this is bbc news, i'm sally bundock with the latest headlines for viewers in the uk and around the world. a new drug — the first to slow the progression of early stage alzheimer's disease — is being heralded as momentous and historic. this is so exciting because now we're getting results, the first results that are indicating that the drug is successfully treating the underlying cause and is slowing down the symptoms of cognitive impairment. jubilation from england fans as they triumph in the battle of britain at the world cup, beating wales 3—0 and going through to the knockout stages. joy too for usa fans — as they go through with

a 1—0 victory over iran. the founder of the us right wing oath keepers militia group is convicted of seditious conspiracy over last year's attack on the capitol. the prince and princess of wales head to the us city of boston for their first international trip since take—up of their new titles. it's also the first time they have been to america since the duke and duchess of sussex have moved here. there are currently no plans for william and catherine to meet harry and megan. —— harry and meghan. and chinese astronauts arrive at the tiangong space station — completing the country's first—ever crew handover in orbit.

a very warm welcome. and we have a packed programme for you today, so let's get started. it's being described as a momentous and historic breakthrough. a major trial of an experimental dementia drug has shown — for the first time — that the progression of early stage alzheimer's disease can be slowed down. nearly 2000 patients took part in the study, including some here in the uk. full results have been published in the new england journal of medicine. the effects of the treatment were small, but have prompted huge excitement among researchers. 0ur medical editor, fergus walsh, reports. could you get the broccoli out of the fridge for me, please, love? yeah. 0k. david essam is 78 and has early stage alzheimer's. it's taken away his independence. he's now totally reliant on me or other people around him. he used to be a joiner, but no longer remembers how to use his woodworking tools.

i would have liked to have still been making my furniture, which i can't do. so i'm just going to show you the hippocampus, i and that's where all our- short—term memory is stored. alzheimer's gradually destroys key areas of the brain involved in memory and understanding. david is one of nearly 2,000 patients who took part in a major trial of a new drug — lecanemab. as normal, if you just - lift your arm up there for me. it involved having an infusion every two weeks. lecanemab didn't stop alzheimer's... i'lljust get you started here. ..but over 18 months, it's slowed its progression by about a quarter. this is so exciting because now we're getting results, - the first results that - are indicating that the drug is successfully treating the underlying cause . and is slowing down -

the symptoms of cognitive impairment and also the behavioural- symptoms associated - with alzheimer's disease. david and his wife cheryl can't be sure if the drug is making a difference, but they're delighted to have taken part in the trial. when we first began this two and a half years ago, we didn't necessarily think it would help us, but we felt we were doing something and could help future generations. it's just a horrible, nasty thing because if you... if you... if somebody can slow it down, and then eventually get it stopped altogether, you know, it'd be brilliant. at least half a million people across the uk are living with alzheimer's — by far the most common form of dementia. lecanemab is designed to help those in the early stages of the disease, but if it gets approved, that will still mean there'll

be a huge demand for the drug. you look good when you laugh. you look happy. the drug has potential side effects, such as brain swelling, but despite all the limitations, this is a significant moment in the fight against alzheimer's. fergus walsh, bbc news. there is more detail on that story on our website if you wish to have a look. at the world cup in qatar — england, the usa, senegal and the netherlands have all qualified for the knockout stages. england beat wales 3—0 in what was billed as the battle of britain. the result ensured top spot in group b for england while the welsh head home. after a goalless first half, england exploded into life after the break. marcus rashford with the first of his two goals just five minutes after half time. phil foden then guided in harry

kane's cross at the far post. and rashford took advantage of a goalkeeping error 20 minutes from the end. and rashford took advantage of a goalkeeping error 20 minutes from the end. england progress to a knockout match against african champions senegal. but for many, marcus rashford was the star of the night. here's harry maguire. i'm really pleased for rashy. he's obviously had a tough time out out of the team now for a year or so, but he's come back in, he looks a different player this season — that's credit to him, he's worked his socks off and we all know his talent. he's an unbelievable player. i can't speak highly enough of him. he's a massive player for my club and i think again tonight he's proven again that this is his stage. in group b's other match, usa were 1—0 winners over iran who could only manage one shot on target the entire match. christian pulisic scored the crucial goal just before half time, and the usa go into the last

