the issue contains more relevant information. see you at 19:00. new year, new impressions, new emotions and travel, someone likes to stay at home with fragrant tea and under a blanket on winter weekends, and someone is looking for new experiences, together we will build new routes with the lermontov house of culture. i met a craftswoman who makes dolls, charms of the lyudmila lomaka collection of more than 200 guards , eyes run wide, we will visit unique places in our country about friends. i felt like i was in a real fairy tale. it's not just everything is done with the soul. and also very elegant and just have fun with a mitten. give it back. no need to do everything like that , three two one. watch in the program

the route is built on belarus 24 tv channel, if a fight is inevitable, it is necessary to beat. the first to speak as it is and always learn to work in real conditions. this is not good. this is not bad. it's just a fact we are a wonderful country. we have a wonderful state , wonderful vertical of power, but there is no ideal propaganda genius, puppeteers in that they offer us a solution problems that would not exist if these same puppeteers weren’t next to us, the problem must be solved, and not dabbling and hunting from their presence, a simple formula for both political and personal happiness, the author’s view. igor dura to the main event in the country and the world. do not miss the new releases of the propaganda project on belarus 24 tv channel. the sun is sneaking

quietly so with bated breath, and this court that the trunk is big. the scientific community first heard about this concept relatively recently only in the nineties of the last century. exactly then american diagnostician leo hunger suggested using a patient-oriented

approach in the field of diagnosis and treatment of diseases. and now, 30 years later, doctors all over the world are literally on the verge of a real revolution of transition to a new type of medicine and it is called personalized or otherwise personified in the air of science addiction. my name is ekaterina beretskaya. hello. and today we will figure it out. why the future in the field of medicine? so definitely much closer than we seem to see in the program. individual approach to the patient not only and why the main features of personalized medicine, health, how our geneticists help physicians improve standard treatments. and the pill is not for everyone focus on personification in pharmacology. the development of personalized medicine is one of the priority areas of our science, what it is in general and what personalized medicine should be, my colleagues have already asked

the director of the institute of physiology of the academy of sciences, it is there that most of the issues of interest to us today are being resolved. yes this issue is related to personalized medical care. we, as a scientific organization, are most in line with work in cells in this respect. that is, we have a laboratory of cell technology, which has boxes that have different cell cultures to achieve the effectiveness of treatment. not only enough of such extensive er, oncological diseases, no cells. we have in our data bank. well, all the same, there are such interesting directions, considering that the clinic is largely behind the institute. we have learned some variants of cells to be printed on a bioprinter and to carry out selective tests of already printed cells, because the primary

models that we made in 1819 , the so-called simply 3d monologues there are already four printers that actually make a multilayer combination of cells. and this culture is multi-layered. she has to keep herself alive. there are special solutions there that do not allow these cells to lose their viability, and they do not stop dividing and washing with such multilayered cellular we are no longer engaged in crops only with medical preparations, but testing in some cosmetic products is less. uh, some lab animals involved, and more are already involved. yes , cell cultures in order to re-sectify this or that approach for the treatment of some external defects. in general, of course, for inified medicine - this is the main future, because even aspirin preparations, which prescribe prerequisites for the sake

of vascular diseases. not all patients are suitable, some are, so even there special tests. adf aspi test, which allows you to evaluate the aggregation ability of platelets. and in general, what kind of anti-aggregate do these cells react to, because people after 50 years of age who receive yes, after 60 they have even more aspirin-like drugs, so as not to run into such complications, in principle, they are most often gastrointestinal, of course, should be evaluated for specificity. we are investigating insurance 450 in order to evaluate yes , the effectiveness of this chromium quote on the metabolism of incoming drugs, in addition moreover, this is a huge reason that some treatments, especially oncological diseases. they all come from the legal code of a particular

excellent cool cell. the genetics of the red is very important, but the diseases and the genetics of the patients, so, of course, all cases. difficult, yielding to the traditional treatment regimen, they just lie in the field of genetic coding in oncology, in general, or the treatment of any of the diseases is impossible without a preliminary genetic academy, but having increased, of course, we have such methods for everyone today we can’t instill this strength, clinical experience and intuition for victory in sports arenas, not only strength, endurance and speed are needed, but intelligence, like muscles, needs to be constantly trained. how well belarusian

athletes understand sports. rifle what we play i choose the game dyna of ours. what is the name of the team of the support group and the hockey club dinamo minsk andrey pervyy caught, watch the intellectually entertaining show heading on belarus 24 tv channel belonging to the varta people strive relatives and tradition, we set off on an expedition along the patches of our ukraine to get to the place of destination, we tried to drive

