welcome to the daily global, where we'll bring you the top stories from around the world. we begin with news of a medical breakthrough that could save millions of lives around the world. the world health organization revealed a new malaria vaccine has been found to be 75% effective in phase three trials. those trials took place in four african countries and involved 4,800 children. the results mean, it is the most effective jab developed against the disease so far. let's just remind ourselves how deadly malaria is. the most recent figures from the who show there were 619,000 global malaria deaths in 2021. that year, there were 2a7 million new cases of malaria.

95% of all malaria cases are in who's african region. children underfive — are the most vulnerable group affected by malaria, in 2021, they accounted for nearly 80% of all malaria deaths in the african region. here's our medical editor, fergus walsh. malaria has been causing untold human suffering for millennia. the parasitic infection has spread —— is spread by mosquitoes. africa is the worst affected, particularly the areas marked in red here which account for 95% of the global burden of malaria. in 2021, there where an estimated 234 million cases and 593,000 deaths from malaria in africa. most of those where children

under the age of five. the oxford vaccine is called our 21 and requires children to have four doses. trials run by oxford's institute show it is around 75% effective. —— r21. crucially, the world's biggest vaccine manufacture, the serum institute in india, has agreed to produce 100 million doses agreed to produce 100 million doses a year of the oxford jab between two and $4 a dose. this will be africa's second malaria vaccine, the first, rts as from pharmacy giant, costing about twice as much since 2019, just 1.7 millionjobs have been administered. so the new 0xford vaccine could be delivered at a much bigger scale. vaccine could be delivered at a much bigger scale-— bigger scale. today is a great day for health, _ bigger scale. today is a great day for health. a _ bigger scale. today is a great day for health, a great _ bigger scale. today is a great day for health, a great day _ bigger scale. today is a great day for health, a great day for- bigger scale. today is a great day| for health, a great day for science and a _ for health, a great day for science and a great — for health, a great day for science and a great day for vaccines. the

malaria _ and a great day for vaccines. the malaria researcher —— as a malaria researcher. — malaria researcher —— as a malaria researcher, used to dream of a day is when _ researcher, used to dream of a day is when we — researcher, used to dream of a day is when we would have a safe and effective — is when we would have a safe and effective vaccine against malaria. now we _ effective vaccine against malaria. now we have two.— now we have two. that was our medical editor. _ today's announcement follows a major trial of the oxford malaria vaccine involving nearly 5,000 children across four african countries, lasting several years. 0ur correspondent anne soy witnessed some of the children getting booster doses in tanzania and has this report. a life—saving jab, giving protection against one of the biggest killers of african children — malaria. it has taken decades to find. three—year—old hajdra was one of hundreds of volunteers in the clinical trials. her mother, 39—year—old mosemi saif, had a compelling reason to enrol the youngest of her six children in the study. translation: i lost my nephew, he was only four when _ he died from malaria.

that's why when i heard that there was a malaria vaccine trial i said i wanted to participate because it would help us. here in bagamoyo 600 children took part in the trial. experts are urging people to continue using the proven weapons of preventing infection, even with the discovery of a new vaccine. the results of the final phase of the research surpassed expectations. what we have shown in one year, after the three doses the efficacy is about 75%, again well above the goal set by the who malaria community, and this is really exciting. thejob is farfrom done. the vaccine now needs to be delivered to villages and towns across africa. for families like mosemi's, it will bring much needed relief

from disease and keep her children alive. anne soy, bbc news, bagamoyo. the chief executive of the serum institute of india, the world's largest vaccine manufacturer told me earlier about the significance of this breakthrough. it is earlier about the significance of this breakthrough.— earlier about the significance of this breakthrough. it is not 'ust a landmark moment i this breakthrough. it is not 'ust a landmark moment for h this breakthrough. it is not 'ust a landmark moment for us, _ this breakthrough. it is notjust a landmark moment for us, but. this breakthrough. it is notjust a | landmark moment for us, but the world, as you just mentioned, the deaths that happen due to this terrible disease and limited intervention that we had at our disposal now we finally have a second vaccine. you know, after many, many years of collaborating and working together with the university of oxford and the institute together have come about this and point where the who has not recommended this vaccine for prequalification which means finally next year this vaccine can go into patients.

