voice-over: this is bbc news. we'll have the headlines and all the main news stories for you at the top of the hour, straight after this programme. at first glimpse, it is a typical training session but these both our wearing kids made from recycled materials. right from the start they were not great solutions but now we can get to that they we can see

these lads running around just fantastic. these lads running around 'ust fantastic. �* , ., , fantastic. and it is not 'ust the clothing. i fantastic. and it is not 'ust the clothing. there h fantastic. and it is not 'ust the clothing. there is h fantastic. and it is notjust l the clothing. there is plastic everywhere, water bottles, shinpads, the bids are made of polyester, and even if the banks themselves, they are made of plastic. birmingham county fa have already won awards for their initiatives on plastics, with 80,000 plays, they can make a big difference. over time, make a big difference. over time. the — make a big difference. over time, the messages - make a big difference. over| time, the messages starting make a big difference. over i time, the messages starting to get through and people see the benefits in making the game more sustainable. long journeys start with small steps. hi, i'mjack, with the catch up. we are going to talk politics because the deputy prime minister and justice secretary dominic raab design today after this report was published into his behaviour around the people

he worked with. an investigation was launched last year because those people made a series of appalling allegations which he denies. it is pretty complicated but these are some of the main points. during a meeting as foreign secretary he acted in an intimidating way, the report found. that word was used again about how we gave feedback as justice secretary and he won't describe some work as utterly useless. but the report did not find abuse or misuse of power when he was brexit secretary and no persuasive evidence that he shouted at people. so if the report did not call for him to resign, why did he? because i said i would. _ resign, why did he? because i said i would. i— resign, why did he? because i said i would. i am _ resign, why did he? because i said i would. i am true - resign, why did he? because i said i would. i am true to - resign, why did he? because i said i would. i am true to myl said i would. i am true to my weight and politicians should be but i do think it's that a very dangerous precedent. the prime minister _ very dangerous precedent. the prime minister accepted his resignation with great sadness and the lip of the labour party said this. , ., .,

said this. the question for the prime minister _ said this. the question for the prime minister is, _ said this. the question for the prime minister is, why - said this. the question for the prime minister is, why he - said this. the question for the prime minister is, why he wasj prime minister is, why he was so weak to appoint him in the first place. the second question is why he did not sack him and now it is left to dominic raab to resign. with mr rub out of _ dominic raab to resign. with mr rub out of the _ dominic raab to resign. with mr rub out of the place, _ dominic raab to resign. with mr rub out of the place, there - dominic raab to resign. with mr rub out of the place, there is - rub out of the place, there is a new deputy pm and secretary. we leave you with ten seconds of island living. forget animal crossings, you can buy your very own island for realjust off the coast of scotland. there is no electricity or running water and you would be the only person living there. it is up for 150 grand. i will see you there, by. from the

moment we arrive on this planet we are heading in the same direction. n we are heading in the same direction-— we are heading in the same direction. _, _, , direction. i could come up with a date predicting _ direction. i could come up with a date predicting when - direction. i could come up with a date predicting when you - direction. i could come up withj a date predicting when you will die. ~ ., , , die. well, thanks, but may be the way the — die. well, thanks, but may be the way the years _ die. well, thanks, but may be the way the years play - die. well, thanks, but may be the way the years play out - die. well, thanks, but may be the way the years play out is l the way the years play out is not inevitable. so how about the idea of being able to increase our health span, live the better years of our life along until we are a0 or 60. there is a 15—17 years of healthy life that is up for grab for all of us. we headed to california _ grab for all of us. we headed to california to _ grab for all of us. we headed to california to meet - grab for all of us. we headed to california to meet the - to california to meet the scientists and founders who want to make it a reality. ageing by itself is the largest risk factor for every single disease, chronic disease so by targeting it, you target all disease together. but targeting it, you target all disease together. targeting it, you target all disease touether. �* ., ., disease together. but how do we se arate disease together. but how do we separate sides _ disease together. but how do we separate sides from _ disease together. but how do we separate sides from snake - disease together. but how do we separate sides from snake oil? l separate sides from snake oil? the longevity industry is worth

