from the moment we arrive on this planet we are all heading in the same direction. but may be the way that the years play out is not inevitable. so how about the idea of being able to increase our health span, live the better years of our life for longer, until we are a0 or 60? i let a system of science and data run my body. there's 15 to 17 years of healthy life that is up for grabs for all of us. we head to california to meet the scientists and founders who want to make it a reality.

do you consider yourself a guinea pig? no, i do not. i consider myself to be an explorer on the frontiers, trying to find out what is possible. tech entrepreneur bryanjohnson is spending millions trying to turn back time on his body. i refer to myself as a professional rejuvenation athlete. it is a new sport i want to create. i'm not a bio—hacker, i'm not a health enthusiast, i am a professional rejuvenation athlete. i love it. working with a team of 30 scientists, his daily life is dictated by an extreme regime of fitness, diet, tablets, tracking and treatments. i am chronologically 45 years old, biologically i am a few hundred ages. my left ear is 64. my fitness test say i'm 18. my heart is 37.

my diaphragm strength is 18. and i playfully say i am trying to become like an 18—year—old. my son is 17 so i always tease him and say, when i grow younger, i want to be like you. where is he taking me? wow. where to start in here! is this one of those devices that measures the age of your skin? that's right. how is yours doing? we've made about 22 years of progress in reversing the age of my skin. it takes all these images of your face and you get about ten reports on pore size, uv spots, reds, browns. your skin is amazing. is this just from your regime or is there other help? other help too, we have some lasers over there, which i'll show you... there are no injections — that'sjust from everything in here? that's right. what do we have next? this is something that also tells you the health of your cardiovascular system, so your age. it looks at advanced glycinate

product in your skin. if you want to try it, you can put your arm on it and it will tell you your age. ideal score would be around two. so i am only a little bit too old for my age, it could be worse. what's next? ok, this is an ultrasound machine, its medical grade, so this is what you would see in a hospital. are you having a baby? who knows with what you're getting up to already! what are you actually using it for? we look at the brain, the lungs, the heart, the pancreos, prostate, tendons, ligaments, everything. it is really a useful technology to have in the clinic to do it on a routine basis. how do you feeljust before you do any of this tracking? do you get a bit nervous, hopeful? do you have expectation? it is a game. some of my most happiest days are when we do these full measurement days. what is your motivation? are you doing this for yourself or for humanity? when i was 21 years old i decided that i wanted to spend my life doing something meaningful for the world. and i didn't know what to do so i said, i'm going to make a whole

bunch of money being an enterpreneur by the age of 30, then i'll decide what to do. since i sold my company, braintree venmo, i made $300 million and this question was, what could i do that would matter in the year 2500? and right now it could be ageing. if we slow the speed of ageing and even reversed it, it would change what it means to be human. do you think you are risking your health here? in all the things you're doing to protect it, do you think there's also some real risk? certainly, there is always risks but there is potentially an argument that we are being more safe than anyone else because we have the rigour of measurement. whilst bryan signed his life away to experimentation, i visit the buck, the world's first institute for ageing research. these scientists are working on drugs that they hope could delay age—related disease.

would you say there has been huge scientific advancement in this field recently or is there just a sudden trend for investment and interest in it? the science has matured in terms of we have been doing this for close to 30 years, understanding the basic mechanism of ageing, number one. number two, the societal needs are there, you have a rapidly ageing population with an increasing burden of chronic diseases. 0ne really important discovery in mice here was the ability to reduce what are called senescent cells. these zombie cells play a useful role throughout our lifetimes but as we age, we acquire many more and as they also lead to inflammation, that increased number ends up providing a hotbed for cancer and all sorts of disease. but maybe we are missing something.

lifestyle is responsible for about 93% of your longevity. only about 7% on your genetics so you can't blame your parents. a lot of exercise, some fasting, a lot of good sleep, a lot of social connection, very little alcohol, try to spend at least 11; hours of your 24—hour day without ingesting any calories. but if they work, why do we need to be trying to deal with this bigger picture of cellular senescence? senescence is still going to happen. hopefully if you exercise, its going to be delayed by 10, 15, 20 years. i don't mean to be saying that lifestyle intervention is all that needs to be done, there is a need for science for the future. what is that thing that people do where they sit on the floor and try to get up without using their hands? whatever eric has been doing seems to be working. this is meant to be some sort of sign of youth, if you can stand up by not