next year this vaccine can go into atients. , , ., , ., patients. yes, it is not 'ust about this partnership _ patients. yes, it is not 'ust about this partnership with _ patients. yes, it is notjust about this partnership with oxford, - patients. yes, it is notjust about i this partnership with oxford, which, we have core side during the pandemic, but what makes this so significant is the number of doses, because, of course, two years ago, we saw the first vaccine arrived which was welcome news, but 100 million doses is what we are talking about here. , . about here. yes, here at the institute. — about here. yes, here at the institute, we _ about here. yes, here at the institute, we produce - about here. yes, here at the i institute, we produce vaccines about here. yes, here at the - institute, we produce vaccines at very high volumes and at a very low price. that is what was really significance, that the supply and demand mismatch that was happening as of 2024, we won't have such a supply constraints now with our capacity being able to bridge that gap- capacity being able to bridge that gap. of course, you know, it is a very affordable vaccine with less than $4. again opens up and is accessible to all of these eligible countries and we can get it out as wide as possible to all the african nation. has wide as possible to all the african nation. �* , ,, wide as possible to all the african nation. ~ , i. _

wide as possible to all the african nation. r ,, , wide as possible to all the african nation. a y r: a nation. as you say it is it 32-34 is the cost, that's _ nation. as you say it is it 32-34 is the cost, that's not _ nation. as you say it is it 32-34 is the cost, that's not the _ nation. as you say it is it 32-34 is| the cost, that's not the challenge. i suppose the challenges while you can provide these doses, can they be administered. in a lot of these places that are struggling when it comes to staff, when it comes to people who can actually administer the dose. . , . people who can actually administer the dose. ., , ., ., ., people who can actually administer the dose. ., , ., , the dose. that is a good point, but one tood the dose. that is a good point, but one good thing _ the dose. that is a good point, but one good thing that _ the dose. that is a good point, but one good thing that came - the dose. that is a good point, but one good thing that came out of. the dose. that is a good point, but| one good thing that came out of the pandemic, at least in these regions was that the health systems have now been strengthened and they have a lot of investment and so many train health care workers that went into it, as you know, we had to train a lot of people and health care workers and infrastructure during the unfortunate covid pandemic. as result now from large vaccination programmes and things like this, we do have that infrastructure and train manpower available to be able to roll out a national immunisation programme for vaccines. that is some

good news as well. i programme for vaccines. that is some good news as well.— good news as well. i guess, you know, good news as well. i guess, you know. for— good news as well. i guess, you know, for many _ good news as well. i guess, you know, for many who _ good news as well. i guess, you know, for many who travel - good news as well. i guess, you know, for many who travel to i know, for many who travel to africa, for those who live in africa, understand the number of nets that have become available in recent years to help prevent this disease and the spread of the disease. the point is that this is a sort of disease that can be cured. it's children from the most vulnerable that are the most impacted by this. that, i think, that are the most impacted by this. that, ithink, is that are the most impacted by this. that, i think, is what is most shocking when you look at these numbers. ~ ,,., , shocking when you look at these numbers. ~ , jun shocking when you look at these numbers. ~ , j~::f ., shocking when you look at these numbers. , j~::f ., numbers. absolutely. 80% of those deaths are children, _ numbers. absolutely. 80% of those deaths are children, and _ numbers. absolutely. 80% of those deaths are children, and that - numbers. absolutely. 80% of those deaths are children, and that is - numbers. absolutely. 80% of those j deaths are children, and that is why the vaccine trials were also in children. and we've demonstrated that, you know, this vaccine is safe and effective. we followed up the patient for 12 months and we continue that follow—up going on to establish long—term safety and effectiveness as well. so, yes, this

