i'm going to the table, son, i'm going. and who put it? i did quit smoking. one person said that smoking. raban every week we are laying new routes in interesting corners of belarus today, i will debunk myths and discover for you, zhidvichi and surroundings. captain let's get acquainted with interesting people, and in many ways they have succeeded. indeed, they often call our palace, and belarusian is universal for our belarusian scale. this is indeed a very significant palace. one of the largest one of the most magnificent palaces, showing local traditions and iconic sights, the territory of the modern national park was inhabited 1,000

years ago. there were many such places here, see the program on belarus 24 tv channel. hello, i want to wish you a happy new year. ksyusha is hard to hear. i want to congratulate you on the upcoming. ksyusha can't hear. repeat strangely, i can hear you perfectly, ksyusha well, girls onions. come here. well, as they say.

i'll go take a look.

see happy new year cool let

's celebrate the new year. thank you knee. sorry, as you can see ordered ahead. so suddenly they took it and suddenly. and what, so every time after the new year, yes, until the very old new year, the girls are once again

the foundation of the year and merry christmas. and in general, today you can go home early. and what happened? my arkady yuryevich returned to me, what did he investigate to prove? hello , excuse me, but bureaus of people are not looking for us. here are such

a oh, this is my naita, her name is glad. but if you want, we will call her knows. i 'll show you my good one. wait. now i told you the same, remember. now wait wait, now just a minute like this, and now to me at night now oh, oh, now wait. here oh now ah well in the woods. i'm telling you, and where she got lost, she got lost in a ravine, there was a strong snowstorm, i then well, a long story many years ago, my father's grandchildren. and this is probably the great-granddaughter. and

the night of naida ahmash, masha, we are confused.

belarusian winter all its little things and all the details. some are so beautiful they are breathtaking. some awkward but together they are one . together, not harmony looking at them

feel the aesthetic pleasure. do you feel that belarus is closer? the scientific community first heard about this concept relatively recently only in the nineties of the last century. it was then that the american diagnostician. leo golub suggested using a patient-centered approach in the field of diagnosis and treatment of diseases. and now, 30 years later, doctors all over the world are literally on the threshold of a real

revolution, the transition to medicine of a new type , and it is called personized or otherwise personified on the air. science addiction. my name is ekaterina beretskaya. hello. and today we will figure it out. why the future in the field of medicine? so for sure , much closer than it seems to us, look in the program for an individual approach to the patient and not only study the main features of personalized medicine. change dna for health as our geneticists help physicians improve standard therapies and the pill is not for everyone with an emphasis on the personification of pharmacology. the development of personalized medicine is one of the priorities of our science, what it is in general and what personalized medicine should be, my colleagues have already asked the director of the institute of physiology of the academy of sciences, it is there that most of the issues of

the topic of interest to us today are being resolved. well, regarding issues related to personalized medical care, we, as scientific organizations, are most in line with work in cells in this regard. that is, we have a cell technology laboratory that has e- boxes that have different cultures. uh, cells, you can achieve the effectiveness of treatment is not only sufficient for such extensive e-oncological diseases of such cells. we have in our data bank, but from such interesting directions, given that the institute is largely behind the clinic. we have learned some variants of cells. uh, to print on a bioprinter and to carry out selective tests of already printed cells not on the living organism itself and there are certain in this pair success because the primary models that

we did in the eighteenth nineteenth year. we just press. uh, monolayer 3d printers model of his twenty-first year. we already have a 4d printer that clearly does not make multi-layer cell combinations. and this culture is multi-layered. she has to keep herself alive. there are special solutions that do not allow these cells to lose their viability, and they do not stop dividing and washing with such multilayer cell cultures . we are no longer only dealing with medicines, but also testing in some cosmetic products is less. uh, involved some laboratory animals, and more are already involved. yes , cell cultures in order to re-identify one or another approach for the treatment of some external defects. and in general, of course, for extranified medicines. this is the very future, because even aspirin preparations, which are prescribed for