using your hands. how can anyone do that, pushing yourfeet down, how is it possible? how do you do that? i don't know. i think it means that you are under 20 or something. exactly. i can't do it! 0ur furry friends could get their paws on a life—extending pill first though. # i love my dog to bits... you'll notice there are no great danes here, there are no large dogs here, and it's because they can have a lifespan of six, seven, eight, nine years, almost half that of what a little guy like this could be expected to have. our hypothesis is that the short lifespan of big dogs is a disease. where are you at now with the trial? we are kicking off our big,

pivotal study, we are trying to understand does our drug extend life—span and quality of life? it's a preventative drug, inhibiting the protein that we believe drives big dogs to age fast. and if everything goes to plan we will hopefully have a drug on market in 2025. if successful, loyal�*s drug could hasten the solution for humans, too. dogs eat similar diets to us, they live in the same environment, and they also develop the same age—related diseases as we do, at approximately the same time in our lifespan, so if a drug works in a dog, it is not i—to—i to work in a human but it's much more likely versus, we do a lot of research on mice, and that does not translate out all. meanwhile, i'm off to a longevity meet up. so, are these brainy scientists living the longevity lifestyle? there are still unopened bottles of wine, so probably! tonight we had a longevity friendly mix of food, seaweed and the fish.

other parts of the industry have not been quite so wholesome though. for decades there has been a lot of snake oil, a lot of miracle pills, the god pill, all of this stuff. and many have been desperate to believe, just ask this leading silicon valley doctor. i don't know why people want to gamble with their health. i understand gambling with your money, so, if it is safe and it's not effective like a vitamin — some vitamin — then you are gambling with your money but if it is not proven safe, and it is not proven effective, you are gambling with your health, and then there's people spending a lot of time doing these things and they are not living their life, they are living the version of their life to give themselves a future life, but what happens if the future life never materialises? the good news is with all these new blood tests, there's new breath tests,

there's urine tests, there's wearables, there's apps, there are so many things that track things so if you really want to, like, if you are overweight and you have high blood pressure, and you love your wine and you love your life, but you want a pill to make you live long, guess what? you cannot stop the wind with your hands. whether pills or procedures are proven or not, there are a whole lot of people who are really obsessed. does it sometimes just seem a bit culty, some of this stuff? laughs. i think it can. very culty and i try to protect my people against that culty. we try not to let it become that way. there is one issue that none of this can resolve though. in the united states, the single biggest determiner of your life expectancy is your postcode, where you live. and so that is a problem that cannot be engineered.

and there are bigger questions over how we may need to work longer, the unexpected diseases that will emerge at these older ages, and our planet is already pretty busy. first thing to consider is these changes that we are talking about are not going to happen tomorrow, they are going to be happening slowly, the same way we have doubled our lifespan over the past 150 years, and we slowly adapted. the reality is we know a lot about the science of ageing. squeeze, squeeze, squeeze. but the big scientific breakthroughs just are not there yet, so i guess i come away from this feeling more than ever that it is so important to live your healthiest life, just maybe not quite to the extent of brianjohnson. lucky us, we exist. let's play the most fun games we can for as long as we can.

hello. coming up on the programme... it took penalties to separate them, but manchester united eventually beat brighton to book a place in the fa cup final an electric atmosphere as newcastle embarrass spurs and elevate their own hopes of finishing in the top four and we'll have details of a dream debut as well as a record—breaking

london marathon hello and thanks forjoining us, here's your latest sports news we start with the fa cup, and for the very first time, both manchester clubs have reached the final. city were awaiting the winners of sunday's game between united and brighton...but that match needed extra time and penalties to decide it. natalie pirks reports from wembley. high—flying brighton landed at wembley relish the status as favourites. this egos were pushing for europe in the league and under a great london sky, afe cup finals for the first time in a0 years was at stake. united were looking to respond after a defensive horror show in europe. early on alexis

mcallister put david to help effects to the test. manchester united were buoyed by the return of bruno fernandes. brighton had all the running and came up in the second half with all guns blazing and the manchester united goalkeeper had to be on his toes. tired legs and heads faced an exit time. chances came and went in this slug best nobody could inflict the final bill. even all dependencies were scored until solly march stepped up. he enjoyed a brilliant season but football can be cruel and that proved decisive. lindelof insured united won the sprocket lottery while brighton could only rule what might have been. after an abject performance in europe this was the perfect way to bounce back. it was by no means vintage but now manchester united will attempt to stop their noisy