is the main targeted population and age group that is most affected. that is where, you know, we focus the use of the vaccine. that that is where, you know, we focus the use of the vaccine.— that is where, you know, we focus the use of the vaccine. that was the ceo of serum _ the use of the vaccine. that was the ceo of serum institute. _ the use of the vaccine. that was the ceo of serum institute. now - the use of the vaccine. that was the ceo of serum institute. now to - the use of the vaccine. that was the ceo of serum institute. now to the | ceo of serum institute. now to the united states. donald trump has appeared in court in new york at the start of a civil fraud trial which could have serious consequences for his business interests. the former president denounced the trial as a scam and a sham — as he arrived at court. new york's attorney general is suing mr trump and two of his sons after a judge ruled that they vastly inflated the value of their properties and other assets. our correspondent gary o'donoghue reports now from new york. donald trump, in court yet again. the question this time around is, is he as rich as he says he is? it's a scam, it's a sham. just so you know, my financial statements are phenomenal.

he's being sued by the new york attorney general, who says he spent a decade over inflating the value of his properties in order to secure loans, insurance and lower—interest rates. he's after $250 million in fines and damages. no matter how powerful you are, no matter how much money you think you may have, no one is above the law. and it is my responsibility, and my duty and myjob to enforce it. donald trump is accused of overstating the value of his mar—a—lago club in florida by 25 times. he exaggerated the size of his penthouse apartment in trump tower by 200%. overall, he may have claimed to be $2 billion richer than he really is. before the trial began, the judge had already found donald trump and his two sons liable for fraudulently inflating the value of their properties. so these proceedings are to determine just how big the fines will be. this is a civil case, so they won't go to jail, but they could end up a lot poorer.

this is one of donald trump's prized possessions, 40 wall st, at the heart of new york's financial district. when he bought it, he said it was the greatest property deal in history. if he loses this case, he could have it taken away from him, and with that, a whole chunk of his self—proclaimed reputation as a property genius. gary o'donoghue, bbc news, new york. and as donald trump left court for lunch this is what he said. one doesn't have to be a lawyer to see the danger to anyone doing business in the empire state. anybody that does business in new york state is crazy. when you have a radical left attorney—general like letitia james, a disgrace to our country, who got elected on the fact that she is going to take down president trump, we are going to take him down. but she got elected

on that basis. and we have others likewise. take a look at what is going on in georgia. take a look at jack smith, take a look at these people. this is called the election interference, and where than that, really much worse than that. it doesn't get much worse than election interference, we are talking about a presidential election of 2024. earlier i spoke to our correspondent who brought me up—to—date. have a listen. who brought me up-to-date. have a listen. , _, ., , listen. very combative donald trump toda . we listen. very combative donald trump today- we have _ listen. very combative donald trump today. we have never— listen. very combative donald trump today. we have never seen _ listen. very combative donald trump today. we have never seen him - listen. very combative donald trump today. we have never seen him talk| today. we have never seen him talk at this link inside the courtroom during one of his trials. at this one, because, again, as you mentioned there, his whole entire real estate empire is at stake. this one in particular has very much rattled donald trump. we make the claim there about tomorrow lago. look, he is taking real issue with evaluations of his properties. ——

mar—a—lago. the thing is that these evaluations that the judge referenced in his ruling, finding that donald trump did overvalue his properties by millions, those came from assessors. so when he talks about mar—a—lago, it was the palm beach county assessor who found that mar—a—lago was $18 million, and yet donald trump continues to argue that it is worth over $1 billion, that he could get anyone to buy it. this is the real key issue. we saw an opening statement. kevin wallace from the attorney—general team saying, you know, look, we saw donald trump's team wanting to reverse engineer the values of his assets to get in at a particular network so he could be on the forbes billionaire list. that was his goal. he said it was one thing to exaggerate to forbes commits another to examine certain... —— exaggerated bile that back while doing business in new york. we saw one of his legal spokespeople speak in court, even telling thejudge spokespeople speak in court, even telling the judge that this was politically motivated. she was shot down. thejudge politically motivated. she was shot down. the judge said that that had already been argued. but she