33 km and eight at noon, went to the new polissya, what are we treating the area? yes, i follow her story, name , special images. the oldest cabin, the factories did not improve how the young groom sounded. they never spent at yakim's. let's give the second tradition a new life. on our personalized medicine tv channel we will continue to study in the studio with our guest egor hello hello egor vladimirovich lemeshko head

of the multidisciplinary diagnostic laboratory of the institute of physiology of the national academy of sciences of belarus candidate of medical sciences area of ​​scientific interests instrumental diagnostics medicine telemedicine technologies, legal support of health care cardiology therapy general medical practice human physiology such in general, personalized medicine. then. let's ask you. and what is happening in medicine now, as it is called , which is still a priority all over the world, including in our state today medicine meets the principles. yes, this is a forecast. this is a warning. this is exactly the same personalized medicine and partnership, if you analyze each principle, then the forecast is mine, we predict accordingly. state development. health, the patient has one of the measures - this is for example. that same vaccination everyone knows what it is, but also

other preventive measures that yes, prevent the development of complications of the state, health, personification. here is what it is about . you were just talking about the topic of our today's program. the point is that we we do not treat diseases, but a person was still said by mudrov, somewhere about three centuries ago, then they already came to this term. and today , such a state is being developed as much as possible, when we treat a person with his characteristics. eh, taking into account these features in the first place. this is about psychological characteristics. everyone, in general, has his own type of personality, his own peculiarities, his reaction to certain stimuli, and so on and the second point. if a person is exposed to all kinds of microorganisms. any other external irritants. perhaps, some violations on the part of his function already, which he has. all this will cause certain diseases and the body must resist this. and the first one to react is definitely the autonomic nervous system, and these are the features,

how this system reacts in someone, what features of the mental state it has. all this must be taken into account in order for the treatment to be as correct as possible. not to mention the fact that yes, today we have protocols. we all know about them, and they also have certain benefits. doctors treat first of all unconditionally on them. but if the situation calls for it, then there are mechanisms by which the treatment can be refined, maybe something will change dramatically with the advent of personalized or personified differently called medicine. here is what was, what is, and what will be. here you can. maybe there are some basic criteria about what is there, probably some kind of transitional moment. we have always paid attention to the individual patient, but the protocols determined framework, if such an opportunity arises, it will most likely appear. and when we will treat directly. but one on one with the patient and we will take into account all his

features. it after all depends not only on the doctor. it depends a lot on the organization. how organized is such a personalized approach. to what extent such conditions are created so that a doctor, for example, can directly pay attention. that's specifically one patient well, it's impossible. we have many patients, but there is only one doctor, so we have to look for some compromises. well, and accordingly we have what we have, as it were, but we still go in the direction of personification of the maximum consideration of individual moments. and what happened before there was less knowledge, respectively, they treated what they understood what they could before, there was certainly less burden on the doctor. this is also due to a number of factors, not only because the population there is growing, we have begun to live longer every day, of course, and here there are a lot of factors, yes, which also need to be taken into account, and time leaves us no choice. we can't stand on place as soon as we uh stay put. we are behind for a while. here it is necessary to go forward and keep up and overtake somewhere. this

life is such a basis for intersified medicine, according to experts , molecular genetic studies will become, including such studies are already being carried out at our institute of cytology genetics. let's see the plot. human genetics decides what kind of eyes he will have, what color hair, body type, and most diseases are also laid down at birth, genetic doctors call them the hereditary study of precisely these pathologies is being carried out at the institute of genetics above belarus, if scientists manage to find drugs that meet the individual characteristics of a person, medicine will reach a new level. we are engaged in, if we are talking about science about scientific research, this is the selection of some specific targets for the treatment of oncological diseases, and the second direction is, uh, individual

sensitivity to drugs , the same drug, if we are talking, let's say about the treatment of cardiovascular vascular pathology. these are bisoprolls, these drugs that lower blood pressure. uh, they can use at a dosage of 0.25 mg, then 50 mg and that's it. it also depends and is determined by the genetic characteristics of metabolism. here are the drugs that researchers are also studying the sensitivity to the chosen treatment. there are results of the treatment strategy or it still needs to be changed. joint research with the institute of psychiatry, which allows you to choose the right antidepressants for the treatment of various neurological diseases. uh, uh, probably also one of such interesting developments is the use of a genetic test in the selection of drugs for the treatment of viral hepatitis c, these drugs are very expensive. that is, they cost a few to this court or thousands of

