancer killing of under 40s. ~ the biggest cancer killing of under 405. ~' the biggest cancer killing of under 40s. , the biggest cancer killing of under 40s. ~ , ., . ., 40s. i think across research we are findin: 40s. i think across research we are finding that — 40s. i think across research we are finding that funding _ 40s. i think across research we are finding that funding is _ 40s. i think across research we are finding that funding is being - finding that funding is being reduced. however, there are certain areas that are classically not funded well. i think brain cancer has struggled in the past. however,

see our uk have designated it a cancer of unmet need,. minderoo, who are our partners in this, have also put money forward. i think the groundswell is changing and we are seeing that brain cancer is being taken more seriously as an entity, and i think that nihilism that we saw perhaps five to ten years ago is not there anywhere —— any more, and we realise that with the advent of genetic missing, with the advent of targeted therapies, there is the pathology to really improve not only the prognosis but the cure rate for these types of cancer. find the prognosis but the cure rate for these types of cancer.— these types of cancer. and these es of these types of cancer. and these types of cancer _ these types of cancer. and these types of cancer can _ these types of cancer. and these types of cancer can be _ these types of cancer. and these types of cancer can be so - types of cancer can be so devastating and so brutal and so fast, can't they? the way they kill, they take life so quickly. i fast, can't they? the way they kill, they take life so quickly.— they take life so quickly. i think that is one _ they take life so quickly. i think that is one of _ they take life so quickly. i think that is one of the _ they take life so quickly. i think that is one of the things - they take life so quickly. i think that is one of the things that i they take life so quickly. i think- that is one of the things that makes myjob that is one of the things that makes my job so that is one of the things that makes myjob so difficult, you essentially have a patient who was normal two

weeks ago, you are a husband, partner, whatever. they have a seizure, they don't feel quite right, they come into hospital, they had a ct scan, i will see then probably the following week and tell them, actually, you've got about a year. and i think that the rapid fatality that is associated with this condition really doesn't make it a devastating disease. and the fact that we haven't managed to improve that prognosis over the past sort of 20 years, sort of again adds to that little bit, it compound that, because i think it does reduce the hope that the patient has that actually over that year that something will change. i genuinely hope that this programme, that patients will see that we are change to change that narrative, we are trying to shift things in their favour. , ., ., .., favour. do you feel that medical advances and _ favour. do you feel that medical advances and change _ favour. do you feel that medical advances and change happeningj favour. do you feel that medical- advances and change happening quite quickly now? almost, you know, at such a speed that the real hope is

starting to be offered? i such a speed that the real hope is starting to be offered?— starting to be offered? i think so, i think a lot _ starting to be offered? i think so, i think a lot of _ starting to be offered? i think so, i think a lot of the _ starting to be offered? i think so, i think a lot of the technologies i i think a lot of the technologies that have come in are becoming more accessible to patients in general and through the nhs. i think we are taking those advances into clinic. i think there is, again it used to be that science is done for science purposes and then medicine was different but that translational clap is being breached, —— translational gap,. i think again that this is the sort of programme that this is the sort of programme that will enable that and even advances that have not yet come to pass, as they are discovered, will be able to adopt the framework that we have, you know, envisaged and actioned here in cambridge, they will be able to jump on that bandwagon. and then the idea is obviously to go national. it is amazin: obviously to go national. it is amazing what _ obviously to go national. it is amazing what you _ obviously to go national. it is amazing what you are - obviously to go national. it is amazing what you are doing, good luck with it, and i hope you

continue to make rapid progress. thank you so much for being with us. thank you so much for being with us. thank you. more than 3a0 people are now known to have died in the south african province of kwazulu—natal in the worst flooding in decades. days of torrential rain washed away homes, roads and bridges, prompting the government to declare a state of disaster on wednesday. electricity and water have been restored to some areas, but relief teams are stretched to capacity. 0ur correspondent vumani mkhize has the latest from durban. 3a1 people are now confirmed to be dead. officials say the clean—up operation and the rescue operation are continuing. unfortunately, that number is expected to rise. right now, i am at the durban and north beach, and as you can see behind me, the scale of the debris and devastation that happened here is quite immense. we have a number of volunteers that have come here to essentially try and clean up the beaches and to try

and make sure that the area is usable again. 0n the land of this province, a number of houses and bridges and roads have been rushed away, and the devastation has really been quite significant, after so much rain has fallen over here. and in terms of relief efforts and rescue efforts, what is going on? what are the authorities saying? the what are the authorities saying? iie: authorities what are the authorities saying? "iie: authorities are what are the authorities saying? ii2 authorities are saying what are the authorities saying? i““i2 authorities are saying that what are the authorities saying? ii2 authorities are saying that they are going to be continuing to search for the people who have either been trapped or who have unfortunately been deceased. we have a number of volunteer organisations who are helping people with food and shelter as well. so, essentially, this operation has moved to a humanitarian situation where authorities are trying to help people who are essentially destitute and who have lost all of their

