this is bbc news. i'm rebecca jones with the latest headlines for viewers in the uk and around the world. a teenage girl with seemingly incurable leukaemia is now cancer—free thanks to a revolutionary therapy. heartbreak for england fans as a missed penalty sends harry kane's team packing, losing 2—1 to the reigning champions france. the team are now on their way home. meanwhile, morocco becomes the first african and arab country to reach the semifinals of the football world cup. they will play the defending champions — france — who beat england. authorities in jersey say they are no longer looking for survivors after an explosion that destroyed a block of flats yesterday. they have recovered three bodies so far.

oscar—winning actor reeta moreno has been speaking to bbc 100 women about racial stereotyping and representation in films and tv. and — aiming high, ajapanese company hopes to become the first private operator to land a vehicle on the moon. hello and welcome if you're watching in the uk or around the world. we begin with a world first — a teenage girl's incurable cancer has been cleared from her body using a revolutionary new type of medicine. all other treatments for alyssa's leukaemia had failed. the ground—breaking treatment is known as "base editing" — it involves making genetic changes to donor cells, enabling them to attack her cancer.

our medical editor fergus walsh reports. oh, this one's hard. the whole experience has brought me so much closer with my family. alyssa is back home in leicester thanks to a pioneering new cancer therapy. all other treatment options for her leukaemia had failed. breathe in and breathe out. thank you. that's a good one. so, in may, she received a world first therapy. i know that i've helped other children as well, that other children might be able to get cured because of the research that i've been part in. it is extremely exciting. so, obviously, this is a new field in medicine and it's fascinating that we can redirect the immune system to fight cancer. alyssa's immune system couldn't clear her cancer, so she was given donor cell, which had been tweaked using a new technique called �*base editing'.

in the lab, three precise changes were made to the cells' dna and they were then armed to fight her cancer. base editing is part of a genetic revolution which is transforming our understanding of human biology. it is an incredibly precise tool with huge potential to treat and possibly cure a range of diseases, especially disorders of the blood. ten children with t—cell leukaemia will have the treatment as part of a clinical trial. there's enormous amounts of innovation going on in terms of how we can use these new tools to manipulate and change bits of dna and our applications are to cure diseases, and i think there's enormous potential to do that across the board. # home—grown alligator. # see you later. # gonna hit the road #.

alyssa is still receiving drugs to help herfight infection and she'll have regular hospital checks. for now, cancer is undetectable in her blood. to have had this extra year, even to have this last three months where she's been well and she's been at home and she's been doing what she's wanted, has been... that's like a gift in itself. when you see what she's gone through and the vitality for life that she's brought to every situation is astounding. - and she's got a lot to look forward to. christmas, definitely. my auntie's wedding — i'm going to be her bridesmaid. to go back to school. to hang out with my friends. i want to start riding my bike again, things like that. look at all these beads. there's loads! every one of these beads represents a procedure alyssa has undergone — a collection she's hoping to put away for good. fergus walsh, bbc news. england's footballers are expected to arrive back in the country later today,

after their 2—1 world cup quarterfinal defeat against france in qatar. the reigning champions will now face morocco for a place in the final. let's speak to our sports reporter, john watson who's in qatar. j°y joy for france but what went wrong for england? joy for france but what went wrong for england?— for england? that is the age-old auestion for england? that is the age-old question when _ for england? that is the age-old question when it _ for england? that is the age-old question when it comes - for england? that is the age-old question when it comes to - for england? that is the age-old i question when it comes to england for england? that is the age-old - question when it comes to england in a knockout matches at major tournaments. you can't fault the performance as has been the case in the past, the call has always been vigorous south gate and the players he has at his disposal to play a more attacking style of football and go out fighting which is what they did last night, they had more shots on target and arguably the better opportunities, theyjust came up against a very strong french side who took their chances when they presented themselves and obviously england couldn't do that, having been given the chance from the penalty spot once again, harry kane