dollars, and these drugs are prescribed to the patient for free, but there are several drugs and 25% may be insensitive to a particular drug and with the help of a genetic test. you can determine the non -responsiveness of the patient to this treatment and replace. e, respectively, the drug. naturally, no pills and doctors working in the direction of personalized medicine constantly focus on this will not be able to help if the patient does not change his lifestyle, and doctors, starting from genetic data, somehow guide their wards' lifestyle, nutrition, because it is clear that we all should be physically active , eat right, but most often a person does not think about it, when some problems already appear. and that's exactly the development of personalized medicine with using various tests. it's also genetic. these are chemical e that allow a person to correctly adjust his lifestyle

. in general, do not put him on the fact that he must change his lifestyle and carry out disease prevention. genetic testing, without which individual medicine cannot do, has been passed by 4,000 belarusians at the institute. the most private clients of the investigators are women who have encountered problems when planning a pregnancy. predicting the risks of developing multifactorial diseases is the first turn miscarriage when the use of this test allows women who have problems with our pregnancy to carry out the correct treatment during pregnancy and women give birth to a child. well, that is, this is one of these areas, and the second direction about two years ago we started new research - these are various pathologies of the kidneys in children, er, and primarily in the typology of the kidneys associated with the close development of

various syndromes. many studies that literally 10 years ago seemed fantasy is already on the flow. at the institute of genetics. cytology needs belarus however, much is still ahead. scientists are confident that the future of medicine begins today. by their appearance on the site, they are able to put on a show. which city is called eternal three two one correct answer and sometimes they are a big test for our participants. your answer.

a native minsker goes to the village to find out from its inhabitants, why is it better than the city of smorgon ? well, there was a nuance that there was a plant nearby built. we are so looking went to some historical place than from the factory. how did the locals react? here's to such your mureniya. i think they are happy that the village dies in the village is reborn and even surprised by my

perseverance, a lot of people want to return to nature, to the origins, to those memories that have remained since childhood. grandmothers. yes, we are ready to work, we turn our idea of ​​​​village life together with the heroes of the project. i am from the village. well, it’s definitely not with one here that several resolutions turned out not planned. well, that's because the wood is curved. on the air of science addiction, we continue to understand

medicine, personalized and see further new ways of diagnosing monitoring, how informatization will help build a new type of medicine and why personalized medicine is profitable and what new generation drugs are being developed at the scientific and practical center of oncology and medical radiology you will find out very soon . yegor a at the institute of physiology what research is being done in the direction of personalized medicine? after all, i i know that this is one of the key scientific institutions. that's it for this topic. in the structure of the academy of sciences, the institute of physiology is engaged in the biomedical direction. this is the main scientific institution and, as far as direct medicine is concerned. without let's say biological moments, we are developing a computerized system for monitoring the physical state of

the patient's location. this system. she is completely personal. that is, each patient has an insertable medical device that registers him physiological indicators are transmitted in real time to e, the remote workplace , in turn, the doctor, wherever he is , and he can receive this information, if it is alarming for some parameters, then this allows you to react in time, and not delay the time until next intake. this is just a timely response. it may be simpler than what might follow later, because time has not yet been lost. you can, for example, sit down somewhere, somewhere on time take a pill that corresponds to some other manipulation, and everything will be fine. this is up to the fact that an ambulance brigade will be called to this place where the person is located . he will be proven in his time, emergency medical care, not always a patient is able to notice

such changes in his body. sometimes even life threatening and our system is aimed at detecting such things in time and responding to them. now. let's talk about medicines, because many people think that medicine is personalized. so, all the aspirin citramones will disappear, who helped everyone, and for everyone there will be a pill, respectively, the question arises. where are so many? it will be and how it will be in general, but in fact, in pharmacology yes, the emphasis is also on perstnification, but this is a different situation, i understand correctly, just such a universal pill for a particular patient is very unlikely that we will come to this, maybe someday, but while it is even very difficult to predict. and in general, uh , somehow imagine how, uh, real, uh, of course, medical drugs they will be develop. uh, because the same