neighbours from completing the trouble in the first manchester derby in an fa cup final. natalie pirks bbc news, wendy. it was teased as having the potential to be a closely fought top four battle — but in reality, it was over after 21 minutes — newcastle thrashed tottenham 6—1 in the end. eddie howe�*s side were five goals up in the first half, and added a sixth after harry kane grabbed a consolation for spurs. that result means newcastle up to third in the table, with spurs�* top four hopes taking a massive hit. they're six points off the champions league places, with those above also having games in hand. all in all, a terrible afternoon for tottenham. i want to apologise to everyone, because the first 25 minutes were not enough for this type of game. for me, it was unexpected, this type of performance. but when we changed the system, we played much better,

so maybe my decision to change system was not the right decision. the mood is good but everyone has got a very stable and balanced mindset, we are never too high, never too low especially in this running. we have got seven really tough games and we have to take each won one by one, i know it is very cliche but we cannot look past the opponents at moment and tick them off and see where we end up. there was a massive result for west ham too — they beat fellow strugglers bournemouth a—0. there were four different scorers for david moyes�*s side and it would have been 5—0, if var hadn't ruled out a stoppage time goal. west ham are up to 13th place in the table now, jumping above today's opponents and putting a six point gap between west ham and the bottom three clubs. it has probably been one of our best weeks. started last week against arsenal, then we meet again in midweek, and we scored two against arsenal, scored four in this game

and midweek as well. overall, a really good week. i hope we can build on. we certainly didn't start the season well, but if we finish the season well it will bode well for what we have coming up. not too much to be said about the performance today. we will review and move on to the next game. there are clear reasons why we weren't able to compete with west ham today. it shows how hard it is in the premier league, but if you're slightly off and you don't cope, this is what can happen. we reset and we get ready to go again on thursday. serie a champions—in—waiting, napoli took their lead at the top of the table back to 17 points againstjuventus. juventus have leapt back up the table after their 15 point deduction for false accounting was reversed and they are in third place despite losing 1—0 to napoli, thanks to a stoppage time winner from giacomo raspadori. angel di maria had had a goal ruled out forjuve about ten mins earlier.

inter milan's win over empoli has taken them into fifth place. romelu lukaku with two of inter�*s three goals. la liga leaders barcelona are 11 points clear of real madrid after beating atletico1—0. while valencia beat elche 2—0, there were also wins for mallorca and sevilla arsenal came from behind to claim a 2—2 draw against wolfsburg in the first leg of their women's champions league semi final in germany. the competition's top scorer eva pajor netted her eighth goal in the champions league this season with wolfsburg's first. striker stina blackstenius capped off a tireless display when she equalised for arsenal in the second half to keep their pursuit of a second european trophy alive. the second leg is next monday with over a0,000 fans expected at the emirates. lebronjames and the la lakers are getting ready for game four against the memphis grizzlies and it's all getting a bit heated.

dillon brooks called james "old" after game two and was ejected in game three for striking the lakers man in the groin — but lebron is taking the high ground. i'v e i've been doing this for long and i making of statements. we had an opportunity to come home and they well on our home tour and we did that but this is not my first rodeo. i've had this throughout my career. with certain individuals, you know, it's easy, very easy, .mac we want tonight, that me not start. kenya's kelvin kiptum smashed the course record to win the elite men's london marathon., locking the second fastest marathon time ever. kiptum finished just 16 seconds outside the world record. while seefan hassan from the netherlands also produced a remarkable run to win the elite women's race.

great britain's mo farah finished ninth in his final london marathon. after the race the four—time olympic champion revealed that he'll finish his career at the great north run in september. here's our correspondentjoe wilson. air horn blares. cheers. away we go! this is what the london marathon celebrates, what it plans and what it defends, the right to run, the right to race. that has always been mo farah's instinct. in luminous sleeves, still trying to push himself in his final marathon. and the sport moves on, faster than ever. kelvin kiptum of kenya seemed to be sprinting for the line for miles. he finished in two hours, one minute, 25 seconds, a new course record. we have never seen anything like this on the streets of london! well, here comes another course record. marcel hug was in a class of his own in the men's wheelchair race. fifth victory, third in a row. sprint finish in the women's event, australia's madison de rozario,

the winner here in 2018, got there again. now, sifan hassan. this was her first marathon. a double olympic champion on the track, she told me she was just here to learn. after an hour, it looked to us like she would have to drop out. not in her mind. look at the finish. look at the woman who had been training while fasting through ramadan, who had never run this far before. sifan hassan with one of london's most stirring debuts and one of its very best finishes. and she has been brilliant! sifan hassan is the champion! when i see the finish line, i couldn't believe it was the finish line. i was like, is that true? and, like, am i in a dream or something? now, two british runners finished in front of sir mo farah. his pace was a little slower than he had planned but for the final time, he finished. i definitely enjoyed it. without the crowd, honestly, i would have stopped.