belongings, try and somehow navigate the situation. but the difficulty for the authorities is that more bad weather is expected to stop south african weather service announced recently that excessive rain with strong winds and hail is expected to fall overnight, and that is essentially going to hamper recovery operations here. but equally over that we step —— easter weekend where people were expected to either come to durban or essentially go to religious activities. that is really going to be hampered by the bad weather and this general state of decay of the city at the moment. some breaking sport news — joe root has stepped down as england test captain. let's get the latest on that front louisa pill babe at the liberty sport centre. a lot of leading figures in the but macro i think it is worth starting with the

fact thatjoe root is an open back most successful cricket captain. he is also most successful cricket captain. ii2 is also one of like best players. he is also one of like best players. he is already england's second highest test run scorer of all time and scored 1a centuries as captain. but if we take the last few months, england has that dismal defeat by australia in the ashes at the start of the year where they lost the series four — zero. and a ten wicket humiliation at the third test to west indies. most recently in grenade last month. that takes england to nine matches without a win and that is incredibly important to understand the criticism thatjoe root has faced. he was criticised for his decision making and for talking in cliches saying that there was a lot to learn from these defeats, but not much action and not much change. so, critics began to call for him to go. joe root said in a statement that, i have loved

leaving my country but recently it has hit home how much of a toll it has hit home how much of a toll it has taken on me and the impact it has taken on me and the impact it has had on me away from the game. he's not leaving cricket entirely, of course, he is a crucial player for england, and it may well help his performance if he can just focus on that now without the captaincy. but now all talk will turn to who will take over from but now all talk will turn to who will take overfrom him. ben stokes is the favourite and he is the current vice captain. just butler and even stuart broad who was recently dropped, and james anderson, they are coming to the end of a wicket careers, they have been spoken about. of a wicket careers, they have been spoken about-— spoken about. turning from cricket to football, — spoken about. turning from cricket to football, more _ spoken about. turning from cricket to football, more dramatic- spoken about. turning from cricket to football, more dramatic news i spoken about. turning from cricket to football, more dramatic news in| to football, more dramatic news in the world of football because burnley have sacked their manager, sean dyche. he has been there for ages, ten years, i think. sean dyche. he has been there for ages, ten years, ithink. 0nly sean dyche. he has been there for ages, ten years, i think. only a few games left of the season, it seems a strange time to get rid of your manager. strange time to get rid of your manauer. 2, . strange time to get rid of your manager-— strange time to get rid of your manauer. ., ., .. , manager. you are exactly right, he has been at — manager. you are exactly right, he has been at burnley _

manager. you are exactly right, he has been at burnley for— manager. you are exactly right, he has been at burnley for ten - manager. you are exactly right, he has been at burnley for ten years. | has been at burnley for ten years. he is actually, or was, the premier league's longest serving manager. so, this has been a little bit of a surprise but burnley are four points off safety in the premier league with eight games to go so they are not doing particularly well. and as i mentioned, he is sacked after almost ten years in charge. they lost 2—0, burnley to norwich last weekend, which leaves them facing relegation unless they can perform a miracle at the end of this campaign. quotes from the chairman alan paice, in terms of sean dyche leaving, he says he —— it is an incredible difficult decision but changes needed. so, yeah, pretty surprising, because he has been there for so long but burnley, they are in trouble. , , . ., , long but burnley, they are in trouble. , , 2 2, , 2, ~ trouble. yes, they certainly are. we will see what _ trouble. yes, they certainly are. we will see what happens _ trouble. yes, they certainly are. we will see what happens and - trouble. yes, they certainly are. we will see what happens and who - trouble. yes, they certainly are. we i will see what happens and who comes in to replace him. very —— thank you

very much indeed. the duke and duchess of sussex met the queen yesterday afterflying into the uk. the couple stopped at windsor on their way to the netherlands, for the invictus games. 0ur royal correspondent sarah campbell told us more about their brief visit. it was certainly a flying visit. they were in and out of the country before the media got wind of it. it appears they flew in on wednesday evening, stayed overnight at the cottage in the grounds of windsor castle and made their way sometime yesterday to windsor castle itself and had a meeting with the queen which was confirmed by their spokespeople later in the evening. this is the first time the couple together have been in the country since 2020. meghan has not been back in the uk since 2020, harry was back for the unveiling of the statue of diana and the funeral of prince philip back in april last year, almost exactly one year ago. there has been a lot of water under the

bridge since they left, the oprah winfrey interview, recently ongoing, this high court claim against the home office brought by prince harry talking about protection, it was said in court he does not feel it is safe in the uk to bring his family across. clearly they felt that a stop—off on the way to the hague to the invicta games was something they could fit into their schedule and that's what happened yesterday. a former british national who joined the islamic state group in syria, has been found guilty in the united states of hostage taking and conspiracy related to the murders of four americans in syria. el shafee el—sheikh was part of an is militant cell dubbed the beatles by hostages because of their british accents. the british aid worker, david haines was one of the hostages who was executed by the islamic state in 201a. his brother mike has been speaking to our reporter steve swann.