contends of the other donald trump lawyers contending that this is just them doing business in new york and that they never intended to defraud anything. ihis that they never intended to defraud an hint. , ., anything. his team actually initially tried _ anything. his team actually initially tried to _ anything. his team actually initially tried to sort - anything. his team actually initially tried to sort of - anything. his team actually l initially tried to sort of delay this case, didn't they? and then donald trump did say he was going to appear in court, he was going to take this entire thing quite seriously. take this entire thing quite seriously-— take this entire thing quite seriousl . ., �* , seriously. look, that's right. there have been delays _ seriously. look, that's right. there have been delays throughout - seriously. look, that's right. there have been delays throughout this | have been delays throughout this process leading up to this trial at one point thejudge had to process leading up to this trial at one point the judge had to sanction donald trump, personally $10,000 a day to hand over the documents that were subpoenaed by the attorney—general. we saw the latest attempt in the court of appeals to delay this trial because they were arguing that it should be thrown out completely that these claims were too old under the statute of limits. but we heard the court of appeals and thejudge but we heard the court of appeals and the judge say that these claims aren't too old to be heard. so we do

sit don't not think donald trump's team will appeal after there is a decision in this case, they are not backing down from that, but a lot of the arguments they may have already shot down by the judge. rililur shot down by the 'udge. our correspondent _ shot down by the judge. our correspondent reporting from outside the court. here in the uk, the row over the hs2 high speed rail project has intensified. there is continued speculation that prime minister rishi sunak will axe the stage between birmingham and manchester. but donwing street again said no decision has been made. controversy surrounding its future overshadowed much of the business at the second day of the conservative party conference. the conservative mayor of the west midlands, andy street, urged the prime minister not to give up on the link, but said he was "right to try and get a grip of the situation". here's our political editor chris mason in manchester. monday morning in manchester, and a high—profile visitor.

well, who should be turning up but the former prime minister? are you just here to cause trouble? this time last year, liz truss was in charge, and now she's back, activists queued around the building, up and down staircases. more than 100 couldn't get into the packed room, but some familiarfaces did. liz truss's message was familiar too — cutting corporation tax, reducing energy bills and building more houses. let's be prepared to make conservative arguments again, even if it's unpopular, even if it's difficult. i want everybody in this room to unleash their inner conservative. finally, my friends, let's make britain grow again. thank you. a slogan borrowed and amended from donald trump. remember, conservative activists voted to make liz truss prime minister, and some are still angry tory mps brought her down. meeting some members at the moment... she didn't want to answer questions

today, but she did pose for pictures, and even signed a copy of her mini budget, which prompted economic calamity and political disaster for her. what prompts all of this? the government and labour are increasingly similar, reckons the former leader of the brexit party. we are all here looking for big differences. there aren't really. what is being talked about today effectively was to reset the conservative party after they lose next year. maybe i should whisper this, but how much is this about a party contemplating defeat and thinking about what comes next? what was it queen victoria said? she said the possibility of defeat does not exist. the chancellor of the - exchequer, jeremy hunt. from the fringe to the main stage, jeremy hunt said he will put up the national living wage to at least £11 an hourfrom next april. that's a pay rise for two million workers. and the wages of the lowest paid, over