billions, with hopes of delaying disease extending out sprightly years and maybe even throwing in a few extras. it is throwing in a few extras. it is a system _ throwing in a few extras. it is a system of _ throwing in a few extras. it is a system of science - throwing in a few extras. it is a system of science and - throwing in a few extras. it 3 a system of science and data run at my body and it does a betterjob taking care of me than i can. betterjob taking care of me than i can-— than i can. maybe even our furry friends _ than i can. maybe even our furry friends can _ than i can. maybe even our furry friends can be - than i can. maybe even our furry friends can be with i than i can. maybe even our furry friends can be with usj furry friends can be with us for longer. and the things some people will do to stay young! do you consider yourself a guinea pig?— do you consider yourself a guinea pig? no, i do not. i consider— guinea pig? no, i do not. i consider myself _ guinea pig? no, i do not. i consider myself to - guinea pig? no, i do not. i consider myself to be - guinea pig? no, i do not. i consider myself to be an i consider myself to be an explorer on the frontiers, trying to find out what is possible. trying to find out what is possible-— trying to find out what is ossible. . ~ , possible. take entrepreneur brian johnson _ possible. take entrepreneur brian johnson is _ possible. take entrepreneur brian johnson is spending i brian johnson is spending millions brianjohnson is spending millions trying to turn back time on his body. i

millions trying to turn back time on his body.— millions trying to turn back time on his body. i refer to m self time on his body. i refer to myself as _ time on his body. i refer to myself as a _ time on his body. i refer to myself as a professional i myself as a professional rejuvenation athlete. it is a new spot i want to create. i'm not a bio hacker, health enthusiast, i am a professional rejuvenation athlete. i enthusiast, i am a professional rejuvenation athlete.— rejuvenation athlete. i love it. rejuvenation athlete. i love it- working _ rejuvenation athlete. i love it. working with _ rejuvenation athlete. i love it. working with a - rejuvenation athlete. i love it. working with a team - rejuvenation athlete. i love it. working with a team ofl rejuvenation athlete. i love l it. working with a team of 30 scientists, his daily life is dictated by an extreme regime of fitness, diet, tablets, tracking and treatments. i am 45 ears tracking and treatments. i am 45 years old. _ tracking and treatments. i am as years old, biologically - tracking and treatments. i am as years old, biologically i - a5 years old, biologically i am... my heart is 37, diaphragm, 18 and i am trying to become like an 18—year—old. my to become like an 18—year—old. my son is 17 so i was teasing and say when i grow younger i want to be like you.— want to be like you. where is he taking _ want to be like you. where is he taking me? _ want to be like you. where is he taking me? where - want to be like you. where is he taking me? where to - want to be like you. where is| he taking me? where to start want to be like you. where is i he taking me? where to start in

here! ~ . , , , here! what is this? this is hiih here! what is this? this is high frequency _ here! what is this? this is - high frequency electromagnetic assimilation. we got this machine because we were trying to solve a problem. every night i was getting up one time per night to go to the bathroom. that is actually normal but when i did they produce less quality sleep. i wanted to see if i could get up zero times so we got this machine to trial whether we could strengthen my pelvic floor and bladder so i did not have to get up to go to the bathroom at night. [30 did not have to get up to go to the bathroom at night.- the bathroom at night. do you want to try — the bathroom at night. do you want to try it? _ the bathroom at night. do you want to try it? is _ the bathroom at night. do you want to try it? is it _ the bathroom at night. do you want to try it? is it going - the bathroom at night. do you want to try it? is it going to i want to try it? is it going to vibrate or something? a, want to try it? is it going to vibrate or something? a lot of women use — vibrate or something? a lot of women use this _ vibrate or something? a lot of women use this after - vibrate or something? a lot of women use this after having i women use this after having babies to rebuild the strength of the pelvic floor. this is basically stimulation. i'm going to turn it on and the feeling is going to be a little foreign and it might be shocking initially.- foreign and it might be shocking initially. ok. it is like pins — shocking initially. ok. it is like pins and _ shocking initially. ok. it is like pins and needles. - shocking initially. ok. it is like pins and needles. it. shocking initially. ok. it is like pins and needles. it is sort of tickling but in a quite

hard and oppressive way. how long do you need to do it for? this session is 30 minutes. if. this session is 30 minutes. is this one of those devices that measures the age of your skin? how is it yours? with me we have made 22 years of progress of reversing my skin. you get about ten reports on poor size, uv spots. is there other help as well? we have some lasers. there are no injections? that's right. this tells you the health of your cardiovascular system. if you want to try it, you can put your arm on it and it will tell you your age. the ideal school would be around two. ideal school would be around two, ideal school would be around two. ., ., , two. so i am only a little bit too old for _ two. so i am only a little bit too old for my _ two. so i am only a little bit too old for my age. - two. so i am only a little bit

