what is carried out by the republican molecular kinetic laboratory? well-developed logistics allows to concentrate, and the weight of the biological material of patients in whom the issue of the value of this type of therapy is considered, followed by genetic testing, and the methods of genetic testing are quite diverse; the main ones are polymerase chain reaction , molecular sequencing, legal institutionalization and other methods. these are very time-consuming methods that also require high qualifications of specialists, which determined, just the same, the expediency of concentrating all research in one laboratory. another example of the treatment of oncological neoplasms in personalized medicine is cell therapy. from the name it is already clear that doctors take cells or tissues of the person himself, one of the directions is associated with dendritic cells. they regulate the body's immune response in response to a tumor. and the second direction is actually

ta-lymphocytes, these are killer cells that am destroy, tumor cells, david cells are obtained by laboratories from the monocytes of the patient himself, patients take blood, monocytes are isolated and further. they are loaded with tumor antigens. that is, these are the proteins that are on tumor cells. they tend to be different from proteins, e.g. the rest of the body's normal cells. e and further with the reverse introduction already into the patient's body. they start presenting. it is such a term to represent these tumor antigens those lymphocytes naive these those cells and if provided that u they have corresponding receptors different capable of recognizing this tumor. they are activated in the process of this recognition. and after that, they actively share and have high potential. destruction of tumor cells is formed by specific clone experiments. but it should be noted that this

therapy is more of an auxiliary one, that is, surgical treatment of chemotherapy, no one cancels lymphocytes. there are several subspecies - these are cytokine-induced killer cells - these are , uh, lymphocytes infiltrating the tumor, and finally, and cortex cells are those cells that carry chimeric antigenic recipes; the basis of the method is the same patient's lymphocytes are taken, either from the blood or from the tumor tissue of the surgical operation and beyond. they divide very many times, they are activated due to the fact that we create such conditions and are returned back to the patient by the so-called approved cell therapy. now the raven of a patient of oncology medical radiology is successfully passing the scientific project of doctors treating patients with scalorectal cancer at the fourth stage. these citaki will be equal material cells, but it's too early to talk about the results, because the project started. only in may, we have five patients so far. well, we hope for a good result. i

would like to elaborate on the therapy map. i believe that this therapy is the future, because it is already genetically modified cells of this hotel, the patient's lymphocytes are still in which information is introduced using a virus that encodes a chimeric awesome recipe. this is the recipe that is able to recognize tumor antigens with 100% probability. this, according to scientists is a very promising method and is not available in all clinics of the world, even the leading ones, because the technique is very complicated. the first commercial product was e. it was registered in the usa in 2017 and since then this one has been on the market for these few years . by billions of dollars is, but this is due to the fact that the treatment is very expensive. mm. here is a commercial product. ah, it costs about $500,000 475,000 for a patient. am we have we calculated, as if the approximate cost is somewhere around

50,000, that is, 9 times less there actually 10 the technique is suitable for patients with leukemia or lymphomas. this one has already shown its effectiveness , let's say there are patients who were in the first clinical trials of a commercial product. they have been living for 12 years. these are patients who by that day had exhausted all the possibilities of therapy, that is, patients are still on a mission in our center to treat patients with back cell lymphomas. we have already treated five patients four have already been under observation for quite a long time one patient was seen or cells and sixth during manufacture. by the way, this is a purely development. the belarusian institute of organic chemistry has developed a cellular structure for introduction, and in the center of pediatric oncology they came up with the method of obtaining a cell map. and one more term that we have not yet analyzed is medicine, preventive, what is

this and what is the role of this preventive medicine in medicine, for example, personalized preventive and personalized one into the other, as if without plunging, but these are two approaches that are carried out at once simultaneously with respect to one patient, so everything about prevention. this is how we prevent the development of some complications of the condition. health, the most common thing that absolutely everyone faces. this is a vaccination calendar - they are vaccinated starting from the maternity hospital. and then everything goes according to the calendar. and if he needs to go to africa, relatively speaking, of course, he needs to get certain vaccinations that would prevent possible conditions that he may have there, another question is that there are all kinds of covid pandemic epidemics. eh, that's it recent. yes, there is too. uh, vaccinations also need to be performed if a person is at risk, here in this warning the second point is the way of life, our way of life is largely