16 where they'll face the netherlands on saturday. so delight for these fans in new york as they saw their side through to the knockout stages and, of course, they co—host the next world cup in four years' time. we have the world cup coming in for years, 2026, it's a great moment for us and our young squad, getting that crucial experience to continue going forward in the years to come. trying to get that second goal to get— trying to get that second goal to get over, they were able to do that, — to get over, they were able to do that, they held on strong. those — do that, they held on strong. those last ten having 50 minutes, it was like squeaky bum — minutes, it was like squeaky bum time, as they say, it was tense — bum time, as they say, it was tense and _ bum time, as they say, it was tense and i_ bum time, as they say, it was tense and i got a little bit nervous _ tense and i got a little bit nervous there, which i don't normally— nervous there, which i don't normally do. so nervous there, which i don't normally do.— nervous there, which i don't normally do. so soccer fever is um um normally do. so soccer fever is gripping at _ normally do. so soccer fever is gripping at the _ normally do. so soccer fever is gripping at the us. _ normally do. so soccer fever is gripping at the us. this - normally do. so soccer fever is gripping at the us. this was i gripping at the us. this was president biden's reaction.

usa! that's a big game, man! i spoke to the coach and the players, i said, "you can do this!" they went, "aah. they did it. god love �*em! anyway, just thought you might want to hear. there you go, he looks pretty thrilled about that. we can speak now to sports journalist adam leventhal, host of the athletic football podcast, who's in doha. adam, clearly president biden getting on board now. everyone is talking about it. what a day, so many significant matches to talk about. yes, it was a really — matches to talk about. yes, it was a really busy _ matches to talk about. yes, it was a really busy day - was a really busy day yesterday. it was the first of the final round of group games here at the qatar world cup. earlier on, as you mentioned, in terms of the usa and england's opponentss, we saw senegal advance instead of ecuador. the office they go through with the netherlands and then all the focus was on wales against england and probably even a little bit more on that huge game between the

usa and iran. interesting to hearfrom usa and iran. interesting to hear from that fun saying it was squeaky bum time as far as he was concerned. england are sitting far more comfortably, to be honest, and were never really troubled by wales and advanced with a bit of confidence in my performance thatjust rebuilds belief a little bit after struggling in their second game against the united states and fair play to them, people felt they would maybe not be able to advance and pass iran after their performance against wales, but they did that in the end. there was about nine minutes of stoppage time, but they know advance. england and the usa go through to the round of 16. absolutely. and for the fans of those teams, fantastic news, but we have to say we are so sorry to see wales go out. yes, it's almost — sorry to see wales go out. yes, it's almost been _ sorry to see wales go out. yes, it's almost been a _ sorry to see wales go out. yes, it's almost been a tournament. it's almost been a tournament too far for the set of players.

it was actually really quite sad to see gareth bale, who has been so instrumental in getting wales to this world cup, to the last tournament as well, having to go off at half—time. he felt some tightness in his hamstring and people were wondering whether that may well be it and it would be a real sad end to his international career, but he has vowed to fight on. he wants to head into the qualifiers for the next euros. i may be the next world cup might be a little too far for him, but it never really clicked for wales. you have to remember it was their first world cup since 1958, so the achievement alone is something to celebrate, but unfortunately, they never really turned up at this tournament.— really turned up at this tournament. . . ., ., tournament. adam, we have to talk about— tournament. adam, we have to talk about the _ tournament. adam, we have to talk about the day _ tournament. adam, we have to talk about the day ahead. - talk about the day ahead. argentina is playing. give us your take on what we will see today. it your take on what we will see toda . , . ,