too old for my age. this - two. so i am only a little bit too old for my age. this is l two. so i am only a little bit. too old for my age. this is an ultrasound _ too old for my age. this is an ultrasound machine. - too old for my age. this is an ultrasound machine. this - too old for my age. this is an ultrasound machine. this is l ultrasound machine. this is what you see in a hospital. shire what you see in a hospital. are ou what you see in a hospital. are you having _ what you see in a hospital. are you having a — what you see in a hospital. are you having a baby? who knows with what you're getting up to! tendons, ligaments, everything, it is really a useful technology to have in cleaning to do on a basis.— to do on a basis. how do you feel before _ to do on a basis. how do you feel before you _ to do on a basis. how do you feel before you do _ to do on a basis. how do you feel before you do any - to do on a basis. how do you feel before you do any of- to do on a basis. how do you| feel before you do any of this tracking? it feel before you do any of this trackin: ? , . ., feel before you do any of this trackini? , . ., .. tracking? it is again. some of my happiest _ tracking? it is again. some of my happiest days _ tracking? it is again. some of my happiest days are - tracking? it is again. some of my happiest days are when i tracking? it is again. some of| my happiest days are when we tracking? it is again. some of - my happiest days are when we do these measurement days. what my happiest days are when we do these measurement days. what is our these measurement days. what is your motivation? _ these measurement days. what is your motivation? are _ these measurement days. what is your motivation? are you - these measurement days. what is your motivation? are you doing i your motivation? are you doing this for yourself or humanity? when i was 21 years old i decided that i wanted to spend my life doing something meaningfulfor the my life doing something meaningful for the world. my life doing something meaningfulfor the world. i meaningful for the world. i decided meaningfulfor the world. i decided to make a whole bunch of money and by the age of 30 decide what to do. since i sold my company, i made $300 million and the question was, what could i do that would matter in

the year 2500 and right now it could be ageing. if we slow the speed of ageing or even reverse it, it would change what it means to be human. [30 it, it would change what it means to be human. do you think ou are means to be human. do you think you are risking — means to be human. do you think you are risking your _ means to be human. do you think you are risking your health - you are risking your health here in all the things you're doing to protect it? certainly, there is always _ doing to protect it? certainly, there is always risks - doing to protect it? certainly, there is always risks but - doing to protect it? certainly, | there is always risks but there is potentially an argument that we are being more safe than anyone else because we have the rigour of measurement.— rigour of measurement. while the bright _ rigour of measurement. while the bright side _ rigour of measurement. while the bright side his _ rigour of measurement. while the bright side his life - rigour of measurement. while the bright side his life away i the bright side his life away to experimentation, i visit the world's first institute for ageing research.- ageing research. these scientists _ ageing research. these scientists are _ ageing research. these scientists are working | ageing research. these l scientists are working on ageing research. these - scientists are working on drugs they hope could delay age—related disease. i have two of my postdocs. age-related disease. i have two of my postdocs— of my postdocs. would you say there has _ of my postdocs. would you say there has been _ of my postdocs. would you say there has been huge _ of my postdocs. would you say i there has been huge advancement in the field of make is there such a sub trade for

investment?- such a sub trade for investment? ,. . ., , investment? the science has matured in — investment? the science has matured in terms _ investment? the science has matured in terms of- investment? the science has matured in terms of where l investment? the science hasl matured in terms of where we have been doing this for close to 30 years, understanding the basic tokenism of ageing. the site needs are there, you have a rapidly ageing population and the burden of chronic disease. this place is huge, one of about 20 labs. three, two, one, squeeze. it is notjust drugs and supplements being put through their pacey, it also exercise. through their pacey, it also exercise-— through their pacey, it also exercise. ., . ., .. exercise. how much, how often, aerobics. — exercise. how much, how often, aerobics, anaerobic, _ exercise. how much, how often, aerobics, anaerobic, lifting - aerobics, anaerobic, lifting weight, balance, swimming, which one of these interventions works the best? but one really important discovery was the ability to

reduce what are called senescent cells. these zombie cells and play a useful role in a lifetime but as we age, we acquire many more and as they also lead to inflammation, that increased number and is up providing a hotbed for cancer and all sorts of disease. so biotech companies are trying to create drugs that will reduce that cellular senescence. i can that cellular senescence. i can try to understand _ that cellular senescence. i can try to understand what - that cellular senescence. i can try to understand what types | that cellular senescence. i can | try to understand what types of cells are missing.— cells are missing. unity is usini cells are missing. unity is using this _ cells are missing. unity is using this site _ cells are missing. unity is using this site and - cells are missing. unity is using this site and has i using this site and has achieved a small early—stage clinical trials for a injection to treat macular degeneration which is failing eyesight that glasses cannot fit. i which is failing eyesight that glasses cannot fit.— glasses cannot fit. i can visualise _ glasses cannot fit. i can visualise facially - glasses cannot fit. i can visualise facially where l glasses cannot fit. i can i visualise facially where the cells reside.—

