touncil says he head shields. the council says the head ofthe shields. the council says the head of the un agency _ shields. the council says the head of the un agency for _ shields. the council says the head of the un agency for palestinian i of the un agency for palestinian refugees warned that gaza has become an unlivable wasteland with three quarters of its infrastructure now destroyed. police say a seven—year—old boy has been killed in six people have been injured in a house explosion in newcastle. the new england manager is honoured to get thejob and new england manager is honoured to get the job and he had this to say about being german. i get the job and he had this to say about being german. ”just get the job and he had this to say about being german. i 'ust have a german passport. h about being german. i 'ust have a german passport. i— about being german. ijust have a german passport. i am _ about being german. ijust have a german passport. i am proud - about being german. ijust have a german passport. i am proud to l about being german. ijust have a | german passport. i am proud to be the england manager and out everything to show respect to this role into this country. role and to this country. hello from the bbc sport centre new england manager thomas tuchel says he wants to make dreams come true at the world cup in 2026. the former chelsea boss was presented to the media at a press conference earlier today and will officially take charge on the 1st ofjanuary after signing

an 18—month contract. when asked what he would say to those fans who wanted an englishman in charge, this was his response. i'm sorry. ijust have a german passport but i can just tell them and all of the supporters also felt my passion for the english premier league in my passion for the country and howl league in my passion for the country and how i love to live here and work here and so, my memories are among the highest level and they play a huge role and hopefully, i can convince them and show them and prove to them that i am proud to be an english manager and i would everything to show respect to this role into this country and the target for the next 18 months is nothing else and the biggest in football and never want can be assured that no matter what nationality my passport is.

former england captain gary lineker says tuchel comes with the expereince and pedigree that's required to be a success. it is an interesting appointment thomas tuchel is a great coach and he has won many trophies. so, he is to be respected and people would debate whether england should have an english culture not and having a german coach is interesting. but you will be more and really did, they sat pretty cautious and did not concede and hope for magic moments. it will be interesting to see if he can make them gel and make them believe in themselves that they can go all the way. arsenal and manchester city are in women's champions league action later. arsenal take on norweigan side vorla—renga in what's is their first match since head coachjonas eidervall resigned. arsenal were thrashed in their champions league opener at bayern munich. manchester city go into their game

at austrian side sant polten, top of the wsl and yet to lose this season. city beat barcelona to open their european campaign. england's cricketers will be rueing a missed opportunity after closing day 2 of the 2nd test against against pakistan on 239 for six. responding to the home side's 366, england started strongly. ben duckett, who dislocated his thumb during the first test hit a century before evetually going for 114. at one point england were 211—2 in multan but when the returning ben stokes was caught at short leg, england had lost four wickets for 1h runs in the space of 2a deliveries. they trail by 127 runs heading into day 3. first session, i think it will be huge for us in every ten bats are we can and tried to get as close to the total and i think we will be favourites, favourites, certainly believe that. i think they have shown this game and they will fight every single way to the end of the

game make it as hard as they can for us and will always keep believing and i think they've had a good day today but yeah, that first morning session is going to be huge. great britain have cut new zealand's lead in the america's cup to 11—2 by winning both races today ben ainslie�*s ineos britannia team went a—nil behind on monday in the best—of—13 series in barcelona. new zealand have won the past two america's cups, while britain have never won the competition in its 173—year history. races seven and eight take place tomorrow. henry slade has recovered from injury to make england's 36—man squad for the rugby union autumn internationals, but first—choice scrum—half alex mitchell is out with a neck problem. slade had shoulder surgery in the summer and hasn't played for exeter yet this season. sale flanker tom curry is also recalled after returning from a concussion lay—off and that's all the sport for now.

police say a seven—year—old boy has died after a house explosion in newcastle in the northeast of england. six people were also taken to hospital after the blast and a residential street in the early hours of this morning. three houses have been destroyed and with the fire service is calling a large—scale instance. a number of people have been evacuated from their homes. our reporter is at the scene of that blast. we can see the rescue operation continuing behind me here. earlier, police well, you can see the rescue operation still continuing behind me here. earlier, northumbria police held a very sombre press conference at the scene here where they confirmed the news that a seven year old boy was killed as a consequence of this explosion just before 1:00 this morning. there are six other casualties besides also being treated in hospital, and of those six, that includes another child. there isn't an update as yet on the condition of those people. now, as for the cause of this explosion, well, that's