£9,000 higher than they where in 2010, because if you work hard, the conservative government will always have your back. but, yet again today, the question that's been unanswered for nearly three weeks — will there be a new high—speed rail line between manchester and birmingham? plenty here think the prime minister is about to scrap it. number ten insists no final decision has been taken. people here have waited far too long for a functional railway, and we are not going to sell our own residence down the river and make them wait even longer. gripping this situation means re—examining it. it does not mean giving up and admitting defeat, you could say, or even, you could say, cancelling the future. have you considered resigning over the cancellation of the railway? we are not talking about that. the issue is we are working hard on finding the solution for the prime minister. over to you, prime minister,

to say what you want to do. around the world and across the uk. this is bbc news. let's look at some other stories making news. a police investigation into emad al swealmeen, who detonated a bomb outside liverpool women's hospital in november 2021, found he had a grievance against the state forfailing to accept his asylum claim. that, combined with mental ill health, is likely to have led him to carry out the attack. emad al swealmeen was killed in the blast, which injured one other person. the price of a first class stamp rises today to one pound 25 — up from one pound ten. that's the third price increase in 18 months. royal mail blames increasing cost pressures and the tough economic environment for the latest rise. the price of a second class stamp stays at 75p. a bbc tv presenter says her eyesight has been saved by a routine check—up. injune, bbc wales's lucy owen told her optician she had noticed

white flashes in her right eye. he said her retina was in the process of detaching, and booked her in for an emergency operation. her vision returned and she has resumed presenting. you're live with bbc news. the former ceo of global fashion brand abercrombie & fitch — and his british partner — face allegations of exploitation from men recruited for sex events they hosted around the world. a bbc investigation found a highly organised operation running the events, with a middleman finding young adult men for mikejeffries and his partner matthew smith. jeffries is regarded as the modern day founder of abercrombie and fitch, which also owns the hollister brand. eight men told the bbc they attended these events, some of whom alleged they were exploited or abused. two former us prosecutors who independently reviewed evidence uncovered by the bbc have called for an investigation to determine

whether charges for sex trafficking could be brought. mrjeffries and mr smith did not respond to requests for comment. here's a report from rianna croxford. in the early 2000s, abercrombie and fitch became one of the hottest labels in the us and around the world. sexualised imagery and provocative billboards turned the teen retailer, which also owns the hollister brand, into a multibillion—dollar sensation. the man behind the vision was then—ceo mikejeffries. mike was tireless. he was very energetic and boisterous. he was an incredibly big personality. he would explode into a room. bbc panorama has uncovered a highly organised international operation recruiting young adult men for sex with mikejeffries over several years, when he was the ceo of the brand.

this experience, i think it broke me, and it mentally messed me up. two men have agreed to tell me their accounts on camera. they attended separate events hosted by mikejeffries in 2010 and 2011. both men say they were recruited and auditioned by a middle man, james jacobson, known to the men asjim. david says mrjacobson led him to believe he was pursuing a modelling opportunity. i was made to believe, look, this is where everybody gets their start. this is where you want to get your start. it was like he was selling fame. and the price was compliance. david says compliance meant engaging in a sexual act with mrjacobson. seven more men i've spoken to say they also met with jim. the men say mrjacobson was part

of a well oiled machine which included recruiters, drivers and other staff. mrjacobson told the bbc any encounters were fully consensual, not coercive. he said he had no recollection of making promises of modelling opportunities, and that everyone whom he came into contact with who attended these events went in with their eyes wide open. this is the route the men would have taken when they were on their way to the hamptons, when they were going to go and meet with mikejeffries. once through the audition, the men would then go to an event hosted by mrjeffries and his british partner, matthew smith. some were held at their home here in the exclusive new york coastal community the hamptons. barrett said he was introduced to mrjacobson by an older model who he felt indebted to, and knew there would be some kind of sexual activity. david said he was not expecting sex