missing his second penalty of that much, getting it over the bar. he will be devastated, he set himself a set takes full responsibility as captain of that thing inside and we know harry kane is perhaps not the most vocal players on the pitch, he likes to lead by example and that is easyin likes to lead by example and that is easy in his performances and the goals he scored and he will be bitterly disappointed that he couldn't score the goal that could well have taken that match into extra time and what may well have followed, who knows, we will never know. the question will be asked now of gareth southgate and what his immediate future holds. the most telling thing arguably to come out of last night's showing is a sense of last night's showing is a sense of goodwill and support that has come from the fans, it doesn't always appear that way when england go out of major tournaments. there is perhaps a frustration in the performance or the manner of their exit, there hasn't been that this time. you just have to scan it such a media or any other comments coming out from four players were pundits, all of them fully respect what england have done and have been on board with the way they have gone

about it, there is huge support for gareth southgate and the only person you think it will decide his future is him himself. he said he will reflect on what has played out over the course of the tournament and said it takes a lot out of him personally and emotionally, physically, mentally, as inevitably it will do. he takes on a very presidential role in many ways when he is at a major german like this, the others he has to be with the press, he is having to show the questions over selection, face many difficult questions surrounding some of the great bigger issues at play at this world cup. all the time he handles that very adeptly and astutely and i think he will want some time now perhaps to go home and be with his family before he makes a decision because there is a feeling that england are so close once again, yes, they have gone out of the quarterfinals, not to say finals like the last world cup, such small margins in elite sport, such as these, but i think he will appeal with the support coming from the

fans and his players who are fully behind him, no doubt about that, they said themselves, he will feel that given a little bit of time he will want to come back because the next major tournament, the european championships in germany, just 18 months away now, not a long time, and i think the young players in the side, jude bellingham, at 19 one of the emerging stars of the tournament, bukayo saka who was brilliant last night in winning that penalty, which obviously harry kane took full, phil foden will be instrumental once again when he returns to manchester city, so many of these young players will learn a lot from this experience and just 18 months away now from the next major tournament, the european championships, believe that perhaps they can at long last finally get over the line. there is a sense, an inevitability with thing and that major tournaments, you always feel theyjust major tournaments, you always feel they just lack something major tournaments, you always feel theyjust lack something in those big moments to really get over the line, but perhaps now the future is looking bright and i think that will

be the lasting memory perhaps from the string that, yes, england have gone out of the quarterfinals, it is not a semifinal or a world cup win but it is that unity still between the players and fans just as there was back in 2018 and i think that will surely inspire these fires and gareth southgate and leave them on into the next major tournament. thank you. meanwhile, the viewing figures for last night's match have been published — showing an average audience of 19.1; million tv viewers watched england's defeat to france. the five minute peak was 21 million for the end of the match — it's the most—watched single channel tv moment of 2022 so far. france won the game but there was trouble on the streets of paris after the match. 0ur correspondent hugh schofield told me more. there was riot police on the champs—elysees quite regularly, because they're always

on the ready in case there are crowds that turn violent. yesterday, there were probably 10, 20,000 people, most of it perfectly good tempered, but, and this is quite a regular phenomenon in france, there were elements who decided to take it out on the police and started throwing stones and setting fires. there were 70 or 80 arrests. it sounds a lot, but sadly it is common in france. it mean there is will be a big security presence on wednesday, when morocco/france will be one big game. for all sorts of reasons. of course the semi—final, but the fact there is a moroccan community in france,

the history, colonial memories, this will be a tense moment and the security forces will be alive to the potential for trouble. what has been the reaction across france more widely to the match last night and the win? well, i mean, it goes without saying everyone is delighted and everyone was watching, the figures were 17 million were watching it on tv, it was an exciting match. i think there is a good of respect for the english team and le monde almost implied that england were the better team and that france was lucky to have got away with it, not taking away from the french performance that was in many ways very good as well. there is a feeling that without that failed kick by harry kane towards the end, this could have gone