vascular diseases, are suitable for some. optical therefore, even there, special adf aspitest tests are used, which allows you to evaluate the aggregation ability of platelets. and in general, what kind of anti-aggregate , uh, cells react to this, because people over 50, who get, uh, after sixty, even more sharp on such drugs, so as not to run into some kind of complications. in principle, most often gastrointestinal they should of course be evaluated for specificity. we are studying the p450 cytochobe in order to evaluate the effectiveness of this quote on the metabolism of incoming drugs. in addition, these sensations are great that some methods of treatment, especially oncological diseases. they all go based on the specific legal code. uh, great cool cells, genetics is very important

genetics. new diseases and genetics are a-a patients, so, of course, all cases are difficult to amenable to the traditional treatment regimen. they just lie in the field of genetic coding in oncology, in general, the treatment of any disease is impossible without a preliminary genetic academy, but in some cases, of course, we instill such methods in everyone today, studio with our guest it. hello hello egor vladimirovich lemeshko head of the multidisciplinary diagnostic laboratory of the institute of physiology of the national academy of sciences of

belarus ph.d. we have just learned what personalized medicine is in general. then. let's ask you. and what is happening in medicine now? what is the name of the one that is still a priority all over the world, including in our state, today's medicine meets the principles of the four paragraphs. yes. this is a forecast. this is a warning. this is exactly the same personalized medicine and partnership, if you analyze each principle, then the forecast, this is mine, we predict accordingly. state development. health, in a patient one of the measures is for example those. most vaccinations everyone knows what it is, but other preventive measures that yes prevent the development of complications of the condition, health, personification. here is what it is about . you just said the theme of our today's program. the point is that we do not treat diseases, but a person was still said by

mudrov, somewhere about three centuries ago, then they already came to this term. and today , such a state is being developed as much as possible, when we treat a person with his characteristics. eh, taking into account these features in the first place. this is about psychological characteristics. everyone, in general, has his own type of personality, his own peculiarities, reactions to certain stimuli, and so on. and the second point, if a person is affected by all kinds of microorganisms. any other external stimuli. perhaps, some violations on the part of his function already, which he has. all this will cause certain diseases and the body must resist this. and the first to react is the unconditioned autonomic nervous system, and these are the features, how this system reacts in someone, what features of the mental state it has. all this must be taken into account in order for the treatment to be as correct as possible.

that yes today we have protocols. we all know about them, and they also have certain advantages. doctors treat first of all unconditionally on them. but if the situation requires, then there are mechanisms by which treatment can be refined, maybe something will change dramatically with the advent of medicine, personalized or personified in different ways. here is what was, what is, and what will be. here you can. maybe there are some basic criteria about what is there, probably some kind of transitional moment. we have always paid attention to individual patient, but the protocols defined the scope, if such an opportunity arises, and it most likely will. uh, when we treat ourselves here. one on one with the patient and we will take into account all his features. it after all depends not only on the doctor. it depends a lot on the organization. how organized is such a personalized approach, how are such conditions created so that a doctor, for example, can directly pay attention to

a particular patient well, it's impossible. we have many patients, but there is only one doctor, therefore some compromises have to be found. well, and accordingly we have what we have, as it were, but we still go in the direction of personification of the maximum consideration of individual moments. and what happened before there was less knowledge, respectively, they treated what they understood what they could before, there was certainly less burden on the doctor. this is also due to a number of facts, and not only because the population there is growing, we have begun to live longer every day, of course. leaves us choices we can't stand still once we uh stay put for a while. we're falling behind here. she has to go ahead and succeed. and where to drive. this life is such a basis for intersified medicine, according to experts, molecular genetic studies will become, including at our institute of genetics, these cytology studies are already being carried out. let's see the plot. human genetics decides

what kind of eyes he will have, what color hair , body type, and most diseases are also laid down at birth . genetic doctors call them hereditary study of these particular pathologies. at the institute of genetics of the national academy of sciences of belarus, if scientists manage to find drugs that meet the individual characteristics of a person, medicine will reach a new level. we are engaged in, if we are talking about science about scientific research, this is the selection of some specific targets for the treatment of oncological diseases, and the second direction is, uh, individual sensitivity to drugs , the same drug, if we say, let's say about the treatment of cardiovascular disease. these are bisoprolls, a type of apparatus that lowers blood pressure, and they can be used at a dosage of 0.25 mg, then