to take place at the hamptons. i was taken, chaperoned over to the main house, to the doors that entered into the bedroom where everything was happening. and then...told to disrobe. barrett said he engaged in an intimate act with another man. david says mrjeffries had sex with him. so i didn't feel safe to, like, say no or, i don't feel comfortable with this. i don't really know what would have happened. i didn't feel like i had any choice. both men say they felt leaving didn't seem to be an option because mrjeffries' private staff were supervising the event, including in the bedroom. they also say they were asked to sign nondisclosure agreements beforehand, and were not given any copies to take away. it did feel like they were trying to scare us. that's what it felt like. it felt like intimidation. both men were paid around $2500 after the event they attended. still hoping it may lead to modelling work, david went to further events with mrjeffries and mr smith, both in the us

and around the world. two us lawyers who reviewed evidence uncovered by the bbc said prosecutors should investigate whether the allegations could amount to sex trafficking. the bbc has made repeated attempts to contact mrjeffries and mr smith. they have not responded. abercrombie and fitch told us it is appalled and disgusted by the allegations about their former ceo's behaviour. it said a new executive leadership team has transformed the company's brand and culture, adding, the company has zero tolerance for abuse, harassment or discrimination ofany kind. rianna croxford, bbc news. don't go anywhere. we will be back in the next few minutes. hi there, good evening. it's been another day

of contrasts across the uk — still warm for the time of year with some of the best of the sunshine today across areas of scotland and northern ireland, but also a good scattering of showers here. misty, murky, still humid further south, with outbreaks of rain, but fresher—feeling conditions developing across the board tomorrow. there'll be some sunny spells, but again, some showers — heaviest and most frequent towards the north and the west. now, today's showery outbreaks of rain across england and wales were courtesy of this warm front, pulling out into the north sea overnight tonight, followed by a cold front that will sweep away the humidity and the air. but still, we're likely to see a few more thunderstorms perhaps across east anglia for a time tonight, then it will turn a lot drier. showers fizzling out as they track the way further eastward, some of the coolest of the conditions across northeast scotland — again, a chilly start here to tomorrow morning, but for most, it's still mild for this time in october. now tomorrow, after that initial hangback of cloud clears away from eastern counties, then we're likely to see

more sunshine develop. sunny spells, but then some showers tracking eastwards on a brisk westerly—to—northwesterly wind — again, they're likely to be heaviest out towards western areas of scotland and northern ireland. temperatures are lower, peaking between the mid—to—high teens in celsius, but again, that's slightly above the seasonal average. and that's probably it, in terms of rainfall for the south of the uk for the rest of the week, because high pressure starts to build in from the south as we head through tuesday and into wednesday. so it's likely to be a dry, rather cool night here, milderfurther north. this is where we think the rain will probably be on wednesday, most likely to be heavy, i think, across south western areas of scotland. there are localised weather warnings in force, so most of the rain again towards the north and the west, temperatures on a par with tuesday's. brighter and drier the further south and east you are — and that's also true on wednesday into thursday, too. again, there'll be further weather fronts pushing in from the southwest. the temperatures won't get much past the high teens in celsius, but that is set to change as we head into the weekend.

we start to draw in some very warm air from the south, we've got high pressure building in from europe. so temperatures are likely to rise across the board. here's the outlook for our capital cities — so by the time we get to saturday, temperatures in much of scotland could be in the low 20s, also true for northern ireland and wales. mid—20s further south and east. bye— bye.

this is bbc news, the headlines... the armenian authorities say that

almost the entire population of 120,000 ethnic armenians has now left nagorno—karabakh. foreign ministers from poland, hungary, and latvia fail to show for a historic eu meeting in kyiv. the sexual abuse of young footballers in gabon. bbc africa eye investigates claims fifa failed to take effective action when it was made aware. there are reports that the regional capital of nagorno—karabakh is deserted following the flight of more than a 120,000 ethnic armenians. they fled because of fears of persecution and ethnic cleansing charges denied by azerbaijan, which last month seized the disputed territory. and afp news agency is reporting armenian claims that one person was killed and two injured in cross—border fire today. our correspondent reyhan demytrie reports from goris, in armenia.

playing under a peaceful sky at last.