easily the other way. mbappe was an important player, as always, but not the most important player. what is encouraging is this was a game in which he did not sort of solely leave his mark. the goals were scored by others. he was contained up to a point by the english defence. and that is encouraging in the sense it shows that it is notjust about mbappe and it is a team with plenty of depth as well. well, morocco had an historic victory against portugal to reach the semifinals of the world cup. let's hear from some of the people who were in the stadium for that match — our correspondent in qatar shaima khalil has been speaking to them. there are many ways to describe the atmosphere here. ecstatic, joyful, shocked, euphoric. but one word that would do justice to morocco's performance in defence

presence is the story. this is the first arab and african team to make it to the world cup semifinals. history has been written yet again by morocco's team. the tension was palpable on the pitch and in the stands when the fans chanted go ahead in arabic and until the last minute they held their breath and team belief in many of them are still trying to find ways to describe at that moment really means for them. we came today from morocco and we came this way with my husband. i left my baby, we have a two—month—old baby and we're so happy for the moroccan team, all the muslim world, it is history that we are witnessing. i can't really describe it. it's a mixed feeling.

we're so happy for the victory and so excited for what is coming and hopefully we're going to be getting into the final and what we want now is the cup. we went out here not just to be in the competition, we are here to win. they made us all proud, very proud. we are behind theml until the last minute. we ain't going nowhere. we are not going back. portugal! airport! this way! i want to thank all the arabic countries for their support, for their standing next to us even though they do not speak the same language, they find it a bit difficult but they're asking us how to say it and they were sitting singing moroccan songs.

we were really proud them and we were proud of them and we are proud of our team. it was incredible, - incredible, a lot of emotion and we cried, we cried. this is a huge performance in the world cup history but it is much more than just football, this is a moment of much—needed collective joy across africa and the arab world, for the first time, a team makes it to the semifinals of the world cup, morocco stays and so too the fans. they have changed their ticket, every time morocco one another left to change it again to witness another historic match for their team. the authorities in the channel island ofjersey say they are no longer looking for survivors after the explosion that destroyed a block of flats on saturday. three bodies have been found so far. there were at least nine known residents at the time of the blast, but authorities say as many as 12 could have been killed, as the number of visitors is not clear. the bbc�*s meghan 0wen reports.

candles to mark the lives of those lost, and hope for those still missing. the explosion had thundered over st helier in the early hours of yesterday morning, emergency services were at the scene within minutes. they found a three story block of flats completely flattened. it is a scene of utter devastation. i mean, the building has completely collapsed. it is, it doesn't even look like a building was. smoke stained the skyline of st helier as fire crews helped people from neighbouring buildings. we heard an explosion about four o'clock this morning, 3:30am or 4:00am. we got up, we found that in our flat, all the windows had been put in, the staircase had been damaged. and there was fire everywhere. all available emergency vehicles were sent to the scene. throughout the day and into the night, underfloodlights and in freezing conditions,

the search has continued. local fire crews working alongside specialists flown in from the uk. beyond the rescue, the island has pulled together to help all those affected. jersey is a very close community, it sounds like a cliche, but it is an island community and everybody knows each other here. the team, i have been on the phone a great deal of time today working with various groups of people both in the community, with the police and clergy and others, just trying to co—ordinate an appropriate and helpful response. this is the second tragedy to hitjersey this week, after a ferry collided with a fishing boat on thursday. three men are presumed dead after their vessel sank. just two weeks before christmas, the island is grieving. here in the uk, the health secretary, steve barclay, is being offered the chance to avoid strikes by members of the royal college of nursing in england if he agrees to meet for pay talks. the rcn is due to walk out on the 15th and 20th of december. 0ur political correspondent helen catt gave me this