visualise facially where the cells reside. once you get rid of one of these _ cells reside. once you get rid of one of these cells, - cells reside. once you get rid of one of these cells, it i cells reside. once you get rid of one of these cells, it is i of one of these cells, it is gone _ of one of these cells, it is gone. this would be a small number— gone. this would be a small number of treatments over a iimited — number of treatments over a limited amount of time. what are the things _ limited amount of time. what are the things we _ limited amount of time. what are the things we started i limited amount of time. what are the things we started to l are the things we started to sing, because the fda will not approve drugs for anti—ageing, sages are looking for problems to solve. , . ., , to solve. kidney diseases, liver diseases, _ to solve. kidney diseases, liver diseases, all - to solve. kidney diseases, liver diseases, all of i to solve. kidney diseases, j liver diseases, all of these are diseases that are more prevalent as we get older, to the extent that they have a basis of cellular senescence and these ages could have applicability in other diseases.— applicability in other diseases. . . .. diseases. what have you got here? it looks _ diseases. what have you got here? it looks like _ diseases. what have you got here? it looks like it - diseases. what have you got here? it looks like it is i here? it looks like it is connected to an eye? yes we get normalised — connected to an eye? yes we get normalised and _ connected to an eye? yes we get normalised and diseased - connected to an eye? yes we get normalised and diseased eyes. i normalised and diseased eyes. we can section the eye, a

cross—section of it and put it on a microscope slide. here we are testing different drug candidates on animal models. does the drug inhibit or get rid of it once it is formed? its, rid of it once it is formed? a lot of mass trials have not translated well into humans? irate translated well into humans? we believe it translated well into humans? , believe it translates comparatively well compared to a tumour in a human. i think it is quite cool.— a tumour in a human. i think it is quite cool. but maybe we are missin: is quite cool. but maybe we are missing something. _ is quite cool. but maybe we are missing something. lifestyle i is quite cool. but maybe we are missing something. lifestyle is| missing something. lifestyle is responsible _ missing something. lifestyle is responsible for _ missing something. lifestyle is responsible for about - missing something. lifestyle is responsible for about 9396 i missing something. lifestyle is responsible for about 9396 of i responsible for about 93% of your longevity. 0nly responsible for about 93% of your longevity. only 7% on your genetics so you cant blame your parents. a lot of exercise, some fasting, good sleep, a lot of social connection, very little alcohol, try to spend at least 1a hours of your 2a—hour day without ingesting any

calories. based on the data, i would predict that most people could live to 95 in good health if they did all of the things that we know would promote a healthy lifespan. if they work, why do we need to deal with this bigger picture? this is still going to happen, hopefully if you exercise, it's going to be delayed by ten, 15, 20 years. i don't mean to be saying that lifestyle intervention needs to be done, there is a need for science for there is a need for science for the future. there is a need for science for the future-— the future. what that thing where people _ the future. what that thing where people do _ the future. what that thing where people do where i the future. what that thing l where people do where they the future. what that thing i where people do where they sit on the floor and try to get up without using their hands? whatever eric has been doing seems to be working. this is supposed to be some sort of sign abusive you can stand up by not using your hands. how can anyone do that, putting your feet down, can anyone do that, putting yourfeet down, how can anyone do that, putting your feet down, how is that possible? how do you do that? i don't know. i think—

possible? how do you do that? i don't know. i think it _ possible? how do you do that? i don't know. i think it means i don't know. i think it means ou are don't know. i think it means you are under _ don't know. i think it means you are under 20 _ don't know. i think it means you are under 20 or- don't know. i think it means i you are under 20 or something. i can't do it! our you are under 20 or something. i can't do it! 0urfurry friends get their paws at a life extending pill first though. life extending pill first thou:h. .. �* life extending pill first though-— life extending pill first thou:h. .. . life extending pill first thou:h. ., . . though. you'll notice there are no larie though. you'll notice there are no large dogs _ though. you'll notice there are no large dogs here, _ no large dogs here, great stands, because they have a dogs of six, seven, eight, nine years, almost half of what a little guy — little go like this could be expected to have. the short lifespan of big dogs is a disease. we are a senior dog rescue, and when we take a dog rescue, and when we take a dog like a great dane for instance, there five years old,