today. it is really interesting, - today. it is really| interesting, these today. it is really - interesting, these two today. it is really _ interesting, these two ends in group c and group d. 0bviously, group c and group d. obviously, we have argentina taking on poland. poland are top of the group, argentina second, so they may well be feeling comfortable. however, if poland win that game, or either side win that game, or either side win that game, it will open the doorfor win that game, it will open the door for saudi win that game, it will open the doorfor saudi arabia or win that game, it will open the door for saudi arabia or even mexico to advance. you will remember saudi arabia beat argentina earlier in the tournament, a huge shock at this qatar world cup, but then argentina got back on track, messy mac inspired that victory against mexico, so they will be feeling confident —— messi inspire that victory against mexico. all of the teams could advance or go out of the ternet. in group d, it is a bit more comfortable, france, the holders have looked pretty comfortable so far, only having six points in the bag, and then

it is basically play—off between austria and denmark to see who will advance with france. tunisia have a slight opportunity that they can turn up opportunity that they can turn up a shock against france but thatis up a shock against france but that is looking unlikely because france have looked like, well, world champions. absolutely. adam, thank you. enjoy the day, we will talk to you adam leventhal from the athletic football podcast. stay with us on bbc news, still to come: we will tell you why a trip to boston is prompting questions about the prince of wales and harry and meghan. it's quite clear that the worst victims of this disaster are the poor people living in the slums which have sprung up around the factory. i'm feeling so helpless that the children are dying in front of me and i can't do anything. charles manson is the mystical leader of the hippie cult suspected of killing

sharon tate and at least six other people in los angeles. at 11am this morning, just half a metre of rock separated - britain from continental europe _ it took the drills just i a few moments to cut through the final obstacle. then philippe cozette, a miner| from calais, was shaking hands and exchanging flags| with robert fagg, his opposite number from dover. this is bbc news, the latest headlines. a new drug — the first to slow the progression of early stage alzheimer's disease — is being heralded as momentous and historic. england triumph 3—0 over wales in the world cup, and the usa beat political rivals iran 1—0 — taking both

teams to the knock—out stages. turning to the us now — and stewart rhodes, the leader of the group of militia members called the 0ath keepers, has been convicted of seditious conspiracy. it's in connection with the january 6th storming of the us capitol in washington. rhodes was accused of masterminding the 0ath keepers' participation on that day. the verdict is seen as a win for the usjustice department which sought to prove the attack amounted to a rebellion against the government. 0ur north america correspondent peter bowes has been following the case. this was a case — seditious conspiracy was the charge, which is a rarely heard charge, in large part because it's a difficult charge to prove,

so it's not often brought before a court. and essentially what it means is that the allegation was that he and others had attempted to stop the peaceful transition of power after the 2020 election. so the transition of power would have been between donald trump and joe biden, and the allegation being that it wasn't just something that happened on the day, the storming of the capitol building, but something that stewart rhodes and others had planned in advance, that this had been a plot. and in fact, prosecutors talked about a text message that he'd sent to some of his supporters just after the 2020 election, saying that "we're not going to get through this without a civil war". and clearly that was ringing in the ears of the jury members. that was the heart of the allegation from the justice department that american democracy was at stake, department — that american democracy was at stake, and the jurors believed the prosecution, at least in the case of stewart rhodes and one other. there were three others as part of the group who were found not guilty.

now, before the verdict came in, the bbc spoke to some members of stewart rhodes family in the state of montana, and they talked about what it had been like to grow up with him. from early childhood on, there was adoration towards my father that slowly eroded away. i lived absolutely under the thumb of an emotional terrorist. stewart's obsession with preparing for the apocalypse was his only hobby, his main purpose in life, and consumed our lives entirely. i had a childhood set of body armour. we sporadically attended tacticaltraining, especially when stewart got fully sucked into 0ath keepers. he made his family the centrepoint of this cult of personality that he wanted to build for himself. we were completely isolated. the kids couldn't have friends. they weren't even allowed i to play outside half the time. and it wasjust so intolerable.