still under investigation. engineers from the company, northern gas networks have been working here, but the police and the fire brigade say that will take some time. now, when we got some aerial pictures earlier of what had happened here, you could see the sheer scale of the devastation roofs collapsed in and emergency workers working, firefighters amid the rubble that was left behind there. now, as i say, this investigation will take some time. many of the people living here, well, they've had to be evacuated. they're at a local community centre being cared for there. the british red cross were also brought in to help with that. but as for the damage, we understand the centre of it was two flats. it was a block of flats that were affected, with two flats in particular, it seems, taking the brunt of that blast and this investigation here continues. peter harris,

bbc news, newcastle. the national police chief counsel is warned that organised crime gangs have developed sophisticated tactics for shoplifting. project pegasus, backed plan to dismantle the criminal network possibles trade bodies they say gangs are becoming more calculated will talk now to the ceo of the british independent retailing association and welcome to the programme. this seems to have exploded as a crime. for the programme. this seems to have exploded as a crime.— exploded as a crime. for 18 months that we have _ exploded as a crime. for 18 months that we have seen _ exploded as a crime. for 18 months that we have seen industrial - exploded as a crime. for 18 months that we have seen industrial scale l that we have seen industrial scale increase in the number of incidents that have occurred and there is no doubt that gangs and organised crime is driving that increase. we doubt that gangs and organised crime is driving that increase.— is driving that increase. we have all seen the _ is driving that increase. we have all seen the footage _ is driving that increase. we have all seen the footage and - is driving that increase. we have all seen the footage and it - is driving that increase. we have | all seen the footage and it strikes me as quite often now, it is absolutely brazen and the nature of what we are seeing. i absolutely brazen and the nature of what we are seeing.—

absolutely brazen and the nature of what we are seeing. i have seen cctv footage that — what we are seeing. i have seen cctv footage that members _ what we are seeing. i have seen cctv footage that members of _ what we are seeing. i have seen cctv footage that members of sent - what we are seeing. i have seen cctv footage that members of sent to - what we are seeing. i have seen cctv footage that members of sent to us l footage that members of sent to us and people are not trying to hide the fact that they're stealing, they're opening with huge bags and just sweeping the shelves and is resulting in retail is putting our dummy products to protect their stock and it's just really hard for them to deal with. just stock and it'sjust really hard for them to deal with.— them to deal with. just a few moments — them to deal with. just a few moments ago, _ them to deal with. just a few moments ago, not _ them to deal with. just a few moments ago, not that - them to deal with. just a few moments ago, not that long | them to deal with. just a few - moments ago, not that long ago, used to be alcohol, cigarettes and now it can be just about everything. eager? can be 'ust about everything. every broad can be just about everything. every broad range _ can be just about everything. every broad range of _ can be just about everything. every broad range of businesses - can be just about everything. er broad range of businesses and survey last month suggested that 71% of them to experience this type of crime and any type. 71% in any type of business is the target. and crime and any type. 71% in any type of business is the target.— of business is the target. and tell us, the of business is the target. and tell us. the impact — of business is the target. and tell us, the impact that _ of business is the target. and tell us, the impact that has _ of business is the target. and tell us, the impact that has on - of business is the target. and tell us, the impact that has on staff l us, the impact that has on staff because it is the potential of violence and intimidation and are

your members telling you? these --eole your members telling you? these people are _ your members telling you? these people are not — your members telling you? these people are not only _ your members telling you? these people are not only more - your members telling you? life people are not only more emboldened, their more aggressive should people try to intervene because it is backed by gangs and a part of a group, theyjust feel as they have no right to be challenged and they are going to do crime irrespective. and the staff and the owners are traumatised in many ways in the best way to describe it, it's like being burgled every day and if you can imagine that since they are being burgled in your home every day and it feels like that to the shop owners. ~' it feels like that to the shop owners. ~ ., owners. thinking that might well have in just _ owners. thinking that might well have in just a _ owners. thinking that might well have in just a final— owners. thinking that might well have in just a final thought - owners. thinking that might well have in just a final thought then l have in just a final thought then because shops of security guards now, the larger ones. what is the solution or part of the solution thatis solution or part of the solution that is required?— solution or part of the solution that is required? alongside pro'ect peaasus that is required? alongside pro'ect pegasus which fl that is required? alongside pro'ect pegasus which is i that is required? alongside pro'ect pegasus which is funded �* that is required? alongside pro'ect pegasus which is funded by i that is required? alongside project pegasus which is funded by retail l pegasus which is funded by retail and retail sector working with the police and the government, there's retail action plan next september and we need to make sure that