already starting to age so much, and it would be like a miracle cure if we could have something that does live longer and lives as long as these are small dogs. m5 and lives as long as these are small dogs-— and lives as long as these are smalldois. m . �*. small dogs. ms robinson, that's for ou. small dogs. ms robinson, that's for you. where _ small dogs. ms robinson, that's for you. where are _ small dogs. ms robinson, that's for you. where are you - small dogs. ms robinson, that's for you. where are you at i small dogs. ms robinson, that's for you. where are you at now. for you. where are you at now with the trail? _ for you. where are you at now with the trail? we _ for you. where are you at now with the trail? we are - for you. where are you at now with the trail? we are kicking| with the trail? we are kicking off a big. _ with the trail? we are kicking off a big, pivotal— with the trail? we are kicking off a big, pivotal study, i off a big, pivotal study, trying to understand does our drug extend the life span and quality of life? it's an inhibitive drug that inhibits the protein that we believe drives dogs to age faster. and have everything goes to plan we will have a drug on market in 2025. ii will have a drug on market in 2025. , . . , , , will have a drug on market in 2025. ,.. ,, 2025. if successful, this could hasten a solution _ 2025. if successful, this could hasten a solution for - 2025. if successful, this could hasten a solution for humans| 2025. if successful, this could i hasten a solution for humans as well. has there been any sort of scientific breakthrough that has made possible what you are trying to do?— trying to do? people don't realise that _ trying to do? people don't realise that there - trying to do? people don't realise that there have i trying to do? people don't i realise that there have been hundreds of drugs that are shown life expansion, health expansion in mice, but you can't develop a drug just for a

pure logistical standpoint. decades before i find out that your have a lifespan. dogs have a similar environment to us and they also develop age—related diseases as we do, so if the drug works in a dog, it is not i-to-i drug works in a dog, it is not 1—to—1 as any human but is much more likely versus we do a lot of research in mice that does not translate out all. ’ not translate out all. ' humans, and if we want to reduce the age that our bodies seems rather than is, then we need to find a way to measure it. i was really put through my paces with this test, assessing my baseline, then pushing me to my baseline, then pushing me to my physical limits. was this really necessary...?

my physical limits. was this really necessary. . . ?- really necessary. . . ? really nice guy. _ really necessary. . . ? really nice guy. you _ really necessary. . . ? really nice guy. you got - really necessary. . . ? really nice guy, you got this! i really necessary. . . ? reallyl nice guy, you got this! good job. nice guy, you got this! good 'ob. �* . , .. nice guy, you got this! good 'ob. �* . , ., .~ nice guy, you got this! good 'ob. �* . , ., . job. i'm ready to take that off! i've — job. i'm ready to take that off! i've recovered - job. i'm ready to take that off! i've recovered so i job. i'm ready to take that off! i've recovered so how| job. i'm ready to take that i off! i've recovered so how fit and my?— off! i've recovered so how fit andm? ., . and my? you've done a really nice job. _ and my? you've done a really nice job. a — and my? you've done a really nice job, a nice _ and my? you've done a really nice job, a nice test. - and my? you've done a really nice job, a nice test. at i and my? you've done a really nice job, a nice test. at least| nice 'ob, a nice test. at least i nice job, a nice test. at least i discovered _ nice job, a nice test. at least i discovered at _ nice job, a nice test. at least i discovered at the _ nice job, a nice test. at least i discovered at the end i nice job, a nice test. at least i discovered at the end that i j i discovered at the end that i have a fitness age of 36, seven years lower than my years. but there is an easier way, if you drops of blood and this scientist's invention, known as the epigenetic clock can assess my biological age and possibly the date of my demise.- my biological age and possibly the date of my demise. there is this rim the date of my demise. there is this grim age — the date of my demise. there is this grim age which _ the date of my demise. there is this grim age which is _ the date of my demise. there is this grim age which is out i the date of my demise. there is this grim age which is out best i this grim age which is out best mortality predictor and unfortunately mortality predictor and u nfortu nately you mortality predictor and unfortunately you are a little bit older than you should be, it says a9 years. bit older than you should be, it says 49 years.— it says 49 years. that's unfortunate! _ it says 49 years. that's unfortunate! is - it says 49 years. that's unfortunate! is a i it says 49 years. that's unfortunate! is a very i unfortunate! is a very important _ unfortunate! is a very important to - unfortunate! is a very important to have i unfortunate! is a very important to have a i unfortunate! is a very i important to have a sense of humour when one looks at these reports. i could come up with a