it was just a dark and depressing existencej and very hard to remember that there was life - outside of that house. getting out was terrifying. heart pounding, i adrenaline racing. getting out was... ..was one of the hardest things, and really up- until we got out, we did not know if we were all - going to get out alive. it's a difficult situation - all the way around, but it's a much, much better situation with him in prison. _ i'm safer, the kids are safer, and the rest of the country . is safer with him in prison. now, at this stage, it isn't known how long stewart rhodes will spend in prison. he'll be sentenced at a later date. but on just the one charge of seditious conspiracy — that carries up to 20 years behind bars. it's a serious offence with a serious amount

of time in prison. and as far as the 0ath keepers are concerned, there are at least two more trials still to start. in fact, starting next monday, four members of the group will go on trial, and i'm sure officials at thejustice department will be analysing the decision made by thejury, perhaps deciding on how to move forward in terms of their legal tactics with the cases still to come. peter bo was there. —— peter bowes there. some spectacular scenes at the world's biggest active volcano — mauna loa in hawaii — which started erupting on saturday. this time lapse footage gives you an idea of the scale of what is going on. experts from the us geological survey are confident that the lava flows do not pose a risk to property, but hawaiians have been advised to wear facemasks to protect against ash and harmful

volcanic toxins. here is more from wendy or kurt. —— wendy urquhart. mauna loa has been belching smoke and ash since sunday and fountains of red—hot lava can be seen spouting up to 25 metres high on the slopes of the volcano. the last time this happened was in the spring of 1984, so naturally tourists and locals are keen to take a closer look, but they are kept well away from dangerous areas. right now, the lava flows are not a threat to property, and experts on the ground are already determining how much lava has erupted so far and where it might go next. as plumes of smoke from mauna loa drift towards nearby communities, residents are being advised to wear facemasks to protect against volcanic fog and sulphur dioxide. and hawaii governor david ige says special mechanisms on the island are being used to determine air quality. we have a series of air quality monitors all around the island, and so certainly

we are encouraging those who have respiratory challenges to be mindful and stay away from the summit and the fissures where the eruption is occurring. he has also issued a proclamation to allow emergency services to respond immediately if the worst happens, and he has instructed residents to be vigilant and ready to evacuate at a moment's notice if the lava flows change direction. but for now, they are just enjoying mauna loa's spectacular show. wendy urquhart, bbc news. in their first international trip since becoming prince and princess of wales, william and catherine will arrive in boston today for the second annual earthshot prize awards ceremony, which is taking place in the city on friday. the prize was launched by prince william to reward environmental innovation and is expected to be a star—studded event.

0ur royal correspondent, daniela relph, reports from boston. it is a first visit to boston for the prince and princess of wales — a three—day trip culminating in the earthshot prize ceremony. william and catherine come here with a sense of history. archive: the royal couple arrived in washington - this afternoon— for their first visit together to the united states. diana was the last princess of wales to visit america. archive: the princess's bright red woollen - suit, with its crystal carrington shoulder line, drew the crowds�* admiration. her star power made a huge impact, but her son and his wife are said to want to carve out their own way of doing things. we have been working on... it is boston that will also be on show this week with the city's mayor as host. iremember growing up as a young girl and in an immigrant family. my mother barely spoke english,

but she followed princess diana every step and just felt so connected. that is the power that i think the royal family has, the legacy. moulding that to this current moment and the actions and the challenge to come together that we really need. boston is, of course, home to american royalty. president kennedy was born here and his family remained strongly connected to the city. we choose to go to the moon. the work and words ofjfk still matter. his moonshot speech in 1962 inspired the whole earthshot vision. we choose to go to the moon in this decade and do- the other things not. because they are easy, but because they are hard. he wanted ambition and urgency in space travel. earthshot shares the same values — fighting climate change. this is an important trip for the prince and princess of wales, both professionally and personally, a chance

to establish themselves in their new roles on a global stage. but it's also the first time they've been to america since the duke and duchess of sussex moved here. there are currently no plans for william and catherine to meet harry and meghan. now boston and beyond are - preparing to welcome the prince and princess of wales. final preparations are under way... for the local media, a royal visit makes headlines. i think people are excited to see them. the places that they've chosen to go show a desire to really interact with bostonians. boston can be a very tough town. people here don't like a phoney. the prince and princess of wales will get to know this city well over the coming days as they take their message stateside. daniela relph, bbc news, boston. chinese astronauts have arrived at the tiangong space station and completed the country's first—ever crew handover in orbit. the new team is expected to