50 mg and that's it. it also depends and is determined by the genetic characteristics of metabolism. here are the drugs that researchers are also studying the sensitivity to the chosen treatment. there are results of the treatment strategy or it still needs to be changed. joint research with the institute of psychiatry, which allows e, the right choice of antidepressants for treatment of various neurological diseases. uh, uh, probably also one of such interesting developments is the use of a genetic test in the selection of drugs for the treatment of viral hepatitis c, these drugs are very expensive. that is, they cost several hundreds of thousands of dollars, and these drugs are prescribed to the patient for free, but there are several drugs and 25% may be insensitive to a particular drug and with the help of a genetic test. it is possible to determine

the patient's insensitivity to this treatment and replace. e, respectively, the drug. naturally, no pills and doctors working in the direction of personalized medicine constantly focus on this will not be able to help if the patient does not change his lifestyle, and doctors, starting from genetic data, somehow guide their wards' lifestyle, nutrition, because it is clear that we all should be physically active , eat right, but most often a person does not think about it, when some problems already appear. and that's it the development of personalized medicine using all kinds of tests. this and genetic biochemical e, allows a person to correctly adjust his lifestyle . in general, do not put him on the fact that he must change his lifestyle and carry out disease prevention. genetic testing, without which individual medicine cannot do, has

been passed by 4,000 belarusians at the institute. the most frequent client of female investigators encountered problems when planning a pregnancy. development risk predictions multifactorial diseases - this is primarily miscarriage, when the use of this test allows women who have problems with our pregnancy to carry out the correct treatment during pregnancy and women give birth to a child. that is, this is one of these areas and the second direction two years ago. we have taken up new cases - these are various pathologies of the kidneys in children, er, and first of all, these pathologies of the kidneys are associated with the risk of developing various syndromes. many studies that literally 10 years ago seemed like a fantasy, they are already on the stream, at the institute of genetics and cytology above belarus

. however, much is still ahead, scientists are sure the future of medicine begins today in the air of science addiction. we continue to understand personalized medicine and see further new ways of diagnosing monitoring, how informatization will help build a new type of medicine and why personalized medicine. it is profitable and you will soon find out what new generation drugs are being developed at the scientific and practical center of oncology and medical radiology. yegor a at the institute of physiology what research is being done in the direction of personalized medicine? after all, i know that this is one of the key scientific institutions. exactly on this topic in the structure of the academy of sciences and the essence of physiology is engaged in the biomedical

direction. this is the main scientific institution and, as far as direct medicine is concerned. without let's say biological moments, we are developing a computerized system for monitoring the physical state of the patient's location. this system. she absolutely personalized. that is, each patient has an inserted medical device that registers his physiological parameters in real time, transmits to e, a remote workplace , in turn, a doctor, wherever he is, he can receive this information, if it is alarming for some parameters, then this allows you to react in time, and not delay the time until the next appointment, for example. this is just a timely response. it may be simpler than the one that could follow later, because time has not yet been lost. you can, for example, sit down somewhere, somewhere in time, take a pill that corresponds to some other manipulation, and everything will be fine. this is up

to the point that an ambulance brigade will be called to this place where a person is located and he will be proved his time, emergency medical care, not always a patient is able to notice such changes in his body sometimes even life threatening and our system is aimed in order to detect such things in time and respond to them. now. let's talk about medicines, because many people think that personalized medicine. this means that aspirin citramone, which helped everyone, will disappear, and everyone will have their own pill, so the question arises. where are so many pharmacies? color and how it will be in general, but in fact, in pharmacology yes, the emphasis is also on impersonation, but this is a different situation, i understand correctly, just such a universal pill for a particular patient is very unlikely that we are going to this we will come, maybe someday, but so far it is even