date almost predicting when you were today. date almost predicting when you were today-— were today. when you think it is iioin were today. when you think it is going to — were today. when you think it is going to occur, _ were today. when you think it is going to occur, according i were today. when you think it j is going to occur, according to this? ~ .. �* is going to occur, according to this? ~ ., �* , .,, this? we don't give people this. this? we don't give people this- itut — this? we don't give people this. but you _ this? we don't give people this. but you know, - this? we don't give people this. but you know, you i this? we don't give people i this. but you know, you know the answer — this. but you know, you know the answer to _ this. but you know, you know the answer to this _ this. but you know, you know the answer to this question? | this. but you know, you know| the answer to this question? i have a way calculated. tell i the answer to this question? i i have a way calculated. tell me! no, i have a way calculated. tell me! no. i won't. — have a way calculated. tell me! no, iwon't, and _ have a way calculated. tell me! no, i won't, and the _ have a way calculated. tell me! no, i won't, and the reason i have a way calculated. tell me! no, i won't, and the reason is i no, i won't, and the reason is things change, people develop healthy habits or bad habits, bad luck, so it's essentially not very informative for you. you can't even tell me the likelihood of which illness it is, it isjust likelihood of which illness it is, it is just that my body is aiding a bit faster? i don't want to go back to this, but it's a bit concerning. the question _ it's a bit concerning. the question is _ it's a bit concerning. the question is really - it's a bit concerning. the question is really why. i it's a bit concerning. ike: question is really why. we it's a bit concerning. iie: question is really why. we have a lot of good news for you. i wanted to start with the bad news. look at that, your female age is 36.5, seven years younger than expected. white maximo biological age is 36, my

chronological age is 43, and my disease risk is a lot higher thanit disease risk is a lot higher than it should be... i won't worry too _ than it should be... i won't worry too much _ than it should be... i won't worry too much though, i than it should be... i won'tl worry too much though, it's very early days for these tests. how about this one? in fact i keeping my spirits up and i am after longevity meet up. a these brainy scientists living the longevity lifestyle? there are still unopened bottles of wine, so probably! tonight we had a longevity friendly mix of food, seaweed and so on. friendly mix of food, seaweed and so om— and so on. other parts of the industry have _ and so on. other parts of the industry have not _ and so on. other parts of the industry have not been - and so on. other parts of the industry have not been quite| and so on. other parts of the i industry have not been quite so wholesome though. in industry have not been quite so wholesome though.— wholesome though. in four decades there _ wholesome though. in four decades there has - wholesome though. in four decades there has been . wholesome though. in four decades there has been a i wholesome though. in four. decades there has been a lot wholesome though. in four- decades there has been a lot of snake oil, a lot of miracle pills, the god all of this stuff. a , pills, the god all of this stuff. , ., pills, the god all of this stuff. , . , pills, the god all of this stuff. . , ,, . stuff. many have been desperate to believe. _ stuff. many have been desperate to believe, just _ stuff. many have been desperate to believe, just ask— stuff. many have been desperate to believe, just ask this - to believe, just ask this leading silicon valley doctor.

i don't know why people want to gamble with their health. i understand gambling with money, if it is safe and not effective like abatement, some maintenance, then you are gambling with your money but if it is not proven safe, and it is not proven effective you are gambling with your health, and then there are people spending a lot of time doing these things and they are not living their life, they are living the version of their life to give themselves a future life, but what happens if the future life never materialises? the repurposing _ never materialises? the repurposing of - never materialises? the repurposing of current l never materialises? the repurposing of current jugs repurposing of currentjugs might hold some promise to preventing age—related disease and some don't even want to wait for the clinical trials. especially in silicon valley amongst techies, it's hard to find somebody who isn't taking metformin, this diabetic drug that these people are not diabetics and they are typically quite healthy, but they have seen some of the studies and even though it has not been approved as an