remain in space for six months. the tiangong space station is the centrepiece of beijing's ambitious space programme as it looks to catch up with the us and russia. tom brada reports. as tall as a 20—storey building, china's long march rocket roared into the night sky. on board were three astronauts heading away from earth and towards china's newly—built tiangong space station. translation: announce the shenzhou-15 manned j spacecraft launch mission a complete success. not long after setting off and they'd arrived. tiangong will be the second permanently inhabited outpost in orbit after the nasa—led international space station, and the team already out there were excited to receive visitors, too. the palace in the heavens is looking forward to your arrival.

tiangong is expected to operate for around a decade and run experiments in near—zero gravity. china is not part of the international space station and has been excluded since 2011 after the us banned nasa from interacting with the country. but with this latest mission, there may be more calls for collaboration. the opportunities are, of course, countless, i would say. i mean, all the range of science you can do in low—earth orbit, important for knowledge and improvement of the situation on earth, but also science to prepare for going further, doing the next step, going to the moon, maybe to mars. china's space programme has already put robotic rovers on mars and the moon. this expedition could be another landmark moment as china races to assert itself as the dominant power in space. tom brada, bbc news.

all the top business stories are right here next. strike action taking place across the uk today, we will tell you all you to know. —— all you need to know. hello again. yesterday we had some pretty big temperature contrasts across the uk. western areas had the mildest weather, with temperatures reaching around 12 or 13 celsius with some bright skies. meanwhile, across parts of england, we had low cloud and mist linger all day and that's kept the temperatures pegged back at three. however, i think we've got a much bigger change in our weather patterns taking place over the next seven to ten days. we're going to lose the influence of the atlantic southwesterly winds. and instead we've got a big area of high pressure that's going to build across greenland into next week. and what that will do is it will drive these bitterly cold polar winds across the uk towards the end of next week. and with that comes the threat for some snow, particularly across the hills of northern scotland, so we'll be watching out for signs of a change.

it is seven to ten days off, but it looks like it could get quite cold next week. before we get there, the immediate concern that we have right now is mist and fog. it's certainly quite murky through the welsh marches. across north—east england, visibility has dropped to 100 metres and it's very murky too for parts of scotland, notably around the central belt. for many of you, starting off the day on a frost—free note, but cold for northern scotland where we start off with temperatures around five or six celsius below freezing. now, bear in mind, with that mist and fog around, you might need to leave a little bit of extra time for your early morning journey. and just like yesterday, some of this low cloud and fog willjust lift into mist and loiter across eastern areas. where that happens, temperatures probably staying at around four or five degrees. still for many of you, the weather will brighten up as we head through the day. the mildest weather again across western areas. temperatures again reaching double figures here. now we'll take a look at the weather picture into thursday. we've still got high pressure dominating the scene across england and wales, but these weak weather fronts just bringing the threat of some rain into the far north—west.

some damp weather for mainland scotland. the heaviest rain will be across 0rkney and shetland during thursday. otherwise it's a largely dry picture again with some mist and fog patches to start the day with poor visibility, and things generally turning a bit brighter as we head into the afternoons. temperatures — england and wales about seven to ten celsius, but the mildest weather for west scotland and for northern ireland, 11 or 12 degrees here. however, through friday and the weekend it starts to get cooler, but the really cold air starts to arrive towards the end of next week. we'll be keeping a close eye on developments here.

this is bbc news with the latest business headlines fighting the cost of living crisis — the eu is expected to see a slight drop in inflation, after prices hit a record high last month. 0utperforming its rivals — india's had the fastest—growing major economy this year. its latest economic figures are out shortly, and we'll be crossing live to new delhi for the latest. open for business — with low taxes and a strong focus on developing innovation, we'll tell you why north carolina tops the us start—up scene. and travelex goes on a hiring spree. the firm fell into administration two years ago but has been boosted by the return to travel.

we'll be speaking to its boss shortly.