update. the nurses�* union said they have had many years of below inflation increases and it has left a lot of their members in difficult circumstances. so they are calling for a much bigger rise of 5% over the rp! rate of inflation, which is 14%. that would be a pay rise of 19%. what pat cullen of the rcn has done today is say we will press pause on this action this week if the health secretary will come to the table and talk about pay. this is what she said. 0ur position has not changed, absolutely not, but what i'm saying is the health secretary can choose negotiation over picket lines. my door is open. if he doesn't want to speak

to me in a one—to—one, i'm offering him conciliation through acas and we can start to do that tomorrow morning at whatever time he wants to be available. that is really important. so that was pat cullen calling for talks. the question is, how likely is the government to agree to talks? at the moment it doesn't sound like that is very likely. the health secretary has had talks with the rcn about improving conditions for nhs staff, but on pay it doesn't look like they're going to go there. james cleverley, the foreign secretary, told laura keunssberg why that was. the job of union leadersj is to negotiate on behalf of their members, they do an importantjob but theyl negotiate with their employers . and in this instance the employer is the nhs. now, the... throughout my time in politics-

i have always been told with things like the nhs and these kind i of things, people want to take the politics out, which is why we have the independent- pay review body. now people want to bring the politics back in. - james cleverley mentioned the independent pay review body, there are those for a number of areas and they recommend to the government what the pay rise should be. the government say we have accepted their recommendation and we won't get involved in talks. labour are saying, hang on, the rcn is putting this offer on the table to stop the action, it is an open goal for the government to do that. labour's shadow health secretary wes streeting was pressed on whether or not if labour were in power they would be agreeing to a 19% pay rise. we would be prepared to talk about pay, terms and conditions

and conditions and the way the pay review body works. the staff who are going on strike feel their backs are against the wall. would you give them more money? we would be willing to talk, but i would not create a hostage to fortune for a labour government, the worst thing i could do is make promises we can't keep. when i come on programmes and say we are going to deliver the biggest expansion of staff in nhs history, it is because i'm confident of keeping it. i would be prepared to negotiate if we were in government today. and in the newspapers he indicated the labour party couldn't afford that rise and found himself in a clash with a health union, the doctors' union, in the newspaper, he is quoted as saying the nhs shouldn't be treated like a shrine

and he criticised the bma for his response when he said the nhs needed reform. he said they were treating him like a heretic. now it's time to turn to our 100 women series — and meet the oscar—winning actress reeta moreno. perhaps best—known for the role of anita in the 1961 film west side story — but now, at the age of 90, she's speaking out about racial stereotyping and representation in films and on tv. 0ur correspondent nomia iqbal went to meet her. when i could understand what movies were, i wanted to be a movie star. that was the word, not an actress but a movie star. and i still hear that among very young people and i said to them, oh, let me tell you a few things. you went to hollywood during the golden age of cinema. and you were bigger than life.

when i got my contract at mgm studios, which was the studio of my dreams because that was the studio that made all the great musicals and when i met mr louis, can you imagine what that meant to this 15, 16—year—old girl? the men who produced all of those great mgm musicals and they wanted me to sign a contract with them? it was just unbelievable. unbelievable. they did not know what to do with me because my name was rosita dolores alvario. they changed it to rita moreno. what was that like? because these people have your career in their hands. in their hands, ifelt like a prisoner in their hands and it really

worried me because i was one of those kids that was just afraid to say no to anything. i'm sure you've lost count of some of the racist encounters that you had in the industry, notjust being stereotyped, being puerto rican. tell me what that was like. i was always an island girl. and it seemed just fine at first and then it began to occur to me that that would limit me quite a bit because normally, those kinds of people have accents and almost always the makeup was dark and that went all the way up to west side story. any actress that plays anita is compared to you, how do you feel about that? i can't tell you how i feel about that. i suppose it is inevitable. i did win some wonderful awards, i won the oscar, of course.

