oh, that's it, that's it, that's it, run, so, here we have, here we have professor goose, they are not very happy, it's not for nothing that they saved the goose, eh, no one needs to be saved, guys, relax, we 're leaving, we live on, we continue, we breathe, inhale-exhale. so what's inside, and how do they, and how do they, it seemed to me that they live in water, well , in general, water is needed only so that their fur has a treacherous appearance, so that they can wash themselves, well, in general, they are clean animals, they always wash all their food first, only after that they eat, oh, in front of you, did you come to meet them or do you want to run away, they are very sharp teeth very more hello, oh so uninteresting. does not look like beavers, swamp

wobblers, and i was also told that here you can meet real knights, that's how bestuka, yes, hello, the knight's club was founded in the ninety-third year since that time on the territory of rechitsa is engaged in historical reconstruction. you are created life, culture, history, and also pays special attention to equipment clothes, well you understand, yes, i have to try it on, say that it is comfortable, no, but i feel more confident, yes more protected for this truth, of course, the process is not fast, obviously you need experience, listen, well, it's a bit hard, comfortable , no, but... but it's reliable, well, of course, a sword,

necessarily the attributes of a knight, thank you very much to the knights for the warm welcome and hospitality, and i've already forgotten why i came to the equestrian complex, now i'll ride a horse a couple of laps and go to... another equally colorful place. hello!

what do we need for this? so, first we take kefir, well, i see that there are no supernatural products here, everything that everyone has in the refrigerator, i i think, i think that every housewife will always have this, this is kefir, we pour in soda, we extinguish it with kefir, so that it, so that they then pancakes will rise, we take a pinch of soda, then we add eggs, a little sugar, a little salt the most important ingredient is flour, what consistency should it be? like thick sour cream, oh, everyone says, like thick sour cream, in the end it always turns out differently, that's what it means, that's exactly what we need, that's it, yes, yes, let's, let's also mix it thoroughly, it seems to me, that you can already make some kind of pie out of this, and not a pancake, everything is great, the dough is ready, we go to the oven, great, under the guidance of the hostess we pour the dough onto the heated...

frying pan and put it in the oven, and so we put the pancake on the coals so that it becomes ruddy, crispy, we put it on the coals, here, that's right. not far and we wait, i don't cover it with a lid, we don't cover it with a lid, nothing, nothing, there is enough heat there, our pancake with you will be baked yellow, ruddy, it will be like a round sun, beautiful and delicious, the first pancake is not so good and that makes me happy, the second and third were much easier, i'll praise myself a little, in my opinion my pancakes turned out very beautiful, let's taste this beauty, well, bon appetit, thank you , well i'll note this incredible smell once again, mm, with sour cream - it's just some kind of magnificence, m, now it will be hard

to stop me, you're welcome, thank you, you can safely recommend the recipe, you know not only recommend it, but also use it, cook it for your whole family and please yourself and your loved ones. everyone, that's for sure, very tasty pancakes, and as i understand it, this is the very museum that the owner was talking about, what we have here, household items, suitcases, well, beauty, some kind of retro radio or transmitter, i'm honestly not strong in this, here i ... will need the help of a guide, it's interesting, here is a very interesting exhibit, for example, it very much

resembles the means of transportation of one well -known character, or to be more precise , a woman, a very famous one, such fascinating, well, see you on new routes in our beautiful belarus! production of medicines - quite a responsible mission, we, of course, understand for ourselves where we work, we know

that in the future these drugs will be taken by people, for some this drug may be the only hope for improving their health, therefore we approach our work with maximum responsibility. the goal is one - to develop an effective and safe drug that will subsequently help save human life and health. my name is olga zakharevich, i am the head of the drug development laboratory of the borisov plant of medicines drugs. our company is trusted with the most valuable thing - health.