despite the change in government, we do not lose momentum in that area and we have seen some of these gangs disrupted by project pegasus and we have seen the labour manifesto of policing and we haven't heard much about it and we need to know what that commitment, what, we hope it means more policing on the streets, they'll be a good deterrent.- they'll be a good deterrent. thanks for cominu they'll be a good deterrent. thanks for coming and _ they'll be a good deterrent. thanks for coming and talking _ they'll be a good deterrent. thanks for coming and talking to _ they'll be a good deterrent. thanks for coming and talking to us - they'll be a good deterrent. thanks for coming and talking to us about| for coming and talking to us about it today. signed to submit a discovery that could slow down ageing and prevent scarring and artificial skin they were that the precise way from stem cell and how they are turned off during the ageing process and the atlas project in his the science correspondent. professor mustafa hanifa is trying to find out how

humans are built one cell at a time. it's one of the most ambitious research programs in biology, and the potential benefits are enormous. if we knew how we can actually manipulate the skin from not ageing, we will have fewer wrinkles, enhance our heart, all of those things that can rejuvenate organs. so how can you understand what happens during development, adulthood, ageing, you can then try to actually intervene and say, how do i make the heart younger? how do i make the skin younger? so it sounds like the human cell atlas was invented for someone like me. i think. it was invented for all of us. humans, and all plants and animals are made from cells. these develop in the womb and after we're born, to make up every part of our body, such as our skin and our arms and legs. and this happens because microscopic genes inside each cell give instructions on which bits to grow and when. this is a slice of skin just a few millimetres in depth.

you can see a hair follicle on the surface. now, if we zoom right in, you can see what looked like fairy lights. these are in fact, individual genes that are turned on that make its different components. the ones in orange are responsible for the topmost layer, and in yellow are the genes responsible for its colour. now if we look over here, we can see a developing leg. you can see again, all sorts of genes are turned on to make the bone, muscle and cartilage. this happens all across the human body. to grow the organs and tissues we need. these dishes contain skin cells that have been artificially grown by researchers, by using what they've learned to turn the right genes on and off, which they do by adding chemicals to the cells. the details have been published today in the journal nature. look closely and you can see tiny hairs growing out of them.

that's incredibly exciting because it's giving us new insights into physiology, anatomy, and a really a new understanding and a rewriting of the textbooks in terms of our cells and their molecular constituents and our tissues and organs and how they function. these pictures show different parts of our body growing. they give us a deeper understanding of how the human body works, and should lead to better treatments to hold back the diseases of ageing and help us live longer, healthier lives. pallab ghosh, bbc news, cambridge. thank you so much forjoining us and it's an incredible story and tell us more about what you have done here. it is actually fantastic. it's just amazing to have a map in terms of the recipe in knowing how the skin is built essentially with dismounted

and we learned how to grow the skin in the dish and added some immune cells in there which helped facilitate the skin to mature and it provides fantastic windows of opportunity of how hair grows after the original has stopped growing and have the skin heals without scarring and you're comparing it to the reindeer skin, the endless skin and the atlus skin doesn't scar as the others and you see the skin that doesn't scar and all of this is going to have huge implications and being able to grow skin in the dish for transplant purposes, burn victims and skin diseases in we can watch how the disease evolves and try to work out how to prevented or

reverted. . , , ., reverted. incredible in terms of the potential here. _ reverted. incredible in terms of the potential here. what _ reverted. incredible in terms of the potential here. what are _ reverted. incredible in terms of the potential here. what are perhaps . reverted. incredible in terms of the i potential here. what are perhaps the hurdles that you still have to get over and what is the likely timeline before you can do some of those things that you just outlined? we before you can do some of those things that you just outlined? things that you 'ust outlined? we do not have a things that you just outlined? we do not have a product _ things that you just outlined? we do not have a product off _ things that you just outlined? we do not have a product off the _ things that you just outlined? we do not have a product off the shelf - not have a product off the shelf that you can use, so to speak. by thinking a few years' time, this is going to be a reality in terms of being able to stop us from losing hair, for example and having much more youthful skin and being able to make a massive difference for patients with skin diseases. i predict somewhere in the timeline of three to five years, we'll get very close and will have a map of the skin is built and what happens is a fantastic start and having such a map and you can travel very far and in 1431 00:1