anti—ageing drug, they are taking it, the same with others, so you have a lot of people who are going off book, going doctor shopping, looking for those doctors that will give them the pills that might be for something else but have shown an effect on extending life in animals. i shown an effect on extending life in animals.— shown an effect on extending life in animals. i get asked by ounu life in animals. i get asked by young men — life in animals. i get asked by young men in _ life in animals. i get asked by young men in their _ life in animals. i get asked by young men in their 40s, - life in animals. i get asked by l young men in their 40s, should i take _ young men in their 40s, should i take metformin. young men in their 40s, should itake metformin. and my young men in their 40s, should i take metformin. and my first question— i take metformin. and my first question is are you ready to lose — question is are you ready to lose half— question is are you ready to lose half of your testosterone? there _ lose half of your testosterone? there are — lose half of your testosterone? there are no medicines without side _ there are no medicines without side effects. there are no medicines without side effects-— side effects. the good news with all these _ side effects. the good news with all these blood - side effects. the good news with all these blood tests, | with all these blood tests, breath tests, urine tests, wearables, apps, there are so many things that attract things so if you really want to, like if you are overweight and have high blood pressure, and you love your wine and your life, but you want appealed to make you live long, guess what? you cannot stop win with your hands. i5 cannot stop win with your hands. , , , hands. is probably getting close to this _ hands. is probably getting close to this last - hands. is probably getting i close to this last bedtime, they really value sleep. i want

to wake uo — they really value sleep. i want to wake up naturally, - they really value sleep. i want to wake up naturally, becausei to wake up naturally, because your cortisol levels, which is your cortisol levels, which is your stress hormone go down as your stress hormone go down as you sleep and right when you wake up a spike. ads, you sleep and right when you wake up a spike.— you sleep and right when you wake up a spike. a lack of good sleep good _ wake up a spike. a lack of good sleep good disrupt _ wake up a spike. a lack of good sleep good disrupt them - wake up a spike. a lack of good sleep good disrupt them and i wake up a spike. a lack of good sleep good disrupt them and in| sleep good disrupt them and in turn lead to unnecessary information and a higher risk of disease.— of disease. it's like ageing, so ou of disease. it's like ageing, so you want _ of disease. it's like ageing, so you want to _ of disease. it's like ageing, so you want to do - of disease. it's like ageing, l so you want to do everything you can to decrease the inflation in your body. the pills and supplements and the cryo and all this stuff, they tout it does that, but show me the measurements outside of people saying i feel better. because by the way, placebo, people feel better and i'm not saying that is placebo because there is lots of interesting science in there.— there is lots of interesting science in there. whether pills or procedures _ science in there. whether pills or procedures are _ science in there. whether pills or procedures are proven - science in there. whether pills or procedures are proven or. or procedures are proven or not, there are a whole lot of people who are really upset — obsessed. some of this stuff seems a bit cultlike, this stuff. , . ~ . , stuff. very cultlike and i try

to protect _ stuff. very cultlike and i try to protect my _ stuff. very cultlike and i try to protect my people - stuff. very cultlike and i try l to protect my people against that colt aspect. irate to protect my people against that colt aspect.— to protect my people against that colt aspect. we try not to let it become _ that colt aspect. we try not to let it become that _ that colt aspect. we try not to let it become that way. - that colt aspect. we try not to let it become that way. there | let it become that way. there is one issue _ let it become that way. there is one issue that _ let it become that way. there is one issue that none - let it become that way. there is one issue that none of- let it become that way. there is one issue that none of this| is one issue that none of this can resolve though. in is one issue that none of this can resolve though.- can resolve though. in the united states _ can resolve though. in the united states the - can resolve though. in the united states the single i united states the single biggest determiner of your life expectancy is your postcode, where you live. that is a problem that cannot be engineered.— problem that cannot be engineered. problem that cannot be enuineered. . , . engineered. once drugs are developed. _ engineered. once drugs are developed, will _ engineered. once drugs are developed, will they - engineered. once drugs are developed, will they not. developed, will they not further enhance the inequality, because he was going to access the drugs and when? the model, the drugs and when? the model, the wa it the drugs and when? the model, the way it works, _ the drugs and when? the model, the way it works, the _ the drugs and when? the model, the way it works, the drugs - the way it works, the drugs become a valuable if they actually are demonstrated to be valuable to insurance companies, and we expect the same thing to happen with all drugs that will be developed together. 50 drugs that will be developed touether. ., , , together. so where does this leave us? — together. so where does this leave us? there _ together. so where does this leave us? there is _ together. so where does this leave us? there is exercise, | leave us? there is exercise, but... . , , . leave us? there is exercise, but... ., , . . . but... exercises hard, magic ills but... exercises hard, magic pills are _ but... exercises hard, magic pills are easy. _ but... exercises hard, magic pills are easy. one - but... exercises hard, magic pills are easy. one a - but... exercises hard, magic pills are easy. one a six - pills are easy. one a six months, another gets a year, and your pcs together and we are living to the age of 85,