my working day begins at 8:00 in the morning, i come to work, assess the situation. test dissolution medium, phosphate buffer solution with a ph of 6.8, volume 900 ml, speed of the spare crusher 50 rpm, time 120 minutes, well, we have

many laboratories, but each performs its own function, that is, there is an analytical laboratory in which drugs are tested during drug production. each series is subject to control quality. there is a microbiological laboratory, it is also responsible for quality control, but already by... there is a production and technological laboratory, which is engaged in the improvement of existing technologies . the sanitary and industrial laboratory conducts tests of maximum permissible concentrations in the air in the working area. in our laboratory , the first steps of a drug begin and, accompanied by our specialists, it takes pride of place. now we are in the room

of process engineers and chemists, where employees are working with documents, victoria is currently working on a drug that is at the initial stage of development, she is selecting the composition and suggests a technological process. for the treatment of diabetes, the drug development laboratory is engaged in the development of drugs, as a rule, these are reproduced drugs, the molecule of which is already on the market, the so-called generics, the development of drugs is a complex multi-stage process, the development period varies from 3 to 5 years, the average amount of development. from 400 thousand belarusian rubles, sometimes the amounts are calculated in millions, but everything

depends on the specifics of the drug. development of drugs is carried out within the framework of the import substitution program, the state scientific and technical program, sometimes with the involvement of budgetary funds, within the framework of the working program of the enterprise. today, in the working prospective program 40 drugs, each is at its own stage of development, which begins development, on the basis of market analysis, the marketing department proposes a particular drug for development. we receive an offer from the ministry of health or a holding company, but it is included in the development program only after an assessment of the possibility of production on existing equipment. for the production of some forms , it is necessary to purchase additional

equipment, additional materials, and sometimes it is necessary to build a new production site, a drug that is appropriate for development is included in the development program, then there is a search for substances, source materials, a patent search is carried out, that is, does the drug have any patent protection after? we begin development in laboratory conditions, the choice of the manufacturer of the substance and auxiliary substances, the quantitative composition, the qualitative composition of the drug, occurs at the development stage. the purchase of substances, auxiliary materials is carried out in different countries. there are indian, chinese, italian substances. we are in the storage department of raw materials,

active pharmaceutical ingredients excipients. mainly in the production of solid dosage forms , excipients such as microcrystalline cellulose, sodium starch glycolate, lactose, sodium carbonate, glucose, monohydrate and others are used. it should be said that on... our laboratory is well equipped, this is high-precision equipment, we have technological equipment that is as similar as possible to production equipment in its design features, which allows us to reduce the risks when transferring technologies to industrial conditions. after the engineer -technologist has calculated the preparation of the tablet mass and prepared. stations and auxiliary substances, he begins experimental laboratory loadings.

this type of production is as close as possible to production, there is equipment in terms of design features, very similar to production, only smaller in size. in this case , the production of the mass was carried out first by moistening, at this stage it is carried out. granulate carcass, the next stage will be granulation to obtain a more uniform granulate, followed by powdering, after which we will have tableting. coating with a shell, and after that we will work out quality control methods in our laboratory, on our analytical base. this experimental batch is produced in small quantities, necessary for further testing. after completing the development work in laboratory

conditions, we need to develop a pilot industrial series for drug registration. pilot industrial series is produced in industrial conditions, will be used for clinical trials or for testing quality control methods. as a rule, clinical trials are not conducted for all medicinal feed, injection solutions, ointments, clinical trials are usually not conducted. mandatory conditions for conducting clinical trials on people must have a report on the comparative dissolution kinetics test in laboratory conditions. what is this test? simulates the gastrointestinal human tract. the tablets dissolve in three environments: in an acidic environment, hydrochloric acid and

alkaline. and when dissolving the original drug and the drug. we develop in our laboratory, we must achieve a certain similarity coefficient, a report is compiled, the methods of this test are validated, in the future we can say with confidence that the drug can be used in human studies. groups of volunteers take the original drug and the drug being developed at the same time. our plant, equivalence is determined by the level of the active substance in the volunteer's blood, as if the drug is recognized as equivalent or not equivalent to the original. clinical trials are conducted to prove the effectiveness and safety of the drug and equivalence

to the original drug. after conducting clinical trials ...

from a wide range of action, twelve pharmacotherapeutic groups, treatment of cardiovascular diseases, neurological diseases, infectious diseases, diabetes mellitus, at the plant liquid dosage forms are produced, these are injection solutions, tinctures, soft dosage forms, liniment, ointments, gels, solid dosage forms, tablets, capsules, powders for injections. a solid dosage form, yes, it is

a really affordable form, uh, which you can always take with you and... therefore, of course, the largest production of our enterprise is solid dosage forms. before the start of tablet production , a preparatory operation takes place, equipment cleaning, a mandatory condition is compliance with the microclimate, therefore the workshop personnel always monitor the air preparation, temperature of the production premises. we receive permission to manufacture products from the quality control service after the conclusion on the proper cleaning of the equipment. we find. in the workshop for the production of solid dosage forms number four. in this workshop, the production of tablets, capsules, film-coated tablets

