for all, emphasis on personification in pharmacology the development of personalized medicine is one of the priority areas of our science, what is it in general, and the director of the institute of physiology of the academy of sciences , it is there that most of the issues of the topic of interest to us today are being resolved. a technology that has boxes that have different cultures, uh, cells , can achieve the effectiveness of the treatment of not only such extensive e oncological diseases such such cells. we have in our databank, but of such interesting directions, given that the institute is largely supported by selective tests of already printed cells, namely, in the main living organism, there are certain successes in this regard, because

the primary models that we did in the eighteenth nineteenth year, and the so- called. just a monastery for the twenty- first year. we already have four printers that are a combination of cells. and it's a multi-layered culture. it must support its life activities. there are special solutions that do not give these. and lose their viability, and they do not stop dividing and washing with such multi -layered cellular ones, some kind of laboratory animals are involved, and it is more cell cultures that are already involved in order to persist one or another approach for the treatment of some pure external defects. in general, of course, infected medicine is the main future, because even aspirin preparations, which are prescribed for prevention, are radiovascular diseases. not all patients are suitable , some are sensitive, so even

there is used special tests adf and a test that allows you to evaluate the aggregation ability of there colors. and in general, what kind of anti-aggregate do the cells react to, because people over 50, who receive even more asterine drugs after sixty, in order not to run into such complications, in principle, xro. 450 in order to evaluate the effectiveness of this cytochrome work on the metabolism of incoming drugs, in addition to science, it is a huge adventure that some methods of treatment, especially oncological diseases. they all go based on the genetic code of a particular. uh, excellent power cell. the genetics of the genetics of the red disease and the genetics of the patients are very important, therefore, of course, all cases are difficult to respond to traditional treatment regimens. they just lie in the field

of genetic coding of oncology, in general, the treatment of any disease is impossible. what techniques we can’t do for everyone today , here comes a whole clinical experience and is interested. each journey for them the real quest of one side did not sound, but it is connected directly with this place - an ancient cemetery of microbes, which is more than 400 years old. well, i don’t know, i don’t know where to look for this underground passage, the swedish mountain is a whole archaeological complex. and what is behind us behind our backs is one of the tips of the iceberg. travel and solve cultural and historical puzzles, ready. let's go let's drive the project stone,

paper, scissors, watch on belarus 24 tv channel . northern gate. and there is one more gate south which was, that at least since the eighteenth year my traffic jams. their aunts lived here. that's what people are here for. he is wonderful.

belarus is intellectual and the whole country we are once again convinced of this we are building an innovative future and actively developing scientific and technological potential for the first time showed a vaccine that helps fight cancer laser technology, chips and microcircuits, completely on domestic components our specialists successfully enter the instrumentation competencies in various industries and allow us today to overcome the pressure of sanctions with dignity and help our ally in the main air project in this. watch on belarus 24 tv channel. we will continue to study him in the studio with our guest hello hello yegor vladimirovich lemeshko head of the multidisciplinary diagnostic laboratory of the institute

of physiology of the national academy of sciences of belarus candidate of medical sciences area of ​​scientific interests instrumental diagnostics in medicine telemedicine technologies, legal support health care cardiology therapy general medical practice human physiology. we have just learned what personalized medicine is in general. then. let's ask you. what is happening in medicine now? what is the name of the one that is still a priority all over the world, including in our state, today's medicine meets the principles of the four paragraphs. yes. this is a forecast. this is a warning. this is exactly the same personalized medicine and partnership, if you analyze each principle, then, uh, a forecast. this is mine, respectively. we predict geoprophylactic measures that prevent the development of complications. i am not health, personification. this is what you just talked about. the theme of our today's program. the point is that we

do not treat diseases, but a person was still said by mudrov, somewhere about three centuries ago, then they already came to this term. and today , such a state is being developed as much as possible, when we treat a person with his characteristics. eh, taking into account these features in the first place. this is about psychological characteristics. each in in general, he has his own type of personality , his own peculiarities, reactions to certain stimuli, etc., and some violations on the part of his function that he already has. all this will cause certain diseases and the body must resist this, and the first reacts unconditionally in the autonomic nervous system. and these are the features, how this system reacts in someone, what features of the mental state it has. all this must be taken into account in order for the treatment to be maximum. not to mention yes today we have protocols. we are all about them to the hook requires, then, uh, there are mechanisms

by which treatment can be refined, maybe something will change dramatically with the advent of personalized or personified differently called medicine. here is what was, what is, and what will be. here you can. maybe there are some basic criteria about what is there, probably some kind of transitional moment. we always paid attention to the individual patient, but the protocols set the framework, if such an opportunity arises, and it is more likely. all its features. it after all depends not only on the doctor. it depends a lot on the body. how organized is such a personalized approach, how are such conditions created so that a doctor, for example, can directly pay attention. that's specifically one patient well, it's impossible. we have many patients, but there is only one doctor, so we have to look for some compromises. well, and, accordingly, we have what we have, as it were, but we still go in the direction of the personified. actions of maximum consideration of individual moments, and what happened earlier there was less knowledge,