95, healthily.— are living to the age of 85, 95, healthily. will the drugs come? there _ 95, healthily. will the drugs come? there are _ 95, healthily. will the drugs come? there are a - 95, healthily. will the drugs come? there are a time - 95, healthily. will the drugs come? there are a time of. come? there are a time of companies _ come? there are a time of companies who _ come? there are a time of companies who are - come? there are a time of companies who are trying l come? there are a time of. companies who are trying to capitalise on this enthusiasm, raising a lot of money, but then you get to the very hard yards of actually science, bench to science, putting something in human body and actually having at work. find actually having at work. and there are — actually having at work. and there are bigger— actually having at work. and there are bigger questions over how we may need to work longer, the unexpected diseases that will emerge at these older ages, and our planet is already pretty busy. ages, and our planet is already pretty busy-— pretty busy. first, thing to consider — pretty busy. first, thing to consider as _ pretty busy. first, thing to consider as these - pretty busy. first, thing to consider as these changes | pretty busy. first, thing to i consider as these changes we are talking about are not going to happen tomorrow, they are going to be happening slowly, the same way we have doubled our lifespan over the past 150 years, and we slowly adapted to. r , ., �* ., years, and we slowly adapted to. as for brian... what has the reaction _ to. as for brian... what has the reaction been _ to. as for brian... what has the reaction been from i to. as for brian... what has i the reaction been from doctors and scientists are what you are doing, because i guess it has

been kind of mixed? the reaction _ been kind of mixed? the reaction has _ been kind of mixed? the reaction has been - been kind of mixed? i“ie: reaction has been very mixed. there are quite a few people who are excited that this is happening and it's a good blueprint for them. there has also been a colossal amount of hate, which i love. i love every bit of it. i hate, which i love. i love every bit of it.— hate, which i love. i love every bit of it. i think brian is a true — every bit of it. i think brian is a true pioneer. - every bit of it. i think brian is a true pioneer. is - every bit of it. i think brian is a true pioneer. is there i every bit of it. i think brian i is a true pioneer. is there not a bit of a _ is a true pioneer. is there not a bit of a risk _ is a true pioneer. is there not a bit of a risk in _ is a true pioneer. is there not a bit of a risk in what - is a true pioneer. is there not a bit of a risk in what he i is a true pioneer. is there not a bit of a risk in what he is i a bit of a risk in what he is doing to himself.- a bit of a risk in what he is doing to himself. there is a concern. — doing to himself. there is a concern, we _ doing to himself. there is a concern, we will _ doing to himself. there is a concern, we will see - doing to himself. there is a concern, we will see what l concern, we will see what happens to him in the long—term. happens to him in the long-term.— happens to him in the lona-term. , , , long-term. so his numbers look rood, he long-term. so his numbers look good, he claims _ long-term. so his numbers look good, he claims to _ long-term. so his numbers look good, he claims to be _ long-term. so his numbers look| good, he claims to be extremely happy, _ good, he claims to be extremely happy, it's— good, he claims to be extremely happy, it's an interesting experiment for us watch. delicious! the reality is we know a lot about the science of ageing. know a lot about the science of auaein. ,, , ageing. squeeze, squeeze, st ueeze ageing. squeeze, squeeze, squeeze a- _ ageing. squeeze, squeeze, squeeze a. but _ ageing. squeeze, squeeze, squeeze a. but the - ageing. squeeze, squeeze, squeeze a. but the big i squeeze a. but the big scientific _ squeeze a. but the big l scientific breakthroughs squeeze a. but the big i scientific breakthroughs are just not there yet, so i guess i come away from this feeling more than ever that it is so important to live your healthiest life, just maybe not quite to the extent of brian

johnson. my , , johnson. lucky us, we exist. let's play — johnson. lucky us, we exist. let's play the _ johnson. lucky us, we exist. let's play the most - johnson. lucky us, we exist. let's play the most fun i johnson. lucky us, we exist. i let's play the most fun games we can for as long as we can.

live from washington, this is bbc news. welcome to viewers on pbs in america. the us supreme court blocks new restrictions set by lower courts on a widely used abortion pill. western allies meet in germany to discuss further backing for ukraine. and the uk's deputy prime minister resigns, following an inquiry into bullying allegations. hello, i'm sumi somaskanda. we start here in washington. the us supreme court has ruled in favour of maintaining access to an abortion pill, while a legal appeal against its use is still considered. the decision temporarily blocks a lower court's ruling in texas that restricted the use of drug.