david was my little brother. hejust had this charisma around him. he was a bubbly person. he drew people in. when david started talking with refugees, he changed. we saw for the first time a sense of purpose. he had found his calling. then you heard the news he'd been kidnapped. yeah. i thought it was the worst day of my life. having to tell my mum, our mum, our parents, our family that he had been taken. ijust couldn't imagine anything worse. we firmly believed that once isis knew that they had british

and american hostages, they were dead men walking. itjust took them 18 months of hell. and then you heard the worst news possible. can you tell us about that? so the 13th of september was the night when my family were torn apart. just a few days before hand, i had moved most of my family to my home. we had people sleeping on the couch, on air beds, all sorts of places. the 13th of september was a beautiful day. we filled it full of family love and laughter and hope... we hoped my brother would come home safe. there had been an outcry around the world calling for the release

of the humanitarian worker called david haines. we had all gone to our beds. i'm sat on the side of my bed undressing and my phone began to ring. it was three minutes past 11 at night. and there was a blackness inside of me. because i knew it was the call that i had been dreading since day one. it was my team leader here in london telling me that david was no longer with us. and i gathered my family together. i took my mum's hands... and told her her son

couldn't be hurt any more. that was truly the worst night of my life. terrorists with any attack are looking to spread hatred. their actions of murdering my brother were about hate. and if i hate, they win. they hold a big part of my life because i have hate for them. so i will not give them hate. david's remains lie rotting in the desert somewhere. he was not brought home.

and for me, that is not important. because david walks with me still. the brother of the british aid worker david haines, who was one of the hostages executed by islamist state in 201a. once it was a gathering forfree—spirited bohemians — where anything goes. now it's become a festival of social media influencers and celebrities. burning man is a unique counter—culture event that takes place in the black rock desert in nevada. but this year some of its artwork has been put on display in what can only be described as slightly more genteel surroundings. navtej johal went to have look. in the heat of the nevada desert, they come in their tens of thousands. burning man, an annual arts and cultural gathering which first began more than 30 years ago, creates a temporary city in the black rock desert.

it's renowned for its huge sculptures, parties and what it calls a focus on radical self—expression. it is in every way, thousands of miles from here. chatsworth house in the peak district is the home of the duke and duchess of devonshire, and they've decided to share the grounds for a while with some of burning man's most eye—catching attendees. burning man wanted to put some of their art at chatsworth in a park in a different landscape to what it's used to. and of course, we were thrilled because we love doing new things, we've always done new things. because i can see it out of my window. out of your bedroom window? yes, i can see it. and so at the moment, this is the favourite, but it'll change. you know, when i get to know the other ones better, it'll change. you ask me in a month, it'll be something different. well, this is the first time that any artwork from burning man has been in the uk. and although this landscape is more used to sheep and deer, for the next six months, it will be home to creatures like this.

benjamin langholz has recreated a recent artwork he featured at burning man for chatsworth using locally quarried stone. as soon as i got here, i sort of had this idea for this spiral, this upwards movement. i like to build at scale and bring a little bit of the idea of like risk and responsibility, like who is responsible for the fact that you start walking higher and higher? i think it's you. some people think it's health and safety of chatsworth. there will be 12 installations in total, ranging from bears made of pennies to a militaryjet with hand—blown glass flowers. all of them free for the public to visit. but not everyone seems convinced that the desert and derbyshire can work together. i'm sure there's better places for it, but uh... j tough crowd! yeah, sorry to be negative, but you did ask. _ it's really cool, like juxtaposition, isn't it? yeah, yeah. like the new with the old. i'm impressed. i think it's a bit strange that they've got it here, to be honest. you think it's a bit strange?