50% according to this condition, it determines our state of health, how we organized it for ourselves and how we carry it out what we organized. this is where our state of health depends on you, according to the formula. who, in addition to a healthy lifestyle . our health is also influenced by genetics. well, 20% is also the environment. here, perhaps to change a person can move to another place and to the other side and so on. yes, it will change, wedge is only 10% transported to health care and rely on doctors. uh, here, so that they fully carry out this preventive approach. it's not entirely correct, though. patient yes the chief of preventive medicine is he decides to go to the doctor or not to go to the doctor. it is he who decides there what way of life to lead he decides whether he will have bad habits or whether he will not have bad habits, all this will definitely influence. our state of health. i am i say, well, i have no more questions left. thank you very much for taking the time for our

program, but the company is coming to an end today, we tried to look into the future and understand such a new concept as personalized medicine. i hope our guests impressed you with ideas and scientific research. health to you and your families and see you on the air. everything changes very quickly time goes by imperceptibly minutes days of the year we never have enough time to stop and think about those who are waiting for us it is at this moment that it is worth remembering those without

whom we will be so lonely on this earth, it's time to say you know mom, i miss or listen to dad right now, without putting it off for later, you need to say. i'm here, i'm here appreciate the time spent with your loved ones. literally yesterday, we started excavations and found material that confirms the version that there was some kind of handicraft production, most likely. we stumbled upon the jeweler's workshop piping hot. we are standing at the place where 1,000 years ago there was a furnace and a jeweler's work.

a master fact that truly amazes the imagination and another reason to be proud of the belarusian archaeologists about literally ten meters away the legendary river flows, which gave the name to the beloved capital today it’s hard to believe, but the history of the megapolis began right here near the modern village of gorodishche now it’s quiet and a quiet place about, glorious, whose past is reminiscent only of quaint hills, signposts and inscriptions on boulders. but in the tenth -eleventh centuries, life was seething here. we found trade craft posad settlement on the river, where there were some workshops. business trade is not far from here. in the very menka, probably 50 meters away, there was most likely some kind of pier, where small boats could land, ships with goods for historians and archaeologists gorodishche fertile ground for research, these specialists do not build theories, they rely solely on the evidence base . here it

is this summer. they disappear not in the archives, but on the site of one of the thousand-year-old settlements in general, if hmm look at the structure of a medieval city - as a rule, fortified settlement ledenets and posad open such settlements settlement of the archaeological complex ment four such seven bream around the settlement we are now on the territory of settlement number two, which is located on the left bank of the handle from the mind, when you imagine, that this earthen rampart is more than ten centuries old, then it makes a greater impression than the great wall of china in the place of empty space. in the center. it used to be a real city. wives and ten-meter walls, in which the princes, artisans, merchants lived, the population density here was one of the highest in the principality of polotsk, archaeologists found spirit, fragments of dishes, weapons, artifacts from scandinavia, byzantium and egypt, we found seven trade seals of lead with the image of princely days, saints with such seals

sealed goods and they also sealed the skins of fur animals, which were the main settlement material - the weights of the coins were found in the tenth-eleventh century, and also found a large number of all kinds of non-ferrous metal melts chopped tin ingots. which indicates that here, in addition to trade, there would also be a craft and not just a craft, but jewelry precision , ancient jewelry that was lying in the ground yesterday surprises with the elegance of execution. here, look at this part of vitov's ring. there's still a patch left here. that's when persia is molded . the sprue channel and on the edge of the product such a kantik is called a flash, then the master bites off this rebound and protects it with files and the finished product is obtained. it's still here, not cleaned, most likely, the product broke during the manufacturing process and the jeweler put it aside for a while, you need to understand that the