respectively, they treated what they understood what they could before, there was certainly less burden on the doctor. this is also due to a number of factors, and not only because the population is growing there. it is every day. well, they began to live longer, of course, and there are a lot of factors, yes, which also need to be taken into account, and time leaves us no choice we are somewhere to overtake. this life is such a basis for intersified medicine, according to experts , molecular and genetic research will become, including at our institute of genetics, these such cytology is already carried out. let's see the plot. the genetics of a person decides what kind of eyes he will have, what color hair , type of physique, and most diseases are also laid down at birth , genetic doctors call them hereditary studies of these particular pathologies. at the institute of genetics. national academy of sciences of belarus, if scientists manage to find

drugs that are responsible for what we are doing, if we are talking about science, about scientific research. this is the selection of some specific targets for the treatment of oncological diseases, and the second the direction is, uh, individual sensitivity to drugs , the same drug, if we are talking, let's say about the treatment of cardiovascular pathology. these are bisoprolls. type pirates who reduce this real pressure. uh, they can use at a dosage of 0.25 mg, then 50 mg and that's it. it also depends and is determined genetically. according to the peculiarities of the metabolism of these drugs , researchers are also studying the sensitivity to the chosen treatment. there are results of the treatment strategy or it still needs to be changed. joint research with the institute of psychiatry, which allows e, the right choice of antidepressants for the treatment of various neurological diseases. e, and. uh , probably, also one of such interesting

developments is the use of a genetic test in the selection of drugs for the treatment of viral hepatitis c, these drugs are very expensive. that is, they cost a few 500 or there thousand dollars, and these drugs are prescribed to the patient free of charge with the help of a genetic test. it is possible to determine the patient's sensitivity to this treatment and replace. e, respectively, the drug. naturally, no pills and doctors working in the direction of personalized medicine constantly focus on this will not be able to help if the patient does not change his lifestyle, and the doctors started from genetic data, as if directing their wards. people are being corrected, and the way of life is nutrition, because it is clear that some problems are called. and that's it development of personalized medicine using all kinds of tests. it's also genetic. it's chemical uh allow a person to correctly say to correct his question of life. in general

, do not put it that he must change in the way of life and carried out prevention for understanding. 4,000 belarusians have undergone genetic testing, without which individual medicine cannot do. the most frequent clients of the researchers are women who have encountered problems when planning a pregnancy. predicting the risks of developing multifactorial diseases is primarily miscarriage when using this test allows women who have problems with our pregnancies to withdraw the correct treatment during pregnancy and women give birth to a child. well, that is, this is one of these directions and the second direction is some two back. we took over again. we follow - these are various pathologies of the kidneys in children, and , first of all, the type of pathology of the kidneys

associated with the close development of various syndromes. these cytology to us in belarus however, a lot and still ahead for scientists, the future of medicine begins today. hello larisa anatolyevna svetlana my name is a patronymic. yes larisa larisa girl larisa girl larisa is very nice. walrus you are a master of disguise. that is, i know you. i already see, not for the first time. here you are the star thank you and doing the moonwalk. michael jackson you like. she is more in a hat today on saturday morning after the holiday you wake up a little earlier than she brings her i don’t know what turn on me and

the tv man. you are watching the project a good difference, belarus with svetlana borovskoy, breakfast is generally the most the interesting thing is that i never overeat at night, so i always have breakfast with such pleasure. that is, here i wake up right, and my mood rises, because i understand that i am looking for breakfast. we will help make the first meal tasty and healthy by selecting a few fruits. do not be shy and smell their sour smell, which indicates that most likely the fruit is overripe and even the process of decay has begun. and if you are a fish lover, then it's also very interesting, and zumba is so popular. today, that they cooperate with the company, but

world stars, such as, for example, shakira , we will not forget, we are an invigorating exercise. the movement takes place in our shoulder blades, the shoulder blades move behind the ribs, they are good along them, and we add to this movement the movement of the body. watch the breakfast of champions on belarus 24 tv channel in the program. together, we will pay attention to the events that became a global catalytic event, after which we will look for the cause of what happened and analyze who tends to talk a lot, but do nothing, europe was multicultural and tolerant only in words stupidity and the fear of liberals does not depend on the country and passport. but this is different in the author's project is different. watch new releases on belarus 24 tv channel. on the air of science addiction, we

continue to understand personalized medicine and save millions of new models. why personalized medicine is beneficial and what new generation drugs are being developed at the scientific and practical oncology center for medical radiology, you will find out very soon. that is, i know that this is one of the key scientific institutions. that's it for this topic. in the structure of the academy of sciences , the institute of physiology is engaged in the biomedical direction. this is the main institution scientific and uh, as regards directly non-property the location of the patient. this system is completely personalized. that is, each patient has a wearable medical device that registers his physiological parameters