yeah, well, because they have it in the desert and everybody's kind of... it's true that burning man has a reputation for hedonism, but the organisers say there's more to it than that. ultimately, it's a place of making and creative expression. and for some people, the easy thing is to say, "hey, somebody�*s naked at burning man." it's a pretty simple and not that interesting way to think about something as special as black rock city. can you imagine yourself ever going to visit burning man? in theory. in practice, i'm not too keen on camping. in the meantime, the duke is hoping plenty will be keen to welcome chatsworth's latest guests. navteonhal, bbc news. researchers have warned that the cactus family of plants is facing a severe threat from climate change, despite the ability of many species

to endure heat and drought. a study of more than a00 cactus species concluded that 60% could be at greater risk of extinction by the middle of this century. the authors note that despite their reputation for being hardy survivors many cacti depend on very specific environmental conditions, which are likely to change as the world heats up. and a bit of news that's come from germany, where the berlin zoo celebrated the birthday of a rather special gorilla. her name is fatou and yesterday, she turned a remarkable 65 years old. the average lifespan for most western lowland gorillas is roughly 35 to a0 years. so, the zoo presented fatou with a cake made of rice and fruit.

she is enjoying that very much indeed, happy birthday to her. you have been watching bbc news. the easter long weekend upon us now and over the next few days, the weather is not looking too bad at all, we are going to see high—pressure largely dominating things so temperatures will be doing well for this time of year, some sunshine, perhaps some rain around later in the weekend, particularly easter sunday and into easter monday. high—pressure is sitting out in the east of the uk, you can see it here. over the next few days, a couple of fronts are trying to nudge in from the atlantic but generally, they will tend to fizzle out. friday, a bit of mist and murk around parts of eastern england and eastern scotland but also through the irish sea coast, some murkiness. a few splashes of rain across

northern ireland but most places avoiding rogue showers and staying predominantly dry. temperatures are possibly high as 22 degrees n one or two spots. this evening and overnight, a few spots of rain but most places looking dry. reasonably clear skies through the nights for parts of eastern england, here temperatures will fall down into mid single figures but a frost free start to your saturday morning. saturday, the north in the west of the uk will see most of the low cloud and mistiness through the morning. lots of sunshine from the word go and skies will tend to brighten up through the day like they will today so long spells of sunshine during the afternoon and temperatures between 13 to 19 for most of us but we could see 20 degrees and one or two spots. 0vernight, saturday into sunday, we start to see a weak front moving in from the west and that pets up a little bit as we had three sunday night into easter monday as well. ten need to weaken as it moves into the area of high pressure but it does mean a bit of a changing to

easter sunday and we will see a bit more cloud across northern ireland and scotland and later in the day that rain in the far west will be working its way in but for many central and eastern parts of the uk, you will keep the sunny, dry conditions through the course of the day, and again warm with there's light southerly winds, temperatures up light southerly winds, temperatures up to about 19, possibly 20 degrees. attach clever easter monday of the frontal system works its way across the uk, not bringing too much rain but it will be followed by blustery showers in from the north—west. in the sunny spells, it will feel warm, ten to 17 degrees. bye—bye.

this is bbc news ? welcome if you re watching here in the uk or around the globe. i m ben brown. our top stories: the flagship of russia's black sea fleet has sunk after an explosion on wednesday. ukraine claims it hit the moskva with missiles, but russia says the ship sank after a fire. meanwhile, russia claims to have struck a factory outside kyiv which produces anti—ship missiles — and warns it will intensify attacks around the capital. in an exclusive bbc interview in his war bunker, ukraine's president says continuing attacks from russia are damaging chances of a peace deal.

bucha is in this process closing these possibilities. bucha, borodyanka, mariupol. so i don't have, you know, it's not about me, it's more about russia. the first asylum seekers could be flown from the uk to rwanda in weeks, according to the british government. the scheme aims to deter people crossing the english channel, but critics say it is inhumane more than 3a0 people are now known to have died in the south african province of kwazulu—natal, in the worst flooding there in decades. the russian defence ministry says it has warned it'll intensify attacks around kyiv after accusing ukraine of targeting russian border towns. moscow also claims its sea—based

cruise missiles have struck a factory outside kyiv which produces anti—ship missiles, including the type which, according to ukraine, hit russia's flagship, the moskva. russia confirmed the 12,000—ton cruiser from its black sea fleet had sunk but says it went down in rough seas as it was being towed to port after a fire caused its ammunition to explode. tim allman reports. the scourge of the black sea now buried at the bottom of it. but how the moskva got there is still disputed. ukraine says it hit the ship with cruise missiles launched from the coast. russia would only admit there had been an explosion onboard and it then sank in bad weather. if the ukrainians were responsible, it would be the biggest warship to be sunk by enemy action since the second world war. this is a tremendous victory for ukraine, even if they didn't directly contribute to the sinking. and it's an enormous defeat

for russia because it indicates that the russian armed forces simply aren't up to snuff in terms of modern military capabilities. perhaps not, but it does beg the question how will russia react? these were air raid sirens heard overnight in the western city of lviv for the first time in several days. and there were reports of powerful explosions in the capital kyiv. in his latest video message, president zelensky made reference to the fate of the moskva. he praised the ukrainian people, those who stopped the advance of endless columns of russian equipment, those who proved that russian planes were defenceless, and those who proved that russian ships can only go to the bottom of the sea. but in the east of the country, invading troops continue their operations. the ukrainian government fears their main goal now is to destroy the donbas region.