the crowd kept me going. i kept pushing myself. well, for marathon terms, from london... this is it, this is it. thank you so much. thank you, thank you. every individual has a story, a unique motivation, and in greater numbers than ever, they took part, for themselves, for their families, for charities, for the fun, for the achievement. joe wilson, bbc news, at the london marathon. john higgins secured a quarterfinal place at the world snooker championship in style with a 13 frames to two victory over kyren wilson. higgins had dominated the match from start to finish and was on for a 1—a—7 in the final frame, but missed this key red. the four—time world champion will play either gary wilson or mark selby in the quarterfinals which start on tuesday. the other match tonight saw china's sijiahui maintain his lead over robert milins 11 frames to five.

you can get all the latest sports news at our website — that's bbc.com/sport. from me and the rest of the team at the bbc sport centre, goodbye. hello. in this past week, we have had the warmest day of 2023 so far, 21 degrees recorded in western scotland going on into the new week. then possibly hard to believe that in some areas temperatures will be around 15 degrees lower. why? we're going to start pulling in arctic air. this area of low pressure that brought cloud and rain through the weekend pulls off towards the continent behind it and northerly air stream establishing itself on monday and arctic air eventually sweeping all the way south across the uk for tuesday and wednesday. here we are on monday.

some rain across wales and south west of england pushing across to the south east, colder air, digging in to scotland, turning showers to snow, gales around northern and eastern coast. the cold air already in place monday afternoon to the north of the uk seven on the thermometer for aberdeen. we'll feel closer to freezing in the wind and then look at the temperatures overnight. a widespread frost developing across the uk. the winds ease off a little bit. we'll have clear skies and that arctic air. so lows, possibly minus five in some of the scottish glens. the winds ease because this finger of high pressure will extend south across the uk for tuesday. a lot of fine weather on tuesday. i think a lot of sunshine to start the day. the winds a little lighter still potentially a few snow showers for northern and eastern scotland. some high cloud building during the day, turning the sunshine. hazy temperatures relatively similar to monday, but with a slightly lighter wind. the cold may feel a little less biting, but certainly chillier than last week. and then as for wednesday,

pretty similar pressure pattern, finger of high pressure across the uk, a bit more cloud, maybe trying to get into the southwest later on, maybe even squeezing out a little bit of light rain or drizzle. but i think a lot of fair weather to come for wednesday, some cloud building through the day. light winds again, a chilly feel, but perhaps not as cold as it will feel on monday. after wednesday, however, it looks like this finger of high pressure will drift away eastwards and we'll start to see atlantic activity heading in once again. and as that starts to push in, it will start to pull in milder air. still quite cold on thursday, though, to the north of scotland, but there should be at least some sunshine around here. elsewhere, i think we're talking about more in the way of cloud, potentially some rather persistent rain pushing into england and wales, but the temperatures do come up. however, of course they will be offset by the arrival of that wetter weather thursday into friday. this area of low pressure rolls through during the course of thursday night through friday. it looks like it should pull away eastward some eastern counties.

so maybe starting the day with some wetter weather, hang back of clouds. but generally, i think some brighter spells come the afternoon. and in the sunshine across england and wales, we're pretty much back to where we should be for this time of year, with many areas starting to see temperatures creeping up into the teens and then looking further ahead. at the moment, the models are somewhat favouring high pressure building across the uk for next weekend and on into the following week. and if that happens, that will mean some more settled weather and potentially hooking us in to some relatively warm air from further south in europe. it could well be the case based on this model run. obviously, it does change from run to run that as we look at our forecast towards the start of may, we could even begin to talk about temperatures being above average. but in the shorter term, for the start of this week, we have some chilly prospects to come and unfortunately, our temperatures will feel distinctly below average.

welcome to newsday, reporting live from singapore. i'm monica miller. the headlines... several countries evacuate diplomats and citizens from sudan's capital as fierce fighting continues to rage in khartoum. police in kenya say they've now exhumed a7 bodies thought to be members of a cult who believed they would go to heaven if they starved themselves to death. across the uk, mobile phones ring out in a test for an emergency alert system, but the government is looking into why some phones didn't respond. live from our studio in singapore... this is bbc news.

it's newsday.