very difficult to predict. and in general, uh , somehow imagine how, uh, real, uh, of course, they will develop medical preparations, because the same microorganisms do not stand still. they also improve, too, they have protective mechanisms. all this needs to be studied and, accordingly, new medicines should be developed, and they will certainly be made and used in practical healthcare. while the development of drugs . it will probably be like this we see it now, in order to have time to overcome the obstacles that we have. in general, in the life of some such universal tablets. well, it doesn't seem to be. it is possible to imagine in general such that research in the direction of personification of pharmacology is already being carried out in the npc, oncology and radiology. i suggest watching the story. it used to be that all

malignant tumors have approximately the same components. that is why they talk at night at the practical center of oncology, radiology and treatment regimens, in fact were the same today, the doctor knows the molecular biological characteristics of all people are different, and this is a new task for doctors to create a drug that takes into account the characteristics of tumor development at the genetic level, the tumor is a unique genetic level, which directly affects the effectiveness of therapy and her aggressive behavior. these characteristics may change over the course of treatment, so chemotherapy regimens that are initially effective may not be effective as they progress. progression of the disease, a personalized approach does not contradict the generally accepted therapy regimens, but complements them and makes them more effective. its essence lies in the use of specific drugs targeting molecular targets

, therefore, they are not called target -directed or targeted drugs; targeted drugs act more selectively. the main thing is to find molecular targets in the tumor, genetic testing copes with this task. the official action on starket drugs is based on conducting molecular genetic testing. currently. uh, the entire spectrum of molecular genetic research for the selection of targeted therapy for oncological patients, and in the republic the republican molecular kinetic laboratory is carried out, the proven logistics allows concentration. uh, all biological material of patients, uh, in whom the issue of prescribing this type of therapy with subsequent genetic testing is being considered, and the methods of genetic testing are sufficient diverse main ones are polymerase chain reaction, molecular souveniring and naturally such prioritization and other methods. these are very time-consuming methods

that also require highly qualified specialists, which makes it just the same expediency to concentrate all research in one laboratory. another example of the treatment of oncological neoplasms in personalized medicine. this is cell therapy, from the name it is already clear that doctors take cells or tissues of the person himself from one of directions associated with dendritic cells. they regulate the body's immune response in response to a tumor. and the second direction is actually tha-lymphocytes, these are killer cells that destroy, tumor cells of other cells are received by laboratories from the monocytes of the patient himself, patients take blood, monocytes are secreted and further. they are loaded with tumor antigens. that is, these are the proteins that are on tumor cells. they tend to be different from proteins, e.g. the rest of the body's normal cells. e and further with the reverse

introduced into the patient's body. they start presenting. it is such a term to represent these tumor antigens those lymphocytes naive, these those cells and if, provided that they have the appropriate receptors, different ones are able to recognize this tumor. they are activated in the process of this recognition. and after that, they actively share and have high potential. the destruction of tumor cells is formed by specific clone experiments. but it should be noted that this therapy is more of an auxiliary, that is, surgical chemotherapy treatment, no one cancels lymphocytes. there are several subspecies - these are cytokines, strangled, killer cells - these are, uh, lymphocytes infiltrating the tumor, and finally, cortex cells are the cells that carry the chimeric antigenic recipe; the basis of the method is the same; lymphocytes are taken from the patient either from the blood or from the tumor tissue surgery and beyond. they divide very

many times and are activated due to the fact that we create such conditions and return back to the patient the so-called cell therapy. now in the internet of oncology, medical radiology is successfully passing the scientific project doctors treat patients with colorectal cancer at the fourth stage. here is a quote to rush equal cells, but it's too early to talk about the results, because the project started only in may, we still have five patients. well, we hope for a good result. i would like to elaborate on the therapy map. i believe that this therapy is the future, because it is already genetically modified cells, this patient's lymphocytes are still in which information is introduced using a virus that encodes chimeric antigenic recipes. this is the receptor that is able to recognize tumor antigens with 100% probability. this, according to scientists, is a very promising method and is far from being available in all clinics of the world, even the leading ones, because the