russia may have sustained a heavy defeat, but it is still very much in this war. tim allman, bbc news. 0ur correspondent in moscow, jenny hill, told me what the russians are saying about the ship's sinking. the statement from the authorities says that the ship sank while it was being towed back to port in stormy seas. they say that it had suffered significant damage, in particular to its hull, following a fire and explosion of ammunition on board. interestingly, this morning, state television has not dwelt on the topic beyond citing that particular statement from the authorities. the statement came too late to make it into the paper editions of the morning newspapers but their online editions are starting now to include a little bit more in the way of commentary. some are talking about what could have caused the fire.

they are very much sticking to the script from the authorities and noting that perhaps this ship, some a0 years old, of course, had rather outdated and inefficient firefighting systems onboard. very much sticking to the kremlin's script. certainly, no official response to the suggestion from ukraine that its missiles were responsible for sinking the ship. speaking about scripts, obviously very different script throughout this war from the ukrainian side, from the russian side, from kyiv and from moscow, what is the latest the russian defence ministry are saying about the war in general? we have actually had another update this morning, they say that moscow plans to increase the frequency and the scale of strikes on facilities in kyiv in retaliation for what it says are ukrainian attacks on russian territory. this has been building for the last couple of days. it follows a similar threat

a couple of nights ago. it is difficult to know whether the actual number of reported attacks from ukraine into the regions in russia which border the country have increased in recent days or whether the russian authorities, i suspect this is probably the case, are now talking about them with more frequency. many of these attacks, as we put it, are unverified, it is difficult to get independent verification of what is happening there. but the russian authorities are talking about ukrainian strikes on russian soil and yesterday officials in one region said that low—flying ukrainian military helicopters had conducted air strikes in a residential area leaving seven civilians injured and residential buildings damaged. russia is now saying in response to this, it will step up strikes on kyiv. we have to see how that situation develops but certainly it seems to be an escalating one. i'm joined now byjames bosbotinis, uk—based specialist in martime

strategy, defence and international affairs. how big a humiliation as the sinking of a flagship vessel for the russians? it of a flagship vessel for the russians?— of a flagship vessel for the russians? , , ,., ., , , the sinking of the flagship of the black sea fleet in what the russians aren't even calling of war and it was one of the largest ships in the russian navy and has now been sent to the bottom of the black sea so it is a huge blow to the russians. had uuite a is a huge blow to the russians. had quite a relatively old vessel. do we believe the ukrainians when they say they had it with a missile or more than one missile or do we believe the russians who say there was a fire and ammunition blew up and then it sank on its way into port? i

would be inclined to believe the ukrainians. the russians will be right that if there was a fire on board most likely because by the impact of a ukrainian anti—ship missile unless the russians attempted to intercept and incoming threat and one of their own missiles set off secondly did —— secondary detonations. whilst it was old it was a powerful surface combat and remained in the core of russian surface competence. the russians toda sa surface competence. the russians today say the _ surface competence. the russians today say the attack _ surface competence. the russians today say the attack to _ surface competence. the russians today say the attack to factory - surface competence. the russians| today say the attack to factory near kyiv which produced the neptune missiles which ukraine say hit the moskva, which implies that the ukrainians and that hurt it and it

was a revenge attack by the russians in that factory. it was a revenge attack by the russians in that factory-— in that factory. it reflects the fact of the — in that factory. it reflects the fact of the russian _ in that factory. it reflects the fact of the russian campaign| in that factory. it reflects the - fact of the russian campaign has been very poorly executed and flowed from the start. the russians really should have conducted those sorts of strikes at the very outset of the campaign but they were too complacent and did not regard the ukrainians as posing a real threat to them and they have learned the hard way no that ukraine does indeed have the ability to fight back and impose heavy losses on russia. essen impose heavy losses on russia. even so, the russians _ impose heavy losses on russia. even so, the russians have _ impose heavy losses on russia. even so, the russians have plenty more naval vessels and they have been blockading ukraine. how important do you think a naval strategy is in this conflict? we have talked so much about land fighting and the success of ukrainians in terms of anti—tank missiles hitting and taking out russian tanks, but we haven't talked that much about naval strategy? {iii haven't talked that much about naval strate: ? , , ., ., , haven't talked that much about naval strate: ? ,, . ., , .,, strategy? of the russian navy has -la ed an strategy? of the russian navy has played an important _ strategy? of the russian navy has played an important support - strategy? of the russian navy has played an important support role l strategy? of the russian navy has. played an important support role to the overall campaign. they have imposed a de facto blockade on the