microorganisms. they don't stand still. they also improve, too, they have protective mechanisms. all this needs to be studied and, accordingly, new medicines should be developed, and they will certainly be made and used in practical healthcare. while the development of drugs . it will probably be like this, as we will see it now, in order to have time to overcome the obstacles that we have. in general, in the life of some such universal tablets. well not yet appears. it is possible to imagine such a thing. i know that research in the direction of personification of pharmacology is already being carried out in the npc, oncology and radiology. i suggest watching the story. previously, it was believed that all malignant tumors have approximately the same components. that is why, on the night at the practical center of oncology, radiology and treatment regimens are essentially the same. today, doctors

know the molecular biological characteristics of all people are different, and this scientists set a new task for physicians to create a drug that takes into account the peculiarities of tumor development at the genetic level, the tumor is a unique genetic level, which directly affects the effectiveness of therapy and the aggressiveness of its behavior. these characteristics may change during treatment, therefore, initially effective chemotherapy regimens may not be effective as the disease progresses, a personalized approach does not contradict conventional therapy regimens, and complements them and makes them more effective, its essence lies in the use of drugs specific to targeted molecular solutions, therefore, they are not called target-directed or targeted drugs; targeted drugs act more selectively. the main thing is to find molecular targets in the tumor, genetic testing copes with this task.

official action on targeted drugs is based on current molecular genetic testing , and the entire spectrum molecular genetic studies for the selection of targeted therapy for oncological patients, and in the republic the republican molecular genetic laboratory is carried out, the developed logistics allow concentrating, e, all the biological material of patients, e, in which the issue of the significance of this type of therapy is considered, followed by genetic testing, and methods genetic testing is quite diverse, the main ones are polymerase chain reaction, molecular rastinirovanie prioritization institute and other methods. these are very time-consuming methods that also require highly qualified specialists, which makes it just the same expediency to concentrate all research in one laboratory. another example of the treatment of oncological neoplasms in

personalized medicine. this is cell therapy from the name it is already clear that doctors take cells or tissues of the person himself, one of the directions is associated with dendritic cells. they regulate the immune response body in response to a tumor. and the second direction is actually ta-lymphocytes, these are killer cells that destroy tumor cells, david cells. uh, the laboratories receive blood from the patient's own monocytes , monocytes are isolated and further. they are loaded with tumor antigens. that is, these are the proteins that are on tumor cells. they tend to be different from proteins, e.g. the rest of the body's normal cells. e and further with the reverse introduction already into the patient's body. they start presenting. this is such a term present these tumor antigens to those lymphocytes naive to these cells and if,

provided that they have the appropriate receptors, they are different capable of recognizing this tumor. they are activated in the process of this recognition. and after that , the experience of a specific clone is actively dividing and having a high potential for the destruction of tumor cells . there are several subspecies. it cytokine-induced killer cells are , e.g., lymphocytes infiltrating the tumor and finally, and cortex cells are cells that carry chimeric antigenic recipes; the basis of the method is the same, lymphocytes are taken from the patient, either from the blood or from the tumor tissue of the surgical operation and beyond. they divide very many times and are activated due to the fact that we create such conditions and return to the patient the so-called comfortable cell therapy. now in the internet

of oncology, medical radiology is successfully passing the scientific project, doctors treat patients with 4-stage calorectal cancer with these cytokiller cells, but it's too early to talk about the results, because the project started only in may, we still have five patients, but we hope for a good result. i would like to elaborate on the therapy map. i believe that this therapy is the future, because these are already genetically modified cells of this hotel, the patient's lymphocytes, which are still being entered with the help of a virus that encodes chimeric antigen receptors. this is the recipe that can recognize tumor antigens with 100% probability. this, according to scientists, is a very promising method and is far from being available in all clinics of the world, even the leading ones, because the technique is very complicated . dollars is, but

this is due to the fact that the treatment is very expensive. mm. this is a commercial product, and it costs about $500,000 475,000 for a patient. and we have calculated, as it were, an approximate its cost is around 50,000. that is, nine times less there 10, in fact, the technique is suitable for patients with leukemia or foma. it has already shown its effectiveness, for example, there are patients who were in the first clinical trials of a commercial product. they have been living for 12 years. these are patients who by that day had exhausted all the possibilities of therapy, that is, patients are still in remission in our center, we treat patients with acellular forms. we have already been treated.