and, yes. you were called the pioneer in the community. la pionera. i think of other people who have come after you who were as famous and notable as you and they are not a lot. it is better but we are seriously underrepresented in the hispanic community which is shocking to me, i'm very upset about it. there should be more of you. there should be so many more of me and then some. it is still difficult. and it breaks my heart. i not only feel it, but i see in how i am employed and what kind of films, the quality of the films that are offered to me, i am still in that bind. and it is not in any way that i mind playing a hispanic, it is the kind of hispanic.

i would've gotten farther, which is my deepest regret, had it not been for the fact that i'm hispanic. i would've had a different career. i know it. you are watching bbc news. as the temperatures in the uk drop, mountain rescue teams are bracing themselves for a busy few months. volunteers in cumbria, in north west england, say around 30% of rescue call—outs are avoidable. it comes as the lake district's fell top assessors have restarted their work. every day in winter they walk to the top of helvellyn mountain to provide data about the conditions, warnings which many walkers disregard. jonathan swingler reports. the hills are definitely a lot busier and we are seeing a lot more things that make us wince.

seeing something on social media does not necessarily give a whole picture of what it is like to get to that place, what the conditions could be like when they get there and what could happen if it actually goes wrong. every day from now until easter, the fell topp assessors head up helvellyn. we're not fell top policeman, but we are providing information to give people information to keep them safe on the fells. it is very deceptive as well, when we set off today from the car park, you can see the tops of the hills, you could see there quite clearly, then we come up here and you look around here, the cloud is very low and the summits themselves are all in the clouds. unfortunately, 2021 was a record—breaking year. the mountain rescue teams were called out almost 700 times. i think it's going to get worse before it gets better. i think we will have more callouts

before we can get the education message out there completely. approximately 30% of our callouts could be avoidable. we are encouraging people to plan theirjourneys ahead. we do see people scrabbling around on steep icy slopes, without grapples and ice axes. there is a steep slope and then a 200—foot cliff at the bottom, and they're just not... that lack of imagination, about what could happen if things went wrong. we see it all the time. you know, i followed a couple along striding edge in full winter conditions and they were injeans and trainers. a day like this is going to be pretty slick, sort of damp atmosphere. even on christmas day, you will find a fell top assessor making the journey up here. they take vital measurements to give us an idea of what to expect. 0n clear days, at over 3000 feet, they can capture some of these stunning views. i'm notjust going to get my camera out anywhere to take a photo, because i'm looking down a lot, i know places where i can get my camera out and do that safely without risk of falling off.

last christmas was described as absolutely chaotic by the mountain rescue teams. know when to turn back. the hill will always be here for another day. if you get into conditions you're not comfortable with, always turn back. now it's time for a look at the weather with helen. hello. some have woken to the first dusting of snow of the season and snow showers are being warned of throughout the rest of today and overnight tonight. freezing fog, as well, has been more extensive and of course, the ice. all the details on the website. so the snow will continue to fall across parts of the north—east of england, parts of south—east scotland, northern scotland throughout the rest of the day. one or two flurries across central areas, but the freezing fog slow to clear. it will be colder than yesterday, temperatures struggling

to get to freezing. 0vernight, another widespread frost, but concerns for the first dusting of snow across south—eastern areas, particularly kent, essex, sussex, but we could see some of that push north into east anglia and across towards 0xfordshire, as well. around the london region, perhaps a dusting here by morning. a bitterly cold night, —12 over the highland glens of scotland over the snow cover. so still a few wintry flurries around across southern and eastern areas, pushing towards the midlands, east anglia as well. freezing fog again an issue and another very cold day tomorrow. hello this is bbc news. a teenage girl with seemingly incurable leukaemia is now cancer—free thanks to a revolutionary therapy. heartbreak for england fans as a missed penalty sends harry kane's team packing, losing 2—1 to the reigning champions france. the team are now on their way home.

meanwhile, morocco becomes the first african and arab country to reach