ukraine black sea coast and russian amphibious forces were used in support of the seas of mariupol and from the very start russia has used its calibre cruise missiles hitting strategic targets in ukraine so whilst the action has taken place largely on land the maritime aspect is important and playing an important supporting role. thank you ve much important supporting role. thank you very much indeed. _ ukraine's president volodymyr zelensky says european countries that continue to buy oil from russia are aiding the country's war against them and they will have blood on their hands. he's urged western leaders to speed up the delivery of military aid to help ukraine. he's been talking to the bbc�*s clive myrie who sat down with president zelensky in his wartime bunker.

how difficult is it to do this without your family? fight! how difficult is it to do this without your family? and very difficult. at — without your family? and very difficult. at the _ without your family? and very difficult. at the start - without your family? and very difficult. at the start they - without your family? and very i difficult. at the start they walked around here _ difficult. at the start they walked around here without _ difficult. at the start they walked around here without lighting. - are whole country is going through the darkness. thus

are whole country is going through the darkness.— the darkness. as we enter what is called the situation _ the darkness. as we enter what is called the situation room - the darkness. as we enter what is called the situation room he - the darkness. as we enter what is called the situation room he gets| the darkness. as we enter what is| called the situation room he gets a call. it is president macron. he has dropped you a message. so we are holding up mr macron. i can see the code for paris. a few minutes later he returns. how difficult has it been for you to be here throughout this without your family? it's myjob. i have to do it. it is difficult without family. to be anywhere. his wife and children are safe at an undisclosed location. his companions here, heavily armed troops, sandbags and mines.

there was no light at all? at the start of the war, they walked around in the darkness. afraid of russian shelling. it is our country. it's going through the darkness to do the victory, i hope so. how do you sit across the table to try to stop the war? how do you do that? the first two years of my presidential tour, i did all i could to have meetings with them. to have negotiations with them. to stop the war with them. putin is in this process, closing these possibilities. bucha, mariupol,, it's not about me. it's more about russia. they will not have so many chances. some european countries are helping but we need it sooner, we need it now. is it helping? i don't think so. , ., y words are quickly, the priority words are quickly, the priority words are quickly, the priority words are now. he words are quickly, the priority words are now.— words are quickly, the priority words are now. , . , , ., words are now. he is a president who has been cut — words are now. he is a president who has been cut off _ words are now. he is a president who has been cut off from _ words are now. he is a president who has been cut off from his _ words are now. he is a president who has been cut off from his people, - has been cut off from his people, citizens suffering unimaginable horrors and he says he is full of hate for russia and its leader gradually limiting the prospects for peace talks. haifa gradually limiting the prospects for -eace talks. ., ., , ., gradually limiting the prospects for -eace talks. ., ., i. , gradually limiting the prospects for -eace talks. ., ., , peace talks. how do you sit across the table trying — peace talks. how do you sit across the table trying to _ peace talks. how do you sit across the table trying to stop _ peace talks. how do you sit across the table trying to stop the - peace talks. how do you sit across the table trying to stop the war? i bucha is in this process closing these possibilities. bucha, borodyanka, mariupol. so i don't have, you know, it's not about me, it's more about russia.

they will not have so many chances in the long period to speak with us. and what of those european countries despite other sanctions still sending billions to russia and oil and gas revenues? translation: we don't understand how you can make money out of blood. - unfortunately, this is what some countries have been doing. before the invasion i spoke to chancellor merkel and said if a full scale invasion is happens it will be on your borders. how do you maintain hopein on your borders. how do you maintain hope in the future giving everything

that's happened? it’s hope in the future giving everything that's happened?— that's happened? it's not hope, its certain . that's happened? it's not hope, its certainty- that _ that's happened? it's not hope, its certainty. that she _ that's happened? it's not hope, its certainty. that she win? _ that's happened? it's not hope, its certainty. that she win? yes, - that's happened? it's not hope, its certainty. that she win? yes, of i certainty. that she win? yes, of course. let's go live now to anna foster who's in kozarovychi, north of kyiv. that is one of the bombarded by the russians. i think you have some evidence next to you.— russians. i think you have some evidence next to you. there are so many places _ evidence next to you. there are so many places like — evidence next to you. there are so many places like this _ evidence next to you. there are so many places like this around i evidence next to you. there are so many places like this around kyiv l many places like this around kyiv that have experienced russian bombardment. this was a missile. you can see how big it was, probably write three or four metres long and the ladies who live in the house next door describe how this fell from the sky on the 10th of march and everybody living in the street was terrified and did not want to commit it for a few days but you can