technique is very complicated. dollars is, but this is due to the fact that the treatment is very expensive. mm. this is a commercial product, and it costs about $500,000 475,000 for a patient. and we have calculated, as if the approximate cost is somewhere around 50,000. that is, nine times less there 10 in fact, the technique is suitable for patients with leukemia or foma has already shown its effectiveness, say there are patients who were in the first clinical trials of a commercial product. they have been living for 12 years. these are patients who on that day had exhausted all the possibilities of therapy, that is, patients until now. in condition mission in our center we treat patients with back cell lymphomas. we have already treated

five patients, four have been under observation for quite a long time. one patient last week saw either cells, uh, and six in the making. by the way, this is a development of a purely belarusian institute of organic chemistry, which developed a cellular structure for administration, and in the center of pediatric oncology they came up with the very method of obtaining a cell map. and one more term that we have not yet analyzed is medicine, preventive here what is this and what is the role of this preventive medicine in medicine, for example, personalized preventive and personalized one into the other, as if not plunging, but these are two approaches that are carried out simultaneously in relation to one patient, therefore everything that concerns prevention. this is how we prevent the development of some complications of the condition. health, the most common thing that absolutely everyone faces. this is a vaccination calendar - they are vaccinated starting from the

maternity hospital. and then everything goes according to calendar. and if he needs to go to africa , relatively speaking, of course, he needs to get certain vaccinations that would protect him from those possible conditions that he may have there, another question is that there are all kinds of covid pandemic epidemics. eh, just recently. yes, there is too. uh, vaccines too. it is necessary to carry out if a person is at risk, here in this warning the second point is the way of life, our way of life is largely 50% according to who, determines our state of health, as we do to ourselves organized and how we carry out what we have organized, this largely depends on our state of health, according to the formula. who, in addition to a healthy lifestyle. our health is also affected by genetics. well, another 20% is the environment. here, perhaps, a person can change, move to another place and in the other direction, and so on. yes , the glue will change, only 10% is allocated to

health care and rely on doctors. uh, here, so that they fully carry out this preventive approach. this is not entirely correct. still a patient. yes chief yes, yes preventive medicine. it is he who decides to go to the doctor or not to their doctor. it is he who decides there what way of life to lead it he decides whether he will have bad habits. they will have bad habits. all of this has an impact on our health. i say, well, i have no more questions left. thank you very much for taking the time for our program, but who is not coming to an end today, we tried to look into the future and understand such a new concept as personalized medicine. hope our guests with you ideas and scientific research impressed you. health to you and your families and see you on the air. why

they should not be responded to without serious evidence. do you agree that sazana doesn't want to talk, let's talk, but the facts on the table are important to understand that if we don't see something, it doesn't mean that it doesn't exist. what are new values, and why they are being imposed on us by a strong enemy is not beneficial, who thinks the same or this is different , we will collect evidence, consider different versions and show the contradictions in the project. it other. watch in new releases on belarus 24 tv channel.

in our project, we will show you unique personalities, in general, i am a person who even builds on intuition. that is, i'm still more of an artist than a businesswoman. i do n't understand. where it comes from, i can't even put my idea down on paper. they just flies off from somewhere above me, and do not break stereotypes by an example from my own experience, walking around a fabric store. i caught my eye, a certain fabric, which was probably the impetus. i realized that here this is my bagnovich. he was that incarnation. it seems to me the end of this stage of imperfection in the father's life. watch the

program to break stereotypes on channel belarus 24. ekaterina tikhomirova is on air now in the studio. hello, the income of teachers , retired doctors and the military, the salary and allowance of state employees. today they discussed in the palace of independence alexander lukashenko held a meeting on the main connection between payments and the real economic sector. that is, the more efficient. he will work. from the more opportunities will be indicated and yet according to the president. this is constant.