, modified- release tablets is carried out. now we are at the first stage of production, this is weighing necessary components for a series of medicinal products. we are currently in the department of preparation of tablet mass by the wet granulation method. unfortunately, not all components are free-flowing and can be produced by direct mixing. for this purpose, there is a wet granulation method. initially, the components are moistened, then transferred to the drying stage. in this way, we obtain granulate that is heterogeneous in fractional composition. next, in order for us to have a homogeneous granulate, we transfer it to the granulation stage, the mass is passed through a certain sieve diameter, and we get

a uniform granularity, we just need to add sliding substances in order to fill the matrix of the rotary table in the tablet press , we get tablets that are uniform in weight and uniform in dosage, then comes the stage... are transferred to the stage of packing the package. film coating can serve to mask the taste of the tablet, to make it easier

to swallow, there are enteric coatings and other coatings that are needed for a certain function in the body. tablets have different shapes, and can have spherical shape, flat-cylindrical. tablets may have a risk. to divide the dose into two equal parts, the size of the tablet depends on the dosage of the drug, there are large-dose, there are small-dose drugs, as well as auxiliary components that are part of the tablets. the size of the tablets can vary from 6 mm in diameter to 14 mm in diameter, different heights have. tablets, the size of the tablet determines the equipment in which it will be further packed. after the packaging stage, the blisters are sent to

packaging line, the line is equipped with control systems. one control system allows you to evaluate the correctness of the insertion of blisters into the pack, that is, if the insertion is insufficient, the system rejects this pack. here. we see that there is nothing in this pack. the next control system is the correctness and clarity of the application of data on the expiration date and series of drugs. if the data is not clearly visible, the system will also stop the machine or reject this or that paste. control is carried out during the production process quality. intermediate products before packaging, samples of the drug are taken, transferred to the quality control laboratory, tests are carried out,

a quality certificate is issued, and then the product is transferred to the packaging stage, and after the packaging stage it undergoes repeated quality control, a passport is issued for the finished product, which indicates compliance.

production is almost continuous, since we are obliged to ensure the release of sterile injection drugs. now we are in the heart of ampoule production, here the filling and sealing of ampoules takes place. this line is in the highest frequency class b and is equipped with local zones a. the filled ampoule comes out. and then gets into the autoclave, in which the sealing is checked or the ampoules are sterilized, depending on what kind of drug we produce, we produce drugs in ampoules from one to 5 ml. the second workshop produces liquid and soft drugs. the third and fourth

workshops are solid dosage forms, tablets, capsules. the fifth workshop specializes in on the release of sterile antibiotic powder. number five produces up to 28.5 million vials per year. in particular, this is the name of sterile powder for injection in a dosage of 0.5.1 g. raw materials are received in sterile containers, which are then moved to the raw materials. frequency class b rooms and then from these first rooms after all the studies are carried out, it is moved directly to the salting stage, then with the help of a microgalzirovanie machine it is first poured into vials, sealed with sterile rubber stoppers and crimped sterile aluminum caps with a plastic flip, then undergoes

the procedure... chipping, visual inspection, labeling of the package. in this form, the finished product is moved to quarantine storage, and then loaded by the workshop to the finished product warehouses and from there moved to consumers. when taking medications, the dosage should be taken into account, if the instructions for use contain a recommendation. doctor, then this must be done without fail, also after you have purchased the drug in the pharmacy, even my big request, be sure to take into account the storage conditions, if the drug is photosensitive, then under the influence of light there may be some changes, the effectiveness of this drug may fall, in each

leaflet. the insert indicates how when to take the drug before meals, after meals, before bed, in the morning, and so on. the information specified in the instructions for use is not written just like that, but so that the consumer strictly follows it. the effectiveness and the safety of this drug and its effect on the body. the pharmaceutical industry in belarus is at a fairly high level. our drugs are in no way inferior in quality to imported drugs, since raw materials of proper quality are used to produce these drugs. in the development process , efficiency and safety are proven, in the production process, all production stages are monitored and the quality

of drugs is controlled. every year about 50% the products are exported, the sales geography covers such countries as the republic of moldova, the eac countries, the cis countries, turkmenistan, tajikistan, uzbekistan, iraq, syria, afghanistan and other countries.