see the destruction we have seen repeated in so many parts of northern and western kyiv, places where peoples homes are being completely destroyed and places where people were trying to put their lives back together and these three blasts ahead in the south of kyiv overnight we russia says it attacked a factory that was making anti—ship and anti aircraft missiles, it makes people who are nervous, not so nervous they don't want to get back to some semblance of normality but those threats coming from russia towards the capital in particular are making people a little concerned. and you mention that attack and that factory making neptune anti ship missiles and that is what the ukrainians are saying the used to fight against the flagship of the black sea russian fleet, moskva, it looks like that could have been a revenge attack by the russians but how symbolically humiliating you think the sinking of

that vessel is for the russians, the russian navy and the military? here in ukraine, hugely. they are seeing this as a major victory because obviously ukraine is not known for its power at sea so for them to strike a blow at russia like this and take out the flagship of the fleet and don't forget this as a ship that became famous here in ukraine a few weeks ago when it approached snake island and as the inhabitants to surrender and it told them where to go and they even have postage stamps here with them in ukraine now so for people here who have seen the pushback in areas around kyiv to see something like that, ukraine claiming it has attacked and eventually sunk the russian flagship, it feels for people here particularly as fighting rages in the east like a real boost. plans to send some asylum seekers who arrive in the uk to live

in rwanda have been described as "absolutely chilling" by charities and politicians. britain's home secretary, priti patel, who travelled to rwandan capital kigali to sign the deal said the vast majority of those arriving in the uk illegally would be considered for relocation to rwanda. the government says the system would reduce people—smuggling and discourage people from trying to reach britain in small boats. but the united nations' refugee agency said people fleeing conflict and persecution deserved compassion and empathy — and should not be traded like commodities. earlier i spoke to our political correspondent jonathan blake, and began by asking him whether we've got any more details on how the scheme will work. a bit more in terms of the timescale the government wants to work to, the prime minister said yesterday when he announced the policy that he did not expect it to be in place overnight

and that was taken as an assumption and an acknowledgement that it would take some time to get this in place. but we heard from the downing street head of policy last night saying it last night saying it would be a matter of weeks, if not, a small number of months when the first flights take people arriving in the uk relocating them to rwanda, to attempt to claim asylum there. that, i have to say, seems an ambitious target given the logistical and possible legal hurdles the government will have to overcome to get this policy up and running which the prime minister himself acknowledged yesterday. there are still questions about how it is going to work, not least about the amount of money it is going to cost. the home office minister has said this morning that he could not put a cost on it, it will depend on the numbers of people involved, those who end up going to rwanda and their individual circumstances. he said the government had little other option available to it to stop the problem of people crossing the channel in small boats trying to reach the uk. we have to get this under control.

it is completely unacceptable and unsustainable to have thousands of people making these dangerous crossings of the channel, for example, as we move forward. and that is why doing this in this way will help us to stop that. it is one intervention amongst many but it should mean that not only are people not risking their lives, but we are also getting under control some of these costs. for example, we are spending nearly £5 million a day at the moment accommodating people in hotels. i think your viewers at home would say that's unsustainable and not acceptable. 0pposition parties were quick to criticise these plans by the government, calling them immoral, unworkable, and the lib dems said they were destined to failure. labour said they would be extortionate in terms of the amount of money they would cost. some criticism is coming the government's way from its own party, the conservative mp and international development secretary andrew mitchell has spoken out against the plan. the problem with this scheme they have announced is that i do not think it will work, it is not practical, it is being condemned by the church and civil society, it is immoral and above all

for conservative advocates it is incredibly expensive. the costs are eye watering, sending people 6,000 miles into central africa... that is not the majority view among conservative mps. those i have heard from are positive about this plan. they accept there are limitations but they think it will go down well with conservative and potential conservative voters. for all the criticism coming the government's way, it does them no harm to attempt to talk tough on immigration, it is safe territory as borisjohnson would see it for his government and his party at a time when, given the fine he has received as a result of breaking lockdown rules during the pandemic and further recriminations over partygate, he will be all too keen to talk about something else.