inhabitants of the era took everything that was best and necessary with them, moving from place to place. but broken dishes, torn worms or such a broken one in half, the ring remained behind the new cultural layer , metallography shows that most of the jewelry found here is made of tin and its alloys. confirmation from excavation sites, we rise to the earthen ramparts and get. in the very heart of the city. have you ever heard that we have our own danube, but this is not a river, but a narrow stream, and it was on it that they began to settle. from the middle of our millennium, the minchuk parents began the movement of slavic tribes to develop new territories, since this territory was very poorly populated. the settlement potential is still quite large. the most important thing is that the floodplain, the upper reaches of the rivers are bird-like. this copper is very beautiful land. for farming,

in general, the practically ideal future settlement determined the path from the varangians to the greeks, and powerful walls were erected for strengthening. now it is we are standing on the vakh, the so-called settlement, this is the original settlement of the iron age, to which slavic tribes of oxen came in the ninth century. here they were a little less filled up. they were there when they were hanging out, and these big ones, in order to strengthen the defenses of this settlement, however, the ancient metropolis, together with its jewelry workshop, did not have long to exist. on whistle. one of the largest fortifications. at that time, the thirties, the eyes again showed the dun that minsk obeyed the shift. here in this book, 50 things can be said, could minsk have shifted and moved to the svisloch, rather, this is how the minchuks moved, taking the name of the city with them , academician mikhail yesinsky was the first to put forward this hypothesis, and belarusian

researchers. vasily tarasenko, who immediately after the war began to carry out excavations at the minsk castle, confirmed this idea. this is a layout of the yak looked like an armenian suede on a horse, let's say so on the twelfth and eight, which is minskskaya, more often, where we are on a nemeze and svislok times more than a castle of moments, but there is a settlement in the roundabout mountains, and here on the eleventh side zero is told. well, maybe there is one there, one there, two maximum hegel's answer for a long time lay at the base of the bulk shafts, the excavations that were carried out during the construction of the roman metro in the middle, the eighties, our hero was lucky to touch history with his own hands until 20

cm, no more, and luda and these are nine rolls so 9 m in berlin itself and at home there is a shaft of 15 m. you know, multiply this is the sound of a mathematician, and the circle that circles the circle on the whistle is practically 1 km. and so gorky demanded that the dried-up berlin be laid down in order to serve this shaft. i'll tell you archaeologists have treated none. you think 40,000 trunks. you are the key to the pines, according to modern estimates, this territory occupies up to 16 football fields, a grandiose construction site at the confluence of the nemiga. unfolded at the end of the 11th century. prince vseslav nicknamed the wizard and this required colossal human resources. glory was

to score such fast what would control all this, that is, it was pulled off by all the economic flows of everyone, england phenomena courts on the nemise, i began to be called a nanny and he defeated that posada , he was not here, there were no peers. let's live in the army and the name of this fortress city was worn, correspondingly, being located on the banks of the nemiga river, by the way, in the annals, the simultaneous mention of two cities was preserved. minsk and neza. i got in myself. and the volost, of this carriage, all of you, and even bowed. yes, the territory. what she was, she was caught by the minsk parish, and that, having named the capital of natural exchange, there are courts for a nanny three hectares,

surrounded by a steep tree, an earthen rampart, which reached a height of seven meters and a width of up to 30 such was the legendary minsk castle, archaeologists were amazed by those depths , which opened before them back in 1984. and then it was even possible to walk along the streets of the ancient city, our operating grain. here it will be 18. here is our excavation of the eighty-fourth fifth of the eighty- sixth year, that is, the very, very great two thousand square meters. and so the roller we conceived began here, this end, where are the reports on us. come on us where we stand. right here behind us is the end of the bottle of this projector, this is the courts. here you find the avenue with two bottles passes here with them there, yes, schoolchildren,