in real time and transmits it to the remote workplace, in turn, the doctor, wherever he is. and can receive this information, if it is disturbing for some reason parameters, this allows you to react in time, and not delay the time until the next dose somewhere in time. take a pill that corresponds to some other manipulation, and everything will be fine. this is up to the point that robin's team will be called to this place where the person is located to notice similar changes in the body. sometimes even life-threatening, and our system is aimed at detecting such things in time and responding to them. now. let's talk about drugs, because many people think that, that is, they fixed medicine means that everything will disappear . aspirin is citramone, which helped everyone, and there will be a pill for everyone, so the question arises. where will there be so many pharmacies and how will it be,

but in fact, pharmacology, yes, the emphasis is also on personification, but this is a different situation. i understand correctly, of course, just such a universal pill for a particular patient is very unlikely that we will come to this. maybe someday, but so far it is even very difficult to predict. and in general, uh somehow imagine how calculated this mechanism is. and all this needs to be studied and , accordingly, new medicines should be developed, and they will certainly be made and used in practical healthcare until the development of medicines . it will probably be like this, as we will see it now, in order to have time to overcome the obstacles that we have. in general, in the life of some such universal tablets. well, so far, nelogiy is already being conducted in the rpc of oncology and radiology. i suggest watching the story. earlier

it was believed that all malignant tumors have approximately the same components. that is why they tell in the scientific and practical center of oncology the ideologies and treatment regimens were essentially the same. today, the doctor knows the molecular biological characteristics of all people are different, and this does not pose a new task for the medic create a drug that would take into account the characteristics of tumor development, but the genetic level is a unique genetic level, which directly affects the effectiveness therapy and the aggressiveness of her behavior. and these characteristics can change during treatment, so initially effective chemotherapy regimens may turn out to be ineffective as the disease progresses, a personalized approach does not contradict conventional therapy regimens, but complements them and makes them more effective. its essence lies in the use of specific drugs aimed at the molecular solution, therefore they are not called target-directed or

targeted drugs. act more selectively. the main thing is to find molecular targets in the tumor , genetic testing copes with this task. the official effectiveness of targeted drugs is based on conducting molecular genetic testing at the present time, and the entire spectrum of molecular genetic studies for the selection of targeted therapy for cancer patients, and in the republic , the republican molecular kinetic laboratory is carried out the material of patients, e, in which the issue of the significance of this type of therapy is considered, followed by genetic testing, and the methods of genetic testing are quite diverse; the main ones are polymerase chain reaction molecularity, quinning, legal institutes and other methods. these are very time-consuming methods that also require highly qualified

specialists, which determines the expediency of concentrates. it is clear that doctors take the cells or tissues of the person himself one of the directions is associated with dendritic cells. they regulate the body's immune response in response to a tumor. this is a tumor cell on the third cell, e., the laboratory receives blood from the monocytes of the patient himself, the patient's blood is taken, monocytes are isolated and further. they are loaded with tumor antigens. that is, these are the proteins that are on tumor cells. they are usually from a vibrator administered already in the patient's body. they begin to present it, well, such a term to represent these tumor antigens those lymphocytes naive these those cells and if provided they have the appropriate receptor. they are able to recognize this tumor. they are activated in the process of this recognition. and after that , they actively divide and have a high potential for the destruction of tumor cells . a specific clone is formed by experience. but

you need talifocytes, there are several subspecies. these are cytokines, strangled killer cells. this is, uh, lymphocytes, infiltrating the tumor, and finally, cortex cells are the cells that carry the chimeric antigenic recipe, the basis of the method is the same lymphocytes are taken from the patient, either from the blood or from the tumor tissue during the surgical operation and beyond. they are very many times divided are activated at the expense. now oncology medical radiology is successfully passing the scientific project doctors treat patients with colorectal cancer at the fourth stage. here are the cells from the outside, but it's too early to talk about the results, because the project started only in may, we still have five patients. well, we hope for a good result. i would like to elaborate on the therapy map. i think that behind this therapy is the future, because it is already genetically modified cells this, hotel lymphocytes are able to recognize.

tumor antigens with 100% probability is, according to scientists, a very promising method and is far from available in all world clinics, even leading ones, because the technique is very complicated . the first commercial product was, uh, registered in the usa in 2017 and since then for several years, the market has been worth more than one and a half billion dollars, but this is due to the fact that the treatment is very expensive. mm. here it is, and we have calculated, as if the approximate cost is somewhere around 50,000. that is, nine times less there 10, in fact , the technique is suitable for patients with leukemia or lymphomas. it has already shown its effectiveness , for example, there are patients who were in the first clinical trials of a commercial product. they have been living for 12 years already, this patient, who on that day they had exhausted all the possibilities of therapy, that is , patients are still in remission in our center, we treat patients with running cellular

minimum forms, we have already treated five four patients have already been under observation for quite a long time. one patient last week saw either cells, uh, and a sixth.