tensions are high in occupied eastjerusalem as christians, jews and muslims prepare to celebrate easter, passover and ramadan at the same time. there have been clashes between israeli forces and palestinian demonstrators at al aqsa mosque. tear gas has been fired and reports suggest at least 150 palestinians and three israeli policemen were injured. more than 3a0 people are now known to have died in the south african province of kwazulu—natal in the worst flooding in decades. days of torrential rain washed away homes, roads and bridges, prompting the government to declare a state of disaster on wednesday. electricity and water have been restored to some areas, but relief teams are stretched to capacity. 0ur correspondent vumani mkhize has the latest from durban. 3a1 people are now confirmed to be dead. officials say the clean—up

operation and the rescue operation are continuing. unfortunately, that number is expected to rise. right now, i am at the durban and north beach, and as you can see behind me, the scale of the debris and devastation that happened here is quite immense. we have a number of volunteers that have come here to essentially try and clean up the beaches and to try and make sure that the area is usable again. 0n the inland of this province, a number of houses and bridges and roads have been rushed away, and the devastation has really been quite significant, after so much rain has fallen over here. and in terms of relief efforts and rescue efforts, what is going on? what are the authorities saying? the authorities are saying that they are going to be continuing to search for the people who have either been trapped or who have unfortunately been deceased. we have a number of volunteer organisations who are helping people with food and shelter as well. so, essentially, this operation has moved to a humanitarian situation where authorities are trying to help

people who are essentially destitute and who have lost all of their belongings, try and somehow navigate the situation. but the difficulty for the authorities is that more bad weather is expected to stop south african weather service announced recently that excessive rain with strong winds and hail is expected to fall overnight, and that is essentially going to hamper recovery operations here. particularly over the easter weekend where people were expected to either come to durban or essentially go to religious activities. that is really going to be hampered by the bad weather and this general state of decay of the city at the moment.

researchers have warned that the cactus family of plants is facing a severe threat from climate change — despite the ability of many species to endure heat and drought. a study of more than a00 cactus species concluded that 60% could be at greater risk of extinction by the middle of this century. the authors note that — despite their reputation for being hardy survivors — many cacti depend on very specific environmental conditions, which are likely to change as the world heats up.

hello. the easter long weekend upon us now and actually over the next few days, the weather's not looking too bad at all. we're going to see high pressure largely dominating things. so temperatures are going to be doing well for this time of year. there'll be some sunshine, perhaps some rain around later in the weekend, particularly later easter sunday and on into easter monday as well. but for the here and now, it is high pressure that's sitting out towards the east of the uk. you can see it here over the next few days. we've got a couple of fronts that are just trying to nudge in from the atlantic, but generally, as they bump into that high pressure that we tending to fizzle out. so friday, then we've had a bit of mist and murk around some parts of eastern england, eastern scotland, but also through these irish sea coasts. bit of low cloud and murkiness few splashes of rain across northern ireland later on today. most places, though, avoiding any of those rogue showers and staying predominantly dry. temperatures about 12 to 20,

possibly as high as 22 degrees in one or two spots moving through this evening and overnight. moving through this evening and overnight just a few spots of rain in the far north west of the uk. but most places today looking dry, reasonably clear skies holding on through the night for parts of eastern england. it's here that temperatures will fall lowest down into mid single figures, but certainly a frost free start to your saturday morning. so saturday, then, it's the north and the west of the uk that will see most of the low cloud and mist us. i think through the morning, lots of sunshine from the word go down towards the southeast and skies will tend to brighten up through the day like they will today as well. so long spells of sunshine during the afternoon and temperatures between about 13 to 19 for most of us. but again, we could see 20 degrees in one or two spots. 0vernight, then, saturday into sunday, we're going to start to see a weak front moving in from the west, and that peps up a little bit as we head through sunday night and into eastern monday as well, tending to weaken as it moves into that area of high pressure. but it does mean a bit

of a change into easter sunday. then we will see a bit more cloud ahead of that front across northern ireland and scotland and later in the day that rain in the far west will be working its way in. but for many central and eastern parts of the uk, you'll keep the sunny, dry conditions through the course of the day and again warm with those light southerly winds. temperatures up to around about 19, possibly 20 degrees. a touch cooler for easter monday, as that frontal system will have worked its way across the uk not bringing too much rain, but it will be followed by some blustery showers in from the north west. but in the sunny spells again, it's going to feel warm, around about ten to 17 degrees. bye— bye.

this is bbc world news, the headlines. the flagship of russia's black sea fleet has sunk, after an explosion on wednesday. ukraine claims it hit the moskva with missiles, but russia says the ship sank after a fire. meanwhile, russia claims to have struck a factory outside

kyiv which produces anti—ship missiles — and warns it will intensify attacks around the capital the first asylum seekers could be flown from the uk to rwanda in weeks, according to the british government. the scheme aims to deter people crossing the english channel, but critics say it is inhumane more than 3a0 people are now known to have died in the south african province of kwazulu—natal, in the worst flooding there in decades. the duke and duchess of sussex met the queen yesterday afterflying into the uk. the couple stopped at windsor on their way to the netherlands, for the invictus games. 0ur royal correspondent sarah campbell told us more about their brief visit. it was certainly a flying visit. they were in and out of the country before the media got wind of it. it appears they flew in on wednesday evening, stayed overnight at the cottage in the grounds of windsor castle and made

their way sometime yesterday to windsor