turning back every day, thousands of people pass by the house of an athlete not even suspecting. what a treasure is under their feet exactly at the modern exit of the metro station by them, in the direction of the sports palace, there were entrance gates, and pobediteley avenue crosses the dil castle in half, these places keep it and another secret in 1993 at this place a form for murkov was laid out temple, elk well, such an abundant memorial place, and i’ll even say that this is not a temple above the temple from the cover there, and we have shares of your god booths not above the temple. well, in general, the orthodox church came out to know such a miracle, found here archaeologists. and another very important object that echoes the legend of the city's foundation by a strongman, a sign and a miller meniscus is the largest excavation. here, the eighties were carried out

during the construction of the excavation of the metronium station. yes, and during these excavations, the foundation of the building was discovered, which the archaeologist peter russov identified as put up with the 15th century. this mill was mentioned. uh, they brought me to the magdeburg law. 499 years perhaps this is the mill and became the prototype of the legendary mill to me a little after all. it is known that in it there were four water wheels. the king, the polish grand duke, the lithuanian sigismund, the third vase gave permission for the construction of two more wheels, it would have turned out six wheels, almost like the seven of the medic , this mill was destroyed on the night of april 22, 1751 as a result of an armed performance by the minsk chernisiatrist, which was very colorful the character of minsky void antony tattooirovich is childish , nicknamed the rhinoceros, and he could become the prototype of the very meniscus that grinded stones into flour,

however, real confirmation of the legend. so no one and did not find it, but between minsk of the period of the magdeburg law and the center of the specific principality, many important historical events lay. here is minska for the role. here is such a cardinal center. we have a belly knitted it. i think the prince is enough for us in the moments of minsk bread. this was the son of all glory to the wizard and i am to you a memory where he divided his land and his possessions, in addition to six sons, and you are all beauty. bread became not only a youth of its own, but a sheet of experience to give and for a big role it was hiding to fight with the kiev princes. behind that the persecution was full and he sat at, and it was precisely this that he personally showed that all the handsomes were such a center, that is, where all the princely chambers were, and there the squad was sitting right there at first to succumb from the church or i pressed memory to you. they say minsky has finished his life all over the place, so minsk is losing its independence, but not its main function of managing nearby lands. ah, the brightness

is so self-sufficient, one warehouse is large, or as i bring polyustovsky. here they become the center, and that's what a and after this improvement belarusian lands, namely this part of 1793, although before russia becomes the city of bern, the idea for the trunk of its status is already yes, for now, the revolution and that's it. this time the city grows first around the castle, the city posad is formed, the most ancient street later the settlement on the left bank of the svisloch, 16-17 years old, led. it seems to me that this is trinity rotten. by the way, the trinity opera and ballet theater. this is rakurska, although we have leaves behind them on troitskaya mountain. we had a dairy market. such viscous. these are torchs, where they served everything, and there where all these machines were mined - these were some kind of under-wall beards the lower market, but the upper city has long been considered the most prestigious place already in the middle ages, the richest

, the largest choirs can already be first for the knights, in one place they had, you know , their own, and she rolled the temples conceived vermicelli, that is, according to misha, there were none of them, that is, all sorts of houses stood close to one to the bottom of one aller rarely and he would have raised his neck for one and a half or two upwards. it must be said here that minsk was wooden for a long time, so it burned down more than once for the same reason, the town hall of tu that we can see now was not built to the ground for the same reason, was built in modern times at the beginning. of the 21st century, and here is a unique preserved house in which two eras converged at once, minsk became a stone highway of the russian empire, we can afford to give fireplaces home, maybe only the richest, and the zhikhars landlords from the vakulnye vesok and yards and russian officials oh my god, er rich ball, and she lived in the axis. i'm just in a house such as the state, that is, only any tall stone near moore

often the master could be placed, and some temples, uh, for example, now at the replanting will be yakovlevne, tady . i open important living quarters - these were drones, as minsk residents lived in those days. we had five helmets for wood-burning stoves. teplita so and why are they all a feasting wife, and natural products according to wine memory, that the christian tradition often had fasts. there she passes a meat ride, a market got along. if you don’t know how to follow the hedgehogs, the gentlemen didn’t require to go far, because the difference between us, probably, top market. here you can. and besides, the legislator of the polish-lithuanian commonwealth, the grand duke of lithuania, was not allowed to sell more, that we established a sovereign tax, a new page in the history of the city opens in the 19th century, for the first time in minsk a whistle. steam locomotives resounded in november 1871, when a section of the railway was opened in the direction of smolensk-minsk, brest. this gave a powerful impetus to the emergence of the first

enterprises . we have the first minsk had a central water supply and electricity, and the guests were spitting like that. everything in this desire helped to hide. according to primitive rumors, a taxi, but only wealthy garages could use such services, and guests of the city were available for everyone else, the minsk race. we are now near the car. this is how it looks like. minsk icon, and as a rule it was painted in such a blue color and next to it you are met by such a person who was called the conductor. he's done well with his such a special uniform something reminiscent of a lyceum, he had such tickets, paper tear-off tickets, the cost was very cheap and then there were 2 kopecks. four kop. and on average, the fare cost up to 20 kopecks. on the central line, then there were no

public transport stops, as well as the rules of the road, the kunku was caught with the words, stop, and went out on demand to warn their passengers that the transport was now becoming, or would move, here hung like this loudly called, so constantly this podkap sound of iron roads, and this bell rings constantly, so the competition was heard from everywhere in any part of minsk, but it replaced the first public transport. in 1929. tram. however, this is a completely different story. we will continue our story. about minsk very soon. you look, and you can tear off never suitable, a charge of emotions of a stumble. i consider absolutely not

a creative person to be so hard-nosed anymore. well , such a stubborn person. here, this is my art. i think so, there are moments when people just, well, they were denied, yes, that is, they were closed alone the doors, the second ones, they don't try any further. here. well, i 'm going, that's until they open it, the belarusians are a project of updated people. we are all births, we are from childhood yes, and i don’t remember at what point the project was born, it was born for some time, and it was a series of some of my street choices, as we are, you and i are thermos sandwiches and discuss the most important matters precisely on center of the lake not yet. yes, we will discuss, but we will not come to a common concept. we don't leave the lake. this is how we like to have fun and work on our tv channel. catch weaving is now very well represented

by our masters. it is reborn. it is saved masha lecture will popularize it. so naturally, not only baskets are woven, they are woven, the most diverse product. here it can be a vase of talk. it could be furniture. these are some decorative abstract forms to decorate their dwellings, but not only dwellings. now such a direction in the eyes of weaving is in great demand. how culture is done, sadovo parkovaya , it can also be abstract, or maybe in the form of some animals or specific objects and very much in demand right now. uh, weaving living trees from people. they are also called baby roots. we still have the name northern palm, because in its outline in its outline. they are very similar to palm trees. who is the most difficult thing for masters today is the preparation of material or directly working with it , the most difficult thing, of course, is the preparation. this is just

hellish work of their students. from the very beginning, i scare you in all the details, how hard it will be for people to imagine? what is their waiting, if you weave wild material, you need to find it; it grows in such pribalochennyh places somewhere on the banks of the rivers, and the lakes have to get there. it's already hard physically. there it is necessary to resemble zhenya growing up. it’s not the same as in the factory. yes , everything is made one to one, the same length, the same thickness. you just need to find it, then you need to assemble it, tie it on yourself, take it to some car, bring it to the house, and at home we are waiting for more processing. it must be boiled, debarked , planed. it's a very, very long twosome. process. here in the lieutenant or quality, for example, there are patterns. and if they have banned you, he prohibitors have their own basic methods of weaving, which are repeated, in principle, among all

the peoples of the world. they haven't changed in many, many years. these are the same weaving techniques that our distant distant ancestors had. the same ones are used now, but at the same time we use these elements. we will come up with something new by combining them in different ways. we can create new patterns.

in the region with you daria tarasova good evening and briefly about halloween i'm sweating in this issue of provocation thin luda osvoid to be on duty on the vodskhovychny monitor, etiquette. radish puts a stop to winter fishing, how do you spend ice paste on me, as a formula for effective processes in the minsk region.